Motif ID: ETS1,2.p2

Z-value: 1.816


Transcription factors associated with ETS1,2.p2:

Gene SymbolEntrez IDGene Name
ETS1 2113 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
ETS2 2114 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)



Activity profile for motif ETS1,2.p2.

activity profile for motif ETS1,2.p2


Sorted Z-values histogram for motif ETS1,2.p2

Sorted Z-values for motif ETS1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ETS1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_132759045 4.143 NM_198180
QRFP
pyroglutamylated RFamide peptide
chr16_+_29581783 3.745 NM_001030288
SPN
sialophorin
chr1_+_18680010 3.186 NM_152375
KLHDC7A
kelch domain containing 7A
chr16_+_2145810 2.937 TRAF7
TNF receptor-associated factor 7
chr16_+_29582069 2.900 NM_003123
SPN
sialophorin
chr16_+_29582065 2.885 SPN
sialophorin
chr17_-_959007 2.832 NM_001092
ABR
active BCR-related gene
chr5_+_180582905 2.814 NM_033549
NM_201627
TRIM41

tripartite motif containing 41

chr22_+_22435207 2.768 NM_182520
C22orf15
chromosome 22 open reading frame 15
chr1_+_24755152 2.579 NM_001010980
C1orf130
chromosome 1 open reading frame 130
chr9_+_129893948 2.570 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr2_+_113648020 2.534 NM_012455
PSD4
pleckstrin and Sec7 domain containing 4
chr8_+_22493928 2.380 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr22_+_17337970 2.313 DGCR5
DiGeorge syndrome critical region gene 5 (non-protein coding)
chr2_+_113648036 2.247 PSD4
pleckstrin and Sec7 domain containing 4
chr1_+_3378030 2.225 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr19_+_60589110 2.214 NM_000991
NM_001136134
NM_001136135
NM_001136136
NM_001136137
RPL28




ribosomal protein L28




chr11_+_46679140 2.204 NM_001184751
ZNF408
zinc finger protein 408
chr5_+_180582880 2.184 TRIM41
tripartite motif containing 41
chr12_+_131577229 2.146 NM_001142641
FBRSL1
fibrosin-like 1
chr16_+_2145765 2.136 NM_032271
TRAF7
TNF receptor-associated factor 7
chr11_-_3104413 2.128 OSBPL5
oxysterol binding protein-like 5
chr10_-_88707299 2.128 NM_024756
MMRN2
multimerin 2
chr11_+_2378559 2.121 TSSC4
tumor suppressing subtransferable candidate 4
chr19_+_16860807 2.081 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr8_+_144428083 2.063 GLI4
GLI family zinc finger 4
chr12_-_55920741 2.044 NM_020142
NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr19_+_17723285 1.995 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr9_+_94766379 1.988 FGD3
FYVE, RhoGEF and PH domain containing 3
chr19_+_16860871 1.984 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr11_-_46678715 1.942 ARHGAP1
Rho GTPase activating protein 1
chr17_-_7036490 1.919


chr11_-_67528103 1.907 NM_030930
UNC93B1
unc-93 homolog B1 (C. elegans)
chr9_+_126671321 1.892 ARPC5L
actin related protein 2/3 complex, subunit 5-like
chr11_+_46678892 1.891 NM_024741
ZNF408
zinc finger protein 408
chr11_+_7574992 1.870 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr19_+_52451642 1.862 CCDC9
coiled-coil domain containing 9
chr3_-_130600931 1.781 RPL32P3
ribosomal protein L32 pseudogene 3
chr6_+_43507466 1.772 NM_033450
ABCC10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr2_+_241156776 1.758 NM_018226
RNPEPL1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr17_+_4283967 1.752 NM_182538
SPNS3
spinster homolog 3 (Drosophila)
chr3_+_50259329 1.750 NM_001166425
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr16_-_30274182 1.708 NM_006110
CD2BP2
CD2 (cytoplasmic tail) binding protein 2
chr1_+_12108542 1.678 NM_152942
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr9_+_139292094 1.673 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr3_-_150533948 1.673 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr7_-_5533621 1.667 ACTB
actin, beta
chrX_+_67830204 1.651 NM_001142504
STARD8
StAR-related lipid transfer (START) domain containing 8
chrX_+_67830215 1.626 STARD8
StAR-related lipid transfer (START) domain containing 8
chr11_-_46678736 1.615 ARHGAP1
Rho GTPase activating protein 1
chr19_+_16157198 1.610 NM_014077
FAM32A
family with sequence similarity 32, member A
chrX_+_55043447 1.596 NM_014481
APEX2
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
chr16_+_30993223 1.556 NM_014699
ZNF646
zinc finger protein 646
chr16_+_88154582 1.554 NM_000977
NM_033251
RPL13

