Motif ID: NR3C1.p2

Z-value: 0.976


Transcription factors associated with NR3C1.p2:

Gene SymbolEntrez IDGene Name
NR3C1 2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)



Activity profile for motif NR3C1.p2.

activity profile for motif NR3C1.p2


Sorted Z-values histogram for motif NR3C1.p2

Sorted Z-values for motif NR3C1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR3C1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_62764839 1.637 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr7_+_105390892 1.129 NM_152750
CDHR3
cadherin-related family member 3
chr15_-_68781662 1.129 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr22_+_21042091 1.046 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr22_+_21053972 1.034


chr3_-_69212192 0.809 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr1_-_156800017 0.799 NM_001160325
OR6P1
olfactory receptor, family 6, subfamily P, member 1
chr11_-_121492010 0.787 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr7_-_132131742 0.770 CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr11_-_4924905 0.754 NM_001005329
OR51A4
olfactory receptor, family 51, subfamily A, member 4
chr21_+_30929425 0.731 NM_181616
KRTAP20-2
keratin associated protein 20-2
chr21_-_30720100 0.708 NM_181622
KRTAP13-3
keratin associated protein 13-3
chr8_+_103633023 0.700 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr3_-_112796855 0.694 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr15_-_43280664 0.685 NM_138356
SHF
Src homology 2 domain containing F
chrX_-_83644054 0.662 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr5_+_143171918 0.618 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr1_+_160868932 0.613 DDR2
discoidin domain receptor tyrosine kinase 2
chr14_-_20098929 0.590 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chrX_+_118598325 0.577 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr6_-_133008834 0.567 NM_138327
TAAR1
trace amine associated receptor 1
chr11_+_110631916 0.557 NM_198498
C11orf53
chromosome 11 open reading frame 53
chr6_+_150731720 0.552 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr8_+_11877238 0.540 NM_001033017
DEFB135
defensin, beta 135
chr11_+_4799126 0.505 NM_001004753
OR51F2
olfactory receptor, family 51, subfamily F, member 2
chr5_-_149304475 0.500 NM_000440
PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr7_+_20621769 0.499 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr7_-_122627235 0.485 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr10_+_77212524 0.477 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr8_-_13018123 0.472 NM_001164271
DLC1
deleted in liver cancer 1
chr17_-_60439764 0.471 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr20_+_30831298 0.470 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr7_+_116182676 0.470


chr1_+_67168470 0.466 NM_001077701
NM_001077704
MIER1

mesoderm induction early response 1 homolog (Xenopus laevis)

chr9_-_7789609 0.460 NM_033428
C9orf123
chromosome 9 open reading frame 123
chr9_-_41944687 0.459 MGC21881
hypothetical locus MGC21881
chr3_+_99350859 0.438 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr21_-_31049566 0.421 NM_181619
KRTAP21-1
keratin associated protein 21-1
chr1_-_184684478 0.415 NM_022576
PDC
phosducin
chrX_+_18618965 0.413 NM_006240
NM_152224
NM_152226
PPEF1


