Motif ID: SOX2.p2

Z-value: 0.655


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2



Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_21087435 1.771 APOB
apolipoprotein B (including Ag(x) antigen)
chr2_-_21084077 1.331 APOB
apolipoprotein B (including Ag(x) antigen)
chr3_-_192531018 1.314 NM_198152
UTS2D
urotensin 2 domain containing
chr20_+_11846536 1.301 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr5_+_147754467 1.284 FBXO38
F-box protein 38
chr2_+_152900076 1.147 FMNL2
formin-like 2
chr17_+_63252704 1.141 BPTF
bromodomain PHD finger transcription factor
chr20_+_2892918 1.090 PTPRA
protein tyrosine phosphatase, receptor type, A
chr16_+_21518633 1.065 METTL9
methyltransferase like 9
chr3_+_142587973 1.037


chr2_+_62787534 0.992 NM_001142614
EHBP1
EH domain binding protein 1
chr2_+_203207912 0.980 FAM117B
family with sequence similarity 117, member B
chr17_+_63252668 0.953 BPTF
bromodomain PHD finger transcription factor
chr4_+_146623405 0.938 NM_001003688
SMAD1
SMAD family member 1
chr1_+_61320213 0.918 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr1_+_61319976 0.905 NM_001145512
NFIA
nuclear factor I/A
chr6_+_122762449 0.897 HSF2
heat shock transcription factor 2
chr2_+_101680594 0.895 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chrX_+_86659370 0.883 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr2_+_120233676 0.862 NM_002830
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr4_-_101658094 0.853 NM_001159694
NM_016242
EMCN

endomucin

chr2_-_174475528 0.816


chr4_+_110968594 0.802 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr14_+_31868229 0.790 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr6_-_127882192 0.784 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chr6_+_122762384 0.768 NM_001135564
NM_004506
HSF2

heat shock transcription factor 2

chr13_+_23042722 0.752 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr10_+_49184658 0.739 MAPK8
mitogen-activated protein kinase 8
chr8_+_21833162 0.734 XPO7
exportin 7
chr4_+_113372287 0.722 NM_001128426
NM_018569
AP1AR

adaptor-related protein complex 1 associated regulatory protein

chr6_+_64414389 0.722 NM_015153
PHF3
PHD finger protein 3
chr9_+_90193058 0.703 NM_006717
SPIN1
spindlin 1
chr3_+_186563529 0.698 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr10_-_11614279 0.696 NM_001080491
USP6NL
USP6 N-terminal like
chr14_-_30927931 0.686 NM_015473
HEATR5A
HEAT repeat containing 5A
chr2_+_169021039 0.671 NM_203463
LASS6
LAG1 homolog, ceramide synthase 6
chr18_+_3441589 0.671 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr2_+_181554048 0.670 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr9_-_85773899 0.670 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr10_-_61570665 0.666 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr9_+_114289178 0.664 KIAA1958
KIAA1958
chr2_-_63518589 0.662 NM_001042692
WDPCP
WD repeat containing planar cell polarity effector
chr10_+_114699953 0.622 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr9_+_112470871 0.621 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr7_+_94135384 0.620 PEG10
paternally expressed 10
chr16_+_55373241 0.612 NUP93
nucleoporin 93kDa
chr1_+_90233238 0.611 NM_182975
NM_182976
ZNF326

zinc finger protein 326

chr6_+_144649142 0.610 UTRN
utrophin
chr8_+_21833111 0.599 NM_015024
XPO7
exportin 7
chr15_+_47502666 0.599 NM_002009
FGF7
fibroblast growth factor 7
chr6_-_128263868 0.596 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr6_-_50045296 0.587 NM_001037729
DEFB113
defensin, beta 113
chr17_+_55269974 0.578


chr13_-_40491491 0.571 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr15_+_50098724 0.569 MAPK6
mitogen-activated protein kinase 6
chr15_+_50098700 0.560 NM_002748
MAPK6
mitogen-activated protein kinase 6
chr4_+_115762971 0.558 NM_003360
UGT8
UDP glycosyltransferase 8
chr8_+_81560971 0.557 NM_001105539
NM_023929
ZBTB10

zinc finger and BTB domain containing 10

chr9_+_71009746 0.539 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr2_-_37752272 0.537 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr13_-_98428244 0.536 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr12_-_10464308 0.533 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr7_+_16759845 0.528 NM_014399
TSPAN13
tetraspanin 13
chr5_+_36912656 0.527 NIPBL
Nipped-B homolog (Drosophila)
chrX_+_123062143 0.526 STAG2
stromal antigen 2
chrX_+_44617346 0.524 NM_021140
KDM6A
lysine (K)-specific demethylase 6A
chr1_+_183281173 0.522 NM_007212
RNF2
ring finger protein 2
chr1_+_198975227 0.519 NM_203459
CAMSAP1L1
calmodulin regulated spectrin-associated protein 1-like 1
chr6_-_128883125 0.517 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr12_-_65359019 0.513 GRIP1
glutamate receptor interacting protein 1
chr12_-_11041740 0.512 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr3_+_153469421 0.508 MBNL1
muscleblind-like (Drosophila)
chrX_+_84385693 0.508 ZNF711
zinc finger protein 711
chr6_+_157141565 0.499 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr2_+_198377561 0.497 NM_006226
PLCL1
phospholipase C-like 1
chr14_+_22059174 0.496


