Motif ID: NFATC1..3.p2

Z-value: 1.924


Transcription factors associated with NFATC1..3.p2:

Gene SymbolEntrez IDGene Name
NFATC1 4772 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 4773 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 4775 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3



Activity profile for motif NFATC1..3.p2.

activity profile for motif NFATC1..3.p2


Sorted Z-values histogram for motif NFATC1..3.p2

Sorted Z-values for motif NFATC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_246635918 3.311 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr12_+_13240983 2.686 EMP1
epithelial membrane protein 1
chr2_-_55090759 2.620 NM_007008
RTN4
reticulon 4
chr12_+_13240987 2.617 EMP1
epithelial membrane protein 1
chr6_+_88024152 2.601 ZNF292
zinc finger protein 292
chr11_+_57714481 2.518 NM_001005283
OR9Q2
olfactory receptor, family 9, subfamily Q, member 2
chr12_-_11178109 2.440 NM_001097643
TAS2R30
taste receptor, type 2, member 30
chr18_-_49944986 2.227 MBD2
methyl-CpG binding domain protein 2
chr3_+_189425886 2.219 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr3_+_99465777 2.091 NM_001005479
OR5H6
olfactory receptor, family 5, subfamily H, member 6
chr18_+_64616296 2.065 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr1_+_39694849 2.064 MACF1
microtubule-actin crosslinking factor 1
chr5_+_43645018 2.064 NNT
nicotinamide nucleotide transhydrogenase
chr12_+_13240868 2.051 NM_001423
EMP1
epithelial membrane protein 1
chr4_-_72868598 2.032 NM_000583
GC
group-specific component (vitamin D binding protein)
chr3_+_69216747 2.028 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr8_-_82522175 1.986 NM_002677
PMP2
peripheral myelin protein 2
chr1_+_85819004 1.840 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr1_-_156816312 1.831 NM_001004477
OR10X1
olfactory receptor, family 10, subfamily X, member 1
chr21_-_26345294 1.815


chr9_-_21192201 1.728 NM_021057
IFNA7
interferon, alpha 7
chr3_+_88270951 1.701 NM_018293
ZNF654
zinc finger protein 654
chr14_-_106193403 1.674 IGKV3-20
immunoglobulin kappa variable 3-20
chr20_+_12937616 1.585 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr5_+_86712376 1.572


chr1_+_160868932 1.569 DDR2
discoidin domain receptor tyrosine kinase 2
chr17_+_7732759 1.558 NM_001005273
NM_005852
CHD3

chromodomain helicase DNA binding protein 3

chr1_+_157246305 1.547 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr10_-_108448990 1.544 SORCS1
sortilin-related VPS10 domain containing receptor 1
chr1_-_246503738 1.531 NM_001004695
OR2T33
olfactory receptor, family 2, subfamily T, member 33
chr12_-_88573949 1.529 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr19_+_41419165 1.510 ZNF146
zinc finger protein 146
chr12_-_10846435 1.510 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr1_+_98899734 1.508 NM_015976
NM_152238
SNX7

sorting nexin 7

chr6_-_132980901 1.508 NM_014626
TAAR2
trace amine associated receptor 2
chr3_-_174341653 1.488 NM_031955
SPATA16
spermatogenesis associated 16
chr10_-_51678318 1.478 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chr1_+_78243181 1.468 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr3_+_103029523 1.458 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr21_-_26867138 1.446 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr22_-_39189369 1.444 MKL1
megakaryoblastic leukemia (translocation) 1
chrX_+_56772391 1.435 LOC550643
hypothetical LOC550643
chr9_-_27519434 1.428 NM_024761
MOBKL2B
MOB1, Mps One Binder kinase activator-like 2B (yeast)
chr3_-_18455207 1.428 NM_001131010
SATB1
SATB homeobox 1
chr1_+_12325632 1.418 VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr9_+_35528890 1.417 RUSC2
RUN and SH3 domain containing 2
chr12_-_11215396 1.397 NM_001098538
NM_006250
PRH1-PRR4
PRR4
TAS2R14
PRH1
PRH1-PRR4 read-through transcript
proline rich 4 (lacrimal)
taste receptor, type 2, member 14
proline-rich protein HaeIII subfamily 1
chr19_+_41418723 1.389 ZNF146
zinc finger protein 146
chr7_+_80145461 1.387 CD36
CD36 molecule (thrombospondin receptor)
chr20_+_42644633 1.378 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr2_-_215967442 1.376 FN1
fibronectin 1
chr8_+_144802972 1.365 NM_014789
ZNF623
zinc finger protein 623
chr6_-_128883125 1.352 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr14_+_62740878 1.336 NM_020663
RHOJ
ras homolog gene family, member J
chr2_-_37727472 1.326 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr4_+_95595419 1.313 PDLIM5
PDZ and LIM domain 5
chr6_-_110843432 1.306 NM_003649
NM_004032
DDO