ribosomal protein L13

chr1_+_44208236 1.530 NM_001039589
NM_001384
DPH2

DPH2 homolog (S. cerevisiae)

chr1_+_3360880 1.526 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr22_+_37193961 1.525 NM_006855
NM_016657
KDELR3

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

chr22_+_36412277 1.523 NM_024313
NOL12
nucleolar protein 12
chr16_-_1419345 1.504 NM_001010878
C16orf91
chromosome 16 open reading frame 91
chr9_+_115396020 1.493 NM_144489
RGS3
regulator of G-protein signaling 3
chr16_+_658081 1.480 NM_138769
RHOT2
ras homolog gene family, member T2
chr9_-_138387903 1.479 CARD9
caspase recruitment domain family, member 9
chr16_-_30274064 1.470 CD2BP2
CD2 (cytoplasmic tail) binding protein 2
chr6_-_33398656 1.466 NM_001141969
NM_001141970
NM_001350
DAXX


death-domain associated protein


chr11_-_46678691 1.460 NM_004308
ARHGAP1
Rho GTPase activating protein 1
chr2_+_219818428 1.459 NM_001008910
STK16
serine/threonine kinase 16
chr7_-_74953472 1.448 NM_001099415
POM121C
POM121 membrane glycoprotein C
chr1_+_6008999 1.446 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr8_+_56954946 1.442 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr9_-_129707392 1.439 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr7_+_2524022 1.438 NM_002304
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr9_-_139043035 1.431 NM_212533
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr6_+_10663934 1.430 NM_001491
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr15_+_79376295 1.428 NM_004513
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr19_+_748452 1.426 PTBP1
polypyrimidine tract binding protein 1
chr6_+_37081387 1.403 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr19_+_52451570 1.400 NM_015603
CCDC9
coiled-coil domain containing 9
chr4_+_141484046 1.394 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr20_+_30501108 1.377


chr1_+_26368969 1.369 NM_015871
ZNF593
zinc finger protein 593
chr9_-_137992967 1.366 NM_016172
UBAC1
UBA domain containing 1
chr12_-_6668787 1.364 NM_001039918
NM_133476
ZNF384

zinc finger protein 384

chr10_+_71060008 1.363 NM_145306
C10orf35
chromosome 10 open reading frame 35
chr9_-_132803809 1.363 FIBCD1
fibrinogen C domain containing 1
chr16_+_658158 1.358 RHOT2
ras homolog gene family, member T2
chr16_-_30993004 1.357 NM_024706
ZNF668
zinc finger protein 668
chr18_+_13610866 1.357 NM_004338
NM_181483
C18orf1

chromosome 18 open reading frame 1

chr8_+_56954899 1.355 NM_001111097
NM_002350
LYN

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

chr15_+_72695248 1.346 CLK3
CDC-like kinase 3
chr16_+_30993252 1.344 ZNF646
zinc finger protein 646
chr11_+_63864263 1.343 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr2_+_96566190 1.334 NM_212481
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr5_-_179951071 1.324 NM_052863
SCGB3A1
secretoglobin, family 3A, member 1
chr19_+_748448 1.320 PTBP1
polypyrimidine tract binding protein 1
chr1_-_1300680 1.319 NM_017900
AURKAIP1
aurora kinase A interacting protein 1
chr11_-_407324 1.304 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr19_+_748444 1.296 PTBP1
polypyrimidine tract binding protein 1
chr19_+_52940610 1.290 GLTSCR2
glioma tumor suppressor candidate region gene 2
chr1_+_6008956 1.281 NM_003636
NM_172130
KCNAB2

