Motif ID: PRDM1.p3

Z-value: 1.382


Transcription factors associated with PRDM1.p3:

Gene SymbolEntrez IDGene Name
PRDM1 639 PR domain containing 1, with ZNF domain



Activity profile for motif PRDM1.p3.

activity profile for motif PRDM1.p3


Sorted Z-values histogram for motif PRDM1.p3

Sorted Z-values for motif PRDM1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_21106291 3.005 APOB
apolipoprotein B (including Ag(x) antigen)
chr5_+_73145098 1.583 RGNEF
190 kDa guanine nucleotide exchange factor
chr15_+_94677572 1.568 NM_001145157
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr20_+_56904042 1.478 GNAS
GNAS complex locus
chr1_+_210848763 1.453 ATF3
activating transcription factor 3
chr14_+_23675233 1.326 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr14_+_23675206 1.299 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr1_+_210848726 1.258 ATF3
activating transcription factor 3
chr1_+_210848592 1.257 NM_001040619
NM_001674
ATF3

activating transcription factor 3

chr2_+_205118801 1.232 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr1_-_8406288 1.217 NM_001042682
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr12_-_69289889 1.125 NM_002837
PTPRB
protein tyrosine phosphatase, receptor type, B
chr10_+_92970487 1.106 PCGF5
polycomb group ring finger 5
chr1_-_7998265 1.055 ERRFI1
ERBB receptor feedback inhibitor 1
chr1_+_220884257 1.021 MIA3
melanoma inhibitory activity family, member 3
chr2_+_205118961 0.952 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr6_+_126282078 0.926 NCOA7
nuclear receptor coactivator 7
chr9_-_34700062 0.917 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr20_+_13924263 0.895 MACROD2
MACRO domain containing 2
chr1_-_142536082 0.814


chr11_-_77730573 0.807 NM_012296
GAB2
GRB2-associated binding protein 2
chr1_+_166172545 0.786 DCAF6
DDB1 and CUL4 associated factor 6
chr10_+_92970302 0.782 NM_032373
PCGF5
polycomb group ring finger 5
chr4_-_153523113 0.781 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr2_+_205118710 0.740 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr11_+_35641234 0.730 TRIM44
tripartite motif containing 44
chr3_+_186529376 0.729 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr4_+_146623405 0.720 NM_001003688
SMAD1
SMAD family member 1
chr20_+_56903595 0.698 GNAS
GNAS complex locus
chr1_+_166172420 0.689 NM_001017977
NM_001198956
NM_001198957
NM_018442
DCAF6



DDB1 and CUL4 associated factor 6



chr14_-_23771399 0.668 NEDD8
neural precursor cell expressed, developmentally down-regulated 8
chr14_+_57781308 0.645 NM_002788
NM_152132
PSMA3

proteasome (prosome, macropain) subunit, alpha type, 3

chr1_-_111548440 0.643 DENND2D
DENN/MADD domain containing 2D
chr14_-_23771312 0.629 NEDD8
neural precursor cell expressed, developmentally down-regulated 8
chr2_-_45648608 0.623 SRBD1
S1 RNA binding domain 1
chr8_+_97575196 0.604 SDC2
syndecan 2
chr16_-_46738061 0.601 NM_033226
ABCC12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
chr3_+_120495906 0.583 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr15_-_35180656 0.579 NM_002399
MEIS2
Meis homeobox 2
chr2_+_230989114 0.567 NM_001080391
NM_003113
SP100

SP100 nuclear antigen

chr8_+_96215118 0.564 NM_024613
PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr7_-_11643113 0.562 THSD7A
thrombospondin, type I, domain containing 7A
chr2_+_230989177 0.561 SP100
SP100 nuclear antigen
chr8_+_97575071 0.555 SDC2
syndecan 2
chr2_+_165858586 0.550 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr20_+_13924014 0.546 NM_080676
MACROD2
MACRO domain containing 2
chr14_-_23685629 0.546 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr14_+_57781352 0.544 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr2_+_234209838 0.543 NM_019075
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr14_-_23771401 0.541 NM_006156
NEDD8
neural precursor cell expressed, developmentally down-regulated 8
chr11_+_32069183 0.539 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr2_-_19421852 0.534 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr14_+_23771464 0.534 NM_001002000
NM_001002001
GMPR2

