Motif ID: SPI1.p2

Z-value: 1.562


Transcription factors associated with SPI1.p2:

Gene SymbolEntrez IDGene Name
SPI1 6688 spleen focus forming virus (SFFV) proviral integration oncogene spi1



Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_42947754 1.392 NM_003404
NM_139323
YWHAB

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

chr20_+_42947764 1.342 YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr15_+_36332258 0.988 NM_152594
SPRED1
sprouty-related, EVH1 domain containing 1
chr11_+_61352348 0.964 FADS2
fatty acid desaturase 2
chr3_-_107070400 0.952 NM_170662
CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr17_+_24742068 0.947 NM_020791
TAOK1
TAO kinase 1
chr3_+_189354167 0.928 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr3_-_88190737 0.902 NM_001008390
NM_003663
CGGBP1

CGG triplet repeat binding protein 1

chr1_+_67168470 0.881 NM_001077701
NM_001077704
MIER1

mesoderm induction early response 1 homolog (Xenopus laevis)

chr2_+_46779827 0.814 NM_144949
SOCS5
suppressor of cytokine signaling 5
chr2_+_85051687 0.777 NM_020122
KCMF1
potassium channel modulatory factor 1
chr14_+_85069217 0.758


chr8_+_104582151 0.747 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chr11_+_61352209 0.744 NM_004265
FADS2
fatty acid desaturase 2
chr17_+_4683280 0.741 NM_001024937
NM_015716
NM_153827
NM_170663
MINK1



misshapen-like kinase 1



chr6_+_87921980 0.725 NM_015021
ZNF292
zinc finger protein 292
chr3_+_108724472 0.718 NM_001142568
NM_020235
BBX

bobby sox homolog (Drosophila)

chr14_-_47213906 0.703 NM_001113498
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr3_+_132095496 0.696 ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr2_+_46779553 0.687 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr1_-_166172901 0.672 NM_001143674
BRP44
brain protein 44
chr18_+_30875297 0.653 NM_014268
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr17_+_35853177 0.653 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chrX_-_50573759 0.646 NM_020717
SHROOM4
shroom family member 4
chr5_+_60663842 0.638 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr20_+_19903778 0.637 RIN2
Ras and Rab interactor 2
chr6_+_21701942 0.635 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr14_+_31616196 0.626 NM_001030055
NM_001173
ARHGAP5

Rho GTPase activating protein 5

chr2_+_27659396 0.623 NM_032434
ZNF512
zinc finger protein 512
chr15_+_65145248 0.621 NM_005902
SMAD3
SMAD family member 3
chr5_+_67547357 0.620 PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr9_-_21965131 0.619 NM_000077
NM_001195132
CDKN2A

cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

chr2_+_187163232 0.616 ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr17_+_43082273 0.600 NM_002265
KPNB1
karyopherin (importin) beta 1
chr15_+_65145215 0.597 SMAD3
SMAD family member 3
chr3_-_189354510 0.597 LOC339929
hypothetical LOC339929
chr7_+_32501665 0.589 NM_015060
AVL9
AVL9 homolog (S. cerevisiase)
chr9_-_5997891 0.582 NM_001017969
KIAA2026
KIAA2026
chr7_+_107171809 0.579 CBLL1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
chr10_+_31648103 0.562 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chr10_+_89409332 0.554 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr10_+_121642204 0.553 NM_007190
SEC23IP
SEC23 interacting protein
chr4_+_145786622 0.546 NM_022475
HHIP
hedgehog interacting protein
chr12_+_21546012 0.541 GOLT1B
golgi transport 1B
chr3_-_151904408 0.536 NM_152394
FAM194A
family with sequence similarity 194, member A
chr7_-_4867963 0.534 NM_020144
PAPOLB
poly(A) polymerase beta (testis specific)
chr17_+_43082302 0.533 KPNB1
karyopherin (importin) beta 1
chr3_+_129253977 0.533 SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr4_+_99401543 0.529 NM_001100426
NM_001100427
NM_001100428
NM_001100429
NM_001100430
NM_021159
RAP1GDS1