potassium voltage-gated channel, shaker-related subfamily, beta member 2

chr3_+_47004457 1.277 NBEAL2
neurobeachin-like 2
chr1_-_154205675 1.272 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr19_+_47079147 1.255 ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
chr19_+_748390 1.251 NM_002819
NM_031990
NM_031991
NM_175847
PTBP1



polypyrimidine tract binding protein 1



chr9_-_132804243 1.251 NM_001145106
FIBCD1
fibrinogen C domain containing 1
chr21_+_41663853 1.241 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr10_+_75174125 1.240 NM_004922
NM_198597
SEC24C

SEC24 family, member C (S. cerevisiae)

chr7_-_1562272 1.232 NM_001097620
TMEM184A
transmembrane protein 184A
chr17_+_59429442 1.225 NM_001164257
NM_001191029
NM_001191030
NM_001191031
C17orf72



chromosome 17 open reading frame 72



chr12_-_6103945 1.220 NM_000552
VWF
von Willebrand factor
chr2_-_219818360 1.216 NM_024506
GLB1L
galactosidase, beta 1-like
chr2_+_3620296 1.215 NM_024027
NM_199235
COLEC11

collectin sub-family member 11

chr16_+_1696162 1.209 NM_001040439
NM_015133
MAPK8IP3

mitogen-activated protein kinase 8 interacting protein 3

chr19_+_17831670 1.208 NM_000980
RPL18A
ribosomal protein L18a
chr3_-_127303080 1.205 NM_001164475
SLC41A3
solute carrier family 41, member 3
chr10_+_75174151 1.204 SEC24C
SEC24 family, member C (S. cerevisiae)
chr18_-_75540255 1.199


chr1_+_155130146 1.198 NM_001080471
PEAR1
platelet endothelial aggregation receptor 1
chr11_+_303852 1.195 NM_003641
IFITM1
interferon induced transmembrane protein 1 (9-27)
chr22_+_19543248 1.194 NM_004782
SNAP29
synaptosomal-associated protein, 29kDa
chrX_-_40479718 1.183 NM_004229
MED14
mediator complex subunit 14
chrX_-_40479607 1.182 MED14
mediator complex subunit 14
chr22_-_19543069 1.179 NM_058004
PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr19_+_60589114 1.177 RPL28
ribosomal protein L28
chr12_-_55917134 1.176 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chrX_-_73751185 1.166 NM_016120
NM_183353
RLIM

ring finger protein, LIM domain interacting

chr16_-_65108605 1.162 TK2
thymidine kinase 2, mitochondrial
chr11_-_65412409 1.156 NM_004214
NM_198897
FIBP

fibroblast growth factor (acidic) intracellular binding protein

chr12_-_6668680 1.153 ZNF384
zinc finger protein 384
chr22_+_36008465 1.153 CYTH4
cytohesin 4
chr19_-_8473473 1.152 NM_032152
PRAM1
PML-RARA regulated adaptor molecule 1
chr12_-_6668880 1.151 NM_001039917
NM_001039919
NM_001039920
NM_001135734
ZNF384



zinc finger protein 384



chr19_+_19487535 1.150 NDUFA13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr7_+_44050842 1.147 DBNL
drebrin-like
chr16_-_65742323 1.144 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr1_+_151596953 1.143 NM_002965
S100A9
S100 calcium binding protein A9
chrX_+_21868635 1.142 NM_004595
SMS
spermine synthase
chr5_+_180583315 1.142 TRIM41
tripartite motif containing 41
chr3_+_46894239 1.139 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr16_-_2258067 1.138 RNPS1
RNA binding protein S1, serine-rich domain
chr20_+_44180355 1.137 CD40
CD40 molecule, TNF receptor superfamily member 5
chr11_+_63498590 1.137 NM_004074
COX8A
cytochrome c oxidase subunit VIIIA (ubiquitous)
chrX_-_73751155 1.133 RLIM
ring finger protein, LIM domain interacting
chr12_+_92595281 1.128 NM_003805
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chrX_+_152699616 1.126 NM_001170760
NM_001170761
NM_014370
SRPK3


