Motif ID: POU5F1.p2

Z-value: 0.699


Transcription factors associated with POU5F1.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1



Activity profile for motif POU5F1.p2.

activity profile for motif POU5F1.p2


Sorted Z-values histogram for motif POU5F1.p2

Sorted Z-values for motif POU5F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_33267646 1.629 NM_000109
DMD
dystrophin
chr9_-_14076901 1.366 NFIB
nuclear factor I/B
chr1_-_215329569 0.930 NM_206594
NM_206595
ESRRG

estrogen-related receptor gamma

chr3_+_174598937 0.783 NM_014932
NLGN1
neuroligin 1
chr5_-_27074407 0.775 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr2_+_108751033 0.674 RANBP2
RAN binding protein 2
chr4_-_110443247 0.665 NM_032518
NM_198721
COL25A1

collagen, type XXV, alpha 1

chr12_-_16649211 0.662 LMO3
LIM domain only 3 (rhombotin-like 2)
chr22_-_35428848 0.654 NM_006078
CACNG2
calcium channel, voltage-dependent, gamma subunit 2
chr2_-_50428395 0.651 NM_138735
NRXN1
neurexin 1
chr14_+_78815406 0.610 NM_001105250
NM_138970
NRXN3

neurexin 3

chr13_-_101852028 0.603 NM_175929
FGF14
fibroblast growth factor 14
chr2_-_210726539 0.600 C2orf67
chromosome 2 open reading frame 67
chr1_+_172683834 0.581 NM_005684
GPR52
G protein-coupled receptor 52
chr3_-_193928038 0.575 NM_004113
FGF12
fibroblast growth factor 12
chr9_-_85773899 0.575 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr15_+_26832300 0.556 LOC100289656
Dexi homolog (mouse) pseudogene
chr3_+_129124591 0.549 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr12_-_11178109 0.547 NM_001097643
TAS2R30
taste receptor, type 2, member 30
chrX_-_15312390 0.546 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chrX_-_123925343 0.537 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1(Drosophila)


chr3_-_152173475 0.529 NM_001195794
NM_174878
CLRN1

clarin 1

chr1_+_168381811 0.519 NM_001136107
METTL11B
methyltransferase like 11B
chr3_+_51837608 0.514 NM_001085479
IQCF3
IQ motif containing F3
chr16_+_24475129 0.512 RBBP6
retinoblastoma binding protein 6
chr3_-_79899748 0.510 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr12_-_7709734 0.494 NM_001644
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr18_+_75968133 0.489 ADNP2
ADNP homeobox 2
chrX_+_72583814 0.486 NM_005193
CDX4
caudal type homeobox 4
chr11_-_34336102 0.477 NM_145804
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr2_+_214984705 0.456 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr4_-_174774368 0.455 NM_006792
MORF4
mortality factor 4
chr10_-_37931864 0.452 NM_001190489
MTRNR2L7
MT-RNR2-like 7
chr17_-_36232366 0.444 NM_000421
KRT10
keratin 10
chr6_-_128263868 0.443 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr14_-_106184988 0.442 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_-_16717887 0.433 BNC2
basonuclin 2
chr10_+_124135574 0.427 NM_001195608
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr1_+_145479805 0.426 NM_004326
BCL9
B-cell CLL/lymphoma 9
chr3_-_64186151 0.418 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr2_-_165259334 0.410 COBLL1
COBL-like 1
chr14_-_105997732 0.409 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_-_51112743 0.409 NRXN1
neurexin 1
chr1_+_116727514 0.403 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr10_+_51246290 0.400 NM_001145262
NCOA4
nuclear receptor coactivator 4
chr10_+_104525877 0.396 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr22_+_28806452 0.391 NM_152510
HORMAD2
HORMA domain containing 2
chr4_+_184257337 0.386 NM_024949
WWC2
WW and C2 domain containing 2
chr1_-_102234959 0.385 OLFM3
olfactomedin 3
chr2_+_114935623 0.383 NM_001178036
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr5_+_54491702 0.382 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr11_-_49960646 0.372 NM_001005270
OR4C12
olfactory receptor, family 4, subfamily C, member 12
chr3_-_18455207 0.366 NM_001131010
SATB1
SATB homeobox 1
chrX_-_6156655 0.366 NM_181332
NLGN4X
neuroligin 4, X-linked
chr9_+_112470871 0.363 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr3_+_99334230 0.355 NM_001005338
OR5H1
olfactory receptor, family 5, subfamily H, member 1
chr14_-_33489708 0.354 NM_022073
EGLN3
egl nine homolog 3 (C. elegans)
chr3_-_133236447 0.352 NM_130808
CPNE4
copine IV
chr13_-_69580459 0.351 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chr5_-_160211623 0.349 NM_025153
ATP10B
ATPase, class V, type 10B
chr2_+_89715037 0.349


