Motif ID: NKX2-3_NKX2-5.p2

Z-value: 0.935


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)



Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_13992351 3.565 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr17_-_71285992 2.629 H3F3B
H3 histone, family 3B (H3.3B)
chr9_+_117955890 2.014 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr12_-_120725210 1.876 LOC338799
hypothetical LOC338799
chr7_-_27171673 1.802 NM_152739
HOXA9
homeobox A9
chr7_-_27171648 1.723 HOXA9
homeobox A9
chr7_-_27171600 1.647 HOXA9
homeobox A9
chr12_+_52696908 1.625 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr6_+_50789215 1.596 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr6_+_155579788 1.341 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr20_+_62266217 1.256 MYT1
myelin transcription factor 1
chr4_+_3341521 1.241 NM_198227
RGS12
regulator of G-protein signaling 12
chr1_+_50342168 1.207 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_+_175041069 1.203 NM_022304
HRH2
histamine receptor H2
chr5_-_88155360 1.197 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr20_+_62266270 1.162 NM_004535
MYT1
myelin transcription factor 1
chr17_+_7682355 1.161


chr3_+_16191159 1.109 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr20_-_62052922 1.094 NM_001193379
UCKL1
uridine-cytidine kinase 1-like 1
chr22_+_38903825 1.090 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr3_-_127810087 1.086 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr1_-_149681265 1.082 NM_207171
POGZ
pogo transposable element with ZNF domain
chr19_-_46504831 1.008


chr12_-_28016182 0.995 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr1_+_556968 0.991


chr17_-_36209672 0.987 NM_181535
KRT28
keratin 28
chr22_-_36836620 0.984 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr13_-_93929719 0.964 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr2_+_171280046 0.957 NM_001003845
SP5
Sp5 transcription factor
chr16_+_10878539 0.948 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr6_-_33862690 0.890 NM_001143944
LEMD2
LEM domain containing 2
chr12_+_52697160 0.876 HOXC5
HOXC6
homeobox C5
homeobox C6
chr6_-_46401174 0.875 RCAN2
regulator of calcineurin 2
chr9_+_129900637 0.875 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr2_+_171280182 0.873


chr9_+_129900590 0.869 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr4_-_38710376 0.863 NM_024943
TMEM156
transmembrane protein 156
chr14_+_91858677 0.849 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr22_-_36836478 0.815 BAIAP2L2
BAI1-associated protein 2-like 2
chr12_-_51233001 0.803 NM_033448
KRT71
keratin 71
chr13_-_35327798 0.797 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr14_-_100105883 0.786 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr3_+_46894239 0.776 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr15_-_64108718 0.773


chr6_+_16251260 0.767 MYLIP
myosin regulatory light chain interacting protein
chr1_+_203503214 0.748 TMCC2
transmembrane and coiled-coil domain family 2
chr17_-_1211263 0.741 YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr17_-_76064842 0.736 NM_002522
NPTX1
neuronal pentraxin I
chr4_+_140806536 0.721 MGST2
microsomal glutathione S-transferase 2
chr3_-_152517204 0.706 NM_023915
GPR87
G protein-coupled receptor 87
chr5_+_169713458 0.693 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr13_+_97856148 0.685


chr17_-_19290745 0.683


chr16_+_7322751 0.678 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr3_+_69895651 0.676 NM_006722
MITF
microphthalmia-associated transcription factor
chr12_-_89922888 0.673 NM_004950
EPYC
epiphycan
chrX_-_18600108 0.670 NM_000330
RS1
retinoschisin 1
chr20_+_9146036 0.669 NM_182797
PLCB4
phospholipase C, beta 4
chr4_-_83566045 0.655


chr12_-_10173947 0.651 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr20_-_43163021 0.645 NM_002251
KCNS1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chr11_+_7574992 0.644 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr2_+_161980865 0.643 NM_006593
TBR1
T-box, brain, 1
chr17_+_56843893 0.637 NM_203425
C17orf82
chromosome 17 open reading frame 82
chr1_-_149004852 0.633 CTSS
cathepsin S
chr4_+_9094611 0.633 NM_001040071
LOC650293
seven transmembrane helix receptor
chr4_-_153493133 0.630 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr22_-_43987010 0.627 NM_015264
KIAA0930
KIAA0930
chr6_+_134800533 0.626 LOC154092
hypothetical LOC154092
chr1_+_17817397 0.622 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr14_+_31868229 0.614 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr7_-_115458047 0.609 TFEC
transcription factor EC
chr16_-_21571463 0.609 NM_005849
IGSF6
immunoglobulin superfamily, member 6
chrX_-_19598912 0.600 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr13_+_26896614 0.600 NM_002097
GTF3A
general transcription factor IIIA
chr4_-_83566246 0.588 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr11_+_91724909 0.583 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr16_-_21571409 0.582 IGSF6
immunoglobulin superfamily, member 6
chr12_-_51200347 0.582 NM_000424
KRT5
keratin 5
chr7_+_113842284 0.573 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr19_-_13925192 0.571 NM_001146254
NM_001146255
PODNL1