protein phosphatase, EF-hand calcium binding domain 1


chr2_-_37727472 0.411 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chrX_+_105932536 0.405 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr21_+_37713076 0.404 NM_130436
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr20_+_43283423 0.390 NM_003008
SEMG2
semenogelin II
chr8_-_92122219 0.381 NM_018710
TMEM55A
transmembrane protein 55A
chr9_+_102244005 0.381 NM_001198812
C9orf3-TMEFF1
C9orf30
C9orf3-TMEFF1 readthrough
chromosome 9 open reading frame 30
chr12_-_9804682 0.380 NM_001781
CD69
CD69 molecule
chr7_-_16811131 0.379 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr14_+_19365447 0.369 NM_001004723
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr1_-_145699308 0.366 NM_181703
GJA5
gap junction protein, alpha 5, 40kDa
chr6_+_49575629 0.364 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr6_-_89984214 0.347 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr4_+_91035025 0.338 NM_007351
MMRN1
multimerin 1
chr2_+_107969410 0.334 NM_021815
SLC5A7
solute carrier family 5 (choline transporter), member 7
chr3_+_125586241 0.321 KALRN
kalirin, RhoGEF kinase
chr4_+_114190233 0.316 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr7_-_88262966 0.315 NM_152706
C7orf62
chromosome 7 open reading frame 62
chr1_-_181889070 0.313 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr7_-_124192265 0.312 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr1_+_22852268 0.306 NM_000491
C1QB
complement component 1, q subcomponent, B chain
chr12_-_89976261 0.306 NM_007035
KERA
keratocan
chr6_+_64289585 0.299 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr7_-_122126422 0.298 NM_139175
RNF133
ring finger protein 133
chr22_-_15453440 0.294 NM_014406
CCT8L2
chaperonin containing TCP1, subunit 8 (theta)-like 2
chr11_-_59390518 0.291 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr7_-_25186218 0.291 NM_138811
C7orf31
chromosome 7 open reading frame 31
chr5_-_16791346 0.290 MYO10
myosin X
chrX_+_65299157 0.289 NM_138737
HEPH
hephaestin
chr14_+_73153300 0.288 NM_001037162
ACOT6
acyl-CoA thioesterase 6
chr8_-_53484753 0.287 NM_014682
ST18
suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
chr9_+_124355211 0.287 NM_001004457
OR1N2
olfactory receptor, family 1, subfamily N, member 2
chr16_-_70591377 0.286 NM_181536
PKD1L3
polycystic kidney disease 1-like 3
chr6_-_132064233 0.284 NM_030908
OR2A4
olfactory receptor, family 2, subfamily A, member 4
chr11_+_19328846 0.284 NM_001111018
NAV2
neuron navigator 2
chr12_+_91654395 0.283 NM_001004330
PLEKHG7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr21_+_42792810 0.282 NM_018964
SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr1_+_12325632 0.280 VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr11_+_61794205 0.280 NM_002411
SCGB2A2
secretoglobin, family 2A, member 2
chrX_+_22200950 0.276 NM_152577
ZNF645
zinc finger protein 645
chr1_+_160868822 0.273 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr11_-_117628211 0.272 NM_198275
MPZL3
myelin protein zero-like 3
chr19_+_63262418 0.271 NM_001164527
NM_001164529
NM_001164530
NM_003436
NM_007134
ZNF135




zinc finger protein 135




chr4_-_20594645 0.270 KCNIP4
Kv channel interacting protein 4
chr2_-_99412694 0.269 REV1
REV1 homolog (S. cerevisiae)
chr1_-_60164912 0.268 NM_000775
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr11_+_59804634 0.263 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr3_+_150065732 0.260 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr17_+_11726943 0.258 NM_004662
DNAH9
dynein, axonemal, heavy chain 9
chr3_+_46423682 0.257 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr1_-_94359266 0.256 NM_000350
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr14_-_44792354 0.252 NM_018353
MIS18BP1
MIS18 binding protein 1
chr1_-_10779291 0.252 NM_001079843
NM_017766
CASZ1

castor zinc finger 1

chrX_-_70243362 0.251 NM_001025265
CXorf65
chromosome X open reading frame 65
chr14_-_64416307 0.251 SPTB
spectrin, beta, erythrocytic
chr9_+_132579088 0.250 NM_007313
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr19_-_40317829 0.245 NM_139284
LGI4
leucine-rich repeat LGI family, member 4
chr17_-_68100537 0.244 LOC100499467
hypothetical LOC100499467
chr5_+_140541163 0.244 NM_020957
PCDHB16
protocadherin beta 16
chr9_-_124370576 0.242 NM_001004454
OR1L8
olfactory receptor, family 1, subfamily L, member 8
chrX_-_135577102 0.238 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr17_-_31441390 0.238 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr1_+_67404756 0.237 NM_144701
IL23R
interleukin 23 receptor
chr4_-_170915602 0.234 NM_017867
C4orf27
chromosome 4 open reading frame 27
chr7_-_99312591 0.232 NM_001005276
OR2AE1
olfactory receptor, family 2, subfamily AE, member 1
chr3_-_117647011 0.232 LSAMP
limbic system-associated membrane protein
chr1_-_117554999 0.230 NM_024626
VTCN1
V-set domain containing T cell activation inhibitor 1
chr4_+_35962038 0.229 NM_001170700
DTHD1
death domain containing 1
chr10_-_92670764 0.227 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr7_-_122130201 0.223 NM_198085
RNF148
ring finger protein 148
chr5_+_140690387 0.221 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr1_+_74473672 0.220 NM_015978
TNNI3K
TNNI3 interacting kinase
chr13_+_77213295 0.217 NM_144595
SLAIN1
SLAIN motif family, member 1
chr21_-_30774502 0.214 NM_181607
KRTAP19-1
keratin associated protein 19-1
chr7_-_20223467 0.213 NM_182762
MACC1
metastasis associated in colon cancer 1
chr5_+_149867866 0.213 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr7_-_96492064 0.210 NM_005221
DLX5
distal-less homeobox 5
chr20_-_20641122 0.210 NM_020343
RALGAPA2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr1_-_166779825 0.210 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr9_-_106401514 0.209 NM_001004482
OR13C5
olfactory receptor, family 13, subfamily C, member 5
chrX_-_100434700 0.209 NM_024885
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr10_+_116571485 0.208 NM_001135051
NM_020940
FAM160B1

