Motif ID: IRF1,2,7.p3

Z-value: 1.496


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7



Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_111900650 2.933 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr15_+_42790951 2.645 NM_004048
B2M
beta-2-microglobulin
chr10_+_91082218 2.623 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_+_78858675 2.534 NM_006820
IFI44L
interferon-induced protein 44-like
chr10_+_91142301 2.310 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr1_+_157246305 2.037 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr15_-_42790805 1.967


chr14_+_34521945 1.695 SRP54
signal recognition particle 54kDa
chr4_+_144654526 1.561


chr9_+_21399132 1.455 NM_002170
IFNA8
interferon, alpha 8
chr6_-_138231006 1.444


chr10_+_91051685 1.436 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr7_+_10979978 1.420 NM_014660
PHF14
PHD finger protein 14
chr20_-_45410033 1.355 ZMYND8
zinc finger, MYND-type containing 8
chr19_+_17377502 1.340 LOC100507535
hypothetical LOC100507535
chr10_+_91077581 1.316 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr19_-_17377383 1.283 NM_004335
BST2
bone marrow stromal cell antigen 2
chr6_+_87921980 1.164 NM_015021
ZNF292
zinc finger protein 292
chr11_-_63087430 1.154 NM_017878
HRASLS2
HRAS-like suppressor 2
chr1_+_157167965 1.151 NM_152501
NM_198928
NM_198929
NM_198930
PYHIN1



pyrin and HIN domain family, member 1



chr9_-_21375258 1.123 NM_000605
IFNA2
interferon, alpha 2
chr14_+_34521854 1.120 NM_001146282
NM_003136
SRP54

signal recognition particle 54kDa

chr2_-_55090759 1.113 NM_007008
RTN4
reticulon 4
chr11_-_27637771 1.100 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr2_+_230900121 1.056 NM_138402
SP140L
SP140 nuclear body protein-like
chr4_-_77163609 1.050 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr4_+_144654005 1.017 NM_003601
SMARCA5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr3_+_139388770 1.011 NM_014154
NM_015396
NM_213654
ARMC8


armadillo repeat containing 8


chr10_+_101532544 1.011 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr1_-_89261021 1.010 NM_018284
GBP3
guanylate binding protein 3
chr11_-_102331643 1.009 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr14_+_57781308 0.998 NM_002788
NM_152132
PSMA3

proteasome (prosome, macropain) subunit, alpha type, 3

chr14_+_57781352 0.994 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr12_-_61283474 0.979 NM_175895
C12orf61
chromosome 12 open reading frame 61
chr4_+_142777172 0.977 NM_000585
NM_172174
IL15

interleukin 15

chr14_+_57781210 0.967 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr10_+_101532450 0.964 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr13_-_40533072 0.947 ELF1
E74-like factor 1 (ets domain transcription factor)
chr6_+_118976134 0.938 NM_002667
PLN
phospholamban
chr14_+_31100330 0.929 NM_025152
NUBPL
nucleotide binding protein-like
chr14_+_90650720 0.921 NM_001102367
C14orf159
chromosome 14 open reading frame 159
chr12_+_38905053 0.898 NM_198578
LRRK2
leucine-rich repeat kinase 2
chr16_+_74239135 0.885 NM_018975
TERF2IP
telomeric repeat binding factor 2, interacting protein
chr6_+_88026338 0.873 ZNF292
zinc finger protein 292
chr19_+_49361054 0.872 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr2_+_190014432 0.865 WDR75
WD repeat domain 75
chr1_+_40977092 0.857 NFYC
nuclear transcription factor Y, gamma
chr17_+_38719371 0.853 NM_145041
TMEM106A
FLJ77644
transmembrane protein 106A
hypothetical LOC728772
chr2_+_230989150 0.844 SP100
SP100 nuclear antigen
chr4_+_89597257 0.836 NM_016323
HERC5
hect domain and RLD 5
chr16_-_3783475 0.824 CREBBP
CREB binding protein
chr6_+_131498540 0.813 AKAP7
A kinase (PRKA) anchor protein 7
chr2_+_190014403 0.805 NM_032168
WDR75
WD repeat domain 75
chr17_+_75851984 0.796