SRSF protein kinase 3


chr20_+_44180296 1.126 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr6_+_41714171 1.125 NM_005586
MDFI
MyoD family inhibitor
chr11_+_834445 1.123 NM_001025237
TSPAN4
tetraspanin 4
chr5_+_324700 1.122 NM_013232
PDCD6
programmed cell death 6
chr21_+_42509255 1.119 NM_207629
ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr3_+_46591048 1.118 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr16_+_2593351 1.118 LOC652276
hypothetical LOC652276
chr9_-_138387926 1.116 NM_052813
NM_052814
CARD9

caspase recruitment domain family, member 9

chr17_-_42621535 1.111 CDC27
cell division cycle 27 homolog (S. cerevisiae)
chr7_-_44985175 1.109 MYO1G
myosin IG
chr17_-_74501365 1.108 CANT1
calcium activated nucleotidase 1
chr9_+_139255559 1.100 TUBB2C
tubulin, beta 2C
chr8_+_56954953 1.099 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr12_-_121780835 1.099 NM_032554
GPR81
G protein-coupled receptor 81
chrX_+_65152004 1.099


chr7_+_44050809 1.098 DBNL
drebrin-like
chr22_-_16060485 1.097 NM_177405
CECR1
cat eye syndrome chromosome region, candidate 1
chr11_+_65414450 1.094 NM_006848
CCDC85B
coiled-coil domain containing 85B
chr19_+_47079089 1.089 NM_004706
NM_198977
ARHGEF1

Rho guanine nucleotide exchange factor (GEF) 1

chr14_-_80934523 1.083 NM_033104
STON2
stonin 2
chr1_+_15955719 1.082 FBLIM1
filamin binding LIM protein 1
chr12_+_52708460 1.071 NM_004503
HOXC6
homeobox C6
chr7_-_44985084 1.070 MYO1G
myosin IG
chr3_-_13032130 1.062


chr17_-_60208083 1.062 LOC146880
hypothetical LOC146880
chr19_+_458475 1.060 NM_033513
C19orf20
chromosome 19 open reading frame 20
chrX_-_40480005 1.060 MED14
mediator complex subunit 14
chr9_-_131444098 1.058 NM_017873
NM_177999
ASB6

ankyrin repeat and SOCS box containing 6

chr15_+_38430517 1.058 NM_001145643
PHGR1
proline/histidine/glycine-rich 1
chr17_+_7549138 1.058 NM_001406
EFNB3
ephrin-B3
chr11_+_65100074 1.055 NM_001099409
EHBP1L1
EH domain binding protein 1-like 1
chrX_-_102396704 1.054 NM_001006684
NM_153333
TCEAL8

transcription elongation factor A (SII)-like 8

chr12_+_122030825 1.052 NM_001002251
NM_001002252
NM_016638
NM_018694
ARL6IP4



ADP-ribosylation-like factor 6 interacting protein 4



chr17_-_77244034 1.048 C17orf90
chromosome 17 open reading frame 90
chr15_+_32304477 1.044 NM_016454
TMEM85
transmembrane protein 85
chr3_-_55489973 1.043 WNT5A
wingless-type MMTV integration site family, member 5A
chr16_+_30102426 1.040 CORO1A
coronin, actin binding protein, 1A
chr22_+_48740143 1.038 NM_001001852
PIM3
pim-3 oncogene
chr19_+_52940604 1.036 NM_015710
GLTSCR2
glioma tumor suppressor candidate region gene 2
chr19_+_3457264 1.036 NM_016263
FZR1
fizzy/cell division cycle 20 related 1 (Drosophila)
chrX_-_73751152 1.035


