Motif ID: HBP1_HMGB_SSRP1_UBTF.p2

Z-value: 2.142


Transcription factors associated with HBP1_HMGB_SSRP1_UBTF.p2:

Gene SymbolEntrez IDGene Name
HBP1 26959 HMG-box transcription factor 1
HMGB2 3148 high-mobility group box 2
HMGB3 3149 high-mobility group box 3
SSRP1 6749 structure specific recognition protein 1
UBTF 7343 upstream binding transcription factor, RNA polymerase I



Activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2.

activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2


Sorted Z-values histogram for motif HBP1_HMGB_SSRP1_UBTF.p2

Sorted Z-values for motif HBP1_HMGB_SSRP1_UBTF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HBP1_HMGB_SSRP1_UBTF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_12398514 7.154 NM_001168319
NM_001955
EDN1

endothelin 1

chr2_-_21084077 5.445 APOB
apolipoprotein B (including Ag(x) antigen)
chr6_+_114285209 5.365 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr6_-_74284522 5.190 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr14_+_20226762 4.490 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr6_+_130381408 4.291 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr14_+_36196523 4.185 NM_006194
PAX9
paired box 9
chr6_+_89847183 3.843 PNRC1
proline-rich nuclear receptor coactivator 1
chr6_+_89847019 3.791 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr22_+_29696662 3.720


chr5_+_138705445 3.305 PAIP2
poly(A) binding protein interacting protein 2
chr8_-_125785611 3.256 MTSS1
metastasis suppressor 1
chr11_+_101488380 3.237 NM_001195045
YAP1
Yes-associated protein 1
chr5_+_138705469 3.158 PAIP2
poly(A) binding protein interacting protein 2
chr10_-_11614279 3.156 NM_001080491
USP6NL
USP6 N-terminal like
chr20_+_30409649 3.083 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr11_+_20005704 3.049 NAV2
neuron navigator 2
chr5_+_138706029 2.991 NM_001033112
PAIP2
poly(A) binding protein interacting protein 2
chr6_-_138231006 2.917


chr1_+_153366559 2.906 EFNA1
ephrin-A1
chr3_-_188936941 2.861 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr2_+_101874809 2.770 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr2_+_86800898 2.750 NM_022780
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr2_+_86800940 2.735 RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr2_+_86801081 2.715 RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr2_+_101680594 2.692 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr13_+_107753764 2.599


chr2_+_196229715 2.559 NM_001127257
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr1_-_191422346 2.527 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr2_+_171280046 2.520 NM_001003845
SP5
Sp5 transcription factor
chr11_+_66764064 2.517 KDM2A
lysine (K)-specific demethylase 2A
chr14_-_56342097 2.516 NM_172337
OTX2
orthodenticle homeobox 2
chr6_+_64414389 2.473 NM_015153
PHF3
PHD finger protein 3
chr18_+_3443771 2.451 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr7_+_77005287 2.396 NM_001131008
NM_001131009
PTPN12

protein tyrosine phosphatase, non-receptor type 12

chr2_+_120233676 2.395 NM_002830
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr2_+_86521939 2.389 KDM3A
lysine (K)-specific demethylase 3A
chr20_+_11846536 2.388 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr11_+_66764060 2.360 LOC100131150
hypothetical protein LOC100131150
chr5_+_149845503 2.342 NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr2_+_86521781 2.323 NM_018433
KDM3A
lysine (K)-specific demethylase 3A
chr18_+_3441589 2.297 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr1_+_61319976 2.280 NM_001145512
NFIA
nuclear factor I/A
chr6_+_153060722 2.253 NM_025107
MYCT1
myc target 1
chr13_-_32678142 2.236 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_+_86521999 2.191 NM_001146688
KDM3A
lysine (K)-specific demethylase 3A
chr7_+_134114957 2.158 CALD1
caldesmon 1
chr2_+_54638957 2.147 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr1_+_153366928 2.147 NM_004428
NM_182685
EFNA1