chr5_-_36337756 0.348 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr13_+_96797290 0.348


chr12_+_14409875 0.348 NM_018179
ATF7IP
activating transcription factor 7 interacting protein
chr2_-_36929520 0.347 STRN
striatin, calmodulin binding protein
chr15_+_55298908 0.340 NM_207040
TCF12
transcription factor 12
chr4_-_91979113 0.340 NM_183049
TMSL3
thymosin-like 3
chr3_+_88270951 0.340 NM_018293
ZNF654
zinc finger protein 654
chr13_-_85271329 0.338 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr3_-_166397142 0.337 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr20_-_604822 0.337 NM_033129
SCRT2
scratch homolog 2, zinc finger protein (Drosophila)
chr6_+_53043729 0.330 NM_012347
FBXO9
F-box protein 9
chr15_-_70288071 0.330 PKM2
pyruvate kinase, muscle
chr2_-_40593074 0.328 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr2_-_200038055 0.327 NM_001172517
SATB2
SATB homeobox 2
chr4_+_73116384 0.325 NM_004885
NPFFR2
neuropeptide FF receptor 2
chr10_-_21847126 0.322


chr11_-_56067308 0.322 NM_001005245
OR5M11
olfactory receptor, family 5, subfamily M, member 11
chr6_+_88021644 0.320 ZNF292
zinc finger protein 292
chr19_-_45253947 0.318 NM_001005851
ZNF780B
zinc finger protein 780B
chr1_+_107485071 0.318 NTNG1
netrin G1
chr6_+_45404031 0.317 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chrX_-_77801480 0.317 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr5_-_39238818 0.316 FYB
FYN binding protein
chr4_-_184480572 0.316 NM_001185149
CLDN24
claudin 24
chr14_-_105948734 0.315 LOC100126583
IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
hypothetical LOC100126583
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr5_-_43326922 0.314 HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr1_+_191044791 0.314 NM_002923
RGS2
regulator of G-protein signaling 2, 24kDa
chr2_+_189547358 0.313 COL3A1
collagen, type III, alpha 1
chrX_-_105169370 0.311 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr13_-_60887210 0.309 PCDH20
protocadherin 20
chrX_-_24575375 0.308 NM_001163265
NM_004845
PCYT1B

phosphate cytidylyltransferase 1, choline, beta

chr11_-_114880275 0.307 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr1_+_190811479 0.302 NM_002922
RGS1
regulator of G-protein signaling 1
chr14_-_106352471 0.301


chr2_+_102456193 0.300 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr4_+_124540114 0.299 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr1_-_151296611 0.297 NM_005988
SPRR2A
small proline-rich protein 2A
chr4_-_163304567 0.296 NM_001128427
NM_001128428
NM_020116
FSTL5


follistatin-like 5


chr14_-_106064887 0.296 LOC100126583
IGHV3-48
IGHA1
IGHM
hypothetical LOC100126583
immunoglobulin heavy variable 3-48
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant mu
chr14_+_61532293 0.294 NM_031914
SYT16
synaptotagmin XVI
chr2_-_210744158 0.293 NM_152519
C2orf67
chromosome 2 open reading frame 67
chr7_-_38915306 0.286 NM_014396
NM_080631
VPS41

vacuolar protein sorting 41 homolog (S. cerevisiae)

chr5_+_140411144 0.286 NM_013340
PCDHB1
protocadherin beta 1
chr4_-_116254381 0.284 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr3_+_189413414 0.283 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr3_+_99370233 0.282 NM_001005515
OR5H15
olfactory receptor, family 5, subfamily H, member 15
chrX_-_106846924 0.282 NM_004089
TSC22D3
TSC22 domain family, member 3
chr20_-_39680405 0.282 NM_032221
CHD6
chromodomain helicase DNA binding protein 6
chrX_-_106846684 0.281 TSC22D3
TSC22 domain family, member 3
chr1_+_162795328 0.280 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr11_-_51269023 0.279 NM_001005272
OR4A5
olfactory receptor, family 4, subfamily A, member 5
chr5_-_146238336 0.279 NM_004576
NM_181675
NM_001127381
PPP2R2B