chr7_+_128290162 1.030 ATP6V1F
ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
chr3_-_184756101 1.027 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr1_+_35031185 1.027 NM_002060
GJA4
gap junction protein, alpha 4, 37kDa
chr19_-_13122088 1.025 STX10
syntaxin 10
chr17_+_71065478 1.022 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr14_+_104244998 1.015 INF2
inverted formin, FH2 and WH2 domain containing
chr7_-_44985202 1.010 NM_033054
MYO1G
myosin IG
chrX_-_73751135 1.009 RLIM
ring finger protein, LIM domain interacting
chr7_+_128290092 1.007 NM_001198909
NM_004231
ATP6V1F

ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F

chr5_+_132230214 1.007 NM_014402
UQCRQ
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
chr7_-_100078270 1.006 TFR2
transferrin receptor 2
chr21_+_45184394 1.003


chr15_+_65217412 1.003 NM_001145103
SMAD3
SMAD family member 3
chr14_-_103248193 1.002 XRCC3
X-ray repair complementing defective repair in Chinese hamster cells 3
chr19_+_60878422 0.998 EPN1
epsin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.20 1.01e-07 GO:0044260 cellular macromolecule metabolic process
1.18 1.56e-07 GO:0043170 macromolecule metabolic process
1.08 1.03e-06 GO:0009987 cellular process
1.24 1.89e-05 GO:0048518 positive regulation of biological process
1.25 1.88e-04 GO:0090304 nucleic acid metabolic process
1.27 2.13e-04 GO:0048583 regulation of response to stimulus
1.10 3.29e-04 GO:0065007 biological regulation
1.27 8.54e-04 GO:0016070 RNA metabolic process
1.18 1.02e-03 GO:0071840 cellular component organization or biogenesis
1.56 1.38e-03 GO:0016044 cellular membrane organization
1.11 1.53e-03 GO:0050794 regulation of cellular process
1.18 1.73e-03 GO:0016043 cellular component organization
1.55 1.80e-03 GO:0061024 membrane organization
1.25 2.03e-03 GO:0010467 gene expression
1.52 2.12e-03 GO:0001775 cell activation
1.22 2.15e-03 GO:0048522 positive regulation of cellular process
1.10 2.83e-03 GO:0050789 regulation of biological process
1.11 3.21e-03 GO:0044238 primary metabolic process
1.46 4.66e-03 GO:0071822 protein complex subunit organization
1.53 4.82e-03 GO:0002684 positive regulation of immune system process
1.20 5.34e-03 GO:0044267 cellular protein metabolic process
1.24 5.40e-03 GO:0043412 macromolecule modification
1.91 6.28e-03 GO:0002697 regulation of immune effector process
1.38 7.28e-03 GO:0048584 positive regulation of response to stimulus
1.29 1.04e-02 GO:0002376 immune system process
1.18 1.23e-02 GO:0019538 protein metabolic process
1.11 1.32e-02 GO:0044237 cellular metabolic process
1.36 1.35e-02 GO:0043933 macromolecular complex subunit organization
1.09 1.96e-02 GO:0008152 metabolic process
1.23 2.18e-02 GO:0006464 protein modification process
1.19 2.28e-02 GO:0006950 response to stress
1.39 2.48e-02 GO:0002682 regulation of immune system process
1.45 3.81e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.17 4.23e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.44 5.60e-03 GO:0030529 ribonucleoprotein complex
1.05 8.24e-03 GO:0005622 intracellular
1.07 9.79e-03 GO:0005737 cytoplasm
1.20 1.17e-02 GO:0005829 cytosol
1.18 1.19e-02 GO:0031974 membrane-enclosed lumen
1.21 1.23e-02 GO:0031981 nuclear lumen
1.05 1.53e-02 GO:0044424 intracellular part
1.18 2.12e-02 GO:0043233 organelle lumen
1.18 3.88e-02 GO:0044428 nuclear part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 1.35e-08 GO:0005515 protein binding
1.35 1.38e-02 GO:0042802 identical protein binding