ephrin-A1

chr6_+_148705421 2.110 NM_015278
SASH1
SAM and SH3 domain containing 1
chr5_+_36912656 2.106 NIPBL
Nipped-B homolog (Drosophila)
chr7_+_134114912 2.069 CALD1
caldesmon 1
chr13_+_96726415 2.040 MBNL2
muscleblind-like 2 (Drosophila)
chr2_+_62787534 2.031 NM_001142614
EHBP1
EH domain binding protein 1
chr6_-_128263868 2.023 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr15_+_22751162 2.019 NM_003097
NM_022804
NM_005678
SNRPN
SNURF

small nuclear ribonucleoprotein polypeptide N
SNRPN upstream reading frame

chr2_+_196230096 2.009 NM_020342
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr5_+_65258316 2.002 ERBB2IP
erbb2 interacting protein
chr7_+_134226690 1.964 NM_033139
NM_033140
CALD1

caldesmon 1

chr2_-_21084911 1.947 APOB
apolipoprotein B (including Ag(x) antigen)
chr13_+_36291306 1.927 NM_000538
RFXAP
regulatory factor X-associated protein
chr20_+_31613800 1.921 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr18_+_53863865 1.919 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr12_+_68028397 1.913 NM_000239
LYZ
lysozyme
chr7_+_134226727 1.891 CALD1
caldesmon 1
chr10_+_112621665 1.887 PDCD4
programmed cell death 4 (neoplastic transformation inhibitor)
chr10_-_98326435 1.887 TM9SF3
transmembrane 9 superfamily member 3
chr2_-_200033445 1.865 SATB2
SATB homeobox 2
chr17_+_63252704 1.848 BPTF
bromodomain PHD finger transcription factor
chr2_+_101874765 1.848 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr17_+_63252668 1.827 BPTF
bromodomain PHD finger transcription factor
chr3_+_189425886 1.811 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr10_+_114699953 1.810 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr2_+_36436873 1.789 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr9_+_71009746 1.780 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr13_+_96726197 1.776 MBNL2
muscleblind-like 2 (Drosophila)
chr2_+_203207912 1.772 FAM117B
family with sequence similarity 117, member B
chr4_+_146623405 1.735 NM_001003688
SMAD1
SMAD family member 1
chr7_-_26202626 1.717 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr5_+_78567604 1.683 NM_152405
JMY
junction mediating and regulatory protein, p53 cofactor
chr6_-_111995213 1.679 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr17_-_46479127 1.666 SPAG9
sperm associated antigen 9
chr2_-_162717159 1.666 NM_002054
GCG
glucagon
chr10_+_112621585 1.660 NM_014456
NM_145341
PDCD4

programmed cell death 4 (neoplastic transformation inhibitor)

chr3_-_71625318 1.646 FOXP1
forkhead box P1
chr1_+_61320213 1.642 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr14_+_31868229 1.626 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr3_+_180348818 1.624 NM_006218
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr5_+_78568094 1.608


chr10_+_111959978 1.607 NM_001008541
MXI1
MAX interactor 1
chr1_+_165564904 1.601 NM_001198783
POU2F1
POU class 2 homeobox 1
chr20_-_33705244 1.588 NM_003915
CPNE1
copine I
chr1_+_70459592 1.586 SRSF11
serine/arginine-rich splicing factor 11
chr14_+_62740878 1.581 NM_020663
RHOJ
ras homolog gene family, member J
chr4_+_86968069 1.579 ARHGAP24
Rho GTPase activating protein 24
chr3_-_116272911 1.557 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr15_+_50098730 1.550 MAPK6
mitogen-activated protein kinase 6
chr20_+_5935897 1.547 NM_001127458
CRLS1
cardiolipin synthase 1
chr7_+_94130752 1.546 PEG10
paternally expressed 10
chr15_+_65145248 1.540 NM_005902
SMAD3
SMAD family member 3
chr13_+_75232797 1.534 NM_015842
LMO7
LIM domain 7
chr11_+_65026382 1.530


chr6_+_122762449 1.521 HSF2
heat shock transcription factor 2
chr1_+_148603769 1.495 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr6_+_122762384 1.484 NM_001135564
NM_004506
HSF2