D-aspartate oxidase

chr14_+_80491461 1.300 NM_000369
NM_001018036
NM_001142626
TSHR


thyroid stimulating hormone receptor


chr11_+_89624017 1.292


chr16_-_80602546 1.291 NM_145168
SDR42E1
short chain dehydrogenase/reductase family 42E, member 1
chr7_+_80069439 1.256 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr22_+_36401558 1.255 NM_002305
LGALS1
lectin, galactoside-binding, soluble, 1
chr1_-_145699308 1.247 NM_181703
GJA5
gap junction protein, alpha 5, 40kDa
chr6_-_90081655 1.236 NM_002043
GABRR2
gamma-aminobutyric acid (GABA) receptor, rho 2
chr21_-_27261276 1.233 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr10_-_126706442 1.228 NM_022802
CTBP2
C-terminal binding protein 2
chr5_-_86739683 1.222 CCNH
cyclin H
chr4_+_91035025 1.221 NM_007351
MMRN1
multimerin 1
chr11_+_22652957 1.210 GAS2
growth arrest-specific 2
chr2_-_189363075 1.204 NM_052952
DIRC1
disrupted in renal carcinoma 1
chr9_-_99746923 1.202 NM_018437
HEMGN
hemogen
chr17_-_36451189 1.182 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr4_-_120445047 1.180 NM_001170330
C4orf3
chromosome 4 open reading frame 3
chr9_-_103185621 1.179 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr3_-_71715431 1.175 NM_001012505
NM_032682
FOXP1

forkhead box P1

chr20_+_16312 1.174 NM_153325
DEFB125
defensin, beta 125
chr21_-_26294332 1.173 APP
amyloid beta (A4) precursor protein
chr3_-_180467483 1.166 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr8_+_9990471 1.158 NM_001135671
MSRA
methionine sulfoxide reductase A
chr11_+_55776251 1.155 NM_001004747
OR5T3
olfactory receptor, family 5, subfamily T, member 3
chr11_+_56187713 1.155 NM_001004730
OR5AR1
olfactory receptor, family 5, subfamily AR, member 1
chr5_-_88235624 1.153 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr11_-_102219450 1.147 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr6_-_30188845 1.146 NM_007028
TRIM31
tripartite motif containing 31
chr15_+_38296920 1.146 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr6_+_154373323 1.145 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr6_-_151754337 1.145 NM_020861
ZBTB2
zinc finger and BTB domain containing 2
chr10_+_96433240 1.139 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr12_-_44919818 1.138 SLC38A1
solute carrier family 38, member 1
chr18_+_30589937 1.134 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr7_+_93388951 1.117 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr20_+_15125503 1.114 NM_001033087
MACROD2
MACRO domain containing 2
chr5_-_132300702 1.107


