Motif ID: HSF1,2.p2

Z-value: 1.827


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2



Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_44723116 2.072 NM_001190823
SMAD7
SMAD family member 7
chr14_-_21108714 1.651 NM_001005465
OR10G3
olfactory receptor, family 10, subfamily G, member 3
chr22_-_35011703 1.431 MYH9
myosin, heavy chain 9, non-muscle
chrX_+_115215985 1.338 NM_000686
AGTR2
angiotensin II receptor, type 2
chr10_+_104525877 1.154 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr13_-_97916768 1.052 STK24
serine/threonine kinase 24
chr2_+_113973130 1.031 NM_012184
FOXD4L1
forkhead box D4-like 1
chr18_+_29573152 1.003 ASXL3
additional sex combs like 3 (Drosophila)
chr19_-_47638890 0.986 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr9_+_108726257 0.978 ZNF462
zinc finger protein 462
chr17_+_9686572 0.975 GLP2R
glucagon-like peptide 2 receptor
chrX_+_27736027 0.956 NM_182506
MAGEB10
melanoma antigen family B, 10
chr9_-_72926333 0.949 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr3_+_191588354 0.943 NM_006580
CLDN16
claudin 16
chr2_-_240613480 0.914 NM_004544
NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr11_-_404975 0.908 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr5_+_147423727 0.908 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr2_-_100125402 0.889 NM_002285
AFF3
AF4/FMR2 family, member 3
chr2_-_210876560 0.878 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr16_-_2254318 0.850 RNPS1
RNA binding protein S1, serine-rich domain
chr22_+_38652555 0.848 GRAP2
GRB2-related adaptor protein 2
chr8_-_13018123 0.847 NM_001164271
DLC1
deleted in liver cancer 1
chr1_+_149437602 0.826 NM_001135636
NM_001135637
NM_001135638
NM_003557
PIP5K1A



phosphatidylinositol-4-phosphate 5-kinase, type I, alpha



chr5_-_110090264 0.794 NM_001039763
TMEM232
transmembrane protein 232
chr17_-_60439764 0.791 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr12_-_11230809 0.789 NM_181429
TAS2R42
taste receptor, type 2, member 42
chr20_+_35583020 0.785 NM_005386
NM_181689
NNAT

neuronatin

chr4_-_160175782 0.785 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr2_-_240613357 0.753 NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr12_+_8557402 0.746 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr9_+_83748234 0.744 NM_207416
FAM75D3
family with sequence similarity 75, member D3
chr9_-_21218132 0.743 NM_021268
IFNA17
interferon, alpha 17
chr15_+_45263517 0.733 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr21_+_30724442 0.728 NM_181600
KRTAP13-4
keratin associated protein 13-4
chr13_-_99422163 0.715 NM_033132
ZIC5
Zic family member 5 (odd-paired homolog, Drosophila)
chr13_+_51496679 0.713 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr12_+_1596482 0.709 NM_030775
WNT5B
wingless-type MMTV integration site family, member 5B
chr8_-_125649926 0.708 MTSS1
metastasis suppressor 1
chr4_-_122304925 0.708 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr2_+_214984705 0.699 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr1_+_179164195 0.696


chr12_+_4569504 0.692 NM_003845
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr10_+_95838801 0.682 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr4_-_101658094 0.682 NM_001159694
NM_016242
EMCN

endomucin

chr14_+_74968589 0.676 NM_001135049
JDP2
Jun dimerization protein 2
chr20_+_9146036 0.676 NM_182797
PLCB4
phospholipase C, beta 4
chr15_+_52092392 0.672 NM_001080534
UNC13C
unc-13 homolog C (C. elegans)
chr17_+_7125702 0.667 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr11_-_56137553 0.664 NM_001004740
OR5M1
olfactory receptor, family 5, subfamily M, member 1
chr5_-_42211112 0.655


chr2_-_224611568 0.647 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr14_+_102636233 0.645 NM_001077594
EXOC3L4
exocyst complex component 3-like 4
chr12_-_14024187 0.642 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr7_+_18296569 0.636 HDAC9
histone deacetylase 9
chr12_-_119172339 0.631 NM_025157
PXN
paxillin
chr2_-_37727472 0.626 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr19_+_6086650 0.624 NM_030924
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr12_-_51298599 0.619 NM_175068
KRT73
keratin 73
chr6_+_54281161 0.615 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr16_+_88207216 0.605 NM_001128141
DPEP1
dipeptidase 1 (renal)
chr12_+_6514645 0.602 GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chrX_-_107112244 0.594 NM_031273
TEX13B
testis expressed 13B
chr2_-_219742950 0.593 NM_001144889
NM_001144890
NM_144712
SLC23A3