chr15_+_50098730 0.496 MAPK6
mitogen-activated protein kinase 6
chr4_+_166350620 0.491 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr2_+_46779827 0.485 NM_144949
SOCS5
suppressor of cytokine signaling 5
chr15_-_23204887 0.483 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr2_+_166137091 0.481 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr17_+_50333021 0.481 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr7_-_11838260 0.479 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr17_-_53420473 0.477 VEZF1
vascular endothelial zinc finger 1
chr2_-_156897286 0.474 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr2_+_203208064 0.474 NM_173511
FAM117B
family with sequence similarity 117, member B
chr2_-_55413253 0.472 CCDC88A
coiled-coil domain containing 88A
chr2_+_36436873 0.468 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr6_+_144654565 0.467 NM_007124
UTRN
utrophin
chr6_+_64340408 0.465 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr7_-_26202626 0.464 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr5_+_138705445 0.462 PAIP2
poly(A) binding protein interacting protein 2
chr16_-_69876262 0.461 FTSJD1
FtsJ methyltransferase domain containing 1
chr7_+_106897737 0.461 NM_005295
GPR22
G protein-coupled receptor 22
chr20_-_33705244 0.459 NM_003915
CPNE1
copine I
chr12_-_65359148 0.457 NM_001178074
NM_021150
GRIP1

glutamate receptor interacting protein 1

chr3_-_150993299 0.455 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr4_+_39376058 0.455 NM_001111112
NM_001111113
NM_005339
UBE2K


ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)


chr21_+_29593607 0.454 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr20_-_48980858 0.453 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr4_+_35959638 0.453 NM_001136536
DTHD1
death domain containing 1
chr5_+_138705469 0.452 PAIP2
poly(A) binding protein interacting protein 2
chr6_+_64340388 0.450 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr2_-_55053398 0.448


chr8_+_110415725 0.448 NM_001193557
NM_020189
ENY2

enhancer of yellow 2 homolog (Drosophila)

chr4_+_144654005 0.443 NM_003601
SMARCA5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr5_-_44424423 0.443 NM_004465
FGF10
fibroblast growth factor 10
chr1_-_151296611 0.443 NM_005988
SPRR2A
small proline-rich protein 2A
chr17_+_36642240 0.441 NM_031962
KRTAP9-9
KRTAP9-3
keratin associated protein 9-9
keratin associated protein 9-3
chr1_-_52293634 0.437 NM_015913
TXNDC12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr2_-_188021117 0.434 NM_005795
CALCRL
calcitonin receptor-like
chr8_-_110415448 0.434 NM_032869
NUDCD1
NudC domain containing 1
chr7_+_116099648 0.434 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr15_+_21361546 0.433 NM_005664
MKRN3
makorin ring finger protein 3
chr2_-_36929520 0.431 STRN
striatin, calmodulin binding protein
chr2_+_114935623 0.428 NM_001178036
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr6_+_57062974 0.427 ZNF451
zinc finger protein 451
chr17_-_53420595 0.427 NM_007146
VEZF1
vascular endothelial zinc finger 1
chr5_+_102493155 0.426 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr10_+_92970302 0.425 NM_032373
PCGF5
polycomb group ring finger 5
chr1_-_95165037 0.424 CNN3
calponin 3, acidic
chr9_+_18464090 0.421 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr3_-_121065112 0.419


chr6_-_33028790 0.418 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr4_+_144654526 0.418


chr2_+_54537842 0.417 SPTBN1
spectrin, beta, non-erythrocytic 1
chr2_+_187163232 0.417 ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr20_+_30831298 0.416 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr12_-_23995220 0.415 SOX5
SRY (sex determining region Y)-box 5
chr12_-_23995109 0.415 SOX5
SRY (sex determining region Y)-box 5
chr14_-_22521544 0.415 NM_032876
JUB
jub, ajuba homolog (Xenopus laevis)
chr1_-_95165089 0.414 NM_001839
CNN3
calponin 3, acidic
chr2_-_21081694 0.414 APOB
apolipoprotein B (including Ag(x) antigen)
chr14_+_34831355 0.413 PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr10_+_111959978 0.409 NM_001008541
MXI1
MAX interactor 1
chr2_+_201385019 0.405 BZW1
basic leucine zipper and W2 domains 1
chr2_+_11600238 0.405 GREB1
growth regulation by estrogen in breast cancer 1
chr5_+_10406980 0.405


chr15_+_22751162 0.404 NM_003097
NM_022804
NM_005678
SNRPN
SNURF

small nuclear ribonucleoprotein polypeptide N
SNRPN upstream reading frame

chr5_+_161427225 0.403 NM_000816
NM_198903
NM_198904
GABRG2


gamma-aminobutyric acid (GABA) A receptor, gamma 2


chr20_-_45410033 0.402 ZMYND8
zinc finger, MYND-type containing 8
chr2_+_138438277 0.401 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr2_+_108751033 0.401 RANBP2
RAN binding protein 2
chr3_+_112743615 0.398 NM_005816
NM_198196
CD96