podocan-like 1

chr8_-_102029997 0.569 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr20_+_31713750 0.567 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr1_+_166516901 0.565 NM_005149
TBX19
T-box 19
chr10_-_32707549 0.561 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr9_+_130909926 0.545


chr6_-_86407875 0.536 NM_001159675
NM_001159676
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr2_+_158559936 0.536 NM_001135098
UPP2
uridine phosphorylase 2
chr6_-_74284522 0.533 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr7_-_75794919 0.533 YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr19_+_50100843 0.530 NM_000041
APOE
apolipoprotein E
chr13_-_37070862 0.529 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr2_-_20375497 0.527 PUM2
pumilio homolog 2 (Drosophila)
chr18_+_71051713 0.525 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr6_+_50894397 0.525 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr2_-_215953818 0.524 FN1
fibronectin 1
chr7_-_115458010 0.523 NM_001018058
NM_012252
TFEC

transcription factor EC

chr1_-_180624380 0.522 GLUL
glutamate-ammonia ligase
chr20_+_31287462 0.517 NM_016583
NM_130852
PLUNC

palate, lung and nasal epithelium associated

chrX_+_70682204 0.517 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr10_+_44726635 0.514 NM_001123376
TMEM72
transmembrane protein 72
chr6_+_12824873 0.508 PHACTR1
phosphatase and actin regulator 1
chr17_-_36346240 0.507 KRT23
keratin 23 (histone deacetylase inducible)
chr6_+_12825022 0.502 PHACTR1
phosphatase and actin regulator 1
chr2_+_173394560 0.496 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr12_-_51173238 0.495 NM_005554
KRT6A
keratin 6A
chr6_-_2580296 0.487 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr4_+_71713324 0.485 NM_031889
ENAM
enamelin
chr17_+_72065440 0.482 LOC100507246
hypothetical LOC100507246
chr10_+_80743769 0.481 ZMIZ1
zinc finger, MIZ-type containing 1
chr7_-_41709191 0.478 NM_002192
INHBA
inhibin, beta A
chr11_+_20001130 0.462 NM_001111019
NAV2
neuron navigator 2
chr10_+_124660206 0.461 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr1_+_149299490 0.456 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr10_+_71833920 0.455 EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr7_+_141054621 0.453 NM_001105558
WEE2
WEE1 homolog 2 (S. pombe)
chr1_+_938709 0.449 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr9_-_205892 0.447 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr15_+_91244563 0.446 CHD2
chromodomain helicase DNA binding protein 2
chr18_-_13905534 0.445 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr6_-_169395847 0.444 THBS2
thrombospondin 2
chr17_+_72982919 0.437 NM_001113495
SEPT9
septin 9
chr8_-_17624009 0.436 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr9_-_133574928 0.435 NM_198679
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr20_-_49747397 0.434 ATP9A
ATPase, class II, type 9A
chr1_-_53972464 0.433 NM_147193
GLIS1
GLIS family zinc finger 1
chr15_+_97990705 0.431 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr1_+_154449389 0.431 NM_007221
PMF1-BGLAP
PMF1
PMF1-BGLAP read-through transcript
polyamine-modulated factor 1
chrX_+_21960841 0.430 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr2_-_190635566 0.429 NM_005259
MSTN
myostatin
chr8_-_72436519 0.428 EYA1
eyes absent homolog 1 (Drosophila)
chr6_-_52882419 0.423 NM_000847
GSTA3
glutathione S-transferase alpha 3
chr22_-_16127520 0.421 CECR3
cat eye syndrome chromosome region, candidate 3
chr7_-_104696678 0.419 NM_182691
SRPK2
SRSF protein kinase 2
chr2_+_161981138 0.417 TBR1
T-box, brain, 1
chr4_+_155703581 0.415 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr16_-_20246309 0.415 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr8_+_55691179 0.413 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr10_+_71833905 0.410 EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr11_-_2108035 0.409 IGF2
insulin-like growth factor 2 (somatomedin A)
chr17_+_54587882 0.408 PRR11
proline rich 11
chr1_+_208568218 0.407 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr1_+_149299530 0.406 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr6_+_37081387 0.405 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr11_-_46364681 0.404 NM_000741
CHRM4
cholinergic receptor, muscarinic 4
chr3_-_55489973 0.404 WNT5A
wingless-type MMTV integration site family, member 5A
chr2_+_161981046 0.402 TBR1
T-box, brain, 1
chr5_+_174084137 0.402 NM_002449
MSX2
msh homeobox 2
chr12_-_9913199 0.402 CLEC2B
C-type lectin domain family 2, member B
chr16_+_20682812 0.398 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr1_+_559129 0.397


chr20_-_7869068 0.395 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr7_+_129771865 0.393 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr4_-_176970895 0.393 GPM6A
glycoprotein M6A
chr17_-_10393664 0.391 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr20_-_1921451 0.390 NM_001190892
PDYN
prodynorphin
chr12_-_88269884 0.386 DUSP6
dual specificity phosphatase 6
chr1_+_149299504 0.386 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr6_-_46401363 0.385 NM_005822
RCAN2
regulator of calcineurin 2
chrX_+_68752635 0.383 NM_001005609
NM_001005610
NM_001005612
NM_001005613
NM_001399
EDA