chr2_-_6923215 0.790 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr7_+_134114701 0.770 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr11_+_113672407 0.752 NNMT
nicotinamide N-methyltransferase
chr3_+_133855979 0.744 NM_198329
UBA5
ubiquitin-like modifier activating enzyme 5
chr14_-_94677807 0.736 NM_030621
DICER1
dicer 1, ribonuclease type III
chr11_+_113672378 0.733 NNMT
nicotinamide N-methyltransferase
chr3_-_188935363 0.713 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr7_+_12217343 0.699 NM_001134232
NM_018374
TMEM106B

transmembrane protein 106B

chr17_-_44022595 0.699 HOXB3
homeobox B3
chr14_+_90650466 0.696 C14orf159
chromosome 14 open reading frame 159
chr15_-_48192804 0.689 ATP8B4
ATPase, class I, type 8B, member 4
chr11_-_310775 0.686 NM_021034
IFITM3
interferon induced transmembrane protein 3 (1-8U)
chr9_-_113561613 0.684 NM_001080551
C9orf84
chromosome 9 open reading frame 84
chr3_+_123882355 0.683 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chr10_+_22765996 0.682 LOC100289455
hypothetical LOC100289455
chr12_+_4628521 0.681 NM_005002
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr16_-_74239030 0.681 NM_001130089
NM_005548
KARS

lysyl-tRNA synthetase

chr6_+_20510019 0.672 NM_001949
E2F3
E2F transcription factor 3
chr2_+_86521939 0.669 KDM3A
lysine (K)-specific demethylase 3A
chr9_+_99214000 0.664 NM_014290
TDRD7
tudor domain containing 7
chr11_-_104477367 0.663 NM_001007232
CARD17
caspase recruitment domain family, member 17
chr20_+_226200 0.660 NM_033089
ZCCHC3
zinc finger, CCHC domain containing 3
chr12_+_104025686 0.656


chr12_+_27568311 0.643 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr9_-_34700062 0.642 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr10_-_35143900 0.640 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr2_-_101134146 0.636 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr17_-_36409632 0.620 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr9_+_99214190 0.602 TDRD7
tudor domain containing 7
chr16_-_11783908 0.601 NM_014153
ZC3H7A
zinc finger CCCH-type containing 7A
chr8_+_79740813 0.598 NM_016010
FAM164A
family with sequence similarity 164, member A
chr6_-_138862273 0.595


chr3_+_15222747 0.595 CAPN7
calpain 7
chr1_+_78888064 0.594 NM_006417
IFI44
interferon-induced protein 44
chr4_+_95592067 0.592 PDLIM5
PDZ and LIM domain 5
chr11_+_64950074 0.590 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr3_+_48482625 0.586 TREX1
three prime repair exonuclease 1
chr14_-_34252695 0.585 NM_021914
CFL2
cofilin 2 (muscle)
chr6_-_152542293 0.582 NM_133650
SYNE1
spectrin repeat containing, nuclear envelope 1
chr9_-_21229975 0.581 NM_002172
IFNA14
interferon, alpha 14
chr6_+_12120709 0.577 NM_002114
HIVEP1
human immunodeficiency virus type I enhancer binding protein 1
chr14_+_90650220 0.574 C14orf159
chromosome 14 open reading frame 159
chr14_+_72595055 0.567 RBM25
RNA binding motif protein 25
chr9_-_21295311 0.566 NM_002169
IFNA5
interferon, alpha 5
chr2_+_86521999 0.564 NM_001146688
KDM3A
lysine (K)-specific demethylase 3A
chr11_-_104421240 0.561 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr12_-_9913724 0.558 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr11_+_64950402 0.556


