Motif ID: GATA6.p2

Z-value: 2.194


Transcription factors associated with GATA6.p2:

Gene SymbolEntrez IDGene Name
GATA6 2627 GATA binding protein 6



Activity profile for motif GATA6.p2.

activity profile for motif GATA6.p2


Sorted Z-values histogram for motif GATA6.p2

Sorted Z-values for motif GATA6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_70745615 4.999 NM_033496
HK1
hexokinase 1
chr1_+_22200735 3.380 NM_005747
CELA3A
chymotrypsin-like elastase family, member 3A
chr7_+_129807467 3.335 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chrX_-_50403412 3.074 SHROOM4
shroom family member 4
chr1_+_22176004 3.031 NM_007352
CELA3A
CELA3B
chymotrypsin-like elastase family, member 3A
chymotrypsin-like elastase family, member 3B
chrX_+_38096679 2.590 NM_000531
OTC
ornithine carbamoyltransferase
chrX_+_85404626 2.472 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chrX_-_63362227 2.366 NM_130388
ASB12
ankyrin repeat and SOCS box containing 12
chr1_-_24342158 2.303 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chrX_+_107174855 2.302 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr17_+_53761293 2.257 LOC100506779
hypothetical LOC100506779
chr1_-_42402973 2.227 NM_033553
GUCA2A
guanylate cyclase activator 2A (guanylin)
chr2_+_241456834 2.105 NM_000030
AGXT
alanine-glyoxylate aminotransferase
chr17_+_19255083 2.060 NM_007148
RNF112
ring finger protein 112
chr6_+_31782618 2.025 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr11_-_116213511 2.019 NM_000039
APOA1
apolipoprotein A-I
chr14_-_80934523 1.961 NM_033104
STON2
stonin 2
chr8_+_124263932 1.937 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chrX_+_37750778 1.932 NM_001163335
NM_138780
SYTL5

synaptotagmin-like 5

chrX_+_65152004 1.861


chr9_-_116732403 1.829 NM_001244
TNFSF8
tumor necrosis factor (ligand) superfamily, member 8
chr1_+_43063817 1.817 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr1_+_110795271 1.813 NM_032414
PROK1
prokineticin 1
chr11_+_118463906 1.808 NM_001024382
HMBS
hydroxymethylbilane synthase
chr7_+_150321771 1.743 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr1_-_204179169 1.738 NM_052934
NM_134325
SLC26A9

solute carrier family 26, member 9

chrX_-_55074125 1.734 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr6_+_167624792 1.712 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr12_-_51514328 1.692 NM_175834
KRT79
keratin 79
chr1_+_204484081 1.692 NM_001910
NM_148964
CTSE

cathepsin E

chr19_+_40824486 1.664 NM_014209
ETV2
ets variant 2
chr1_+_152560179 1.663 NM_080429
AQP10
aquaporin 10
chr9_+_117955890 1.656 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chrX_+_119379967 1.630 NM_001142447
NM_012069
ATP1B4

ATPase, Na+/K+ transporting, beta 4 polypeptide

chrX_-_44945025 1.625 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr7_+_142136892 1.598 NM_002769
PRSS1
PRSS2
protease, serine, 1 (trypsin 1)
protease, serine, 2 (trypsin 2)
chr6_+_41118214 1.594 NM_001010873
NM_001159726
TSPO2

translocator protein 2

chr21_-_38792173 1.573 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr17_-_53761119 1.565 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr8_+_124264054 1.557 FAM83A
family with sequence similarity 83, member A
chr12_-_52975823 1.531 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr10_-_48036698 1.434 NM_016204
GDF2
growth differentiation factor 2
chr3_-_55489973 1.433 WNT5A
wingless-type MMTV integration site family, member 5A
chr1_+_173303616 1.426 NM_022093
TNN
tenascin N
chr12_-_52975777 1.391 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr1_+_6226838 1.386 NM_001024598
HES3
hairy and enhancer of split 3 (Drosophila)
chr8_-_27157157 1.360 STMN4
stathmin-like 4
chr3_-_15538164 1.340 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chrX_+_99726445 1.333 NM_022144
TNMD
tenomodulin
chr22_+_21543671 1.330 IGLV4-3
immunoglobulin lambda variable 4-3
chr12_-_6103945 1.324 NM_000552
VWF
von Willebrand factor
chr1_+_15145001 1.320 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr7_-_142369519 1.290 KEL
Kell blood group, metallo-endopeptidase
chr11_-_67047374 1.284 NM_016366
NM_031204
CABP2