family with sequence similarity 160, member B1

chr4_-_155731288 0.207 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr12_+_6925997 0.205 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr1_-_67668654 0.204 SERBP1
SERPINE1 mRNA binding protein 1
chr18_-_51219880 0.204 TCF4
transcription factor 4
chr5_+_55098469 0.204 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr6_-_127882192 0.203 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chr5_+_147628567 0.203 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr19_-_62680703 0.203 NM_001024596
NM_001144068
ZNF772

zinc finger protein 772

chr4_-_95482994 0.202 NM_014485
HPGDS
hematopoietic prostaglandin D synthase
chrX_+_123062143 0.202 STAG2
stromal antigen 2
chr2_-_233586145 0.201 NGEF
neuronal guanine nucleotide exchange factor
chr9_+_96561750 0.201 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr1_-_158759606 0.201 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr4_+_72423633 0.200 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr1_-_219977424 0.199 NM_144728
DUSP10
dual specificity phosphatase 10
chr1_-_151296611 0.197 NM_005988
SPRR2A
small proline-rich protein 2A
chr5_+_171553780 0.194 NM_001171183
EFCAB9
EF-hand calcium binding domain 9
chr6_-_132952517 0.194 NM_003967
TAAR5
trace amine associated receptor 5
chr6_-_152681171 0.194 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr7_-_17946627 0.193 NM_015132
SNX13
sorting nexin 13
chrX_-_101613387 0.192 NM_017809
NM_001099686
NXF2
NXF2B
nuclear RNA export factor 2
nuclear RNA export factor 2B
chr11_-_57752923 0.192 NM_001004471
OR10Q1
olfactory receptor, family 10, subfamily Q, member 1
chr20_+_51235228 0.192 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr14_+_85069217 0.189


chr7_-_97339616 0.188 ASNS
asparagine synthetase (glutamine-hydrolyzing)
chr16_+_24475129 0.187 RBBP6
retinoblastoma binding protein 6
chr2_-_233586164 0.187 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr13_+_45174446 0.185 NM_152719
SPERT
spermatid associated
chr3_-_150858274 0.183 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr1_+_144188375 0.182 NM_153713
LIX1L
Lix1 homolog (mouse)-like
chr7_+_128795280 0.181 AHCYL2
adenosylhomocysteinase-like 2
chr1_-_157950898 0.181 NM_000567
CRP
C-reactive protein, pentraxin-related
chr7_+_93388951 0.180 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chrX_+_115215985 0.180 NM_000686
AGTR2
angiotensin II receptor, type 2
chr7_-_126819953 0.180 NM_176814
ZNF800
zinc finger protein 800
chr1_+_111571803 0.179 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr14_+_99309688 0.178 EML1
echinoderm microtubule associated protein like 1
chr12_-_55730125 0.177 NM_005379
MYO1A
myosin IA
chr20_-_18425811 0.177 NM_006606
RBBP9
retinoblastoma binding protein 9
chrX_-_23955223 0.176 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr18_+_74957475 0.176


