Motif ID: TBX4,5.p2

Z-value: 1.141


Transcription factors associated with TBX4,5.p2:

Gene SymbolEntrez IDGene Name
TBX4 9496 T-box 4
TBX5 6910 T-box 5



Activity profile for motif TBX4,5.p2.

activity profile for motif TBX4,5.p2


Sorted Z-values histogram for motif TBX4,5.p2

Sorted Z-values for motif TBX4,5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4,5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_34387786 1.428 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr1_+_43661383 1.422 NM_015284
KIAA0467
KIAA0467
chr11_+_61204392 1.394 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr8_+_144428083 1.383 GLI4
GLI family zinc finger 4
chr11_+_183079 1.328 NM_145651
SCGB1C1
secretoglobin, family 1C, member 1
chr1_+_149221122 1.208 NM_003568
ANXA9
annexin A9
chr12_+_52665196 1.201 NM_017409
HOXC10
homeobox C10
chr6_-_32121784 1.120 NM_032470
TNXB
tenascin XB
chr11_-_2108035 1.025 IGF2
insulin-like growth factor 2 (somatomedin A)
chr1_-_47468029 0.960 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr8_-_145085616 0.910 NM_201384
PLEC
plectin
chr1_+_154178103 0.887 NM_181885
RXFP4
relaxin/insulin-like family peptide receptor 4
chr16_+_84204424 0.878 NM_014615
KIAA0182
KIAA0182
chr8_-_144726064 0.875 NM_001100878
C8orf73
chromosome 8 open reading frame 73
chr16_+_88517187 0.842 NM_006086
TUBB3
tubulin, beta 3
chr1_+_17719405 0.833 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr22_-_49240594 0.830 SBF1
SET binding factor 1
chr8_-_142446546 0.811 NM_005293
GPR20
G protein-coupled receptor 20
chr19_-_60272708 0.809 NM_138412
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr19_+_55571493 0.801 NM_007121
NR1H2
nuclear receptor subfamily 1, group H, member 2
chr19_+_482688 0.790 NM_004359
CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr15_+_66658626 0.782 NM_006091
CORO2B
coronin, actin binding protein, 2B
chrX_-_19598912 0.779 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_154855709 0.718 NM_021817
HAPLN2
hyaluronan and proteoglycan link protein 2
chr19_+_482737 0.714 CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr11_+_66547391 0.710 NM_177963
SYT12
synaptotagmin XII
chr17_-_45629401 0.705


chr16_-_87460514 0.703 NM_001080487
PABPN1L
poly(A) binding protein, nuclear 1-like (cytoplasmic)
chr4_+_8633116 0.699 NM_080819
GPR78
G protein-coupled receptor 78
chr9_-_34366831 0.689 NM_020702
KIAA1161
KIAA1161
chr19_+_458475 0.688 NM_033513
C19orf20
chromosome 19 open reading frame 20
chr19_-_43919428 0.651 CAPN12
calpain 12
chr11_-_72063059 0.648 NM_002599
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr22_+_36401558 0.628 NM_002305
LGALS1
lectin, galactoside-binding, soluble, 1
chr18_-_42490993 0.623 NM_144612
LOXHD1
lipoxygenase homology domains 1
chr13_-_19244398 0.619 PSPC1
paraspeckle component 1
chr13_+_112789669 0.619 MCF2L
MCF.2 cell line derived transforming sequence-like
chr17_+_4841923 0.612 NM_006612
KIF1C
kinesin family member 1C
chr15_+_88120592 0.610 NM_001039958
MESP2
mesoderm posterior 2 homolog (mouse)
chr10_+_135042684 0.608 NM_152911
NM_207127
NM_207128
PAOX


polyamine oxidase (exo-N4-amino)


chr14_+_20580224 0.606 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr16_-_66523255 0.602 NM_001907
CTRL
chymotrypsin-like
chr19_+_3490154 0.598 NM_001135580
C19orf71
chromosome 19 open reading frame 71
chr12_+_6514645 0.598 GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr9_+_123083540 0.584 GSN
gelsolin
chr16_-_65287967 0.582 NM_178818
NM_181521
CMTM4

CKLF-like MARVEL transmembrane domain containing 4

chr19_+_13848949 0.577 NM_001098622
NANOS3
nanos homolog 3 (Drosophila)
chr5_-_177355848 0.575 NM_006261
PROP1
PROP paired-like homeobox 1
chr16_-_31135895 0.567 NM_152901
PYDC1
PYD (pyrin domain) containing 1
chr3_+_26639300 0.566 NM_052953
LRRC3B
leucine rich repeat containing 3B
chr3_+_127170717 0.559 NM_001012337
ROPN1B
rhophilin associated tail protein 1B
chr11_-_2138984 0.559 NM_000207
NM_001185097
NM_001185098
NM_001042376
INS


