Motif ID: ESR1.p2

Z-value: 0.886


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1



Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_1236766 4.270 NM_001405
EFNA2
ephrin-A2
chr21_-_45786709 3.351 NM_194255
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr16_+_550394 2.604 NM_145270
C16orf11
chromosome 16 open reading frame 11
chr16_+_559970 2.524 NM_004204
NM_148920
PIGQ

phosphatidylinositol glycan anchor biosynthesis, class Q

chr19_-_3927523 2.482 EEF2
eukaryotic translation elongation factor 2
chr3_-_135852514 2.432 NM_178554
KY
kyphoscoliosis peptidase
chr16_+_84204424 2.288 NM_014615
KIAA0182
KIAA0182
chr1_+_178466064 2.242 NM_033343
LHX4
LIM homeobox 4
chr19_+_3457264 2.227 NM_016263
FZR1
fizzy/cell division cycle 20 related 1 (Drosophila)
chr9_+_139202874 2.212 NM_003731
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr14_+_105063975 2.131 NM_025268
TMEM121
transmembrane protein 121
chr1_+_1256585 2.099 NM_152228
TAS1R3
taste receptor, type 1, member 3
chr9_+_137532294 2.046 NM_016034
MRPS2
mitochondrial ribosomal protein S2
chr8_+_144428083 2.036 GLI4
GLI family zinc finger 4
chr19_+_590878 2.027 NM_020637
FGF22
fibroblast growth factor 22
chr7_+_1536847 1.985 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr20_-_60415729 1.977 NM_031215
CABLES2
Cdk5 and Abl enzyme substrate 2
chr19_+_10392128 1.920 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr1_+_62433061 1.841 NM_001164835
NM_019079
L1TD1

LINE-1 type transposase domain containing 1

chr9_-_139202855 1.822 NM_013366
ANAPC2
anaphase promoting complex subunit 2
chr7_+_1543644 1.808 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr1_+_1062137 1.808 LOC254099
hypothetical protein LOC254099
chr16_+_4361775 1.792 NM_138440
VASN
vasorin
chr19_-_14447163 1.785 NM_000955
PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr4_+_1764802 1.782 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr22_+_36632242 1.764 NM_033386
MICALL1
MICAL-like 1
chr19_+_3473953 1.754 NM_001136197
NM_001136198
FZR1

fizzy/cell division cycle 20 related 1 (Drosophila)

chr14_+_99273751 1.696 EML1
echinoderm microtubule associated protein like 1
chr17_-_45562112 1.686 NM_174920
SAMD14
sterile alpha motif domain containing 14
chr9_+_139047441 1.673 C9orf139
chromosome 9 open reading frame 139
chr8_+_145692916 1.672 NM_032902
PPP1R16A
protein phosphatase 1, regulatory (inhibitor) subunit 16A
chr9_-_139202831 1.667 ANAPC2
anaphase promoting complex subunit 2
chr1_+_3360880 1.665 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr19_-_14447122 1.652 PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr1_+_2149993 1.641 NM_003036
SKI
v-ski sarcoma viral oncogene homolog (avian)
chr9_-_139202804 1.631 ANAPC2
anaphase promoting complex subunit 2
chr19_+_15079141 1.566 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr11_+_63883192 1.546 NM_001006944
NM_003942
RPS6KA4

ribosomal protein S6 kinase, 90kDa, polypeptide 4

chr13_+_112789669 1.543 MCF2L
MCF.2 cell line derived transforming sequence-like
chr16_+_711139 1.541 NM_023933
FAM173A
family with sequence similarity 173, member A
chr17_-_40401138 1.528 NM_006688
C1QL1
complement component 1, q subcomponent-like 1
chr1_+_148089251 1.526 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr14_+_104244998 1.500 INF2
inverted formin, FH2 and WH2 domain containing
chr17_+_59429442 1.495 NM_001164257
NM_001191029
NM_001191030
NM_001191031
C17orf72



chromosome 17 open reading frame 72



chr22_+_21742727 1.446 GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr1_+_1557419 1.442 NM_006983
MMP23B
matrix metallopeptidase 23B
chr22_+_49266836 1.438 NM_024866
ADM2
adrenomedullin 2
chr22_-_17517795 1.434 NM_005315
GSC2
goosecoid homeobox 2
chr5_-_577444 1.433 NM_004174
SLC9A3
solute carrier family 9 (sodium/hydrogen exchanger), member 3
chr11_+_1846478 1.425 NM_001013253
LSP1
lymphocyte-specific protein 1
chr19_+_41397343 1.415 NM_001099638
NM_001099639
NM_007145
ZNF146


zinc finger protein 146


chr6_+_41622111 1.400 NM_001012426
NM_001012427
NM_138457
FOXP4


forkhead box P4


chr9_-_139047112 1.398 NM_004479
FUT7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr12_-_123568781 1.390