chr10_+_104493730 1.104 C10orf26
chromosome 10 open reading frame 26
chr4_+_71235259 1.098 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr14_-_20098929 1.078 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr14_-_20969706 1.064 NM_001170629
CHD8
chromodomain helicase DNA binding protein 8
chr15_+_79080341 1.051 NM_022566
MESDC1
mesoderm development candidate 1
chr9_+_35528628 1.050 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr14_-_106282128 1.050 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr11_-_100505667 1.046 NM_000926
PGR
progesterone receptor
chr5_-_101862447 1.042 NM_173488
SLCO6A1
solute carrier organic anion transporter family, member 6A1
chr12_-_11230809 1.040 NM_181429
TAS2R42
taste receptor, type 2, member 42
chr16_-_3783475 1.037 CREBBP
CREB binding protein
chr12_-_5925658 1.036 NM_020373
ANO2
anoctamin 2
chr9_-_21156609 1.034 NM_002175
IFNA21
interferon, alpha 21
chr11_+_124984559 1.031 STT3A
STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
chr11_+_125208420 1.025 NM_001144874
PATE4
prostate and testis expressed 4
chr7_-_18033970 1.019 NM_175886
PRPS1L1
phosphoribosyl pyrophosphate synthetase 1-like 1
chr1_+_160868822 1.019 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr4_-_87593306 1.013 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr3_+_161040439 1.012 SCHIP1
schwannomin interacting protein 1
chr1_-_167865973 1.004 NM_003005
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr12_+_55674496 1.003 NM_007264
GPR182
G protein-coupled receptor 182
chr12_-_89976261 0.995 NM_007035
KERA
keratocan
chr15_+_22781292 0.994 PAR5
Prader-Willi/Angelman syndrome-5
chr8_+_92184022 0.985 NM_001129890
LRRC69
leucine rich repeat containing 69
chr2_+_211166323 0.983 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr8_+_17866373 0.980 PCM1
pericentriolar material 1
chr21_+_25856311 0.976 MIR155HG
MIR155 host gene (non-protein coding)
chr4_+_154397975 0.972 TRIM2
tripartite motif containing 2
chr2_+_170074457 0.969 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr1_-_152394215 0.967 NM_001159484
NM_207308
NUP210L

nucleoporin 210kDa-like

chr14_-_35859545 0.964 NM_001144891
NM_016586
MBIP

MAP3K12 binding inhibitory protein 1

chr4_+_71283383 0.960 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr1_-_120112989 0.960 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr1_+_66772393 0.957 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr18_-_38949481 0.956 NM_002930
RIT2
Ras-like without CAAX 2
chrX_+_128867757 0.956 NM_001166221
NM_006649
UTP14A

UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)

chr5_+_179934143 0.954 CNOT6
CCR4-NOT transcription complex, subunit 6
chr3_+_189413414 0.951 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_-_224993498 0.949 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr1_-_161379606 0.947 RGS5
regulator of G-protein signaling 5
chr16_+_20370359 0.942 NM_001010845
ACSM2A
acyl-CoA synthetase medium-chain family member 2A
chr21_-_30720100 0.940 NM_181622
KRTAP13-3
keratin associated protein 13-3
chr15_+_69626594 0.931 THSD4
thrombospondin, type I, domain containing 4
chr2_-_210876560 0.930 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr5_+_132037271 0.930 NM_000589
NM_172348
IL4

interleukin 4

chr12_-_51153788 0.929 NM_173086
KRT6C
keratin 6C
chr2_-_165520241 0.924 NM_173512
SLC38A11
solute carrier family 38, member 11
chr1_+_156991133 0.914 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chr4_+_88187215 0.912 AFF1
AF4/FMR2 family, member 1
chr1_-_245988330 0.910 NM_012353
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr18_+_59521173 0.906 NM_080475
SERPINB11
serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)
chr20_+_86121 0.902 NM_139074
DEFB127
defensin, beta 127
chr1_-_246804680 0.901 NM_001001821
OR2T34
olfactory receptor, family 2, subfamily T, member 34
chr8_+_76059262 0.899 NM_031461
CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr8_+_36760999 0.892 NM_001031836
KCNU1
potassium channel, subfamily U, member 1
chr11_+_123491313 0.888 NM_001130142
NM_014622
NM_198315
VWA5A


von Willebrand factor A domain containing 5A


chr5_-_150306298 0.884 ZNF300P1
zinc finger protein 300 pseudogene 1
chr11_-_55460451 0.883 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr5_-_41297296 0.880 NM_001115131
C6
complement component 6
chr2_+_211129567 0.877 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr2_-_68332985 0.870 NM_000945
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr6_+_88026338 0.869 ZNF292
zinc finger protein 292
chr1_+_145479805 0.864 NM_004326
BCL9
B-cell CLL/lymphoma 9
chr7_-_87068106 0.857 ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr13_-_48008118 0.854 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr14_+_64001969 0.850 NM_004857
AKAP5
A kinase (PRKA) anchor protein 5
chr5_+_108112537 0.847 FER
fer (fps/fes related) tyrosine kinase
chr14_-_20694023 0.840 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr15_+_46271158 0.833 NM_001145668
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
chr6_+_97117144 0.833 NM_001170807
NM_020482
FHL5