chrX_+_65299352 0.175 HEPH
hephaestin
chr12_+_6926014 0.174 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr10_+_83627422 0.174 NM_001165973
NRG3
neuregulin 3
chrX_+_49223101 0.173 NM_001098405
GAGE12F
GAGE3
GAGE4
GAGE5
GAGE7
G antigen 12F
G antigen 3
G antigen 4
G antigen 5
G antigen 7
chr15_-_31999815 0.173


chr7_-_86526880 0.173 NM_001142749
KIAA1324L
KIAA1324-like
chr6_-_52736231 0.173 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr14_+_67238355 0.171 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr19_-_9470243 0.166 NM_152476
ZNF560
zinc finger protein 560
chr21_-_31041390 0.166 NM_181617
KRTAP21-2
keratin associated protein 21-2
chr4_-_10295412 0.165 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr1_-_177106702 0.165 NM_004673
ANGPTL1
angiopoietin-like 1
chr5_-_95044415 0.163 NM_031952
SPATA9
spermatogenesis associated 9
chr21_-_30614477 0.163 NM_203405
KRTAP26-1
keratin associated protein 26-1
chr12_+_15017222 0.162 NM_006205
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr1_-_159546348 0.160 NM_000530
MPZ
myelin protein zero
chr1_+_62835759 0.160 NM_014495
ANGPTL3
angiopoietin-like 3
chr11_-_26700121 0.160 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr11_+_57738792 0.158 NM_001004458
OR1S1
olfactory receptor, family 1, subfamily S, member 1
chr12_+_20739555 0.158 NM_001145945
NM_001145946
NM_001145944
NM_017435
SLCO1C1



solute carrier organic anion transporter family, member 1C1



chr4_+_147779492 0.158 NM_004575
POU4F2
POU class 4 homeobox 2
chr10_+_91142301 0.158 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr19_-_47724365 0.158 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr19_-_40317450 0.158 LGI4
leucine-rich repeat LGI family, member 4
chr17_-_32730804 0.157 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr9_+_6205804 0.156 IL33
interleukin 33
chr19_-_9087438 0.156 NM_001005192
OR7G1
olfactory receptor, family 7, subfamily G, member 1
chr9_+_128764324 0.155 NM_001190728
RALGPS1
Ral GEF with PH domain and SH3 binding motif 1
chr14_+_80491461 0.155 NM_000369
NM_001018036
NM_001142626
TSHR


thyroid stimulating hormone receptor


chrX_-_48156287 0.155 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chr1_+_164063684 0.153 UCK2
uridine-cytidine kinase 2
chr2_-_36929520 0.152 STRN
striatin, calmodulin binding protein
chr15_+_57696016 0.152 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr1_-_67668686 0.151 NM_001018067
NM_001018068
NM_001018069
NM_015640
SERBP1



SERPINE1 mRNA binding protein 1



chr7_+_123036312 0.151 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr1_-_35692668 0.150 KIAA0319L
KIAA0319-like
chr1_-_149586298 0.149 RFX5
regulatory factor X, 5 (influences HLA class II expression)
chrX_-_55204259 0.149 NM_001166703
FAM104B
family with sequence similarity 104, member B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.15 2.20e-09 GO:0007608 sensory perception of smell
2.88 3.58e-08 GO:0007606 sensory perception of chemical stimulus
2.20 2.41e-06 GO:0007600 sensory perception
1.67 1.75e-04 GO:0003008 system process
1.74 5.10e-04 GO:0050877 neurological system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.30 3.39e-03 GO:0005886 plasma membrane
1.29 5.81e-03 GO:0071944 cell periphery
1.77 1.09e-02 GO:0005615 extracellular space
2.77 2.37e-02 GO:0005882 intermediate filament

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.30 9.49e-11 GO:0004984 olfactory receptor activity
2.09 6.10e-06 GO:0004930 G-protein coupled receptor activity
1.66 2.45e-03 GO:0004888 transmembrane receptor activity
1.47 3.42e-02 GO:0004872 receptor activity
6.19 3.64e-02 GO:0030545 receptor regulator activity
7.33 4.22e-02 GO:0004364 glutathione transferase activity