INS-IGF2
insulin


INS-IGF2 readthrough transcript
chr19_+_10261646 0.557 NM_003259
ICAM5
intercellular adhesion molecule 5, telencephalin
chr16_-_695719 0.556 NM_153350
FBXL16
F-box and leucine-rich repeat protein 16
chr15_+_81567327 0.555 NM_001144903
NM_023003
TM6SF1

transmembrane 6 superfamily member 1

chr8_+_24207524 0.548 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr10_+_135343649 0.545 NM_012147
DUX2
double homeobox 2
chr17_+_19255083 0.540 NM_007148
RNF112
ring finger protein 112
chr10_+_95362334 0.539 NM_006204
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr1_+_6226838 0.532 NM_001024598
HES3
hairy and enhancer of split 3 (Drosophila)
chr16_-_1410710 0.527 C16orf91
chromosome 16 open reading frame 91
chr19_-_15252261 0.527 NM_014299
NM_058243
BRD4

bromodomain containing 4

chr12_+_1608672 0.526 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chr1_+_157441133 0.522 NM_002036
DARC
Duffy blood group, chemokine receptor
chrX_+_153339814 0.519 NM_017514
PLXNA3
plexin A3
chr7_+_30917939 0.517 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chr11_+_834062 0.516 NM_001025234
TSPAN4
tetraspanin 4
chr3_-_52844274 0.516 NM_205853
MUSTN1
musculoskeletal, embryonic nuclear protein 1
chrX_+_152454773 0.515 NM_001001344
NM_021949
ATP2B3

ATPase, Ca++ transporting, plasma membrane 3

chr11_-_1576057 0.511 NM_001004325
KRTAP5-2
keratin associated protein 5-2
chr13_-_49597776 0.507 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr14_+_94148466 0.506 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr10_-_99521701 0.504 NM_003015
SFRP5
secreted frizzled-related protein 5
chr7_+_139750311 0.492 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr9_+_139152595 0.491 GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr16_+_88512769 0.489 MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr12_+_123339662 0.487 NM_181709
FAM101A
family with sequence similarity 101, member A
chr11_+_1897374 0.487 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr1_+_37795101 0.483 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr1_+_15935395 0.480 NM_207348
SLC25A34
solute carrier family 25, member 34
chr3_-_51971915 0.473 NM_033010
PCBP4
poly(rC) binding protein 4
chr14_+_20595820 0.470 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr9_-_72926333 0.469 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr8_-_145097031 0.468 NM_201380
PLEC
plectin
chr5_+_176786279 0.468 NM_001004105
NM_001004106
NM_002082
GRK6


G protein-coupled receptor kinase 6


chr8_-_18710575 0.466 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr1_+_34997928 0.465 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr15_-_41346346 0.462 NM_004245
NM_201631
TGM5

transglutaminase 5

chr16_-_2521359 0.462 NM_001048212
CEMP1
cementum protein 1
chr8_-_29262240 0.462 NM_057158
DUSP4
dual specificity phosphatase 4
chr17_-_59327602 0.461 NM_001317
NM_022640
NM_022641
CSH1


CSH2
chorionic somatomammotropin hormone 1 (placental lactogen)


chorionic somatomammotropin hormone 2
chr5_-_134899537 0.459 NM_006161
NEUROG1
neurogenin 1
chr1_-_11830328 0.458 NM_006172
NPPA
natriuretic peptide A
chr21_+_44856423 0.457 NM_198695
KRTAP10-8
keratin associated protein 10-8
chr20_-_30703219 0.454 NM_182584
C20orf203
chromosome 20 open reading frame 203
chr11_-_128242342 0.454 NM_153764
NM_153765
NM_153766
NM_153767
KCNJ1



potassium inwardly-rectifying channel, subfamily J, member 1



chr19_+_45998020 0.452 NM_053046
EGLN2
egl nine homolog 2 (C. elegans)
chr7_-_44331544 0.452 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr10_+_75343352 0.452 PLAU
plasminogen activator, urokinase
chr19_-_4468715 0.451 NM_001080400
PLIN4
perilipin 4
chr12_+_47009029 0.450 NM_181788
H1FNT
H1 histone family, member N, testis-specific
chr16_+_84202515 0.449 NM_001134473
KIAA0182
KIAA0182
chr17_+_7151368 0.448 NM_001970
EIF5A
eukaryotic translation initiation factor 5A
chr11_+_70926718 0.448 NM_021046
KRTAP5-8
keratin associated protein 5-8
chr20_+_3724385 0.448 NM_004358
NM_021872
NM_021873
CDC25B


cell division cycle 25 homolog B (S. pombe)