RAP1, GTP-GDP dissociation stimulator 1





chr15_+_98960277 0.528 NM_024708
NM_198243
ASB7

ankyrin repeat and SOCS box containing 7

chr6_+_7052985 0.526 NM_001003698
NM_001003699
NM_001003700
RREB1


ras responsive element binding protein 1


chr3_-_126576693 0.524 NM_021964
ZNF148
zinc finger protein 148
chr16_+_54100482 0.522 LPCAT2
lysophosphatidylcholine acyltransferase 2
chr7_+_107171514 0.518 NM_024814
CBLL1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
chr7_+_17304707 0.515 NM_001621
AHR
aryl hydrocarbon receptor
chr17_+_2443983 0.504 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr7_+_106596641 0.498 NM_012257
HBP1
HMG-box transcription factor 1
chr12_+_8958397 0.496 NM_004426
PHC1
polyhomeotic homolog 1 (Drosophila)
chr2_+_218790143 0.489 ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr13_+_25726755 0.488 NM_001260
CDK8
cyclin-dependent kinase 8
chr12_+_21545965 0.477 NM_016072
GOLT1B
golgi transport 1B
chr22_+_39818553 0.474 NM_001429
EP300
E1A binding protein p300
chr15_+_83724743 0.471 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr2_+_85051942 0.471 KCMF1
potassium channel modulatory factor 1
chr10_-_27189898 0.468 ABI1
abl-interactor 1
chr2_+_148495043 0.463 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr8_+_64243662 0.461 NM_152758
YTHDF3
YTH domain family, member 3
chr3_+_195889845 0.460 FAM43A
family with sequence similarity 43, member A
chr1_+_166172545 0.455 DCAF6
DDB1 and CUL4 associated factor 6
chr2_+_218790109 0.455 NM_152862
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr2_+_74007495 0.454 DGUOK
deoxyguanosine kinase
chr14_+_96038521 0.453 PAPOLA
poly(A) polymerase alpha
chr20_+_16658608 0.449 NM_003092
NM_198220
SNRPB2

small nuclear ribonucleoprotein polypeptide B

chr2_+_218790364 0.448 NM_005731
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr14_+_96038479 0.448 PAPOLA
poly(A) polymerase alpha
chr16_+_54100545 0.444 LPCAT2
lysophosphatidylcholine acyltransferase 2
chr12_+_64504835 0.441 HMGA2
high mobility group AT-hook 2
chr2_-_148494732 0.441 NM_001190882
NM_001190879
NM_002552
NM_001190881
NM_181741
ORC4




origin recognition complex, subunit 4




chr8_+_64243741 0.440 YTHDF3
YTH domain family, member 3
chr4_+_184257337 0.440 NM_024949
WWC2
WW and C2 domain containing 2
chr5_+_118719591 0.439 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr10_-_31647925 0.438 LOC220930
hypothetical LOC220930
chr3_+_180348818 0.437 NM_006218
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr2_+_74007523 0.433 DGUOK
deoxyguanosine kinase
chr20_+_33223434 0.428 NM_006404
PROCR
protein C receptor, endothelial
chr6_+_149680747 0.428 TAB2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr3_+_120495906 0.425 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr1_+_144188375 0.424 NM_153713
LIX1L
Lix1 homolog (mouse)-like
chr2_+_124499332 0.424 NM_130773
CNTNAP5
contactin associated protein-like 5
chr1_+_111963920 0.423 NM_001010935
NM_002884
RAP1A

RAP1A, member of RAS oncogene family

chr1_+_36169260 0.422 NM_024852
NM_177422
EIF2C3

eukaryotic translation initiation factor 2C, 3

chr1_+_181708068 0.420 NM_001174061
NM_173156
NM_201568
NM_201569
SMG7



Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)



chr1_+_181708235 0.420 SMG7
Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr15_+_92575767 0.420 MCTP2
multiple C2 domains, transmembrane 2
chr1_-_181708022 0.417 LOC284649
hypothetical LOC284649
chr14_+_96038451 0.415 NM_032632
PAPOLA
poly(A) polymerase alpha
chr3_+_19963534 0.414 NM_004162
RAB5A
RAB5A, member RAS oncogene family
chr15_-_72952648 0.414 NM_005697
SCAMP2
secretory carrier membrane protein 2
chr15_+_66133709 0.414 PIAS1
protein inhibitor of activated STAT, 1
chr16_+_54100410 0.412 NM_017839
LPCAT2
lysophosphatidylcholine acyltransferase 2
chrX_-_134883798 0.409 NM_173470
MMGT1
membrane magnesium transporter 1
chr9_+_33807168 0.409 NM_017811
UBE2R2
ubiquitin-conjugating enzyme E2R 2
chr7_+_114350144 0.407 MDFIC
MyoD family inhibitor domain containing
chr11_+_85017269 0.406 NM_001193537
NM_001193538
NM_018480
TMEM126B


