Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 2.677


Transcription factors associated with AHR_ARNT_ARNT2.p2:

Gene SymbolEntrez IDGene Name
AHR 196 aryl hydrocarbon receptor
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ARNT2chr15_+_78520634-0.514.5e-02Click!
AHRchr7_+_173047070.495.6e-02Click!
ARNTchr1_-_149115771-0.371.6e-01Click!


Activity profile for motif AHR_ARNT_ARNT2.p2.

activity profile for motif AHR_ARNT_ARNT2.p2


Sorted Z-values histogram for motif AHR_ARNT_ARNT2.p2

Sorted Z-values for motif AHR_ARNT_ARNT2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT_ARNT2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_203208064 4.451 NM_173511
FAM117B
family with sequence similarity 117, member B
chr20_+_30409649 4.348 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr18_+_75760434 4.035


chr6_+_43846735 4.030 VEGFA
vascular endothelial growth factor A
chr2_+_203208456 3.635 FAM117B
family with sequence similarity 117, member B
chr5_+_151131655 3.280 NM_005754
NM_198395
G3BP1

GTPase activating protein (SH3 domain) binding protein 1

chr17_+_69939806 3.272 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr5_+_151131709 3.162 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr5_+_151131853 3.052 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr5_+_151131707 3.042 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr5_+_151131704 2.938 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr5_+_151131676 2.782 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr20_+_30410447 2.599 ASXL1
additional sex combs like 1 (Drosophila)
chr20_+_41519947 2.472 SRSF6
serine/arginine-rich splicing factor 6
chr17_+_69939130 2.436 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr8_+_126079929 2.384 SQLE
squalene epoxidase
chr2_+_203207912 2.246 FAM117B
family with sequence similarity 117, member B
chr2_+_26110232 1.979 NM_016131
RAB10
RAB10, member RAS oncogene family
chr10_-_105442868 1.959 SH3PXD2A
SH3 and PX domains 2A
chr20_+_11819364 1.946 NM_181443
BTBD3
BTB (POZ) domain containing 3
chr2_+_200879656 1.931 SPATS2L
spermatogenesis associated, serine-rich 2-like
chr2_+_219283751 1.845 NM_014640
TTLL4
tubulin tyrosine ligase-like family, member 4
chr8_+_126079900 1.835 NM_003129
SQLE
squalene epoxidase
chr6_-_163754903 1.826 LOC100526820
hypothetical LOC100526820
chr2_+_200879737 1.820 SPATS2L
spermatogenesis associated, serine-rich 2-like
chr3_+_57969127 1.819 NM_001164317
NM_001164318
NM_001164319
NM_001457
FLNB



filamin B, beta



chr8_+_126511739 1.805 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr2_-_219141199 1.796 NM_020935
USP37
ubiquitin specific peptidase 37
chr19_+_1358531 1.778 NM_018959
NM_170711
DAZAP1

DAZ associated protein 1

chr16_+_31098963 1.760 FUS
fused in sarcoma
chr19_+_748444 1.751 PTBP1
polypyrimidine tract binding protein 1
chrX_+_152608159 1.744 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr18_+_53253775 1.741 NM_004852
ONECUT2
one cut homeobox 2
chr19_+_748452 1.734 PTBP1
polypyrimidine tract binding protein 1
chr16_+_31098971 1.734 FUS
fused in sarcoma
chr16_+_31098962 1.704 FUS
fused in sarcoma
chr2_+_118562499 1.703 NM_016133
INSIG2
insulin induced gene 2
chr16_+_31098931 1.697 NM_001170634
NM_001170937
NM_004960
FUS


fused in sarcoma


chr19_+_748448 1.694 PTBP1
polypyrimidine tract binding protein 1
chr20_+_31541441 1.692 CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr2_+_26110487 1.688 RAB10
RAB10, member RAS oncogene family
chr16_+_31098959 1.686 FUS
fused in sarcoma
chr1_+_61320213 1.677 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr2_+_152900076 1.607 FMNL2
formin-like 2
chr11_+_809563 1.577 PNPLA2
patatin-like phospholipase domain containing 2
chr20_+_34143983 1.546 EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr2_+_28971007 1.522 NM_015131
WDR43
WD repeat domain 43
chr6_-_48144344 1.501 NM_001013732
NM_207499
C6orf138

chromosome 6 open reading frame 138

chr1_+_968522 1.464 AGRN
agrin
chr2_+_219141546 1.449 RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr2_+_219991342 1.420 NM_001927
DES
desmin
chr20_-_44370537 1.409 CDH22
cadherin 22, type 2
chr20_+_20296744 1.376 NM_002196
INSM1
insulinoma-associated 1
chr2_+_71412348 1.371 NM_001014972
NM_014497
ZNF638