chr12_-_9252227 0.551 NM_002864
PZP
pregnancy-zone protein
chr12_+_25096472 0.548 NM_006152
LRMP
lymphoid-restricted membrane protein
chr8_-_86441115 0.547 NM_001164830
CA1
carbonic anhydrase I
chr5_-_114659863 0.544 NM_152549
CCDC112
coiled-coil domain containing 112
chr6_+_17501589 0.543 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr9_+_89302574 0.542 NM_004938
DAPK1
death-associated protein kinase 1
chr5_+_96237923 0.542 ERAP2
endoplasmic reticulum aminopeptidase 2
chr17_-_74244539 0.536


chr4_-_38342824 0.535 FLJ13197
hypothetical FLJ13197
chr2_+_143351695 0.534 KYNU
kynureninase
chr14_+_72594940 0.526 NM_021239
RBM25
RNA binding motif protein 25
chr3_+_120904555 0.526 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr12_-_28016182 0.524 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr12_+_77963563 0.522 NM_001135806
SYT1
synaptotagmin I
chr11_+_113776582 0.521 NM_016090
RBM7
RNA binding motif protein 7
chr3_+_98966253 0.516 NM_032146
NM_177976
ARL6

ADP-ribosylation factor-like 6

chr17_+_44263370 0.516 NM_005831
CALCOCO2
calcium binding and coiled-coil domain 2
chr14_+_72595020 0.514 RBM25
RNA binding motif protein 25
chr6_-_27948065 0.512 NM_003533
HIST1H3I
histone cluster 1, H3i
chr12_-_9913199 0.511 CLEC2B
C-type lectin domain family 2, member B
chr12_+_95825131 0.511 NM_001135176
NM_001135177
NM_152905
NEDD1


neural precursor cell expressed, developmentally down-regulated 1


chr4_+_187349716 0.508 CYP4V2
cytochrome P450, family 4, subfamily V, polypeptide 2
chr16_+_29739256 0.501 MVP
major vault protein
chr18_+_53863865 0.500 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr10_+_63478974 0.500 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr17_-_30783631 0.499 NM_018042
SLFN12
schlafen family member 12
chr10_-_6059460 0.498 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr9_+_18464090 0.497 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr11_-_4902144 0.496 NM_001005237
OR51G1
olfactory receptor, family 51, subfamily G, member 1
chr17_-_51155073 0.495 NM_018286
TMEM100
transmembrane protein 100
chr8_+_97726768 0.495 PGCP
plasma glutamate carboxypeptidase
chr11_+_113776504 0.492 RBM7
RNA binding motif protein 7
chr4_+_41632125 0.486 TMEM33
transmembrane protein 33
chr12_-_55134692 0.484 NM_012064
MIP
major intrinsic protein of lens fiber
chr3_+_189425886 0.484 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr11_+_32069183 0.483 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr14_+_72594985 0.481 RBM25
RNA binding motif protein 25
chr12_+_25096755 0.479 LRMP
lymphoid-restricted membrane protein
chr18_-_6404900 0.478 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr22_+_22459143 0.476 NM_001007468
NM_003073
SMARCB1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

chr14_+_94160046 0.476


chr2_-_142605739 0.472 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr1_-_242073094 0.472 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr1_+_938709 0.469 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr3_-_150993299 0.465 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr9_+_101717278 0.464 STX17
syntaxin 17
chr18_+_30589937 0.464 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr3_+_85858321 0.458 NM_153184
CADM2
cell adhesion molecule 2
chr11_-_310925 0.457 IFITM3
interferon induced transmembrane protein 3 (1-8U)
chr22_+_34374358 0.454 NM_030641
APOL6
apolipoprotein L, 6
chr11_+_35641234 0.453 TRIM44
tripartite motif containing 44
chr9_+_18464138 0.451 ADAMTSL1
ADAMTS-like 1
chr10_+_93673544 0.448 NM_003972
BTAF1
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)
chr8_-_17797127 0.444 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr10_+_92970302 0.444 NM_032373
PCGF5
polycomb group ring finger 5
chr15_+_41212950 0.440 NM_024956
TMEM62
transmembrane protein 62
chr1_-_58920315 0.439


