Motif ID: TCF4_dimer.p2

Z-value: 2.029


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4



Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_30498948 3.660 NM_001033576
NM_173167
 UNC45B

unc-45 homolog B (C. elegans)

chr11_+_63864263 3.166 NM_032251
 CCDC88B
coiled-coil domain containing 88B
chr22_-_49240594 2.885 SBF1
SET binding factor 1
chr9_+_139292094 2.808 NM_017723
 C9orf167
chromosome 9 open reading frame 167
chr11_+_817584 2.765 NM_173584
 EFCAB4A
EF-hand calcium binding domain 4A
chr2_-_241484245 2.761 NM_001085437
 C2orf54
chromosome 2 open reading frame 54
chr20_-_61669550 2.744 NM_033405
 PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chrX_-_135941498 2.697 NM_054021
 GPR101
G protein-coupled receptor 101
chr22_+_20068039 2.574 NM_001128635
 RIMBP3B
RIMS binding protein 3B
chr11_+_70926718 2.515 NM_021046
 KRTAP5-8
keratin associated protein 5-8
chr1_-_1840564 2.514 NM_178545
 TMEM52
transmembrane protein 52
chr1_+_3360880 2.449 NM_014448
 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr16_+_87232501 2.443 NM_013278
 IL17C
interleukin 17C
chr16_-_87405817 2.425 NM_000485
NM_001030018
 APRT

adenine phosphoribosyltransferase

chr8_-_145088679 2.357 NM_201383
 PLEC
plectin
chr17_+_24095135 2.333 NM_004295
 TRAF4
TNF receptor-associated factor 4
chrX_+_110226030 2.241 NM_002578
 PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr8_-_145609737 2.139 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr17_+_26060617 2.135


chr12_+_120944174 2.135 NM_001024808
NM_020993
 BCL7A

B-cell CLL/lymphoma 7A


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 67 entries
enrichment   p-value GO term description
2.44 3.59e-02 GO:0071299 cellular response to vitamin A
1.57 7.72e-03 GO:0003012 muscle system process
1.56 2.75e-02 GO:0006936 muscle contraction
1.50 8.18e-05 GO:0007411 axon guidance
1.47 4.58e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.46 6.18e-04 GO:0044057 regulation of system process
1.44 4.39e-03 GO:0060284 regulation of cell development
1.43 1.25e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.42 2.11e-04 GO:0032583 regulation of gene-specific transcription
1.42 3.26e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.42 1.89e-02 GO:0006140 regulation of nucleotide metabolic process
1.38 1.87e-06 GO:0030182 neuron differentiation
1.37 9.87e-03 GO:0007409 axonogenesis
1.36 1.56e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.35 1.18e-06 GO:0048699 generation of neurons
1.35 3.73e-03 GO:0006935 chemotaxis
1.35 3.73e-03 GO:0042330 taxis
1.34 5.16e-07 GO:0022008 neurogenesis
1.34 8.83e-03 GO:0000904 cell morphogenesis involved in differentiation
1.34 3.16e-02 GO:0048812 neuron projection morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
1.76 1.98e-04 GO:0030016 myofibril
1.74 1.69e-04 GO:0043292 contractile fiber
1.70 6.96e-03 GO:0030017 sarcomere
1.68 2.72e-03 GO:0044449 contractile fiber part
1.50 6.97e-04 GO:0016323 basolateral plasma membrane
1.39 1.41e-06 GO:0030054 cell junction
1.36 2.79e-02 GO:0005578 proteinaceous extracellular matrix
1.35 8.38e-03 GO:0031012 extracellular matrix
1.31 3.36e-02 GO:0043005 neuron projection
1.26 1.37e-03 GO:0005615 extracellular space
1.24 2.63e-04 GO:0044421 extracellular region part
1.19 1.24e-06 GO:0044459 plasma membrane part
1.14 1.07e-02 GO:0005576 extracellular region
1.11 2.72e-04 GO:0005886 plasma membrane
1.11 4.39e-04 GO:0071944 cell periphery
1.05 3.60e-02 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.33 3.87e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.33 5.75e-03 GO:0030695 GTPase regulator activity
1.30 4.18e-04 GO:0043565 sequence-specific DNA binding
1.25 4.48e-04 GO:0005102 receptor binding
1.24 1.66e-03 GO:0001071 nucleic acid binding transcription factor activity
1.24 1.66e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.23 1.64e-03 GO:0030528 transcription regulator activity