guanosine monophosphate reductase 2

chr20_+_336693 0.532 NM_006462
NM_031229
RBCK1

RanBP-type and C3HC4-type zinc finger containing 1

chr20_+_336963 0.527 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr4_+_76868763 0.525 USO1
USO1 vesicle docking protein homolog (yeast)
chr14_+_57781210 0.517 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr2_+_230900121 0.512 NM_138402
SP140L
SP140 nuclear body protein-like
chr16_+_49333513 0.510 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr2_+_230989150 0.502 SP100
SP100 nuclear antigen
chr6_+_32929902 0.496 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr10_-_35143900 0.487 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr8_+_96215144 0.474 PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr7_-_42938255 0.467 PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr8_+_97575052 0.466 NM_002998
SDC2
syndecan 2
chr1_-_146398501 0.461 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr1_+_149638633 0.459 NM_002796
PSMB4
proteasome (prosome, macropain) subunit, beta type, 4
chr20_+_336717 0.456 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr8_+_97575244 0.456 SDC2
syndecan 2
chr16_+_49333461 0.453 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr5_+_161209969 0.452 NM_001127647
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr7_-_42938304 0.447 NM_002787
PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr15_-_53996597 0.444 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr6_-_112682401 0.428 LAMA4
laminin, alpha 4
chr9_-_116608113 0.423 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr6_-_112682459 0.423 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr4_+_76868830 0.422 USO1
USO1 vesicle docking protein homolog (yeast)
chr1_+_158063130 0.418 SLAMF8
SLAM family member 8
chr7_+_42938463 0.417 NM_031903
MRPL32
mitochondrial ribosomal protein L32
chr9_+_96806235 0.412 C9orf3
chromosome 9 open reading frame 3
chr9_-_16717887 0.410 BNC2
basonuclin 2
chr8_-_79880095 0.400 NM_000880
IL7
interleukin 7
chr4_+_142777172 0.394 NM_000585
NM_172174
IL15

interleukin 15

chr1_-_143232464 0.390


chr12_+_25096472 0.389 NM_006152
LRMP
lymphoid-restricted membrane protein
chr18_+_18989786 0.388 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr6_-_112682573 0.386 LAMA4
laminin, alpha 4
chr11_+_28088406 0.377 METTL15
methyltransferase like 15
chr2_+_6935246 0.375 NM_080657
RSAD2
radical S-adenosyl methionine domain containing 2
chr8_+_39890484 0.374 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr20_+_336941 0.372 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr13_+_107720475 0.371 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr5_-_142795269 0.360 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr9_+_108665168 0.357 NM_021224
ZNF462
zinc finger protein 462
chr14_+_23982017 0.353


chr2_+_234191029 0.348 NM_019076
UGT1A8
UDP glucuronosyltransferase 1 family, polypeptide A8
chr1_-_146543016 0.346


chr2_-_189752575 0.343 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_+_158063278 0.335 SLAMF8
SLAM family member 8
chr3_-_161584137 0.327 NM_001190242
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chr8_-_145132551 0.323 PARP10
poly (ADP-ribose) polymerase family, member 10
chr8_-_145132582 0.316 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr5_-_37220702 0.312 C5orf42
chromosome 5 open reading frame 42
chr1_-_166171838 0.307 NM_015415
BRP44
brain protein 44
chr4_-_76868581 0.302


chr1_-_142535878 0.298 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr12_+_68923043 0.297 NM_014515
CNOT2
CCR4-NOT transcription complex, subunit 2
chr20_+_337346 0.291 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr4_+_76868850 0.287 NM_003715
USO1
USO1 vesicle docking protein homolog (yeast)
chr4_+_88075176 0.287 NM_001166693
AFF1
AF4/FMR2 family, member 1
chr14_-_68329407 0.285 NM_004926
ZFP36L1
zinc finger protein 36, C3H type-like 1
chr5_+_139869819 0.284


chr1_-_152847256 0.283 ADAR
adenosine deaminase, RNA-specific
chr11_-_28086277 0.281 NM_031217
KIF18A
kinesin family member 18A
chr14_+_101297887 0.280 NM_001161725
NM_001161726
PPP2R5C