chr12_-_4628436 0.437 AKAP3
A kinase (PRKA) anchor protein 3
chr11_-_4585947 0.436 NM_018073
TRIM68
tripartite motif containing 68
chr11_+_18300689 0.436 GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr19_+_59068787 0.435 MYADM
myeloid-associated differentiation marker
chr6_+_147568795 0.435 STXBP5
syntaxin binding protein 5 (tomosyn)
chr4_+_95592030 0.433 NM_001011513
NM_001011515
NM_001011516
NM_006457
PDLIM5



PDZ and LIM domain 5



chr3_-_115825742 0.430 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr16_+_29739215 0.429 NM_005115
NM_017458
MVP

major vault protein

chr14_-_34253473 0.429 NM_138638
CFL2
cofilin 2 (muscle)
chr1_-_153915867 0.428


chr9_+_5500544 0.426 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr3_-_28365284 0.423 AZI2
5-azacytidine induced 2
chr3_+_42165740 0.422 TRAK1
trafficking protein, kinesin binding 1
chr3_+_42165829 0.422 TRAK1
trafficking protein, kinesin binding 1
chr19_-_52427698 0.422 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr12_-_57600336 0.421 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr11_+_18300370 0.421 NM_001142307
NM_005316
GTF2H1

general transcription factor IIH, polypeptide 1, 62kDa

chr10_+_4995685 0.418 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr14_-_34169047 0.416 NM_021249
NM_152233
SNX6

sorting nexin 6

chr14_-_69953433 0.416 NM_018373
SYNJ2BP
synaptojanin 2 binding protein
chr17_-_70901303 0.416 GRB2
growth factor receptor-bound protein 2
chr12_+_8499788 0.416 NM_001007033
CLEC6A
C-type lectin domain family 6, member A
chr18_-_63333487 0.414 DSEL
dermatan sulfate epimerase-like
chr2_+_68855436 0.413 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr10_+_115429415 0.411 NM_001227
NM_033338
NM_033339
CASP7


caspase 7, apoptosis-related cysteine peptidase


chr3_+_161189322 0.410 NM_000882
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr2_+_69093641 0.409 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr20_+_44180355 0.409 CD40
CD40 molecule, TNF receptor superfamily member 5
chr9_+_4975082 0.408 JAK2
Janus kinase 2
chr1_+_110254755 0.407 NM_000757
NM_172210
NM_172211
NM_172212
CSF1



colony stimulating factor 1 (macrophage)



chr20_+_56904042 0.404 GNAS
GNAS complex locus
chr1_+_157067729 0.401 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr6_-_121697305 0.401 NM_152730
C6orf170
chromosome 6 open reading frame 170
chr7_+_86619805 0.399 NM_021145
DMTF1
cyclin D binding myb-like transcription factor 1
chr4_+_187349930 0.397 CYP4V2
cytochrome P450, family 4, subfamily V, polypeptide 2
chr1_-_148050534 0.396 NM_001024599
NM_001161334
HIST2H2BF