calcium binding protein 2

chr19_+_40541327 1.270 NM_005304
FFAR3
free fatty acid receptor 3
chr10_+_118340460 1.216 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chr12_-_113326085 1.214 NM_080718
TBX5
T-box 5
chr9_+_96561750 1.197 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr18_+_13610866 1.193 NM_004338
NM_181483
C18orf1

chromosome 18 open reading frame 1

chr12_+_110328126 1.191 NM_005475
SH2B3
SH2B adaptor protein 3
chr9_-_3213007 1.188


chr9_-_96395828 1.187 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chrX_-_100015783 1.181 NM_007052
NM_013955
NOX1

NADPH oxidase 1

chr14_+_75058591 1.173 BATF
basic leucine zipper transcription factor, ATF-like
chrX_+_77889861 1.167 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chrX_+_111005934 1.157 NM_001195576
NM_001195578
LOC100329135

hypothetical LOC100329135

chrX_+_106048245 1.146 NM_001171095
CLDN2
claudin 2
chr11_+_61005160 1.145 NM_001170753
NM_145017
C11orf66

chromosome 11 open reading frame 66

chr5_+_32824701 1.144 NM_024563
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr22_+_21559959 1.131 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr5_+_38481392 1.122 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr2_-_43919392 1.121 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr11_-_47330797 1.116 NM_000256
MYBPC3
myosin binding protein C, cardiac
chr1_-_46789473 1.114 NM_001097611
KNCN
kinocilin
chr1_-_201321711 1.093 MYOG
myogenin (myogenic factor 4)
chr16_+_55456619 1.088 NM_000339
NM_001126107
NM_001126108
SLC12A3


solute carrier family 12 (sodium/chloride transporters), member 3


chr1_-_201321999 1.071 NM_002479
MYOG
myogenin (myogenic factor 4)
chr1_+_87368044 1.071 LOC339524
hypothetical LOC339524
chr19_+_10258642 1.069 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr19_-_45611110 1.065 NM_020956
NM_181882
PRX

periaxin

chr5_+_145296313 1.061 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr1_-_35143570 1.048 NM_001080418
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chrX_-_24600661 1.046 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr10_+_118295417 1.031 NM_000936
PNLIP
pancreatic lipase
chr12_-_119249938 1.023 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr4_-_186934059 1.012 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr11_+_75106512 0.989 NM_025098
MOGAT2
monoacylglycerol O-acyltransferase 2
chr1_+_115373937 0.986 NM_000549
TSHB
thyroid stimulating hormone, beta
chr12_+_70618892 0.969 NM_173353
TPH2
tryptophan hydroxylase 2
chr7_-_142369534 0.967 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr11_+_91724909 0.952 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr5_+_1254709 0.944 NM_001003841
SLC6A19
solute carrier family 6 (neutral amino acid transporter), member 19
chr7_+_142459538 0.941 NM_001001667
OR6V1
olfactory receptor, family 6, subfamily V, member 1
chrX_+_135558001 0.924 NM_000074
CD40LG
CD40 ligand
chr17_-_61655915 0.924 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr20_+_31132978 0.914 NM_182519
C20orf186
chromosome 20 open reading frame 186
chrX_+_15435351 0.904 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr15_+_19883745 0.898 NM_001005241
OR4N4
olfactory receptor, family 4, subfamily N, member 4
chr7_-_99312591 0.896 NM_001005276
OR2AE1
olfactory receptor, family 2, subfamily AE, member 1
chr19_+_15612706 0.873 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr2_+_102294393 0.869 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr5_-_36337756 0.866 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr3_-_57209319 0.857 NM_003865
HESX1
HESX homeobox 1
chr11_-_1026654 0.856 NM_005961
MUC6
mucin 6, oligomeric mucus/gel-forming
chr10_-_48010879 0.836 NM_002900
RBP3
retinol binding protein 3, interstitial
chr19_-_60360768 0.832 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr9_-_131555111 0.827 NM_004878
PTGES
prostaglandin E synthase
chr2_+_158666627 0.826 NM_173355
UPP2
uridine phosphorylase 2
chr1_-_206125877 0.826


chr21_+_36458708 0.817 NM_005128
DOPEY2
dopey family member 2
chr16_-_48418418 0.816 NM_015069
ZNF423
zinc finger protein 423
chr11_+_130745580 0.815 NM_001048209
NTM
neurotrimin
chr13_+_30207668 0.811 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr16_-_20246309 0.803 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr13_+_30207690 0.803 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr19_+_13999959 0.802 NM_080864
RLN3
relaxin 3
chr19_-_60432443 0.796 NM_173804
TMEM86B
transmembrane protein 86B
chr19_+_40632456 0.796 NM_005306
FFAR2
free fatty acid receptor 2
chrX_+_56275510 0.795 NM_007250
NM_001159296
KLF8

