Motif ID: HNF4A_NR2F1,2.p2

Z-value: 2.646


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2



Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_34554800 6.886 CNTFR
ciliary neurotrophic factor receptor
chr6_+_29799095 4.042 NM_001098478
NM_001098479
NM_018950
HLA-F


major histocompatibility complex, class I, F


chr6_+_29799182 3.784 HLA-F
major histocompatibility complex, class I, F
chr2_-_241480058 3.653 NM_024861
C2orf54
chromosome 2 open reading frame 54
chr9_+_126253243 3.455 NM_001161808
GPR144
G protein-coupled receptor 144
chr19_+_44308224 3.421 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr3_-_46879883 3.413 NM_000258
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr6_+_37081387 3.287 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr21_+_44169706 3.245 NM_001037553
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr22_-_22970850 3.205 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr9_-_129752687 3.048 NM_203305
FAM102A
family with sequence similarity 102, member A
chr7_-_150515410 3.024 NM_001142459
NM_001142460
ASB10

ankyrin repeat and SOCS box containing 10

chr16_+_3642940 2.889 NM_005223
DNASE1
deoxyribonuclease I
chr16_+_2954217 2.885 NM_024507
NM_172229
KREMEN2

kringle containing transmembrane protein 2

chr20_-_61462960 2.881 NM_000744
CHRNA4
cholinergic receptor, nicotinic, alpha 4
chr19_+_5082230 2.818 KDM4B
lysine (K)-specific demethylase 4B
chr1_+_9222489 2.792 H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr3_+_9666198 2.785 MTMR14
myotubularin related protein 14
chr19_-_1062972 2.767 SBNO2
strawberry notch homolog 2 (Drosophila)
chrX_-_48655978 2.753 PIM2
pim-2 oncogene
chr16_+_79829794 2.729 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chrX_+_106030049 2.650 NM_001171092
CLDN2
claudin 2
chr3_-_52454082 2.642 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr8_-_142307854 2.624 NM_001080431
SLC45A4
solute carrier family 45, member 4
chr16_-_1419345 2.604 NM_001010878
C16orf91
chromosome 16 open reading frame 91
chr17_+_75766875 2.568 NM_024110
CARD14
caspase recruitment domain family, member 14
chr2_+_95326753 2.563 NM_013434
KCNIP3
Kv channel interacting protein 3, calsenilin
chr17_+_24095135 2.526 NM_004295
TRAF4
TNF receptor-associated factor 4
chr7_+_1543644 2.385 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr1_+_15941503 2.358 NM_001013641
TMEM82
transmembrane protein 82
chr11_-_1549719 2.345 NM_004420
DUSP8
dual specificity phosphatase 8
chr19_+_1156773 2.341 NM_000455
STK11
serine/threonine kinase 11
chr19_-_18196302 2.332 NM_001098819
PDE4C
phosphodiesterase 4C, cAMP-specific
chr1_+_226404037 2.290 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr19_+_748452 2.276 PTBP1
polypyrimidine tract binding protein 1
chr17_+_35075124 2.267 NM_003673
TCAP
titin-cap (telethonin)
chr20_-_62208627 2.258 NM_005286
NPBWR2
neuropeptides B/W receptor 2
chr21_+_45699830 2.244 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chr11_+_268569 2.230 NM_138329
NLRP6
NLR family, pyrin domain containing 6
chr10_-_76529253 2.215 NM_016364
DUSP13
dual specificity phosphatase 13
chr1_+_203740391 2.159 CDK18
cyclin-dependent kinase 18
chr19_+_59333232 2.155 NM_014516
CNOT3
CCR4-NOT transcription complex, subunit 3
chr22_-_24088523 2.131 NM_182492
LRP5L
low density lipoprotein receptor-related protein 5-like
chr11_+_817584 2.113 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr7_+_97679501 2.111 NM_177455
BHLHA15
basic helix-loop-helix family, member a15
chrX_+_106057984 2.063 CLDN2
claudin 2
chr19_+_748444 2.034 PTBP1
polypyrimidine tract binding protein 1
chr19_+_748448 2.026 PTBP1
polypyrimidine tract binding protein 1
chr19_-_15252261 2.019 NM_014299
NM_058243
BRD4