zinc finger protein 638

chr2_+_223433919 1.370 NM_004457
NM_203372
ACSL3

acyl-CoA synthetase long-chain family member 3

chr1_+_44643513 1.370 NM_018150
RNF220
ring finger protein 220
chr20_+_34635362 1.367 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr10_+_101079099 1.363 CNNM1
cyclin M1
chr2_+_200879040 1.335 NM_001100422
NM_001100424
NM_001100423
SPATS2L


spermatogenesis associated, serine-rich 2-like


chr2_+_26110888 1.333 RAB10
RAB10, member RAS oncogene family
chr20_+_21231921 1.331 NM_012255
XRN2
5'-3' exoribonuclease 2
chr10_-_60606195 1.324


chr20_+_41519882 1.301 NM_006275
SRSF6
serine/arginine-rich splicing factor 6
chr14_-_22840249 1.299


chr2_-_213111525 1.292 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr2_+_20510312 1.282 NM_004040
RHOB
ras homolog gene family, member B
chr3_+_195336625 1.275 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr15_+_50098730 1.271 MAPK6
mitogen-activated protein kinase 6
chr2_+_232281491 1.262 PTMA
prothymosin, alpha
chr3_+_195336631 1.240 HES1
hairy and enhancer of split 1, (Drosophila)
chr7_+_150414704 1.240 NM_001042535
NM_031946
AGAP3

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

chr11_+_809696 1.238 PNPLA2
patatin-like phospholipase domain containing 2
chr16_-_85099941 1.237 LOC400550
hypothetical LOC400550
chr20_+_31541565 1.234 NM_001032999
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr20_+_60130866 1.228 NM_144703
LSM14B
LSM14B, SCD6 homolog B (S. cerevisiae)
chr2_+_86521999 1.218 NM_001146688
KDM3A
lysine (K)-specific demethylase 3A
chr2_+_86521939 1.215 KDM3A
lysine (K)-specific demethylase 3A
chr17_+_52517529 1.212 NM_003488
AKAP1
A kinase (PRKA) anchor protein 1
chr16_+_31378319 1.199 ARMC5
armadillo repeat containing 5
chr15_+_50098724 1.194 MAPK6
mitogen-activated protein kinase 6
chr14_+_32478209 1.192 NM_001164749
NM_001165893
NM_022123
NM_173159
NPAS3



neuronal PAS domain protein 3



chr2_+_219283928 1.189 TTLL4
tubulin tyrosine ligase-like family, member 4
chr19_+_1358664 1.183 DAZAP1
DAZ associated protein 1
chr19_+_748390 1.180 NM_002819
NM_031990
NM_031991
NM_175847
PTBP1



polypyrimidine tract binding protein 1



chr17_+_67628763 1.180 SOX9
SRY (sex determining region Y)-box 9
chr4_+_129950222 1.178 NM_024900
NM_199320
PHF17

PHD finger protein 17

chr1_+_148603613 1.176 NM_015203
RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr2_+_96845704 1.156 NM_017623
NM_199078
CNNM3

cyclin M3

chr14_+_23590939 1.149 NM_138360
LRRC16B
leucine rich repeat containing 16B
chr12_+_6513865 1.143 NM_002046
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr2_+_236068029 1.143 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr2_+_73294852 1.128 NM_006062
SMYD5
SMYD family member 5
chr10_+_114699953 1.110 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr10_+_60606352 1.100 NM_032439
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr10_+_104394185 1.091 NM_030912
TRIM8
tripartite motif containing 8
chr11_+_17714070 1.090 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr2_+_32435550 1.083 NM_016252
BIRC6
baculoviral IAP repeat containing 6
chr10_+_114700775 1.076 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr17_+_67628749 1.063 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr20_-_33335703 1.055 EIF6
eukaryotic translation initiation factor 6
chr9_+_33015270 1.044 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr2_+_32435800 1.041 BIRC6
baculoviral IAP repeat containing 6
chr14_+_73073570 1.037 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr16_+_2742657 1.032 SRRM2
serine/arginine repetitive matrix 2
chr20_+_35964912 1.026 NM_080607
VSTM2L
V-set and transmembrane domain containing 2 like
chr10_+_101078784 1.015 NM_020348
CNNM1
cyclin M1
chr2_+_86800940 1.012 RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr16_+_2742677 1.011 SRRM2
serine/arginine repetitive matrix 2
chr16_+_2742635 1.006 SRRM2
serine/arginine repetitive matrix 2
chr17_+_75366524 1.006 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr16_+_2742674 1.005 SRRM2
serine/arginine repetitive matrix 2
chr16_+_2742653 1.004 SRRM2
serine/arginine repetitive matrix 2
chr19_-_10202947 0.993 NM_004230
S1PR2
sphingosine-1-phosphate receptor 2
chr16_+_2742641 0.985 SRRM2
serine/arginine repetitive matrix 2
chr16_+_2742606 0.982 SRRM2
serine/arginine repetitive matrix 2
chr3_-_62334229 0.975 NM_018008
FEZF2
FEZ family zinc finger 2
chr17_-_37586716 0.973 NM_012285
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr20_+_5934964 0.969 CRLS1
cardiolipin synthase 1
chr17_+_41327662 0.965 MAPT
microtubule-associated protein tau
chr20_-_60360789 0.962 LAMA5
laminin, alpha 5
chr2_+_26422404 0.961 NM_033505
EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr5_+_139761608 0.961 ANKHD1
ankyrin repeat and KH domain containing 1
chr1_+_148603208 0.960 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr2_+_236067687 0.955 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr6_+_1336077 0.954