Kruppel-like factor 8

chrX_-_111953009 0.792 NM_001113490
AMOT
angiomotin
chr22_+_18330049 0.789 NM_007310
COMT
catechol-O-methyltransferase
chr19_-_60241424 0.787 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr11_-_56914668 0.785 NM_002728
PRG2
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
chr19_+_16860807 0.782 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr14_+_75058518 0.781 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr16_+_557011 0.777 NM_176677
NHLRC4
PIGQ
NHL repeat containing 4
phosphatidylinositol glycan anchor biosynthesis, class Q
chr16_+_79829794 0.776 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr17_+_72795567 0.770 NM_001113492
SEPT9
septin 9
chr10_-_14856901 0.768 NM_031453
FAM107B
family with sequence similarity 107, member B
chr4_-_123596921 0.760 NM_000586
IL2
interleukin 2
chrX_+_69314060 0.759 NM_198512
DGAT2L6
diacylglycerol O-acyltransferase 2-like 6
chr3_-_52839727 0.759 NM_001166449
NM_002218
ITIH4

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

chr11_+_73034870 0.754 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr19_+_16860871 0.744 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr22_+_21079355 0.742


chr12_+_54132264 0.738 NM_054105
OR6C2
olfactory receptor, family 6, subfamily C, member 2
chr16_+_142853 0.736 NM_005332
HBZ
hemoglobin, zeta
chr17_+_69756099 0.734 NM_052869
TTYH2
tweety homolog 2 (Drosophila)
chr9_+_263025 0.733 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr2_+_169465995 0.729 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr5_+_169713458 0.726 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr22_+_20880159 0.721 IGLV6-57
immunoglobulin lambda variable 6-57
chr12_-_66905802 0.714 NM_018402
IL26
interleukin 26
chr1_-_150092702 0.712 NM_182578
THEM5
thioesterase superfamily member 5
chr2_-_152538694 0.712 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr17_+_70997280 0.709 KIAA0195
KIAA0195
chr8_-_38127489 0.703 NM_000349
STAR
steroidogenic acute regulatory protein
chr17_-_29714293 0.700 NM_002981
CCL1
chemokine (C-C motif) ligand 1
chr10_+_35466715 0.695 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr17_+_65612589 0.690 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr12_+_111829121 0.680 NM_001032409
NM_002534
NM_016816
OAS1


2',5'-oligoadenylate synthetase 1, 40/46kDa


chrX_-_78509662 0.676 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr11_-_65962836 0.676 NM_016050
NM_170738
NM_170739
MRPL11


mitochondrial ribosomal protein L11


chr9_-_116920232 0.676 NM_002160
TNC
tenascin C
chr8_-_145988578 0.673 RPL8
ribosomal protein L8
chr1_+_17121012 0.671 NM_014675
CROCC
ciliary rootlet coiled-coil, rootletin
chr7_+_129720209 0.669 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr1_-_43509187 0.669 EBNA1BP2
EBNA1 binding protein 2
chr12_-_89922888 0.669 NM_004950
EPYC
epiphycan
chr2_+_43919606 0.661 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr6_-_35873034 0.661 NM_001832
CLPS
colipase, pancreatic
chr3_-_152585226 0.659 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chrX_+_21960841 0.658 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr2_+_173794692 0.658 ZAK
sterile alpha motif and leucine zipper containing kinase AZK
chr11_-_6746763 0.657 NM_001004490
OR2AG2
olfactory receptor, family 2, subfamily AG, member 2
chr3_+_46423682 0.657 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr6_-_159386007 0.655 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr12_-_89922875 0.651 EPYC
epiphycan
chr7_+_127020924 0.649 NM_020369
FSCN3
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
chr17_-_2913650 0.646 NM_014566
OR1D4
OR1D5
olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene)
olfactory receptor, family 1, subfamily D, member 5
chr7_+_106293112 0.643 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr9_+_138677197 0.643 NM_201446
NM_016215
EGFL7