bromodomain containing 4

chr2_-_238164042 2.015 RAB17
RAB17, member RAS oncogene family
chr1_-_5974997 1.989 NPHP4
nephronophthisis 4
chr15_-_66284655 1.981 CALML4
calmodulin-like 4
chrX_-_41667174 1.967 NM_001126054
NM_001126055
NM_003688
CASK


calcium/calmodulin-dependent serine protein kinase (MAGUK family)


chr10_-_71002998 1.946 NM_020999
NEUROG3
neurogenin 3
chr1_+_12149662 1.945 TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr22_+_20316968 1.931 NM_152612
CCDC116
coiled-coil domain containing 116
chr19_+_748390 1.931 NM_002819
NM_031990
NM_031991
NM_175847
PTBP1



polypyrimidine tract binding protein 1



chr19_+_4104593 1.922 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr6_+_32034767 1.910 SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr9_+_137694988 1.906 NM_001001676
LCN9
lipocalin 9
chr11_-_61104866 1.894 NM_004200
SYT7
synaptotagmin VII
chr1_+_2508324 1.894 C1orf93
chromosome 1 open reading frame 93
chr3_+_9666184 1.879 MTMR14
myotubularin related protein 14
chr2_-_232499202 1.876 NM_024409
NPPC
natriuretic peptide C
chrX_+_152454773 1.872 NM_001001344
NM_021949
ATP2B3

ATPase, Ca++ transporting, plasma membrane 3

chr1_+_43837096 1.862 PTPRF
protein tyrosine phosphatase, receptor type, F
chr19_-_53558961 1.851 NM_018273
TMEM143
transmembrane protein 143
chr17_+_69950782 1.850 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr19_+_54872220 1.846 PRMT1
protein arginine methyltransferase 1
chr1_+_12149637 1.838 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr19_+_54872304 1.829 NM_001536
NM_198318
PRMT1

protein arginine methyltransferase 1

chr10_+_103976132 1.825 NM_152310
ELOVL3
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3
chr21_+_42946719 1.822 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr9_-_138277467 1.821 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr9_-_135435165 1.807 NM_001080515
FAM163B
family with sequence similarity 163, member B
chr1_-_24307514 1.798 MYOM3
myomesin family, member 3
chr2_+_233093416 1.798 NM_001195129
LOC646960
trypsin serine protease-like
chr8_+_22075112 1.793 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr14_+_22911857 1.773 NM_172314
NM_022789
IL25

interleukin 25

chr6_-_168222645 1.768 NM_024919
FRMD1
FERM domain containing 1
chr20_+_57308876 1.752 NM_000114
NM_207032
NM_207033
NM_207034
EDN3



endothelin 3



chrX_-_148484772 1.750 NM_001164415
NM_016153
HSFX2
HSFX1
heat shock transcription factor family, X linked 2
heat shock transcription factor family, X linked 1
chr11_+_118332217 1.746 NM_006760
UPK2
uroplakin 2
chr1_+_19864366 1.736 NM_000871
HTR6
5-hydroxytryptamine (serotonin) receptor 6
chr11_+_696607 1.736 EPS8L2
EPS8-like 2
chr1_+_1557419 1.735 NM_006983
MMP23B
matrix metallopeptidase 23B
chr11_+_43920385 1.731 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr2_+_113648036 1.721 PSD4
pleckstrin and Sec7 domain containing 4
chr16_-_87646856 1.720


chr1_+_1104939 1.718 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr9_+_126094067 1.713 NM_001166170
NM_001166171
NEK6

NIMA (never in mitosis gene a)-related kinase 6

chr6_+_31731667 1.696 APOM
apolipoprotein M
chr19_-_47328399 1.696 NM_002698
POU2F2
POU class 2 homeobox 2
chr8_+_144711619 1.696 NM_024736
GSDMD
gasdermin D
chr8_+_144192011 1.683 NM_173687
C8orf31
chromosome 8 open reading frame 31
chr12_-_53065758 1.670 ZNF385A
zinc finger protein 385A
chr6_+_31731647 1.661 NM_019101
APOM
apolipoprotein M
chr11_-_404975 1.652 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr19_+_5774817 1.638 NM_004558
NRTN
neurturin
chr1_-_154205675 1.637 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr5_+_131437383 1.627 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr16_-_82830804 1.627 NM_172347
KCNG4
potassium voltage-gated channel, subfamily G, member 4
chr7_-_5534252 1.616 ACTB
actin, beta
chrX_+_148663533 1.613 NM_001164415
NM_016153
HSFX2
HSFX1
heat shock transcription factor family, X linked 2
heat shock transcription factor family, X linked 1
chr1_-_5975068 1.592 NM_015102
NPHP4
nephronophthisis 4
chr16_+_2195709 1.590 MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr19_+_46286207 1.590 NM_000766
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr16_+_162845 1.588 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr3_-_48576204 1.578 NM_033199
UCN2
urocortin 2
chr17_+_3326045 1.577 NM_000049
ASPA
aspartoacylase
chr1_+_22835684 1.576 NM_015991
C1QA
complement component 1, q subcomponent, A chain
chr19_-_7874426 1.569