chr16_-_790699 1.385 NM_016541
GNG13
guanine nucleotide binding protein (G protein), gamma 13
chr3_-_13089547 1.380 NM_001134382
IQSEC1
IQ motif and Sec7 domain 1
chr22_+_21742364 1.369 NM_002073
GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr16_+_1143241 1.362 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr19_+_53819460 1.360 SPHK2
sphingosine kinase 2
chr9_-_138560058 1.354 NM_017617
NOTCH1
notch 1
chr12_+_131577229 1.353 NM_001142641
FBRSL1
fibrosin-like 1
chr2_+_95326753 1.339 NM_013434
KCNIP3
Kv channel interacting protein 3, calsenilin
chr15_+_72695248 1.338 CLK3
CDC-like kinase 3
chr20_-_61933012 1.336 ZBTB46
zinc finger and BTB domain containing 46
chr11_+_822965 1.298 CD151
CD151 molecule (Raph blood group)
chr19_-_50963942 1.294


chr11_+_1812115 1.291 NM_138567
SYT8
synaptotagmin VIII
chr11_+_1830763 1.279 NM_002339
LSP1
lymphocyte-specific protein 1
chr16_-_265868 1.278 NM_003834
NM_183337
RGS11

regulator of G-protein signaling 11

chr19_-_47190160 1.260 NM_152296
ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr3_-_42719322 1.245 NM_020707
HHATL
hedgehog acyltransferase-like
chr19_+_7834124 1.227 EVI5L
ecotropic viral integration site 5-like
chr3_+_50204026 1.218 NM_000172
NM_144499
GNAT1

guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1

chr9_-_137731139 1.215 NM_001012415
NM_001101677
SOHLH1

spermatogenesis and oogenesis specific basic helix-loop-helix 1

chr19_-_47190061 1.210 ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr1_+_225982862 1.192 LOC100130093
hypothetical LOC100130093
chr16_+_658081 1.192 NM_138769
RHOT2
ras homolog gene family, member T2
chr1_+_179148935 1.191 NM_020950
KIAA1614
KIAA1614
chr11_+_56984702 1.190 NM_178570
RTN4RL2
reticulon 4 receptor-like 2
chr5_+_1061900 1.187 NM_033120
NKD2
naked cuticle homolog 2 (Drosophila)
chr13_+_112681626 1.187 NM_024979
MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_+_155097230 1.185 NM_001012331
NM_002529
NTRK1

neurotrophic tyrosine kinase, receptor, type 1

chr19_+_1358750 1.184 DAZAP1
DAZ associated protein 1
chr7_-_150283794 1.178 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr9_-_101621964 1.178


chr7_+_2638156 1.176 TTYH3
tweety homolog 3 (Drosophila)
chr2_-_241480058 1.173 NM_024861
C2orf54
chromosome 2 open reading frame 54
chr12_+_3470685 1.171 NM_019854
PRMT8
protein arginine methyltransferase 8
chr2_+_236067424 1.165 NM_001037131
NM_014914
AGAP1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr12_-_55920741 1.155 NM_020142
NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr19_+_1358531 1.147 NM_018959
NM_170711
DAZAP1

DAZ associated protein 1

chr4_-_8124611 1.142 ABLIM2
actin binding LIM protein family, member 2
chr1_+_155157047 1.141 NM_144702
LRRC71
leucine rich repeat containing 71
chr11_-_117528744 1.139 NM_001142348
NM_174934
SCN4B

sodium channel, voltage-gated, type IV, beta

chr11_+_72765318 1.137 NM_032871
RELT
RELT tumor necrosis factor receptor
chr2_-_98919109 1.134 NM_207362
C2orf55
chromosome 2 open reading frame 55
chr7_-_1946667 1.133 MAD1L1
MAD1 mitotic arrest deficient-like 1 (yeast)
chr22_-_19122047 1.129 SCARF2
scavenger receptor class F, member 2
chr2_+_71016503 1.114 NM_001692
ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr11_-_75599433 1.108 WNT11
wingless-type MMTV integration site family, member 11
chr22_+_17539198 1.107


chr4_+_4912272 1.105 NM_002448
MSX1
msh homeobox 1
chr16_-_73842884 1.099 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr16_+_658158 1.094 RHOT2
ras homolog gene family, member T2
chr7_+_99919485 1.088 NM_173564
C7orf51
chromosome 7 open reading frame 51
chr14_+_105012106 1.084 NM_001312
CRIP2
cysteine-rich protein 2
chr20_+_2581177 1.083 NM_006392
NOP56
NOP56 ribonucleoprotein homolog (yeast)
chr1_+_19864366 1.078 NM_000871
HTR6
5-hydroxytryptamine (serotonin) receptor 6
chr8_-_145090892 1.073 NM_201381
PLEC
plectin
chr11_-_69228286 1.067 NM_005117
FGF19
fibroblast growth factor 19
chr10_+_102881050 1.066 NM_001195517
NM_005521
TLX1