solute carrier family 23 (nucleobase transporters), member 3


chr9_-_106420305 0.593 NM_001001956
OR13C9
olfactory receptor, family 13, subfamily C, member 9
chr8_-_142307854 0.592 NM_001080431
SLC45A4
solute carrier family 45, member 4
chr19_+_2240996 0.589


chr6_+_129245978 0.588 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr11_+_118347626 0.583 NM_181721
FOXR1
forkhead box R1
chrX_-_32340291 0.582 NM_004011
NM_004012
DMD

dystrophin

chr18_+_30427279 0.582 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr11_-_69922112 0.578


chr20_+_56861430 0.576 NM_001077490
NM_080425
GNAS

GNAS complex locus

chr11_+_48303047 0.575 NM_001004702
OR4C3
olfactory receptor, family 4, subfamily C, member 3
chr3_-_57088332 0.574 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr3_+_98016114 0.573 NM_001080448
EPHA6
EPH receptor A6
chr14_+_38714111 0.572 NM_002687
PNN
pinin, desmosome associated protein
chr16_+_82540172 0.563 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr19_-_10152056 0.562


chr3_+_123817151 0.556 NM_152615
PARP15
poly (ADP-ribose) polymerase family, member 15
chrX_-_64055741 0.552 ZC4H2
zinc finger, C4H2 domain containing
chr6_+_32713160 0.552 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr5_+_17270781 0.550 BASP1
brain abundant, membrane attached signal protein 1
chr12_+_10351683 0.550 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr13_-_45577144 0.548 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr9_+_36159384 0.547 NM_005893
CCIN
calicin
chr8_-_125785611 0.546 MTSS1
metastasis suppressor 1
chr2_-_217433018 0.542 NM_003284
TNP1
transition protein 1 (during histone to protamine replacement)
chr17_-_9803490 0.541 NM_003644
GAS7
growth arrest-specific 7
chr1_+_110254979 0.540 CSF1
colony stimulating factor 1 (macrophage)
chr9_+_42707229 0.536 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr17_+_30498948 0.536 NM_001033576
NM_173167
UNC45B

unc-45 homolog B (C. elegans)

chr1_-_102234959 0.534 OLFM3
olfactomedin 3
chr9_-_27287106 0.531 NM_001161585
NM_020641
C9orf11

chromosome 9 open reading frame 11

chr3_-_131081910 0.531 NM_001017395
TMCC1
transmembrane and coiled-coil domain family 1
chr9_-_34579679 0.529 NM_001842
NM_147164
CNTFR

ciliary neurotrophic factor receptor

chr14_-_74400288 0.526 NM_001080408
PROX2
prospero homeobox 2
chr9_-_89939719 0.525 NM_001166137
FAM75C2
family with sequence similarity 75, member C2
chr11_-_121492010 0.524 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr9_+_70107602 0.523 NM_199135
FOXD4L3
FOXD4L6
forkhead box D4-like 3
forkhead box D4-like 6
chr8_+_32698892 0.523 NM_001159996
NRG1
neuregulin 1
chr14_-_56346849 0.522 NM_021728
OTX2
orthodenticle homeobox 2
chr15_+_74416129 0.522 ISL2
ISL LIM homeobox 2
chrX_-_106033202 0.519 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr9_-_21067804 0.519 NM_002176
IFNB1
interferon, beta 1, fibroblast
chr14_-_102500694 0.515 CDC42BPB
CDC42 binding protein kinase beta (DMPK-like)
chr17_+_73738985 0.514 NM_001145529
TMEM235
transmembrane protein 235
chr2_+_207512522 0.514 NM_173077
CPO
carboxypeptidase O
chr9_-_108416 0.514 NM_207305
FOXD4
forkhead box D4
chr11_+_69176391 0.512 CCND1
cyclin D1
chr1_+_157246305 0.508 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr4_+_71298187 0.508 NM_021225
PROL1
proline rich, lacrimal 1
chrX_-_134764397 0.508 NM_001017436
CT45A3
CT45A4
CT45A2
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A4
cancer/testis antigen family 45, member A2
chr9_-_116732403 0.505 NM_001244
TNFSF8
tumor necrosis factor (ligand) superfamily, member 8
chr10_+_90474280 0.504 NM_001080518
LIPK
lipase, family member K
chr22_+_36401558 0.502 NM_002305
LGALS1
lectin, galactoside-binding, soluble, 1
chr22_+_27998367 0.500 EWSR1
Ewing sarcoma breakpoint region 1
chr17_+_7225088 0.499 NM_003985
TNK1
tyrosine kinase, non-receptor, 1
chr9_+_831689 0.496 NM_021951
DMRT1
doublesex and mab-3 related transcription factor 1
chr14_+_88130482 0.495 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr3_+_115495522 0.495 NM_173799
TIGIT
T cell immunoreceptor with Ig and ITIM domains
chr3_+_52212969 0.494 ALAS1
aminolevulinate, delta-, synthase 1
chr4_-_77042599 0.493 NM_006239
PPEF2
protein phosphatase, EF-hand calcium binding domain 2
chr16_+_88207457 0.493 DPEP1
dipeptidase 1 (renal)
chr9_-_96130746 0.493 NM_017561
FAM22F
family with sequence similarity 22, member F
chr5_+_180514548 0.493 NM_206880
OR2V2
olfactory receptor, family 2, subfamily V, member 2
chr17_-_44058612 0.491 NM_024017
HOXB9
homeobox B9
chr3_+_51403760 0.490 NM_013286
RBM15B
RNA binding motif protein 15B
chr19_-_53941835 0.481 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chr17_+_17339059 0.479