chr1_+_151596953 1.567 NM_002965
S100A9
S100 calcium binding protein A9
chr5_+_118993152 1.558 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr11_-_44912662 1.552 TP53I11
tumor protein p53 inducible protein 11
chr2_+_233112680 1.548 NM_005199
CHRNG
cholinergic receptor, nicotinic, gamma
chr20_+_61394982 1.542 NM_020882
COL20A1
collagen, type XX, alpha 1
chr19_+_54786723 1.535 NM_020719
PRR12
proline rich 12
chr1_+_23568028 1.532 C1orf213
chromosome 1 open reading frame 213
chrX_+_138440560 1.527 NM_000133
F9
coagulation factor IX
chr20_+_62266217 1.524 MYT1
myelin transcription factor 1
chr11_+_66367458 1.523 NM_001032279
NM_005133
RCE1

RCE1 homolog, prenyl protein peptidase (S. cerevisiae)

chr4_-_9632192 1.518 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr21_+_43462209 1.516 NM_000394
CRYAA
crystallin, alpha A
chr7_+_100037817 1.513 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chrX_+_69371229 1.504 NM_001013579
AWAT1
acyl-CoA wax alcohol acyltransferase 1
chr17_+_4743645 1.501 NM_001145536
C17orf107
chromosome 17 open reading frame 107
chr17_+_7753428 1.500 CHD3
chromodomain helicase DNA binding protein 3
chrX_+_48529905 1.490 NM_002049
GATA1
GATA binding protein 1 (globin transcription factor 1)
chr11_-_65813031 1.489 YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr2_+_3620296 1.488 NM_024027
NM_199235
COLEC11

collectin sub-family member 11

chr13_+_112825113 1.487 NM_000504
F10
coagulation factor X
chr7_-_155297576 1.480 NM_000193
SHH
sonic hedgehog
chr20_+_62266270 1.476 NM_004535
MYT1
myelin transcription factor 1
chr6_-_34209250 1.472 NM_000841
GRM4
glutamate receptor, metabotropic 4
chr12_+_50981915 1.462 NM_002284
KRT86
keratin 86
chr1_-_110108048 1.460 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr19_+_18164989 1.460 NM_032683
MPV17L2
MPV17 mitochondrial membrane protein-like 2
chr16_+_29942155 1.453 NM_001109659
NM_001109660
C16orf92

chromosome 16 open reading frame 92

chr16_+_65765256 1.452 NM_003946
NM_001185057
NOL3

nucleolar protein 3 (apoptosis repressor with CARD domain)

chr1_-_31154023 1.452 NM_014654
SDC3
syndecan 3
chr19_-_38052481 1.440 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr19_+_45948911 1.439 SNRPA
small nuclear ribonucleoprotein polypeptide A
chr21_+_44530148 1.435 NM_000383
AIRE
autoimmune regulator
chr11_+_1367665 1.432 NM_003957
BRSK2
BR serine/threonine kinase 2
chr15_+_72892205 1.430 NM_021819
LMAN1L
lectin, mannose-binding, 1 like
chr7_-_150702629 1.429


chr8_-_142333339 1.427 SLC45A4
solute carrier family 45, member 4
chr9_+_34448810 1.425 NM_012144
DNAI1
dynein, axonemal, intermediate chain 1
chr10_+_75174125 1.423 NM_004922
NM_198597
SEC24C