protein phosphatase 2, regulatory subunit B, beta


chr1_-_151280201 0.278 NM_006945
SPRR2D
small proline-rich protein 2D
chr5_-_54317102 0.278 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr14_-_106193403 0.278 IGKV3-20
immunoglobulin kappa variable 3-20
chr2_-_191580567 0.278 STAT1
signal transducer and activator of transcription 1, 91kDa
chrX_-_43717864 0.277 NM_000266
NDP
Norrie disease (pseudoglioma)
chr18_+_75967902 0.273 NM_014913
ADNP2
ADNP homeobox 2
chr20_+_55569542 0.272 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr18_+_57308754 0.272 NM_031891
CDH20
cadherin 20, type 2
chr12_+_54231249 0.271 NM_001005494
OR6C4
olfactory receptor, family 6, subfamily C, member 4
chr1_+_190871868 0.270 NM_002927
NM_144766
RGS13

regulator of G-protein signaling 13

chrX_+_50670474 0.269 NM_005448
BMP15
bone morphogenetic protein 15
chr14_-_105785639 0.267


chr14_-_105644300 0.267 IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr14_-_106249999 0.267 IGHA1
immunoglobulin heavy constant alpha 1
chr1_-_118529303 0.267 NM_206996
SPAG17
sperm associated antigen 17
chr3_-_58497913 0.265 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr3_-_78749633 0.265 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr10_-_108448990 0.264 SORCS1
sortilin-related VPS10 domain containing receptor 1
chrX_-_32340291 0.263 NM_004011
NM_004012
DMD

dystrophin

chr14_-_106149623 0.263


chr10_+_115302767 0.260 NM_004132
HABP2
hyaluronan binding protein 2
chr2_-_215953818 0.259 FN1
fibronectin 1
chr14_-_105862080 0.258 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr8_-_23768242 0.258 NM_003155
STC1
stanniocalcin 1
chr1_-_181889070 0.255 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr11_+_62813947 0.255 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr14_-_19553191 0.254 NM_001004712
OR4K14
olfactory receptor, family 4, subfamily K, member 14
chr4_+_70831387 0.252 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr14_-_19572756 0.251 NM_001004714
OR4K13
olfactory receptor, family 4, subfamily K, member 13
chr7_+_142590633 0.251 NM_176881
TAS2R39
taste receptor, type 2, member 39
chr3_-_102194938 0.251 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr16_+_52081836 0.249 RBL2
retinoblastoma-like 2 (p130)
chrX_-_130792297 0.248 LOC286467
hypothetical LOC286467
chr2_-_119322228 0.247 NM_001426
EN1
engrailed homeobox 1
chr3_+_99465777 0.246 NM_001005479
OR5H6
olfactory receptor, family 5, subfamily H, member 6
chr12_-_6642513 0.246 NM_001127582
NM_001127583
NM_001127584
NM_001127585
NM_001127586
NM_016162
ING4





inhibitor of growth family, member 4





chr2_+_196229715 0.245 NM_001127257
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr11_-_107969554 0.245 NM_015065
EXPH5
exophilin 5
chr10_+_95507555 0.244 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr7_+_141342147 0.244 NM_004668
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr1_+_103999824 0.243 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr11_-_26700121 0.242 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr7_-_31347032 0.242 NM_022728
NEUROD6
neurogenic differentiation 6
chr2_-_165768798 0.241 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr10_-_121592020 0.241 MCMBP
minichromosome maintenance complex binding protein
chr10_+_90414125 0.241 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr8_+_104900591 0.240 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr2_+_189547377 0.240 COL3A1
collagen, type III, alpha 1
chr1_+_200018380 0.239 NAV1
neuron navigator 1
chrX_+_15435351 0.239 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr12_+_10015274 0.237 NM_138337
NM_201623
CLEC12A

C-type lectin domain family 12, member A

chr11_-_83706027 0.236 DLG2
discs, large homolog 2 (Drosophila)
chr2_-_51113040 0.236 NM_001135659
NM_004801
NRXN1

neurexin 1

chr4_-_47534815 0.235 NM_006587
CORIN
corin, serine peptidase
chr4_+_74520796 0.234 NM_001134
AFP
alpha-fetoprotein
chr5_+_52131686 0.234 PELO
pelota homolog (Drosophila)
chr12_-_11066436 0.234 NM_176888
TAS2R19
taste receptor, type 2, member 19
chr11_-_558419 0.232


chr2_+_155263338 0.231 NM_002239
KCNJ3
potassium inwardly-rectifying channel, subfamily J, member 3
chr22_+_31080871 0.231 NM_006604
RFPL3
ret finger protein-like 3
chrX_+_144710557 0.230 NM_001144006
NM_001144008
NM_001144009
NM_001144010
SLITRK2