protein phosphatase 2, regulatory subunit B', gamma

chr11_-_40272239 0.279 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr11_-_28086222 0.275 KIF18A
kinesin family member 18A
chr3_+_115099007 0.269 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr14_+_72594985 0.268 RBM25
RNA binding motif protein 25
chr11_-_28086263 0.268 KIF18A
kinesin family member 18A
chr11_+_64946848 0.268


chr21_+_42807052 0.267 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr6_-_112682038 0.266 LAMA4
laminin, alpha 4
chr1_-_166171702 0.265 BRP44
brain protein 44
chr3_+_189354167 0.264 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr16_-_71650034 0.258 NM_001164766
ZFHX3
zinc finger homeobox 3
chr16_+_55580910 0.255 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr10_-_6059460 0.249 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr13_+_107720206 0.241 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr19_-_53239030 0.236 NM_019855
CABP5
calcium binding protein 5
chr8_-_29176490 0.233 NM_015254
KIF13B
kinesin family member 13B
chr11_+_64946820 0.227 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr10_+_63478974 0.227 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr1_-_152847301 0.226 NM_001111
NM_015840
NM_015841
ADAR


adenosine deaminase, RNA-specific


chr14_+_72595020 0.225 RBM25
RNA binding motif protein 25
chr11_-_5662762 0.225 NM_033034
NM_033092
NM_033093
TRIM5


tripartite motif containing 5


chr1_-_143232526 0.223 FAM91A2
family with sequence similarity 91, member A2
chr10_+_69539255 0.217 NM_032578
MYPN
myopalladin
chr3_-_189354510 0.217 LOC339929
hypothetical LOC339929
chr12_+_11694172 0.216 ETV6
ets variant 6
chr10_+_91051685 0.213 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr6_-_11887265 0.212 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr6_-_33389825 0.208 TAPBP
TAP binding protein (tapasin)
chr11_-_4371463 0.208 NM_003141
TRIM21
tripartite motif containing 21
chr1_-_143232275 0.204 LOC728855
hypothetical LOC728855
chr11_+_28086373 0.203 NM_001113528
NM_152636
METTL15

methyltransferase like 15

chr16_-_70763849 0.201 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr3_-_11598829 0.197 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr1_+_158063102 0.196 NM_020125
SLAMF8
SLAM family member 8
chr2_-_202216451 0.194 NM_001044385
ALS2CR4
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4
chr6_-_28663045 0.187 NM_052923
SCAND3
SCAN domain containing 3
chr3_+_108724472 0.187 NM_001142568
NM_020235
BBX

bobby sox homolog (Drosophila)

chr9_+_101717278 0.186 STX17
syntaxin 17
chr12_-_55134692 0.174 NM_012064
MIP
major intrinsic protein of lens fiber
chr5_+_49998528 0.173 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr6_-_33389768 0.171 TAPBP
TAP binding protein (tapasin)
chr1_-_159435440 0.168 NM_005099
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr12_-_55791443 0.163 NM_001178078
NM_001178080
NM_001178081
NM_003153
STAT6



signal transducer and activator of transcription 6, interleukin-4 induced



chr11_-_85015961 0.161 NM_001142699
DLG2
discs, large homolog 2 (Drosophila)
chr6_-_105691675 0.160 BVES
blood vessel epicardial substance
chr13_+_107719977 0.160 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr2_-_37164919 0.159 HEATR5B
HEAT repeat containing 5B
chr3_+_69998064 0.158 NM_198177
MITF
microphthalmia-associated transcription factor
chr11_-_125153914 0.158 NM_212555
PATE2
prostate and testis expressed 2
chr14_-_22549168 0.158 NM_001130706
NM_001130708
NM_021944
C14orf93