SEC24 family, member C (S. cerevisiae)

chr17_+_45979518 1.422 NM_022827
SPATA20
spermatogenesis associated 20
chr9_+_129893948 1.417 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr6_+_30964441 1.416 NM_013994
DDR1
discoidin domain receptor tyrosine kinase 1
chr1_+_203279050 1.408 CNTN2
contactin 2 (axonal)
chr16_+_31312097 1.408 NM_005353
ITGAD
integrin, alpha D
chr19_-_47190160 1.407 NM_152296
ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr3_+_9666116 1.397 NM_001077525
NM_001077526
NM_022485
MTMR14


myotubularin related protein 14


chr10_-_104158910 1.390 PSD
pleckstrin and Sec7 domain containing
chr19_-_60272708 1.389 NM_138412
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr8_+_142501188 1.381 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr1_-_199608941 1.379 TNNT2
troponin T type 2 (cardiac)
chr19_+_55985483 1.378 NM_033068
ACPT
acid phosphatase, testicular
chr20_-_56859352 1.365 GNAS-AS1
GNAS antisense RNA 1 (non-protein coding)
chr4_+_187307320 1.363 NM_001006655
FAM149A
family with sequence similarity 149, member A
chr3_-_195553297 1.359 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr7_+_129807467 1.351 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr8_+_11702803 1.348 FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr16_-_1215254 1.343 NM_012467
TPSG1
tryptase gamma 1
chr19_+_15587028 1.342 NM_007253
CYP4F8
cytochrome P450, family 4, subfamily F, polypeptide 8
chr17_+_21249040 1.338 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chrX_+_26120477 1.338 NM_173523
MAGEB6
melanoma antigen family B, 6
chr1_+_226462363 1.337 NM_001098623
NM_052843
OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

chr12_+_55896844 1.337 NM_007224
NXPH4
neurexophilin 4
chr11_+_66070949 1.336 NM_001104
ACTN3
actinin, alpha 3
chr5_+_149867866 1.334 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr14_+_104402626 1.332 NM_001112726
NM_015005
KIAA0284

KIAA0284

chr4_+_3413489 1.331 NM_001528
HGFAC
HGF activator
chr16_+_30118036 1.330 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr1_+_109594163 1.325 NM_001408
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr22_+_18330049 1.317 NM_007310
COMT
catechol-O-methyltransferase
chr6_-_41811916 1.312 NM_001167827
TFEB
transcription factor EB
chr17_-_33982580 1.306 SRCIN1
SRC kinase signaling inhibitor 1
chr19_+_40716153 1.305 NM_014364
GAPDHS
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr19_+_876984 1.302 NM_005224
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr19_+_458475 1.300 NM_033513
C19orf20
chromosome 19 open reading frame 20
chr19_-_47190061 1.298 ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr17_+_71141108 1.284 NM_001162995
LOC643008
hypothetical protein LOC643008
chr11_+_65140207 1.278 NM_032223
PCNXL3
pecanex-like 3 (Drosophila)
chr11_+_1846478 1.278 NM_001013253
LSP1
lymphocyte-specific protein 1
chr2_+_95303947 1.276 PROM2
prominin 2
chr16_+_56230707 1.274 NM_001145774
GPR56
G protein-coupled receptor 56
chr22_+_19651446 1.271 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr12_-_6535481 1.269 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr19_-_54857003 1.269 IRF3
interferon regulatory factor 3
chr9_-_34366831 1.268 NM_020702
KIAA1161
KIAA1161
chr17_-_37022465 1.257 NM_005557
KRT16
keratin 16
chr6_+_46869052 1.257 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr19_+_17281216 1.256 NM_024050
DDA1
DET1 and DDB1 associated 1
chr9_+_138997265 1.254 NM_207510
LCNL1
lipocalin-like 1
chrX_+_110226030 1.249 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.29 1.50e-05 GO:0042221 response to chemical stimulus
1.24 9.29e-03 GO:0065008 regulation of biological quality
3.83 1.35e-02 GO:0006942 regulation of striated muscle contraction
1.11 4.69e-02 GO:0050896 response to stimulus
1.65 4.73e-02 GO:0030029 actin filament-based process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.24 5.69e-04 GO:0044459 plasma membrane part
1.41 6.22e-04 GO:0005626 insoluble fraction
1.41 7.56e-04 GO:0005624 membrane fraction
1.70 8.67e-04 GO:0015629 actin cytoskeleton
1.30 1.69e-02 GO:0000267 cell fraction
2.05 2.42e-02 GO:0030017 sarcomere

Nothing significant found in function category.