EGF-like-domain, multiple 7

chr1_-_109651140 0.642 NM_001010985
MYBPHL
myosin binding protein H-like
chr3_+_187866464 0.640 NM_000412
HRG
histidine-rich glycoprotein
chr1_-_153477673 0.635 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chr18_+_3437607 0.633 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chrX_+_69371229 0.631 NM_001013579
AWAT1
acyl-CoA wax alcohol acyltransferase 1
chr6_-_2785682 0.628 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr22_+_19458378 0.624 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr13_+_28496746 0.621 NM_001033602
MTUS2
microtubule associated tumor suppressor candidate 2
chr7_+_143646150 0.619 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr11_-_123816190 0.617 NM_012378
OR8B8
olfactory receptor, family 8, subfamily B, member 8
chr6_+_31059463 0.612 NM_001010909
MUC21
mucin 21, cell surface associated
chr2_+_108571336 0.610 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr7_-_100077072 0.608 NM_003227
TFR2
transferrin receptor 2
chr19_+_7647934 0.604 NM_174918
C19orf59
chromosome 19 open reading frame 59
chrX_+_44588192 0.603 NM_022076
DUSP21
dual specificity phosphatase 21
chr3_+_49543374 0.600


chrX_+_65299157 0.600 NM_138737
HEPH
hephaestin
chr1_-_171442937 0.599 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr15_+_38430517 0.596 NM_001145643
PHGR1
proline/histidine/glycine-rich 1
chr12_+_4300607 0.595 NM_020375
C12orf5
chromosome 12 open reading frame 5
chrX_+_34870833 0.594 NM_152631
FAM47B
family with sequence similarity 47, member B
chr8_+_22075112 0.592 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr1_-_120155581 0.591 NM_001159352
NM_001159353
NM_032044
REG4


regenerating islet-derived family, member 4


chr20_+_31334601 0.589 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr1_-_203657803 0.587 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr17_-_68769613 0.585 NM_001129885
CPSF4L
cleavage and polyadenylation specific factor 4-like
chr2_-_121875610 0.585 CLASP1
cytoplasmic linker associated protein 1
chrX_-_49008115 0.584 NM_001114377
NM_014009
FOXP3

forkhead box P3


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.47 1.58e-12 GO:0032501 multicellular organismal process
1.86 2.13e-09 GO:0003008 system process
5.57 7.21e-09 GO:0007586 digestion
1.32 3.65e-07 GO:0050896 response to stimulus
3.27 3.56e-06 GO:0008202 steroid metabolic process
14.53 1.54e-05 GO:0044241 lipid digestion
1.76 3.37e-05 GO:0050877 neurological system process
2.01 3.55e-05 GO:0007600 sensory perception
2.34 5.37e-04 GO:0007608 sensory perception of smell
2.25 6.77e-04 GO:0007606 sensory perception of chemical stimulus
1.52 7.39e-04 GO:0065008 regulation of biological quality
1.82 9.17e-04 GO:0006629 lipid metabolic process
8.98 1.05e-02 GO:0050892 intestinal absorption
3.05 1.65e-02 GO:0042445 hormone metabolic process
13.63 1.94e-02 GO:0030299 intestinal cholesterol absorption
5.77 3.10e-02 GO:0022600 digestive system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.91 6.70e-15 GO:0005576 extracellular region
2.21 1.44e-11 GO:0044421 extracellular region part
1.50 2.12e-11 GO:0071944 cell periphery
1.50 2.19e-11 GO:0005886 plasma membrane
2.29 1.24e-09 GO:0005615 extracellular space
1.48 2.64e-04 GO:0044459 plasma membrane part
1.19 7.68e-04 GO:0016020 membrane
1.25 9.00e-04 GO:0031224 intrinsic to membrane
1.22 1.22e-03 GO:0044425 membrane part
1.24 2.85e-03 GO:0016021 integral to membrane
1.50 4.75e-02 GO:0005887 integral to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.76 5.04e-08 GO:0004872 receptor activity
1.88 1.09e-07 GO:0004888 transmembrane receptor activity
2.05 1.38e-06 GO:0004930 G-protein coupled receptor activity
1.58 1.03e-05 GO:0004871 signal transducer activity
1.58 1.03e-05 GO:0060089 molecular transducer activity
2.28 6.60e-04 GO:0004984 olfactory receptor activity
1.64 1.15e-02 GO:0005102 receptor binding