CD96 molecule

chr8_-_17624009 0.397 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr6_+_89847183 0.396 PNRC1
proline-rich nuclear receptor coactivator 1
chr5_-_160211623 0.394 NM_025153
ATP10B
ATPase, class V, type 10B
chr12_-_97812633 0.392 ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr4_+_146622154 0.390 NM_005900
SMAD1
SMAD family member 1
chr11_+_9552809 0.390 NM_001143976
WEE1
WEE1 homolog (S. pombe)
chr12_+_67919583 0.390 NM_007007
CPSF6
cleavage and polyadenylation specific factor 6, 68kDa
chr4_+_25931745 0.390 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr12_-_11439752 0.387 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr19_+_44886785 0.385 NM_020129
NM_203471
LGALS14

lectin, galactoside-binding, soluble, 14

chr10_+_92970487 0.384 PCGF5
polycomb group ring finger 5
chr8_+_59486376 0.382 NM_001077619
UBXN2B
UBX domain protein 2B
chr4_-_83566045 0.381


chr2_-_207739815 0.375 KLF7
Kruppel-like factor 7 (ubiquitous)
chr2_+_201384889 0.375 NM_014670
BZW1
basic leucine zipper and W2 domains 1
chr6_+_64403668 0.374 PHF3
PHD finger protein 3
chr12_+_94135645 0.372 NM_017599
VEZT
vezatin, adherens junctions transmembrane protein
chr6_-_64087806 0.372 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr10_-_98326435 0.371 TM9SF3
transmembrane 9 superfamily member 3
chr1_-_196776697 0.371 NM_133262
NM_133326
ATP6V1G3

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

chr6_+_64403631 0.371 PHF3
PHD finger protein 3
chr2_+_171280046 0.371 NM_001003845
SP5
Sp5 transcription factor
chr13_-_40491405 0.370 ELF1
E74-like factor 1 (ets domain transcription factor)
chr14_+_56927066 0.370 NAA30
N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr2_+_201384842 0.369 BZW1
basic leucine zipper and W2 domains 1
chr5_+_90711887 0.369 LOC100129716
hypothetical LOC100129716
chr1_+_24158887 0.368 NM_017761
PNRC2
proline-rich nuclear receptor coactivator 2
chr9_+_90193807 0.368 SPIN1
spindlin 1
chr2_+_201384904 0.367 BZW1
basic leucine zipper and W2 domains 1
chr5_+_57914658 0.366 NM_138453
RAB3C
RAB3C, member RAS oncogene family
chr10_+_53744043 0.366 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr2_-_210726539 0.365 C2orf67
chromosome 2 open reading frame 67
chr2_-_18634257 0.363 NM_001002006
NM_033253
NT5C1B-RDH14
NT5C1B

NT5C1B-RDH14 readthrough
5'-nucleotidase, cytosolic IB

chr6_-_134680888 0.362 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr2_+_33213111 0.360 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr2_-_47986160 0.360 NM_001190274
FBXO11
F-box protein 11
chr3_+_23904086 0.359 UBE2E1
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
chr4_+_90252990 0.359 NM_145715
TIGD2
tigger transposable element derived 2
chr4_-_83566246 0.358 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr2_+_214984705 0.358 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr16_-_20610078 0.357 NM_052956
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr6_+_4721825 0.356 CDYL
chromodomain protein, Y-like
chr3_-_153470022 0.354 LOC401093
hypothetical LOC401093
chr14_+_56927014 0.353 NM_001011713
NAA30
N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr6_+_89847019 0.352 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr12_-_88573949 0.351 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chrX_-_33267646 0.350 NM_000109
DMD
dystrophin
chr16_+_24475129 0.350 RBBP6
retinoblastoma binding protein 6
chr3_+_192529567 0.349 NM_174908
NM_178335
CCDC50

coiled-coil domain containing 50

chr6_+_88026338 0.348 ZNF292
zinc finger protein 292
chr7_+_93388951 0.348 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr5_+_65258250 0.347 ERBB2IP
erbb2 interacting protein
chr2_+_201384880 0.347 BZW1
basic leucine zipper and W2 domains 1
chr1_+_87569959 0.347 LMO4
LIM domain only 4
chr6_+_45404031 0.346 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr15_-_48198697 0.346 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.19 4.03e-06 GO:0032501 multicellular organismal process
1.80 8.07e-06 GO:0007608 sensory perception of smell
1.74 1.26e-05 GO:0007606 sensory perception of chemical stimulus
1.15 1.67e-04 GO:0050896 response to stimulus
1.36 1.12e-03 GO:0050877 neurological system process
1.31 1.14e-03 GO:0003008 system process
1.44 4.97e-03 GO:0007600 sensory perception
1.32 7.00e-03 GO:0007399 nervous system development

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.85 7.12e-07 GO:0004984 olfactory receptor activity