transmembrane protein 126B


chr12_+_109203526 0.405 ATP2A2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr3_+_98016114 0.403 NM_001080448
EPHA6
EPH receptor A6
chr15_-_54997964 0.401 LOC145783
hypothetical LOC145783
chrX_+_105932536 0.400 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr2_+_74007439 0.399 NM_080916
NM_080918
DGUOK

deoxyguanosine kinase

chr4_+_183302105 0.398 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr2_-_148495642 0.396 NM_181742
ORC4
origin recognition complex, subunit 4
chr8_-_101384633 0.395 NM_015435
RNF19A
ring finger protein 19A
chr8_+_15442123 0.392 TUSC3
tumor suppressor candidate 3
chr12_-_69289889 0.392 NM_002837
PTPRB
protein tyrosine phosphatase, receptor type, B
chrX_-_44945025 0.391 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr3_-_169295869 0.391 NM_014498
GOLIM4
golgi integral membrane protein 4
chr14_+_70444191 0.391 PCNX
pecanex homolog (Drosophila)
chr9_+_130354490 0.386 NM_001130438
NM_001195532
NM_003127
SPTAN1


spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)


chr2_+_206847658 0.385 NM_020923
ZDBF2
zinc finger, DBF-type containing 2
chr12_+_60940404 0.385 NM_006313
USP15
ubiquitin specific peptidase 15
chr2_+_44249487 0.384 NM_001033556
NM_001033557
NM_002706
NM_177968
NM_177969
PPM1B




protein phosphatase, Mg2+/Mn2+ dependent, 1B




chr10_+_101409159 0.382 NM_020354
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr11_+_126378507 0.378 NCRNA00288
non-protein coding RNA 288
chr12_+_95112385 0.378 ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr15_+_54998115 0.377 NM_003205
NM_207036
NM_207037
NM_207038
TCF12



transcription factor 12



chr6_+_7053183 0.376 RREB1
ras responsive element binding protein 1
chr17_+_26446082 0.376 NF1
neurofibromin 1
chr1_+_166172679 0.375 DCAF6
DDB1 and CUL4 associated factor 6
chr8_+_76059262 0.374 NM_031461
CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr4_+_39376058 0.371 NM_001111112
NM_001111113
NM_005339
UBE2K


ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)


chr6_+_134315940 0.370 NM_004865
TBPL1
TBP-like 1
chr2_+_137239583 0.370 THSD7B
thrombospondin, type I, domain containing 7B
chr2_+_60836858 0.370 NM_022894
PAPOLG
poly(A) polymerase gamma
chr12_-_53071285 0.368 NM_001130967
NM_001130968
ZNF385A

zinc finger protein 385A

chr14_+_55654900 0.368 PELI2
pellino homolog 2 (Drosophila)
chr3_+_186786655 0.367 NM_021627
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr2_+_48395271 0.366 NM_002158
FOXN2
forkhead box N2
chr14_+_31615959 0.365 ARHGAP5
Rho GTPase activating protein 5
chr5_+_49998528 0.362 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr7_+_32501577 0.361 AVL9
AVL9 homolog (S. cerevisiase)
chr2_+_172658453 0.361 NM_001038493
NM_178120
DLX1

distal-less homeobox 1

chr8_+_15442100 0.360 NM_006765
NM_178234
TUSC3

tumor suppressor candidate 3

chr8_+_15442106 0.360 TUSC3
tumor suppressor candidate 3
chr8_-_93099040 0.358 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_+_75688025 0.358 C14orf118
chromosome 14 open reading frame 118
chr3_+_102775716 0.357 NM_020357
PCNP
PEST proteolytic signal containing nuclear protein
chr2_+_191222077 0.357 NM_005966
NAB1
NGFI-A binding protein 1 (EGR1 binding protein 1)
chr14_+_28306633 0.356 FOXG1
forkhead box G1
chr12_+_62524778 0.356 NM_020762
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1
chr3_+_88281582 0.355 NM_173824
C3orf38
chromosome 3 open reading frame 38
chr14_+_75687997 0.354 NM_017926
NM_017972
C14orf118

chromosome 14 open reading frame 118

chr3_+_102775677 0.354 PCNP
PEST proteolytic signal containing nuclear protein
chr13_+_110604036 0.353 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr2_+_135392879 0.353 CCNT2
cyclin T2
chr13_+_81162030 0.353