chr12_+_56435042 0.447 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr13_-_99983945 0.445 NM_033110
A2LD1
AIG2-like domain 1
chr2_+_120820140 0.444 NM_002193
INHBB
inhibin, beta B
chr17_+_14145051 0.442 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr3_+_114414064 0.441 NM_033254
BOC
Boc homolog (mouse)
chr15_-_53369261 0.441 NM_183235
RAB27A
RAB27A, member RAS oncogene family
chr6_+_30142910 0.438 NM_021959
PPP1R11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr22_+_38213174 0.435 NM_001098270
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr6_-_32184975 0.434 NM_019105
TNXB
tenascin XB
chr11_-_128279670 0.434 C11orf45
chromosome 11 open reading frame 45
chr11_+_63876924 0.432 CCDC88B
coiled-coil domain containing 88B
chr3_+_114733907 0.431 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr17_+_24944605 0.429 NM_152345
ANKRD13B
ankyrin repeat domain 13B
chr16_+_4325142 0.429 GLIS2
GLIS family zinc finger 2
chr4_+_3285671 0.425 NM_002926
NM_198229
RGS12

regulator of G-protein signaling 12

chr11_+_834111 0.420 TSPAN4
tetraspanin 4
chr17_+_7151041 0.419 NM_001143760
EIF5A
eukaryotic translation initiation factor 5A
chr14_-_53491019 0.418 NM_130851
BMP4
bone morphogenetic protein 4
chr10_-_80875097 0.416 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr20_+_29870836 0.416 NM_033118
MYLK2
myosin light chain kinase 2
chr12_-_119172339 0.415 NM_025157
PXN
paxillin
chr19_+_54884252 0.414 C19orf76
chromosome 19 open reading frame 76
chr1_+_87368044 0.413 LOC339524
hypothetical LOC339524
chr22_-_35835548 0.413 TMPRSS6
transmembrane protease, serine 6
chr11_+_66140628 0.412 NM_001198845
NM_001198846
NM_001198836
NM_001198837
NM_006328
RBM14-RBM4

RBM14


RBM14-RBM4 readthrough

RNA binding motif protein 14


chr11_-_117203937 0.411 NM_021603
FXYD2
FXYD domain containing ion transport regulator 2
chr17_-_75427644 0.409 NM_003655
CBX4
chromobox homolog 4
chr11_+_817584 0.408 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr6_-_89884324 0.408 NM_080743
SRSF12
serine/arginine-rich splicing factor 12
chr16_+_28797309 0.408 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr8_+_21956335 0.408 NM_003867
FGF17
fibroblast growth factor 17
chr3_+_135996734 0.406 NM_004441
EPHB1
EPH receptor B1
chr17_+_77783432 0.404 NM_001042423
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr8_+_70541631 0.404 SULF1
sulfatase 1
chr3_+_135996990 0.401 EPHB1
EPH receptor B1
chr2_+_241776596 0.399 NM_001001666
NM_001001891
ANO7

anoctamin 7

chr17_+_72958207 0.398 NM_001113496
SEPT9
septin 9
chr14_-_87806913 0.397 NM_138318
KCNK10
potassium channel, subfamily K, member 10
chr3_-_127719283 0.393 NM_001165974
NM_144639
UROC1

urocanase domain containing 1

chr17_+_45979518 0.393 NM_022827
SPATA20
spermatogenesis associated 20
chr14_+_104523660 0.391 NM_174891
C14orf79
chromosome 14 open reading frame 79
chr16_+_65018316 0.390 NM_001136106
NM_001178020
NM_001197224
NM_001197225
BEAN1



brain expressed, associated with NEDD4, 1



chr1_+_39229474 0.390 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr17_+_4776371 0.390 NM_000173
GP1BA
glycoprotein Ib (platelet), alpha polypeptide
chr3_+_10832867 0.383 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr10_-_13584950 0.382 NM_001100912
NM_152751
BEND7

BEN domain containing 7

chr17_-_40858775 0.382 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr9_+_134884627 0.380 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr19_-_8118367 0.378 NM_032447
FBN3
fibrillin 3
chr1_+_110456584 0.377 NM_203412
UBL4B
ubiquitin-like 4B
chr8_-_143830930 0.376 NM_205545
LYPD2
LY6/PLAUR domain containing 2
chr8_-_82916982 0.374 NM_022133
NM_152836
NM_152837
SNX16