heat shock transcription factor 2

chr7_-_27186400 1.483 NM_153715
HOXA10
homeobox A10
chr2_+_171280182 1.483


chr12_+_68028407 1.481 LYZ
lysozyme
chr12_+_12761085 1.481 NM_004064
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
chr13_-_59223074 1.476


chr8_-_93099040 1.468 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_+_148705646 1.465 SASH1
SAM and SH3 domain containing 1
chr16_+_21518633 1.459 METTL9
methyltransferase like 9
chr6_-_139654807 1.459 NM_153235
TXLNB
taxilin beta
chr3_-_137395966 1.457 NM_001145417
MSL2
male-specific lethal 2 homolog (Drosophila)
chr5_+_138705416 1.453 NM_016480
PAIP2
poly(A) binding protein interacting protein 2
chr7_+_106596641 1.452 NM_012257
HBP1
HMG-box transcription factor 1
chr15_+_50098700 1.450 NM_002748
MAPK6
mitogen-activated protein kinase 6
chr15_+_50098724 1.440 MAPK6
mitogen-activated protein kinase 6
chr3_+_142587973 1.431


chr2_+_108571336 1.431 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_-_215953818 1.429 FN1
fibronectin 1
chr16_-_69876262 1.425 FTSJD1
FtsJ methyltransferase domain containing 1
chr2_-_55053398 1.423


chr6_+_148705817 1.409 SASH1
SAM and SH3 domain containing 1
chr2_-_174475528 1.408


chr6_-_47362102 1.403 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr8_-_38324809 1.391 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr21_+_34112456 1.391 ITSN1
intersectin 1 (SH3 domain protein)
chr14_+_38719462 1.386 PNN
pinin, desmosome associated protein
chr17_-_1195096 1.382 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr2_+_33554824 1.380 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr22_+_36928972 1.373 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr3_-_192531018 1.366 NM_198152
UTS2D
urotensin 2 domain containing
chr15_+_97009194 1.359 IGF1R
insulin-like growth factor 1 receptor
chr14_+_101345878 1.351 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr16_+_88517187 1.348 NM_006086
TUBB3
tubulin, beta 3
chr14_+_22911857 1.347 NM_172314
NM_022789
IL25

interleukin 25

chr5_+_126887056 1.347 PRRC1
proline-rich coiled-coil 1
chr11_+_33236435 1.338 HIPK3
homeodomain interacting protein kinase 3
chr4_+_144654526 1.336


chr3_+_100840129 1.327 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr6_-_130224108 1.313 NM_001010876
C6orf191
chromosome 6 open reading frame 191
chr4_+_124537334 1.312 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr4_+_144654005 1.301 NM_003601
SMARCA5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr13_+_99431417 1.301


chr8_-_17624009 1.300 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr1_+_148603613 1.298 NM_015203
RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr7_-_104696678 1.295 NM_182691
SRPK2
SRSF protein kinase 2
chr5_-_32439067 1.292 ZFR
zinc finger RNA binding protein
chr17_+_59053447 1.292 MAP3K3
mitogen-activated protein kinase kinase kinase 3
chr18_+_71051713 1.284 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr14_+_22059174 1.277


chr10_-_116241572 1.260


chr6_+_144654565 1.259 NM_007124
UTRN
utrophin
chr3_+_153469421 1.254 MBNL1
muscleblind-like (Drosophila)
chr2_-_215955206 1.254 FN1
fibronectin 1
chr6_-_47361921 1.247 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr10_+_31650069 1.243 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr5_+_112101454 1.237 NM_000038
NM_001127510
APC

adenomatous polyposis coli

chr5_+_65258250 1.236 ERBB2IP
erbb2 interacting protein
chr1_-_230717850 1.234 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr2_-_225078931 1.233 CUL3
cullin 3
chr2_-_152299229 1.231 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr17_+_59053518 1.227 NM_002401
NM_203351
MAP3K3

mitogen-activated protein kinase kinase kinase 3

chr17_+_59053515 1.225 MAP3K3
mitogen-activated protein kinase kinase kinase 3
chr20_+_56369012 1.223