chromosome 14 open reading frame 93


chr2_-_144711375 0.157 NM_024659
GTDC1
glycosyltransferase-like domain containing 1
chr14_-_23981493 0.152 NM_020195
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr7_+_134483305 0.152 NM_018295
TMEM140
transmembrane protein 140
chr7_-_105106844 0.152 NM_138495
ATXN7L1
ataxin 7-like 1
chr9_+_109085372 0.151 RAD23B
RAD23 homolog B (S. cerevisiae)
chr9_-_14858974 0.151 FREM1
FRAS1 related extracellular matrix 1
chr16_-_10696285 0.150 NM_144674
TEKT5
tektin 5
chr1_-_116185215 0.145 NM_005599
NHLH2
nescient helix loop helix 2
chr22_+_38903825 0.143 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr16_-_70763524 0.140 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr7_+_89681069 0.140 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr12_+_27511009 0.137 NM_001145010
C12orf70
chromosome 12 open reading frame 70
chr11_+_5602782 0.135 NM_021616
TRIM34
tripartite motif containing 34
chr8_-_9046460 0.134 PPP1R3B
protein phosphatase 1, regulatory (inhibitor) subunit 3B
chr1_-_146543102 0.133


chr1_+_159435728 0.131 NM_004550
NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr15_-_40537002 0.131 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr17_+_53602013 0.130 NM_001004707
OR4D2
olfactory receptor, family 4, subfamily D, member 2
chr7_+_134114701 0.129 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr12_-_55791388 0.128 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr8_+_143805595 0.128 NM_016647
C8orf55
chromosome 8 open reading frame 55
chr10_-_113923507 0.127 GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr9_+_109085337 0.127 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr20_-_47327998 0.126 NM_021035
ZNFX1
zinc finger, NFX1-type containing 1
chr8_+_97726757 0.123 PGCP
plasma glutamate carboxypeptidase
chr19_+_61202902 0.123 NM_153447
NLRP5
NLR family, pyrin domain containing 5
chr14_+_72594940 0.123 NM_021239
RBM25
RNA binding motif protein 25
chr7_-_158304062 0.120 ESYT2
extended synaptotagmin-like protein 2
chr1_-_242073094 0.119 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr20_-_34102250 0.119 LOC647979
hypothetical LOC647979
chr6_+_118976134 0.119 NM_002667
PLN
phospholamban
chr2_+_17585462 0.118 VSNL1
visinin-like 1
chr7_-_86686754 0.118 NM_024315
C7orf23
chromosome 7 open reading frame 23
chr8_-_143805371 0.117 LOC100288181
hypothetical LOC100288181
chr6_-_32251877 0.116 NM_006411
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.07 5.13e-03 GO:0009615 response to virus
2.41 8.47e-03 GO:0051704 multi-organism process
2.27 1.86e-02 GO:0009892 negative regulation of metabolic process
6.67 2.84e-02 GO:0031575 mitotic cell cycle G1/S transition checkpoint
6.67 2.84e-02 GO:0071779 G1/S transition checkpoint
2.30 2.86e-02 GO:0010605 negative regulation of macromolecule metabolic process
4.65 2.91e-02 GO:0010498 proteasomal protein catabolic process
4.65 2.91e-02 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
2.37 3.46e-02 GO:0006508 proteolysis
38.99 3.83e-02 GO:0002483 antigen processing and presentation of endogenous peptide antigen
38.99 3.83e-02 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
38.99 3.83e-02 GO:0051552 flavone metabolic process
6.34 4.09e-02 GO:2000045 regulation of G1/S transition of mitotic cell cycle
4.89 4.36e-02 GO:0010565 regulation of cellular ketone metabolic process
7.46 4.40e-02 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
7.46 4.40e-02 GO:0072395 signal transduction involved in cell cycle checkpoint
7.46 4.40e-02 GO:0072401 signal transduction involved in DNA integrity checkpoint
7.46 4.40e-02 GO:0072404 signal transduction involved in G1/S transition checkpoint
7.46 4.40e-02 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
7.46 4.40e-02 GO:0072422 signal transduction involved in DNA damage checkpoint
7.46 4.40e-02 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
7.46 4.40e-02 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
7.34 4.89e-02 GO:0060337 type I interferon-mediated signaling pathway
7.34 4.89e-02 GO:0071357 cellular response to type I interferon

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
7.22 9.31e-03 GO:0000502 proteasome complex
13.00 4.08e-02 GO:0005839 proteasome core complex
64.98 4.41e-02 GO:0071797 LUBAC complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
20.00 8.48e-03 GO:0001530 lipopolysaccharide binding