Motif ID: RORA.p2

Z-value: 0.651


Transcription factors associated with RORA.p2:

Gene SymbolEntrez IDGene Name
RORA 6095 RAR-related orphan receptor A



Activity profile for motif RORA.p2.

activity profile for motif RORA.p2


Sorted Z-values histogram for motif RORA.p2

Sorted Z-values for motif RORA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RORA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_41259973 0.654 NM_001168247
NM_144990
SLFNL1

schlafen-like 1

chr19_-_53832381 0.586 NM_001352
DBP
D site of albumin promoter (albumin D-box) binding protein
chr12_+_54700955 0.521 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr1_-_47468029 0.509 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr1_+_17719405 0.374 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr17_+_38250122 0.360 NM_001158
NM_009590
AOC2

amine oxidase, copper containing 2 (retina-specific)

chr19_-_3930828 0.358 EEF2
eukaryotic translation elongation factor 2
chrX_+_56772391 0.352 LOC550643
hypothetical LOC550643
chr6_-_152664906 0.349 SYNE1
spectrin repeat containing, nuclear envelope 1
chr10_-_52315436 0.346 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr10_-_121286034 0.336 NM_002925
RGS10
regulator of G-protein signaling 10
chr7_+_101715110 0.321 NM_020979
SH2B2
SH2B adaptor protein 2
chr7_+_101715137 0.321 SH2B2
SH2B adaptor protein 2
chr10_-_71811353 0.316 NM_207119
LRRC20
leucine rich repeat containing 20
chr15_-_50270856 0.310 NM_016194
GNB5
guanine nucleotide binding protein (G protein), beta 5
chr17_-_31332568 0.307 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr10_-_52315390 0.302 A1CF
APOBEC1 complementation factor
chr8_-_134141586 0.300 NM_006748
SLA
Src-like-adaptor
chr7_+_97574054 0.276 NM_014916
LMTK2
lemur tyrosine kinase 2
chr7_+_18501876 0.271 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr4_+_110968594 0.269 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chrX_-_102661072 0.247 NM_080879
RAB40A
RAB40A, member RAS oncogene family
chr19_-_60272708 0.240 NM_138412
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr1_-_233879617 0.237 NM_001098722
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chrX_-_108611940 0.234 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr17_-_32730804 0.233 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr17_-_2250967 0.229 NM_020310
MNT
MAX binding protein
chr1_+_40635058 0.225 NM_001198980
SMAP2
small ArfGAP2
chr11_-_6418705 0.219 NM_000613
HPX
hemopexin
chr8_-_142307854 0.219 NM_001080431
SLC45A4
solute carrier family 45, member 4
chr17_-_46140015 0.216 NM_052855
ANKRD40
ankyrin repeat domain 40
chr3_-_24511180 0.207 NM_001128176
NM_000461
NM_001128177
THRB


thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)


chr1_-_148473649 0.205 NM_001136479
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr11_+_106967165 0.191 ELMOD1
ELMO/CED-12 domain containing 1
chr17_+_23394062 0.190 NLK
nemo-like kinase
chr6_-_52217185 0.174 NM_052872
IL17F
interleukin 17F
chr18_-_54447168 0.173 NM_052947
ALPK2
alpha-kinase 2
chr22_-_20235372 0.162 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr22_+_20068039 0.157 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr11_-_64283945 0.157 PYGM
phosphorylase, glycogen, muscle
chr22_+_20101661 0.154 NM_015094
HIC2
hypermethylated in cancer 2
chr16_+_1773004 0.153 NUBP2
nucleotide binding protein 2 (MinD homolog, E. coli)
chr7_+_151792052 0.152 LOC100128822
hypothetical LOC100128822
chr4_+_155703581 0.151 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr11_-_65412409 0.150 NM_004214
NM_198897
FIBP

fibroblast growth factor (acidic) intracellular binding protein

chr11_-_47572478 0.149 NM_031909
C1QTNF4
C1q and tumor necrosis factor related protein 4
chr5_+_38294613 0.146


chr11_+_106967283 0.144 ELMOD1
ELMO/CED-12 domain containing 1
chr19_-_7604569 0.144 NM_174895
PCP2
Purkinje cell protein 2
chr15_-_41000100 0.142 NM_173500
TTBK2
tau tubulin kinase 2
chr4_-_186969202 0.141 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr19_-_8473473 0.140 NM_032152
PRAM1
PML-RARA regulated adaptor molecule 1
chrX_-_102418329 0.137 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr9_+_74110149 0.136