chr14_+_54104383 0.352 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr9_+_33807213 0.351 UBE2R2
ubiquitin-conjugating enzyme E2R 2
chr9_+_76893232 0.350 OSTF1
osteoclast stimulating factor 1
chr3_+_150065732 0.350 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr6_+_108988797 0.349 FOXO3
forkhead box O3
chr2_+_218790159 0.349 ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr22_+_44446378 0.348 ATXN10
ataxin 10
chr11_-_57752923 0.345 NM_001004471
OR10Q1
olfactory receptor, family 10, subfamily Q, member 1
chr2_-_218516950 0.345 NM_022648
TNS1
tensin 1
chr2_+_71412348 0.344 NM_001014972
NM_014497
ZNF638

zinc finger protein 638

chr2_+_115635982 0.344 NM_001178034
NM_001004360
DPP10

dipeptidyl-peptidase 10 (non-functional)

chr14_+_75688042 0.343 C14orf118
chromosome 14 open reading frame 118
chr17_+_42963737 0.342 NPEPPS
aminopeptidase puromycin sensitive
chr3_+_19963865 0.342 RAB5A
RAB5A, member RAS oncogene family
chr4_+_14613395 0.341 NM_001177381
NM_001177382
NM_001177383
NM_001177384
NM_182485
NM_182646
CPEB2





cytoplasmic polyadenylation element binding protein 2





chr12_+_95112131 0.341 NM_005230
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr17_-_59923547 0.340 NM_007215
POLG2
polymerase (DNA directed), gamma 2, accessory subunit
chr6_-_46091238 0.339 NM_016929
CLIC5
chloride intracellular channel 5
chr4_+_38722593 0.338 NM_001007075
NM_001171654
KLHL5

kelch-like 5 (Drosophila)

chr1_-_158190585 0.338 NM_001146172
NM_001146173
NM_033438
SLAMF9


SLAM family member 9


chr20_+_52525538 0.335 NM_018431
DOK5
docking protein 5
chr11_+_95762768 0.335 NM_003772
JRKL
jerky homolog-like (mouse)
chr5_+_49998677 0.335 PARP8
poly (ADP-ribose) polymerase family, member 8
chr10_+_17312654 0.335 VIM
vimentin
chrX_-_83644054 0.335 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr1_+_159899528 0.333 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr12_-_26982474 0.332 NM_018164
C12orf11
chromosome 12 open reading frame 11
chr17_+_5330936 0.330 NM_024039
MIS12
MIS12, MIND kinetochore complex component, homolog (S. pombe)
chr3_+_129253997 0.328 SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chrX_-_107866262 0.327 NM_003604
IRS4
insulin receptor substrate 4
chr11_+_120399966 0.325 NM_001130047
NM_152715
TBCEL

tubulin folding cofactor E-like

chr14_+_19414230 0.324 NM_001005501
OR4K2
olfactory receptor, family 4, subfamily K, member 2
chr1_+_26671488 0.324 NM_005517
HMGN2
high-mobility group nucleosomal binding domain 2
chr20_+_21231921 0.323 NM_012255
XRN2
5'-3' exoribonuclease 2
chr8_+_126511739 0.323 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr17_+_64019693 0.323 NM_212471
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr20_+_32928065 0.322 ACSS2
acyl-CoA synthetase short-chain family member 2
chr7_-_32501394 0.322 NM_001130710
NM_001139499
LSM5

LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)