chr1_+_165565006 1.222 POU2F1
POU class 2 homeobox 1
chr14_+_101346032 1.220 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr15_+_47502666 1.209 NM_002009
FGF7
fibroblast growth factor 7
chr20_+_254205 1.209 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr3_+_89239363 1.206 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr3_+_142175329 1.206 SLC25A36
solute carrier family 25, member 36
chr4_+_159909626 1.204 NM_020840
FNIP2
folliculin interacting protein 2
chr7_+_93388951 1.195 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr11_+_16716751 1.189 C11orf58
chromosome 11 open reading frame 58
chr2_+_33555182 1.183 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr11_+_16716723 1.181 NM_014267
C11orf58
chromosome 11 open reading frame 58
chr5_-_58918031 1.178 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr15_-_53996597 1.173 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr7_-_83662152 1.169 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr11_+_64950402 1.162


chr7_-_27153892 1.154 NM_024014
HOXA6
homeobox A6
chr9_+_114289178 1.152 KIAA1958
KIAA1958
chr10_+_93548261 1.146 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr1_-_7998265 1.141 ERRFI1
ERBB receptor feedback inhibitor 1
chr6_-_29752909 1.135 NM_001109809
ZFP57
zinc finger protein 57 homolog (mouse)
chr4_-_83566802 1.131 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr12_+_14429499 1.128 ATF7IP
activating transcription factor 7 interacting protein
chr3_+_138132006 1.128 NM_001190796
NCK1
NCK adaptor protein 1
chr1_+_183281173 1.128 NM_007212
RNF2
ring finger protein 2
chr20_+_34635362 1.127 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr6_-_94185780 1.126 NM_004440
EPHA7
EPH receptor A7
chr12_-_16649211 1.125 LMO3
LIM domain only 3 (rhombotin-like 2)
chr10_+_92970302 1.122 NM_032373
PCGF5
polycomb group ring finger 5
chr1_-_177106702 1.121 NM_004673
ANGPTL1
angiopoietin-like 1
chr17_-_59818033 1.120 PECAM1
platelet/endothelial cell adhesion molecule
chr13_+_97593469 1.110 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr17_-_59817456 1.110 PECAM1
platelet/endothelial cell adhesion molecule
chr5_-_121842680 1.106