chr14_-_69725342 0.135 NM_033262
NM_058240
NM_182932
NM_183002
SLC8A3



solute carrier family 8 (sodium/calcium exchanger), member 3



chr11_-_70350509 0.133 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr1_-_150328153 0.131 NM_001008536
TCHHL1
trichohyalin-like 1
chr2_+_28892366 0.124 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr15_-_63457378 0.122 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr3_+_48463117 0.122 ATRIP
ATR interacting protein
chr12_-_46405477 0.120 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr1_+_150749943 0.119 NM_178438
LCE5A
late cornified envelope 5A
chr19_+_8384181 0.116 NM_001005415
NM_001005416
NM_016496
MARCH2


membrane-associated ring finger (C3HC4) 2


chrX_-_10504852 0.113 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr10_+_51219558 0.110 NM_002443
NM_138634
MSMB

microseminoprotein, beta-

chr2_+_27358800 0.108 NM_032546
NM_187841
TRIM54

tripartite motif containing 54

chr12_+_119617060 0.107


chr1_+_20269239 0.104 NM_000929
PLA2G5
phospholipase A2, group V
chrX_+_10084984 0.104 NM_001830
CLCN4
chloride channel 4
chr16_-_1772305 0.102 SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr16_+_1772929 0.098 NM_012225
NUBP2
nucleotide binding protein 2 (MinD homolog, E. coli)
chr1_-_35692668 0.096 KIAA0319L
KIAA0319-like
chr15_-_43209348 0.093 NM_144565
DUOXA1
dual oxidase maturation factor 1
chr6_+_43846735 0.090 VEGFA
vascular endothelial growth factor A
chr15_+_38296920 0.090 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr16_-_1772572 0.087 SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chrX_+_150635162 0.086 NM_033085
FATE1
fetal and adult testis expressed 1
chr3_+_48463184 0.085 NM_032166
NM_130384
TREX1
ATRIP

three prime repair exonuclease 1
ATR interacting protein

chr6_+_43846372 0.085 VEGFA
vascular endothelial growth factor A
chr19_+_55013315 0.084 NM_030973
MED25
mediator complex subunit 25
chr17_+_23393744 0.082 NM_016231
NLK
nemo-like kinase
chr1_-_84928473 0.079 NM_001166295
NM_001166417
NM_001166293
NM_001166294
NM_014021
SSX2IP




synovial sarcoma, X breakpoint 2 interacting protein




chr10_+_80735881 0.078


chr16_-_1772577 0.076 NM_080861
SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chrX_+_12834659 0.076 NM_138636
TLR8
toll-like receptor 8
chr6_+_158654464 0.075 TULP4
tubby like protein 4
chrX_-_62564934 0.075 LOC92249
hypothetical LOC92249
chr12_+_54672766 0.074 RAB5B
RAB5B, member RAS oncogene family
chr17_+_68672705 0.072 NM_001050
SSTR2
somatostatin receptor 2
chr11_-_67028415 0.072 PITPNM1
phosphatidylinositol transfer protein, membrane-associated 1
chrX_+_65152004 0.072


chr3_-_127382051 0.072 ALDH1L1
aldehyde dehydrogenase 1 family, member L1
chr1_-_245763763 0.071 NM_198074
OR2C3
olfactory receptor, family 2, subfamily C, member 3
chr13_-_26232777 0.070 NM_005288
GPR12
G protein-coupled receptor 12
chr10_-_64698831 0.068 NM_004241
JMJD1C
jumonji domain containing 1C
chr19_+_47073029 0.068 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr17_-_36113502 0.068 NM_019016
KRT24
keratin 24
chr12_+_50568010 0.067 NM_001130015
NM_182608
ANKRD33

ankyrin repeat domain 33

chr2_+_219180821 0.066 PLCD4
phospholipase C, delta 4
chr6_-_112033752 0.063 TRAF3IP2
TRAF3 interacting protein 2
chr7_+_111850367 0.063 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr3_-_185578621 0.061 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr16_-_88623809 0.061 NM_001214
C16orf3
chromosome 16 open reading frame 3
chr22_-_18807805 0.060 PI4KAP2
PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr17_+_23747422 0.060 SARM1
sterile alpha and TIR motif containing 1
chr6_+_37360144 0.058 TBC1D22B
TBC1 domain family, member 22B
chr11_-_72057755 0.057 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr15_-_31999815 0.055