chr15_+_75500284 0.318 NM_018200
HMG20A
high-mobility group 20A
chr7_-_82629735 0.318 PCLO
piccolo (presynaptic cytomatrix protein)
chr6_+_160068544 0.316 WTAP
Wilms tumor 1 associated protein
chr9_+_113698844 0.316 NM_003358
UGCG
UDP-glucose ceramide glucosyltransferase
chr10_+_114700775 0.315 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr17_+_44643067 0.315 ABI3
ABI family, member 3
chr2_+_187162969 0.315 NM_001145000
NM_002210
ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.16 2.92e-10 GO:0044260 cellular macromolecule metabolic process
1.14 9.83e-10 GO:0043170 macromolecule metabolic process
1.09 3.71e-07 GO:0050789 regulation of biological process
1.10 4.55e-07 GO:0050794 regulation of cellular process
1.09 6.75e-07 GO:0065007 biological regulation
1.06 9.86e-07 GO:0009987 cellular process
1.19 2.12e-06 GO:0044267 cellular protein metabolic process
1.15 7.12e-05 GO:0019538 protein metabolic process
1.20 7.54e-05 GO:0006464 protein modification process
1.51 2.48e-04 GO:0032446 protein modification by small protein conjugation
1.38 3.19e-04 GO:0001775 cell activation
1.09 4.15e-04 GO:0044238 primary metabolic process
1.09 5.95e-04 GO:0044237 cellular metabolic process
1.18 8.20e-04 GO:0043412 macromolecule modification
1.45 1.00e-03 GO:0070647 protein modification by small protein conjugation or removal
1.11 1.59e-03 GO:0051716 cellular response to stimulus
1.49 2.01e-03 GO:0016567 protein ubiquitination
1.07 6.63e-03 GO:0008152 metabolic process
1.12 6.74e-03 GO:0031323 regulation of cellular metabolic process
1.12 7.25e-03 GO:0016043 cellular component organization
1.14 7.78e-03 GO:0048522 positive regulation of cellular process
1.30 8.68e-03 GO:0009057 macromolecule catabolic process
1.13 1.03e-02 GO:0048518 positive regulation of biological process
1.32 1.07e-02 GO:0044265 cellular macromolecule catabolic process
1.21 1.16e-02 GO:0031325 positive regulation of cellular metabolic process
1.11 1.51e-02 GO:0071840 cellular component organization or biogenesis
1.31 2.11e-02 GO:0016071 mRNA metabolic process
1.19 2.12e-02 GO:0009966 regulation of signal transduction
1.21 2.47e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.20 2.48e-02 GO:0009893 positive regulation of metabolic process
1.32 2.51e-02 GO:0007596 blood coagulation
1.32 2.51e-02 GO:0050817 coagulation
1.13 2.55e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.32 2.60e-02 GO:0007599 hemostasis
1.38 2.76e-02 GO:0044257 cellular protein catabolic process
1.16 3.00e-02 GO:0048583 regulation of response to stimulus
1.14 4.05e-02 GO:0048519 negative regulation of biological process
1.38 4.22e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
1.13 4.68e-02 GO:0071842 cellular component organization at cellular level
1.10 4.69e-02 GO:0019222 regulation of metabolic process
1.17 4.72e-02 GO:0023051 regulation of signaling
1.14 4.91e-02 GO:0048523 negative regulation of cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.06 5.16e-10 GO:0005622 intracellular
1.06 1.05e-09 GO:0044424 intracellular part
1.20 3.96e-07 GO:0044428 nuclear part
1.11 3.99e-07 GO:0005634 nucleus
1.16 4.70e-07 GO:0043234 protein complex
1.14 1.38e-06 GO:0032991 macromolecular complex
1.20 7.28e-06 GO:0031981 nuclear lumen
1.24 8.88e-06 GO:0005654 nucleoplasm
1.17 9.44e-06 GO:0043233 organelle lumen
1.17 1.52e-05 GO:0031974 membrane-enclosed lumen
1.03 1.84e-05 GO:0044464 cell part
1.03 1.99e-05 GO:0005623 cell
1.17 4.98e-05 GO:0005829 cytosol
1.07 5.25e-05 GO:0005737 cytoplasm
1.30 7.69e-05 GO:0044451 nucleoplasm part
1.16 1.81e-04 GO:0070013 intracellular organelle lumen
1.06 3.23e-04 GO:0043226 organelle
1.09 3.68e-04 GO:0044446 intracellular organelle part
1.09 4.39e-04 GO:0044422 organelle part
1.05 5.38e-04 GO:0043229 intracellular organelle
1.06 8.32e-04 GO:0043227 membrane-bounded organelle
1.06 1.19e-03 GO:0043231 intracellular membrane-bounded organelle
1.55 4.15e-02 GO:0016607 nuclear speck

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 8.81e-14 GO:0005515 protein binding
1.06 2.24e-08 GO:0005488 binding
1.47 3.92e-03 GO:0019787 small conjugating protein ligase activity
1.46 7.68e-03 GO:0004842 ubiquitin-protein ligase activity
1.69 1.14e-02 GO:0051427 hormone receptor binding
1.41 1.36e-02 GO:0016881 acid-amino acid ligase activity
1.31 1.49e-02 GO:0016874 ligase activity
1.24 1.66e-02 GO:0019899 enzyme binding
1.70 2.95e-02 GO:0035257 nuclear hormone receptor binding
1.31 2.98e-02 GO:0019904 protein domain specific binding