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.38 2.74e-14 GO:0007275 multicellular organismal development
1.35 1.88e-13 GO:0032502 developmental process
1.40 2.85e-12 GO:0048731 system development
1.59 3.33e-12 GO:0009653 anatomical structure morphogenesis
1.37 6.08e-12 GO:0048856 anatomical structure development
1.26 2.05e-11 GO:0032501 multicellular organismal process
1.57 5.39e-11 GO:0007399 nervous system development
1.47 6.39e-11 GO:0030154 cell differentiation
1.45 1.66e-10 GO:0048869 cellular developmental process
1.40 2.01e-08 GO:0048523 negative regulation of cellular process
1.72 5.96e-08 GO:2000026 regulation of multicellular organismal development
1.37 1.61e-07 GO:0048519 negative regulation of biological process
1.61 6.30e-07 GO:0050793 regulation of developmental process
1.27 4.46e-06 GO:0060255 regulation of macromolecule metabolic process
1.59 4.52e-06 GO:0048699 generation of neurons
1.57 6.15e-06 GO:0022008 neurogenesis
1.54 8.23e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.66 8.25e-06 GO:0045595 regulation of cell differentiation
1.71 8.44e-06 GO:0009887 organ morphogenesis
1.66 9.03e-06 GO:0009790 embryo development
2.16 1.06e-05 GO:0003002 regionalization
1.31 1.58e-05 GO:0010468 regulation of gene expression
1.65 1.95e-05 GO:0010628 positive regulation of gene expression
1.36 2.44e-05 GO:0048513 organ development
1.31 2.81e-05 GO:0048522 positive regulation of cellular process
1.15 3.15e-05 GO:0050794 regulation of cellular process
1.92 3.73e-05 GO:0007389 pattern specification process
1.68 4.02e-05 GO:0010629 negative regulation of gene expression
1.53 4.23e-05 GO:0048468 cell development
1.29 4.40e-05 GO:0048518 positive regulation of biological process
1.66 4.40e-05 GO:0045893 positive regulation of transcription, DNA-dependent
1.31 4.76e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.87 5.34e-05 GO:0048598 embryonic morphogenesis
1.74 5.41e-05 GO:0048585 negative regulation of response to stimulus
1.54 6.20e-05 GO:0006351 transcription, DNA-dependent
1.14 6.68e-05 GO:0050789 regulation of biological process
1.64 9.16e-05 GO:0032989 cellular component morphogenesis
1.77 1.09e-04 GO:0023057 negative regulation of signaling
1.77 1.23e-04 GO:0010648 negative regulation of cell communication
1.31 1.56e-04 GO:0051252 regulation of RNA metabolic process
1.29 1.56e-04 GO:0010556 regulation of macromolecule biosynthetic process
1.65 1.81e-04 GO:0000902 cell morphogenesis
1.78 2.30e-04 GO:0009968 negative regulation of signal transduction
1.40 2.43e-04 GO:0009966 regulation of signal transduction
1.57 2.44e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.62 2.62e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.68 2.66e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.70 2.67e-04 GO:0000904 cell morphogenesis involved in differentiation
1.90 2.80e-04 GO:0022603 regulation of anatomical structure morphogenesis
1.60 3.00e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.71 3.30e-04 GO:0072358 cardiovascular system development
1.71 3.30e-04 GO:0072359 circulatory system development
1.36 3.94e-04 GO:0023051 regulation of signaling
1.13 3.98e-04 GO:0065007 biological regulation
1.59 4.23e-04 GO:0051254 positive regulation of RNA metabolic process
1.44 4.28e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.87 4.54e-04 GO:0060284 regulation of cell development
1.45 4.72e-04 GO:0010646 regulation of cell communication
2.25 4.82e-04 GO:0009952 anterior/posterior pattern formation
1.23 4.99e-04 GO:0080090 regulation of primary metabolic process
1.56 6.88e-04 GO:0030182 neuron differentiation
1.54 7.06e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.79 7.31e-04 GO:0048706 embryonic skeletal system development
1.64 7.67e-04 GO:0051253 negative regulation of RNA metabolic process
1.74 7.77e-04 GO:0007409 axonogenesis
1.51 8.30e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.53 8.35e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.29 9.80e-04 GO:0006355 regulation of transcription, DNA-dependent
1.75 1.06e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
2.22 1.38e-03 GO:0048562 embryonic organ morphogenesis
1.49 1.41e-03 GO:0009891 positive regulation of biosynthetic process
1.55 1.71e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.48 1.72e-03 GO:0040011 locomotion
2.33 1.78e-03 GO:0048705 skeletal system morphogenesis