SLIT and NTRK-like family, member 2



chr14_+_38719462 0.230 PNN
pinin, desmosome associated protein
chr2_-_95846109 0.230 LOC150759
hypothetical LOC150759
chr1_+_145892190 0.229 NM_001097616
GPR89C
G protein-coupled receptor 89C
chr1_+_213245507 0.229 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr19_-_58052664 0.228 NM_001008801
NM_199132
ZNF468

zinc finger protein 468

chr21_+_30724442 0.228 NM_181600
KRTAP13-4
keratin associated protein 13-4
chrX_+_16051344 0.228 NM_005314
GRPR
gastrin-releasing peptide receptor
chr6_+_7052798 0.227 NM_001168344
RREB1
ras responsive element binding protein 1
chr14_-_106282128 0.226 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_-_18033970 0.224 NM_175886
PRPS1L1
phosphoribosyl pyrophosphate synthetase 1-like 1
chr2_-_207738858 0.224 NM_003709
KLF7
Kruppel-like factor 7 (ubiquitous)
chrX_+_2934653 0.222 NM_001011719
ARSH
arylsulfatase family, member H
chr3_-_24511180 0.222 NM_001128176
NM_000461
NM_001128177
THRB


thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)


chr6_-_151754337 0.221 NM_020861
ZBTB2
zinc finger and BTB domain containing 2
chr9_+_33016482 0.220 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr8_-_16903911 0.219 NM_019851
FGF20
fibroblast growth factor 20
chr14_-_105681377 0.219 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr5_-_146237826 0.218 PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr18_+_61568825 0.218 CDH7
cadherin 7, type 2
chr17_-_36276987 0.217 NM_000223
KRT12
keratin 12
chr21_-_26175068 0.217 APP
amyloid beta (A4) precursor protein
chr2_+_211166323 0.217 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr14_+_19761708 0.217 NM_001004480
OR11H6
olfactory receptor, family 11, subfamily H, member 6
chr11_+_58980986 0.216 NM_001004708
OR4D6
olfactory receptor, family 4, subfamily D, member 6
chr18_+_61569136 0.215 NM_004361
CDH7
cadherin 7, type 2
chr2_-_215998181 0.215 FN1
fibronectin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.29 1.49e-11 GO:0032501 multicellular organismal process
1.36 3.48e-07 GO:0048731 system development
1.51 7.88e-07 GO:0007399 nervous system development
1.97 8.05e-07 GO:0007606 sensory perception of chemical stimulus
1.30 1.75e-06 GO:0007275 multicellular organismal development
1.28 3.78e-06 GO:0032502 developmental process
1.45 4.94e-06 GO:0003008 system process
1.31 5.94e-06 GO:0048856 anatomical structure development
1.49 1.20e-05 GO:0050877 neurological system process
1.64 2.32e-05 GO:0007600 sensory perception
1.18 8.26e-05 GO:0050896 response to stimulus
1.35 3.13e-04 GO:0030154 cell differentiation
1.83 6.05e-04 GO:0007608 sensory perception of smell
1.33 1.08e-03 GO:0048869 cellular developmental process
1.31 1.88e-02 GO:0048513 organ development
1.46 2.77e-02 GO:0022008 neurogenesis
3.37 4.32e-02 GO:0050909 sensory perception of taste
1.44 4.69e-02 GO:0048468 cell development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.22 3.30e-05 GO:0071944 cell periphery
1.22 4.20e-05 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.64 2.35e-06 GO:0004930 G-protein coupled receptor activity
1.51 2.67e-06 GO:0004888 transmembrane receptor activity
1.41 9.77e-06 GO:0004872 receptor activity
1.89 4.12e-05 GO:0004984 olfactory receptor activity
1.34 5.90e-05 GO:0004871 signal transducer activity
1.34 5.90e-05 GO:0060089 molecular transducer activity
1.50 2.29e-04 GO:0001071 nucleic acid binding transcription factor activity
1.50 2.29e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
5.79 2.52e-03 GO:0008527 taste receptor activity
1.49 1.93e-02 GO:0043565 sequence-specific DNA binding