ectodysplasin A




chr2_-_178681311 0.382 NM_001077197
PDE11A
phosphodiesterase 11A
chr11_+_65023218 0.380


chr8_-_122722674 0.380 NM_005328
HAS2
hyaluronan synthase 2
chr14_+_99633570 0.379 EVL
Enah/Vasp-like
chr10_+_111755715 0.378 NM_019903
ADD3
adducin 3 (gamma)
chr11_+_128067598 0.378 NM_001167681
FLI1
Friend leukemia virus integration 1
chr4_+_71418886 0.373 NM_212557
AMTN
amelotin
chr6_+_158653679 0.372 NM_001007466
NM_020245
TULP4

tubby like protein 4

chrX_+_90976314 0.372 NM_014522
NM_032968
NM_032969
PCDH11X


protocadherin 11 X-linked


chr6_+_152168500 0.371 NM_001122741
ESR1
estrogen receptor 1
chr4_+_71142893 0.368 NM_005212
CSN3
casein kappa
chr3_-_188935363 0.366 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr16_+_79829794 0.366 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr3_+_160269836 0.363 IQCJ
IQ motif containing J
chr3_+_8750485 0.362 NM_033337
NM_001234
CAV3

caveolin 3

chr20_+_43691797 0.361 NM_080753
WFDC10A
WAP four-disulfide core domain 10A
chr12_+_12829807 0.361 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr12_+_48443232 0.359 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr5_+_71538456 0.359 MAP1B
microtubule-associated protein 1B
chr5_+_1278469 0.357 NM_182632
SLC6A18
solute carrier family 6, member 18
chr17_-_64649608 0.356 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr3_-_11585264 0.354 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr20_+_19863716 0.350 RIN2
Ras and Rab interactor 2
chr11_+_65026382 0.350


chr17_+_38412267 0.350 NM_005533
IFI35
interferon-induced protein 35
chr10_-_105835609 0.347 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr3_+_160269734 0.347 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr2_+_220017617 0.346 SPEG
SPEG complex locus
chr1_-_180624494 0.344 GLUL
glutamate-ammonia ligase
chr10_-_97190885 0.343 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr20_-_21442663 0.343 NM_002509
NKX2-2
NK2 homeobox 2
chr1_-_109957195 0.342 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr2_-_160764819 0.340 NM_000888
ITGB6
integrin, beta 6
chr10_+_71833866 0.340 NM_004096
EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr9_-_135379888 0.337 NM_001080483
TMEM8C
transmembrane protein 8C
chr2_+_157822355 0.336 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr1_+_557269 0.336


chr10_-_64246129 0.334 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr6_-_169395972 0.333 NM_003247
THBS2
thrombospondin 2
chr3_-_139960874 0.332 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.41 4.36e-11 GO:0032501 multicellular organismal process
1.43 2.83e-06 GO:0007275 multicellular organismal development
1.40 3.70e-06 GO:0032502 developmental process
1.48 4.94e-06 GO:0048731 system development
1.44 8.44e-06 GO:0048856 anatomical structure development
1.59 6.54e-05 GO:0007166 cell surface receptor linked signaling pathway
1.55 1.95e-04 GO:0048513 organ development
1.34 6.24e-04 GO:0023052 signaling
1.31 1.58e-03 GO:0051716 cellular response to stimulus
1.35 1.60e-03 GO:0007165 signal transduction
1.75 5.74e-03 GO:0009888 tissue development
1.22 6.78e-03 GO:0050896 response to stimulus
3.82 7.28e-03 GO:0048706 embryonic skeletal system development
1.17 7.53e-03 GO:0065007 biological regulation
2.67 1.09e-02 GO:0007517 muscle organ development
1.76 1.86e-02 GO:0007267 cell-cell signaling
5.39 2.10e-02 GO:0071363 cellular response to growth factor stimulus
1.18 2.46e-02 GO:0050794 regulation of cellular process
4.44 2.47e-02 GO:0070848 response to growth factor stimulus
1.51 2.50e-02 GO:0009653 anatomical structure morphogenesis
1.46 2.70e-02 GO:0003008 system process
11.80 4.70e-02 GO:0007603 phototransduction, visible light

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.54 5.63e-06 GO:0005576 extracellular region
1.80 6.43e-06 GO:0044421 extracellular region part
1.83 1.22e-04 GO:0005615 extracellular space
1.24 1.55e-02 GO:0071944 cell periphery
1.24 2.01e-02 GO:0005886 plasma membrane
3.99 2.24e-02 GO:0031983 vesicle lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.84 1.14e-03 GO:0043565 sequence-specific DNA binding
2.73 5.58e-03 GO:0008083 growth factor activity
1.61 7.82e-03 GO:0030528 transcription regulator activity
1.58 2.14e-02 GO:0001071 nucleic acid binding transcription factor activity
1.58 2.14e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
3.78 3.05e-02 GO:0035591 signaling adaptor activity