chrX_-_30817329 0.476 NM_152787
TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr11_-_113971607 0.474 FAM55D
family with sequence similarity 55, member D
chrX_-_33139349 0.474 NM_004006
DMD
dystrophin
chr6_-_128263868 0.472 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chrX_+_134693879 0.472 NM_001017436
NM_152582
CT45A3
CT45A4
CT45A2
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A4
cancer/testis antigen family 45, member A2
chr9_-_138762725 0.471 NM_198946
LCN6
lipocalin 6
chr20_+_44180355 0.469 CD40
CD40 molecule, TNF receptor superfamily member 5
chr2_+_102345528 0.469 NM_003855
IL18R1
interleukin 18 receptor 1
chr12_-_12994584 0.468 NM_018654
GPRC5D
G protein-coupled receptor, family C, group 5, member D
chr8_-_93181091 0.468 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr12_+_11694172 0.464 ETV6
ets variant 6
chr12_-_55614311 0.463 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chrX_-_154216929 0.462 NM_001289
CLIC2
chloride intracellular channel 2
chr17_-_37590910 0.459 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr2_+_210152399 0.459 MAP2
microtubule-associated protein 2
chrX_-_52700674 0.457 NM_173358
SSX7
synovial sarcoma, X breakpoint 7
chr7_-_11643113 0.455 THSD7A
thrombospondin, type I, domain containing 7A
chr14_+_104218487 0.454


chr17_+_35075124 0.452 NM_003673
TCAP
titin-cap (telethonin)
chr18_-_71268576 0.447 NM_001037331
C18orf62
chromosome 18 open reading frame 62
chr14_-_69616616 0.446 NM_182936
NM_001130417
SLC8A3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr15_+_22772545 0.445 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr2_-_39040981 0.445 LOC375196
hypothetical LOC375196
chr5_-_95044415 0.443 NM_031952
SPATA9
spermatogenesis associated 9
chr12_-_21818881 0.443 NM_004982
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr2_+_222871109 0.442 NM_153038
CCDC140
coiled-coil domain containing 140
chr16_-_88358946 0.436 FANCA
Fanconi anemia, complementation group A
chr9_-_126309510 0.436 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr4_+_114433551 0.432 ANK2
ankyrin 2, neuronal
chr16_+_31401939 0.426 NM_003041
SLC5A2
solute carrier family 5 (sodium/glucose cotransporter), member 2
chr4_+_5577783 0.424 NM_005750
C4orf6
chromosome 4 open reading frame 6
chr22_-_30919386 0.422 NM_006605
RFPL2
ret finger protein-like 2
chr12_-_14982708 0.420 NM_152321
ERP27
endoplasmic reticulum protein 27
chr2_+_143603439 0.417 ARHGAP15
Rho GTPase activating protein 15
chr11_-_100959868 0.414 NM_004621
TRPC6
transient receptor potential cation channel, subfamily C, member 6
chr1_+_157824239 0.414 NM_001639
APCS
amyloid P component, serum
chrX_-_131989963 0.413 NM_031907
USP26
ubiquitin specific peptidase 26
chr5_-_112798436 0.410 NM_032028
TSSK1B
testis-specific serine kinase 1B
chr9_-_106401514 0.409 NM_001004482
OR13C5
olfactory receptor, family 13, subfamily C, member 5
chr3_+_189425886 0.409 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chrX_+_152454773 0.404 NM_001001344
NM_021949
ATP2B3