sorting nexin 16


chr20_-_1113116 0.372 NM_018354
C20orf46
chromosome 20 open reading frame 46
chr19_-_13808101 0.372 LOC284454
hypothetical LOC284454
chr16_+_67697622 0.371 NM_138612
HAS3
hyaluronan synthase 3
chr7_-_1465633 0.370 NM_182924
MICALL2
MICAL-like 2
chr12_+_54361596 0.369 NM_152637
METTL7B
methyltransferase like 7B
chr1_+_8928508 0.368 NM_001215
CA6
carbonic anhydrase VI
chr19_+_18312365 0.368 NM_017712
FKBP8
PGPEP1
FK506 binding protein 8, 38kDa
pyroglutamyl-peptidase I
chr11_-_64327197 0.367 NM_004579
MAP4K2
mitogen-activated protein kinase kinase kinase kinase 2
chr17_+_72958330 0.365 SEPT9
septin 9
chr2_-_72906538 0.365 NM_015189
EXOC6B
exocyst complex component 6B
chr1_+_17121012 0.364 NM_014675
CROCC
ciliary rootlet coiled-coil, rootletin
chr11_-_685010 0.364 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr19_+_53664386 0.361 CYTH2
cytohesin 2
chr2_-_180580024 0.359 NM_020943
CWC22
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr20_-_29896981 0.356 NM_004118
FOXS1
forkhead box S1
chr22_+_18447732 0.354 NM_001190326
NM_022720
DGCR8

DiGeorge syndrome critical region gene 8

chr11_+_1846478 0.353 NM_001013253
LSP1
lymphocyte-specific protein 1
chr12_+_10074542 0.353 NM_207345
CLEC9A
C-type lectin domain family 9, member A
chr5_-_131375148 0.353 NM_001009185
NM_015256
ACSL6

acyl-CoA synthetase long-chain family member 6

chr1_+_199884072 0.352 NM_020443
NAV1
neuron navigator 1
chr17_+_7151653 0.350 EIF5A
eukaryotic translation initiation factor 5A
chr6_+_36754433 0.349 NM_000389
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr11_+_65802221 0.349 NM_182553
CNIH2
cornichon homolog 2 (Drosophila)
chr19_-_51829778 0.344 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr11_-_404975 0.341 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr1_-_154665807 0.339 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr9_-_137992967 0.339 NM_016172
UBAC1
UBA domain containing 1
chr8_-_22054939 0.339 NM_025232
REEP4
receptor accessory protein 4
chr17_-_59349867 0.338 NM_000515
NM_022559
NM_022560
NM_022561
NM_022562
GH1




growth hormone 1




chr11_-_565848 0.337 LOC143666
hypothetical LOC143666
chr19_+_53664276 0.335 NM_004228
NM_017457
CYTH2

cytohesin 2

chr10_+_104145421 0.334 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr19_+_43518282 0.334 NM_021185
CATSPERG
cation channel, sperm-associated, gamma
chr15_+_72208751 0.333 NM_001130136
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr6_+_29902734 0.332 NM_002127
HLA-G
major histocompatibility complex, class I, G
chr12_+_54396086 0.332 NM_001487
BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr6_+_36754467 0.331 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr3_+_52254782 0.331 PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr18_+_75760434 0.330


chr12_+_54396099 0.330 BLOC1S1-RDH5
BLOC1S1
BLOC1S1-RDH5 read-through transcript
biogenesis of lysosomal organelles complex-1, subunit 1
chr11_-_75599433 0.330 WNT11
wingless-type MMTV integration site family, member 11
chr7_-_128330615 0.330 KCP
kielin/chordin-like protein
chr13_-_33148899 0.330 STARD13
StAR-related lipid transfer (START) domain containing 13

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.14 1.94e-05 GO:0050789 regulation of biological process
1.13 2.88e-05 GO:0065007 biological regulation
1.35 4.02e-05 GO:0048583 regulation of response to stimulus
1.22 5.72e-05 GO:0023052 signaling
1.14 1.63e-04 GO:0050794 regulation of cellular process
1.18 2.24e-03 GO:0051716 cellular response to stimulus
1.35 2.83e-03 GO:0009966 regulation of signal transduction
1.36 3.23e-03 GO:0051239 regulation of multicellular organismal process
1.41 3.44e-03 GO:0007154 cell communication
1.31 5.77e-03 GO:0023051 regulation of signaling
1.46 9.10e-03 GO:0007267 cell-cell signaling
1.20 9.75e-03 GO:0007165 signal transduction
1.58 9.81e-03 GO:0048585 negative regulation of response to stimulus
1.38 1.14e-02 GO:0010646 regulation of cell communication
1.47 3.06e-02 GO:0010628 positive regulation of gene expression
1.58 3.71e-02 GO:0032583 regulation of gene-specific transcription
1.21 3.84e-02 GO:0048518 positive regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.27 1.72e-04 GO:0044459 plasma membrane part
1.16 3.55e-03 GO:0071944 cell periphery
1.15 7.42e-03 GO:0005886 plasma membrane

Nothing significant found in function category.