1.69 1.96e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.47 2.02e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.68 2.19e-03 GO:0048812 neuron projection morphogenesis
1.20 2.28e-03 GO:0019222 regulation of metabolic process
1.75 2.28e-03 GO:0043009 chordate embryonic development
1.39 2.68e-03 GO:0009893 positive regulation of metabolic process
1.55 2.77e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.63 2.85e-03 GO:0048858 cell projection morphogenesis
1.38 3.01e-03 GO:0051239 regulation of multicellular organismal process
1.53 3.05e-03 GO:0009890 negative regulation of biosynthetic process
2.65 3.66e-03 GO:0055123 digestive system development
1.73 3.67e-03 GO:0009792 embryo development ending in birth or egg hatching
2.77 3.72e-03 GO:0048565 digestive tract development
1.55 3.81e-03 GO:0030030 cell projection organization
1.21 3.84e-03 GO:0031323 regulation of cellular metabolic process
2.98 3.84e-03 GO:0048704 embryonic skeletal system morphogenesis
1.63 3.96e-03 GO:0031175 neuron projection development
1.46 4.12e-03 GO:0031324 negative regulation of cellular metabolic process
1.44 4.26e-03 GO:0032774 RNA biosynthetic process
1.62 4.27e-03 GO:0032990 cell part morphogenesis
1.14 4.35e-03 GO:0050896 response to stimulus
1.67 5.25e-03 GO:0043066 negative regulation of apoptosis
1.58 5.31e-03 GO:0048666 neuron development
1.65 5.77e-03 GO:0051094 positive regulation of developmental process
1.46 6.47e-03 GO:0009888 tissue development
1.24 7.50e-03 GO:0031326 regulation of cellular biosynthetic process
1.64 7.87e-03 GO:0060548 negative regulation of cell death
1.65 8.01e-03 GO:0043069 negative regulation of programmed cell death
1.88 8.46e-03 GO:0050767 regulation of neurogenesis
1.42 9.13e-03 GO:0009892 negative regulation of metabolic process
1.24 9.44e-03 GO:0009889 regulation of biosynthetic process
1.29 9.90e-03 GO:0048583 regulation of response to stimulus
1.94 1.69e-02 GO:0045664 regulation of neuron differentiation
2.62 1.84e-02 GO:0022612 gland morphogenesis
1.79 1.93e-02 GO:0061061 muscle structure development
1.73 2.15e-02 GO:0001501 skeletal system development
1.84 2.35e-02 GO:0040007 growth
1.46 2.59e-02 GO:0007155 cell adhesion
1.46 2.59e-02 GO:0022610 biological adhesion
1.36 2.73e-02 GO:0031325 positive regulation of cellular metabolic process
2.46 2.75e-02 GO:0051271 negative regulation of cellular component movement
1.51 2.88e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.51 3.03e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.75 3.24e-02 GO:0051270 regulation of cellular component movement
1.18 3.91e-02 GO:0023052 signaling
1.79 4.24e-02 GO:0030334 regulation of cell migration
2.36 4.53e-02 GO:0040013 negative regulation of locomotion
1.77 4.92e-02 GO:0001568 blood vessel development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 1.91e-07 GO:0005634 nucleus
1.32 1.74e-04 GO:0031981 nuclear lumen
1.37 3.12e-04 GO:0005654 nucleoplasm
1.27 7.43e-04 GO:0044428 nuclear part
2.02 9.82e-04 GO:0031252 cell leading edge
1.07 3.14e-03 GO:0044424 intracellular part
1.30 5.51e-03 GO:0005856 cytoskeleton
1.43 1.28e-02 GO:0044451 nucleoplasm part
1.06 1.36e-02 GO:0005622 intracellular
2.34 1.53e-02 GO:0030027 lamellipodium
1.46 1.67e-02 GO:0030054 cell junction
1.95 2.13e-02 GO:0005912 adherens junction
1.08 2.94e-02 GO:0043229 intracellular organelle
1.08 2.95e-02 GO:0043226 organelle
2.11 3.09e-02 GO:0030055 cell-substrate junction
1.21 4.08e-02 GO:0043233 organelle lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 2.29e-09 GO:0005515 protein binding
1.58 2.46e-08 GO:0030528 transcription regulator activity
1.56 1.53e-07 GO:0001071 nucleic acid binding transcription factor activity
1.56 1.53e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.64 9.15e-05 GO:0008092 cytoskeletal protein binding
1.85 9.18e-05 GO:0016563 transcription activator activity
1.57 1.01e-04 GO:0043565 sequence-specific DNA binding
1.28 1.48e-04 GO:0003677 DNA binding
1.07 5.05e-04 GO:0005488 binding
1.74 1.83e-03 GO:0003779 actin binding
1.20 2.65e-03 GO:0003676 nucleic acid binding
4.91 3.55e-03 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
4.91 3.55e-03 GO:0019198 transmembrane receptor protein phosphatase activity
1.63 9.41e-03 GO:0000988 protein binding transcription factor activity
1.63 9.41e-03 GO:0000989 transcription factor binding transcription factor activity
2.97 1.57e-02 GO:0008013 beta-catenin binding
1.61 1.57e-02 GO:0003712 transcription cofactor activity
1.80 1.86e-02 GO:0003713 transcription coactivator activity