four and a half LIM domains 5

chr9_+_107249897 0.832 NM_001145313
NM_031919
NM_207647
FSD1L


fibronectin type III and SPRY domain containing 1-like


chr11_+_33306652 0.832 HIPK3
homeodomain interacting protein kinase 3
chr1_+_169421011 0.831 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr9_+_12764988 0.829 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr1_-_205272619 0.826 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr1_-_21310462 0.825 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr12_-_21980894 0.824 NM_005691
NM_020297
NM_020298
ABCC9


ATP-binding cassette, sub-family C (CFTR/MRP), member 9


chr12_+_10348311 0.821 NM_001114396
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr4_-_104240413 0.821 NM_020139
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr6_-_109795925 0.818 CD164
CD164 molecule, sialomucin
chr11_-_55757236 0.817 NM_001004746
OR5T2
olfactory receptor, family 5, subfamily T, member 2
chrX_-_70248022 0.813 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr8_-_93144366 0.812 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_145892190 0.809 NM_001097616
GPR89C
G protein-coupled receptor 89C
chr15_+_57286313 0.808 NM_033195
LDHAL6B
lactate dehydrogenase A-like 6B
chr11_-_56015421 0.807 NM_001005282
OR5M8
olfactory receptor, family 5, subfamily M, member 8
chr10_+_118177371 0.804 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr10_+_104493701 0.797 C10orf26
chromosome 10 open reading frame 26
chr8_-_93144039 0.793


chr12_-_21985433 0.792 ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr18_-_44723116 0.791 NM_001190823
SMAD7
SMAD family member 7
chr6_+_116798791 0.791 NM_013352
DSE
dermatan sulfate epimerase
chr1_+_150852910 0.786 NM_178433
LCE3B
late cornified envelope 3B
chr5_-_146441184 0.785 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr7_-_22518200 0.780 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr10_-_31328426 0.773 NM_001143769
ZNF438
zinc finger protein 438
chr2_-_204108151 0.771 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr3_+_87359088 0.770 NM_014043
CHMP2B
chromatin modifying protein 2B
chr9_+_124551839 0.768 NM_001004453
OR1L6
olfactory receptor, family 1, subfamily L, member 6
chr6_-_119512035 0.767 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr12_+_32578513 0.766 FGD4
FYVE, RhoGEF and PH domain containing 4
chr18_-_29882555 0.765 NM_001198549
NOL4
nucleolar protein 4
chr1_-_150564302 0.764 NM_002016
FLG
filaggrin
chr15_-_63457378 0.761 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr11_+_22652894 0.760 NM_005256
GAS2
growth arrest-specific 2
chr12_-_21649019 0.760 NM_021957
GYS2
glycogen synthase 2 (liver)
chr5_+_57914658 0.760 NM_138453
RAB3C
RAB3C, member RAS oncogene family

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.18 1.75e-18 GO:0007606 sensory perception of chemical stimulus
2.22 1.54e-17 GO:0007608 sensory perception of smell
1.72 1.63e-12 GO:0007600 sensory perception
1.53 1.30e-11 GO:0050877 neurological system process
1.43 5.54e-10 GO:0003008 system process
1.17 3.90e-07 GO:0050896 response to stimulus
1.13 3.73e-02 GO:0032501 multicellular organismal process
4.26 4.46e-02 GO:0030728 ovulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 2.27e-06 GO:0071944 cell periphery
1.19 2.75e-06 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.32 8.68e-20 GO:0004984 olfactory receptor activity
1.70 7.09e-13 GO:0004930 G-protein coupled receptor activity
1.46 1.15e-08 GO:0004888 transmembrane receptor activity
1.34 1.92e-06 GO:0004872 receptor activity
1.30 2.51e-06 GO:0004871 signal transducer activity
1.30 2.51e-06 GO:0060089 molecular transducer activity