T-cell leukemia homeobox 1

chr17_+_77261457 1.065


chr10_-_133971136 1.064 NM_173575
STK32C
serine/threonine kinase 32C
chr3_-_197201497 1.063 SDHAP1
SDHAP2
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2
chr6_+_36346214 1.053 NM_001145717
PNPLA1
patatin-like phospholipase domain containing 1
chr3_-_129690056 1.049 NM_001145661
GATA2
GATA binding protein 2
chr2_+_242398832 1.036 NM_001167600
NM_001167601
NEU4

sialidase 4

chr1_-_229070796 1.035 NM_032800
C1orf198
chromosome 1 open reading frame 198
chr19_+_1389336 1.033 NM_001018
RPS15
ribosomal protein S15
chr10_+_94811010 1.030 NM_183374
CYP26C1
cytochrome P450, family 26, subfamily C, polypeptide 1
chr17_+_4972410 1.027 NM_004505
USP6
ubiquitin specific peptidase 6 (Tre-2 oncogene)
chr11_-_72031083 1.026 NM_001143839
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr17_-_6400470 1.017 NM_001165966
NM_031220
PITPNM3

PITPNM family member 3

chr16_+_751050 1.006 NM_013404
MSLN
mesothelin
chr16_+_666075 1.002 NM_003961
RHBDL1
rhomboid, veinlet-like 1 (Drosophila)
chr19_-_2187246 1.002 NM_018049
PLEKHJ1
pleckstrin homology domain containing, family J member 1
chr19_-_41397822 1.001 NM_001042474
ZNF565
zinc finger protein 565
chr17_-_77462325 0.999 PCYT2
phosphate cytidylyltransferase 2, ethanolamine
chr19_+_3884100 0.999 NM_170678
ITGB1BP3
integrin beta 1 binding protein 3
chr2_+_242398954 0.995 NEU4
sialidase 4
chr11_-_1549719 0.993 NM_004420
DUSP8
dual specificity phosphatase 8
chr22_-_19122107 0.989 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr22_+_41836697 0.987 NM_001197
BIK
BCL2-interacting killer (apoptosis-inducing)
chr19_+_1389397 0.983 RPS15
ribosomal protein S15
chr5_-_172594691 0.982 NM_001166175
NM_001166176
NM_004387
NKX2-5


NK2 transcription factor related, locus 5 (Drosophila)


chr15_+_66658626 0.981 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr17_+_77261440 0.972 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr16_-_87535106 0.970 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr1_-_13712744 0.967 NM_001010847
LRRC38
leucine rich repeat containing 38
chr16_+_87765661 0.964 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr11_+_71613472 0.964 NM_001567
INPPL1
inositol polyphosphate phosphatase-like 1
chr19_+_10388448 0.957 PDE4A
phosphodiesterase 4A, cAMP-specific
chr17_+_77261477 0.954 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr11_+_61032847 0.950 NM_001145077
LRRC10B
leucine rich repeat containing 10B
chr20_+_773283 0.941 NM_031424
FAM110A
family with sequence similarity 110, member A
chr20_-_29896981 0.932 NM_004118
FOXS1
forkhead box S1
chr20_+_54637714 0.927 NM_003222
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr10_+_112247614 0.926 NM_004419
DUSP5
dual specificity phosphatase 5
chr17_+_77261401 0.925 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr4_+_2013517 0.922 NM_001168243
NM_001141936
C4orf48

chromosome 4 open reading frame 48

chr17_+_77453363 0.921 NM_148896
NPB
neuropeptide B
chr16_-_3567354 0.919 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr9_-_85342868 0.914 NM_174938
FRMD3
FERM domain containing 3
chr19_+_7874701 0.912 MAP2K7
mitogen-activated protein kinase kinase 7
chr19_+_16544360 0.912


chr21_-_44485269 0.908 ICOSLG
inducible T-cell co-stimulator ligand
chr8_-_142586487 0.907 NM_207414
FLJ43860
FLJ43860 protein
chr9_-_139060416 0.894 NM_015392
NPDC1
neural proliferation, differentiation and control, 1
chr11_+_65100074 0.894 NM_001099409
EHBP1L1
EH domain binding protein 1-like 1
chr19_+_4423149 0.893 NM_001001520
NM_032631
HDGFRP2

hepatoma-derived growth factor-related protein 2

chr17_+_77261447 0.893 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr1_+_151655623 0.883 NM_176823
S100A7A
S100 calcium binding protein A7A
chr6_+_30002084 0.879