ATPase, Ca++ transporting, plasma membrane 3

chr11_-_113971681 0.403 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr19_+_49455872 0.403 NM_181756
ZNF233
zinc finger protein 233
chr12_-_7153068 0.402 NM_016546
C1RL
complement component 1, r subcomponent-like
chr2_+_241213334 0.400 NM_005301
GPR35
G protein-coupled receptor 35
chr17_-_76897590 0.399 NM_178519
C17orf55
chromosome 17 open reading frame 55
chr7_-_4867963 0.397 NM_020144
PAPOLB
poly(A) polymerase beta (testis specific)
chr2_-_215998181 0.396 FN1
fibronectin 1
chr20_+_44180296 0.396 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr8_-_38324809 0.395 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chrX_-_102234606 0.394 NM_022052
NXF3
nuclear RNA export factor 3
chr9_+_124526089 0.393 NM_001005235
OR1L4
olfactory receptor, family 1, subfamily L, member 4
chr8_-_131483395 0.393 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr17_-_32368033 0.393


chr3_-_184756101 0.392 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr4_+_93444572 0.392 NM_001510
GRID2
glutamate receptor, ionotropic, delta 2
chr17_+_41424665 0.389 MAPT
microtubule-associated protein tau
chrX_-_102661072 0.387 NM_080879
RAB40A
RAB40A, member RAS oncogene family
chr8_-_18710575 0.386 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr17_-_1037312 0.385 NM_001159746
ABR
active BCR-related gene
chr9_-_90983195 0.384 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr14_-_59407103 0.384 NM_021136
RTN1
reticulon 1
chrX_-_102418329 0.383 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr3_-_74652952 0.383 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr19_-_2036227 0.382 MOBKL2A
MOB1, Mps One Binder kinase activator-like 2A (yeast)
chr15_-_77994652 0.382 NM_001100879
ST20
suppressor of tumorigenicity 20
chr9_-_90983501 0.382 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr6_+_159510416 0.381 NM_032532
FNDC1
fibronectin type III domain containing 1
chr10_-_104587069 0.380 NM_000102
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr22_-_25343959 0.378 NM_001887
CRYBB1
crystallin, beta B1
chr12_-_121224676 0.378 NM_001014336
IL31
interleukin 31

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 2.89e-09 GO:0032501 multicellular organismal process
1.18 9.16e-06 GO:0050896 response to stimulus
1.25 1.09e-04 GO:0007275 multicellular organismal development
1.26 7.64e-04 GO:0048731 system development
1.50 1.07e-03 GO:0040011 locomotion
1.33 2.47e-03 GO:0003008 system process
1.30 2.97e-03 GO:0030154 cell differentiation
1.20 3.62e-03 GO:0032502 developmental process
1.23 3.76e-03 GO:0048856 anatomical structure development
1.28 5.88e-03 GO:0048869 cellular developmental process
2.47 1.13e-02 GO:0048754 branching morphogenesis of a tube
1.56 2.17e-02 GO:0006928 cellular component movement
1.42 2.35e-02 GO:0048468 cell development
6.51 3.12e-02 GO:0048880 sensory system development
6.51 3.12e-02 GO:0048892 lateral line nerve development
6.51 3.12e-02 GO:0048895 lateral line nerve glial cell differentiation
6.51 3.12e-02 GO:0048925 lateral line system development
6.51 3.12e-02 GO:0048937 lateral line nerve glial cell development
6.51 3.12e-02 GO:0050935 iridophore differentiation
1.72 3.33e-02 GO:0007411 axon guidance
5.02 3.89e-02 GO:0048484 enteric nervous system development
1.56 4.97e-02 GO:0006935 chemotaxis
1.56 4.97e-02 GO:0042330 taxis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.49 9.71e-06 GO:0044421 extracellular region part
1.20 4.10e-05 GO:0071944 cell periphery
1.20 7.06e-05 GO:0005886 plasma membrane
1.27 1.73e-03 GO:0005576 extracellular region
2.63 5.70e-03 GO:0005604 basement membrane
1.62 1.18e-02 GO:0031012 extracellular matrix
1.41 1.36e-02 GO:0005615 extracellular space
2.15 2.03e-02 GO:0044420 extracellular matrix part
1.65 2.82e-02 GO:0005578 proteinaceous extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.99 3.42e-02 GO:0004866 endopeptidase inhibitor activity
1.97 3.50e-02 GO:0061135 endopeptidase regulator activity
1.94 4.68e-02 GO:0030414 peptidase inhibitor activity