histone cluster 2, H2bf

chr3_+_180348818 0.396 NM_006218
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr16_+_48616593 0.395 NM_153261
TMEM188
transmembrane protein 188
chr14_+_21203136 0.391 NM_001001912
OR4E2
olfactory receptor, family 4, subfamily E, member 2
chr2_+_122229590 0.391 NM_004622
TSN
translin
chr12_+_63132106 0.391 NM_013254
TBK1
TANK-binding kinase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.71 1.18e-08 GO:0009615 response to virus
2.66 1.78e-08 GO:0045087 innate immune response
5.54 3.46e-08 GO:0034340 response to type I interferon
1.80 8.35e-08 GO:0002376 immune system process
2.05 1.77e-07 GO:0006955 immune response
5.38 1.95e-07 GO:0060337 type I interferon-mediated signaling pathway
5.38 1.95e-07 GO:0071357 cellular response to type I interferon
2.54 2.81e-06 GO:0044257 cellular protein catabolic process
2.46 3.69e-06 GO:0044419 interspecies interaction between organisms
2.48 1.24e-05 GO:0051603 proteolysis involved in cellular protein catabolic process
1.84 1.50e-05 GO:0051704 multi-organism process
2.37 2.88e-05 GO:0030163 protein catabolic process
2.08 6.76e-05 GO:0044265 cellular macromolecule catabolic process
2.39 1.20e-04 GO:0019941 modification-dependent protein catabolic process
2.37 1.46e-04 GO:0043632 modification-dependent macromolecule catabolic process
2.38 1.80e-04 GO:0006511 ubiquitin-dependent protein catabolic process
1.66 2.78e-04 GO:0044248 cellular catabolic process
1.79 3.16e-04 GO:0006952 defense response
1.93 3.26e-04 GO:0009057 macromolecule catabolic process
3.41 4.21e-04 GO:0042770 signal transduction in response to DNA damage
3.69 6.85e-04 GO:0030330 DNA damage response, signal transduction by p53 class mediator
2.26 1.14e-03 GO:0031347 regulation of defense response
1.55 1.22e-03 GO:0009056 catabolic process
1.75 1.22e-03 GO:0006508 proteolysis
2.59 3.70e-03 GO:0019221 cytokine-mediated signaling pathway
2.35 3.73e-03 GO:0016567 protein ubiquitination
1.92 5.63e-03 GO:0009607 response to biotic stimulus
3.79 7.14e-03 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.25 7.79e-03 GO:0032446 protein modification by small protein conjugation
1.76 7.89e-03 GO:0002682 regulation of immune system process
2.01 8.43e-03 GO:0051707 response to other organism
2.41 1.14e-02 GO:0071345 cellular response to cytokine stimulus
3.63 1.32e-02 GO:0051352 negative regulation of ligase activity
3.63 1.32e-02 GO:0051444 negative regulation of ubiquitin-protein ligase activity
1.92 1.77e-02 GO:0050776 regulation of immune response
2.13 2.11e-02 GO:0034097 response to cytokine stimulus
5.29 2.12e-02 GO:0032480 negative regulation of type I interferon production
4.43 2.19e-02 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
6.68 2.31e-02 GO:0070534 protein K63-linked ubiquitination
2.77 2.91e-02 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
2.04 3.50e-02 GO:0070647 protein modification by small protein conjugation or removal
2.59 3.87e-02 GO:0002697 regulation of immune effector process
3.50 4.05e-02 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
2.23 4.30e-02 GO:0032269 negative regulation of cellular protein metabolic process
11.33 4.33e-02 GO:0019883 antigen processing and presentation of endogenous antigen
3.64 4.76e-02 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
3.64 4.76e-02 GO:0072395 signal transduction involved in cell cycle checkpoint
3.64 4.76e-02 GO:0072401 signal transduction involved in DNA integrity checkpoint
3.64 4.76e-02 GO:0072404 signal transduction involved in G1/S transition checkpoint
3.64 4.76e-02 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
3.64 4.76e-02 GO:0072422 signal transduction involved in DNA damage checkpoint
3.64 4.76e-02 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
3.64 4.76e-02 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
3.30 4.77e-02 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.28 4.95e-02 GO:0000502 proteasome complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.56 1.65e-04 GO:0004842 ubiquitin-protein ligase activity
2.42 6.78e-04 GO:0019787 small conjugating protein ligase activity
2.24 2.10e-03 GO:0016881 acid-amino acid ligase activity
2.13 4.16e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
15.87 8.95e-03 GO:0047023 androsterone dehydrogenase activity
1.78 4.96e-02 GO:0008289 lipid binding