chr19_+_7874764 0.877 NM_145185
MAP2K7
mitogen-activated protein kinase kinase 7
chr7_-_4965270 0.872 NM_001100600
NM_198403
MMD2

monocyte to macrophage differentiation-associated 2

chr5_-_1165106 0.871 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr17_-_77462506 0.869 NM_001184917
NM_002861
PCYT2

phosphate cytidylyltransferase 2, ethanolamine

chr10_-_103525646 0.867 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chr19_-_11234117 0.857 NM_020812
DOCK6
dedicator of cytokinesis 6
chr22_+_28032950 0.855 NM_006478
NM_152236
NM_152237
GAS2L1


growth arrest-specific 2 like 1


chr22_+_41877502 0.854 TSPO
translocator protein (18kDa)
chr22_+_38720881 0.853 NM_138435
FAM83F
family with sequence similarity 83, member F
chr22_+_41877470 0.851 NM_000714
NM_007311
TSPO

translocator protein (18kDa)

chr19_+_1389410 0.851 RPS15
ribosomal protein S15
chr19_+_41177882 0.848 NM_001042631
SDHAF1
succinate dehydrogenase complex assembly factor 1
chr4_-_2336328 0.838 NM_001172659
NM_001172660
ZFYVE28

zinc finger, FYVE domain containing 28

chr19_+_7874765 0.837 MAP2K7
mitogen-activated protein kinase kinase 7
chr22_-_43783449 0.834 PHF21B
PHD finger protein 21B
chr10_+_50492088 0.832 NM_001142929
NM_001142933
NM_001142934
NM_020549
CHAT



choline O-acetyltransferase



chr16_-_30274182 0.830 NM_006110
CD2BP2
CD2 (cytoplasmic tail) binding protein 2
chr2_+_119697859 0.828 STEAP3
STEAP family member 3
chr22_-_17546296 0.828 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr11_+_823007 0.828 CD151
CD151 molecule (Raph blood group)
chr16_+_517834 0.824 NM_005632
SOLH
small optic lobes homolog (Drosophila)
chr19_-_19599973 0.816 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr19_+_50963484 0.815


chr12_+_130945215 0.815 NM_003565
ULK1
unc-51-like kinase 1 (C. elegans)
chr19_+_7874774 0.813 MAP2K7
mitogen-activated protein kinase kinase 7
chr16_-_342399 0.812 NM_003502
NM_181050
AXIN1

axin 1

chr19_+_3310138 0.808 NM_205843
NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr19_-_41397396 0.805 NM_152477
ZNF565
zinc finger protein 565
chr1_-_29322993 0.804 NM_001003682
TMEM200B
transmembrane protein 200B
chr11_+_6368213 0.802 NM_000543
NM_001007593
SMPD1

sphingomyelin phosphodiesterase 1, acid lysosomal

chr2_+_238200922 0.801 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr16_+_1299693 0.799 UBE2I
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
chr9_-_139060377 0.797 NPDC1
neural proliferation, differentiation and control, 1
chr10_+_75340867 0.795 NM_001145031
NM_002658
PLAU

plasminogen activator, urokinase

chr6_+_30082331 0.795 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr2_+_10969513 0.793 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr22_-_20419975 0.793 NM_013313
YPEL1
yippee-like 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.15 1.43e-05 GO:0065007 biological regulation
1.17 2.53e-05 GO:0050794 regulation of cellular process
1.41 1.90e-04 GO:0023051 regulation of signaling
1.15 2.23e-04 GO:0050789 regulation of biological process
1.43 3.18e-04 GO:0009966 regulation of signal transduction
1.08 6.44e-03 GO:0009987 cellular process
1.21 1.43e-02 GO:0023052 signaling
1.94 1.54e-02 GO:0046578 regulation of Ras protein signal transduction
1.27 2.26e-02 GO:0048519 negative regulation of biological process
1.28 3.97e-02 GO:0048523 negative regulation of cellular process
1.43 4.29e-02 GO:0042127 regulation of cell proliferation

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 2.00e-06 GO:0005515 protein binding
1.08 2.61e-04 GO:0005488 binding
2.35 1.30e-03 GO:0004713 protein tyrosine kinase activity
1.49 1.23e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.61 1.36e-02 GO:0060589 nucleoside-triphosphatase regulator activity
2.83 1.54e-02 GO:0004714 transmembrane receptor protein tyrosine kinase activity
2.55 2.19e-02 GO:0019199 transmembrane receptor protein kinase activity
1.51 2.50e-02 GO:0004672 protein kinase activity
1.45 2.76e-02 GO:0016301 kinase activity
1.59 3.04e-02 GO:0030695 GTPase regulator activity