chr11_-_119514011 0.055 TRIM29
tripartite motif containing 29
chr8_-_6407882 0.055 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr1_+_196148241 0.054 NM_001014434
LHX9
LIM homeobox 9
chr3_+_185520744 0.052 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr5_-_150501393 0.050 NM_001193544
ANXA6
annexin A6
chr10_-_100164877 0.050 NM_032709
PYROXD2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr1_-_246503738 0.050 NM_001004695
OR2T33
olfactory receptor, family 2, subfamily T, member 33
chrX_-_33139349 0.048 NM_004006
DMD
dystrophin
chr7_-_156161130 0.048


chr17_-_17426469 0.047 NM_007169
PEMT
phosphatidylethanolamine N-methyltransferase
chrX_-_32083506 0.047 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chrX_-_71443725 0.047 NM_001144886
CITED1
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chr12_-_40824699 0.046 NM_001099650
NM_173601
GXYLT1

glucoside xylosyltransferase 1

chr14_-_89868006 0.045 NM_017970
NM_199043
C14orf102

chromosome 14 open reading frame 102

chr6_-_34209250 0.044 NM_000841
GRM4
glutamate receptor, metabotropic 4
chr7_+_128795280 0.043 AHCYL2
adenosylhomocysteinase-like 2
chr1_-_155053124 0.043 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr12_-_55134692 0.042 NM_012064
MIP
major intrinsic protein of lens fiber
chr2_+_102294393 0.042 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr1_-_23376860 0.041 LUZP1
leucine zipper protein 1
chr17_+_37941790 0.041 NAGLU
N-acetylglucosaminidase, alpha
chr11_-_119104463 0.041 NM_002855
NM_203285
NM_203286
PVRL1


poliovirus receptor-related 1 (herpesvirus entry mediator C)


chr6_-_24491498 0.040 NM_001195610
DCDC2
doublecortin domain containing 2
chr10_-_103568169 0.039 MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chrX_+_64804235 0.039 NM_002444
MSN
moesin
chr5_+_38294289 0.039 NM_152403
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr10_-_21475493 0.039 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr22_+_40286957 0.039 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr7_-_106991941 0.038 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr11_-_62136778 0.038 NM_153265
EML3
echinoderm microtubule associated protein like 3
chr1_+_46413335 0.037 NM_005727
TSPAN1
tetraspanin 1
chr3_+_44571600 0.035 NM_018651
NM_025169
ZNF167

zinc finger protein 167

chr7_-_150385912 0.035 NM_001164410
NM_004935
CDK5

cyclin-dependent kinase 5

chr1_+_170017430 0.034 METTL13
methyltransferase like 13
chr1_-_19192 0.032 WASH1
WASH3P
WASH2P
WASH7P
WAS protein family homolog 1
WAS protein family homolog 3 pseudogene
WAS protein family homolog 2 pseudogene
WAS protein family homolog 7 pseudogene
chr1_-_51583281 0.031 NM_001144832
TTC39A
tetratricopeptide repeat domain 39A
chr5_+_38294417 0.031 EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr10_-_103568162 0.031 MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr6_+_37429800 0.030 RNF8
ring finger protein 8
chr17_-_17426416 0.030 PEMT
phosphatidylethanolamine N-methyltransferase
chr12_+_103677388 0.030 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr3_-_127382093 0.029 NM_012190
ALDH1L1
aldehyde dehydrogenase 1 family, member L1
chr1_-_171442937 0.029 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chrX_-_57164575 0.029 NM_001006681
NM_001006682
NM_001006683
SPIN2B


spindlin family, member 2B


chr15_-_38118608 0.028 NM_003134
SRP14
signal recognition particle 14kDa (homologous Alu RNA binding protein)
chr3_-_39170038 0.028 CSRNP1
cysteine-serine-rich nuclear protein 1
chr12_-_51887266 0.028 NM_000889
ITGB7
integrin, beta 7
chr17_-_35774467 0.027 NM_152219
GJD3
gap junction protein, delta 3, 31.9kDa
chr3_-_117647053 0.027 NM_002338
LSAMP
limbic system-associated membrane protein
chr1_-_148936123 0.027 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr3_-_24511456 0.027 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr16_-_28210867 0.026


chr4_+_52612197 0.026 NM_145263
SPATA18
spermatogenesis associated 18 homolog (rat)
chr13_+_108046500 0.025 NM_015011
MYO16
myosin XVI
chr5_-_154210341 0.025 C5orf4
chromosome 5 open reading frame 4
chr6_+_42991704 0.024 NM_138296
PTCRA
pre T-cell antigen receptor alpha
chr11_+_55776251 0.024 NM_001004747
OR5T3
olfactory receptor, family 5, subfamily T, member 3
chr15_-_72922533 0.024 ULK3
unc-51-like kinase 3 (C. elegans)
chr17_+_37941715 0.024 NAGLU
N-acetylglucosaminidase, alpha
chr5_-_54866126 0.023 NM_003711
NM_176895
RNF138P1
PPAP2A

ring finger protein 138 pseudogene 1
phosphatidic acid phosphatase type 2A

chr11_+_106967017 0.023 NM_001130037
NM_018712
ELMOD1

ELMO/CED-12 domain containing 1

chr19_+_7607976 0.023 NM_001127396
NM_006949
STXBP2

syntaxin binding protein 2

chr5_+_134209444 0.022 NM_001135586
C5orf24
chromosome 5 open reading frame 24
chr12_-_51887318 0.021 ITGB7
integrin, beta 7
chr2_+_219180862 0.021 PLCD4
phospholipase C, delta 4
chr17_-_36981830 0.021 NM_000226
KRT9
keratin 9
chr6_+_43846155 0.021 VEGFA
vascular endothelial growth factor A
chr12_+_54910086 0.021 NM_173596
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr14_+_93562500 0.020 OTUB2
OTU domain, ubiquitin aldehyde binding 2
chr3_-_50335113 0.020 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chr1_-_16034928 0.019 FLJ37453
hypothetical LOC729614
chr1_+_44217435 0.019 NM_003780
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr12_+_63958949 0.018 NM_001193461
MSRB3
methionine sulfoxide reductase B3
chr7_+_128795178 0.018 NM_001130723
AHCYL2
adenosylhomocysteinase-like 2
chr10_-_103568171 0.018 MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr11_-_2116775 0.018 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chr7_+_134567270 0.018 NM_182489
STRA8
stimulated by retinoic acid gene 8 homolog (mouse)
chr1_-_148868713 0.017 NM_004436
NM_207042
NM_207043
NM_207044
NM_207168
ENSA




endosulfine alpha




chr7_-_83662152 0.017 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr17_+_63346625 0.017 BPTF
bromodomain PHD finger transcription factor
chr19_-_16111695 0.016


chr12_+_63958689 0.015 NM_001031679
NM_001193460
NM_198080
MSRB3


methionine sulfoxide reductase B3


chr2_-_228206045 0.015 NM_001162483
NM_020161
C2orf83

chromosome 2 open reading frame 83

chr15_-_72922532 0.015 ULK3
unc-51-like kinase 3 (C. elegans)
chrX_-_148580602 0.015 NM_005366
MAGEA11
melanoma antigen family A, 11
chr18_-_55136673 0.014 NM_181654
CPLX4
complexin 4
chr17_+_7495436 0.014 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr5_+_134209628 0.014 C5orf24
chromosome 5 open reading frame 24
chr14_-_91268136 0.014 NM_024764
CATSPERB
cation channel, sperm-associated, beta
chr15_-_72922577 0.013 NM_001099436
ULK3
unc-51-like kinase 3 (C. elegans)
chr2_-_191580567 0.013 STAT1
signal transducer and activator of transcription 1, 91kDa
chr14_-_90780604 0.013 NM_001177676
GPR68
G protein-coupled receptor 68

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
69.03 4.00e-03 GO:0034314 Arp2/3 complex-mediated actin nucleation
46.02 1.97e-02 GO:0045010 actin nucleation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
25.10 3.04e-02 GO:0071203 WASH complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
27.61 2.62e-02 GO:0019966 interleukin-1 binding
23.01 4.72e-02 GO:0015929 hexosaminidase activity