chr9_+_33015287 0.952 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr16_+_2742684 0.951 SRRM2
serine/arginine repetitive matrix 2
chr16_+_2742704 0.944 SRRM2
serine/arginine repetitive matrix 2
chr2_+_26422495 0.943 EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr1_+_1396975 0.941 ATAD3B
ATPase family, AAA domain containing 3B
chr16_-_31378083 0.938


chr5_+_139761634 0.937 ANKHD1-EIF4EBP3
ANKHD1
ANKHD1-EIF4EBP3 readthrough
ankyrin repeat and KH domain containing 1
chr10_-_124758178 0.936 NM_022466
IKZF5
IKAROS family zinc finger 5 (Pegasus)
chr16_+_4361775 0.932 NM_138440
VASN
vasorin
chr17_+_41327792 0.932 MAPT
microtubule-associated protein tau
chr16_-_23371952 0.931 NM_153603
COG7
component of oligomeric golgi complex 7
chr16_+_2742709 0.930 SRRM2
serine/arginine repetitive matrix 2
chr20_+_5934560 0.929 NM_019095
CRLS1
cardiolipin synthase 1
chr1_+_148603769 0.922 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr2_+_60962228 0.922 NM_002908
REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr20_+_35964962 0.916 VSTM2L
V-set and transmembrane domain containing 2 like
chr1_+_61319976 0.916 NM_001145512
NFIA
nuclear factor I/A
chr5_+_139761579 0.915 NM_020690
NM_001197030
NM_017747
NM_017978
NM_024668
ANKHD1-EIF4EBP3
ANKHD1



ANKHD1-EIF4EBP3 readthrough
ankyrin repeat and KH domain containing 1



chr14_+_34413157 0.913


chr1_+_153366559 0.912 EFNA1
ephrin-A1
chr3_+_30623376 0.911 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr1_-_59020875 0.910 JUN
jun proto-oncogene
chr20_+_5934761 0.910 CRLS1
cardiolipin synthase 1
chr12_+_6514160 0.910 GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr1_+_1397021 0.896 NM_031921
ATAD3B
ATPase family, AAA domain containing 3B
chr12_+_6514228 0.889 GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr17_-_76622967 0.887 FLJ90757
hypothetical LOC440465
chr5_+_139761656 0.880 ANKHD1-EIF4EBP3
ANKHD1
ANKHD1-EIF4EBP3 readthrough
ankyrin repeat and KH domain containing 1
chr2_+_60962206 0.878 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr16_-_69271428 0.877 MTSS1L
metastasis suppressor 1-like
chr16_+_28741873 0.875 ATXN2L
ataxin 2-like
chr16_-_49742651 0.872 NM_002968
SALL1
sal-like 1 (Drosophila)
chr6_-_119712596 0.872 NM_005907
MAN1A1
mannosidase, alpha, class 1A, member 1
chr17_-_44010543 0.868 NM_024015
HOXB4
homeobox B4
chr1_+_1397020 0.868


chr1_+_93070120 0.866 NM_000969
RPL5
ribosomal protein L5
chr14_-_64040072 0.863 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr2_+_60962279 0.860 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr19_+_1358750 0.857 DAZAP1
DAZ associated protein 1
chr17_+_6495694 0.857 NM_001105520
C17orf100
chromosome 17 open reading frame 100
chr1_+_93070202 0.848 RPL5
ribosomal protein L5
chr20_+_60810610 0.847 NM_002531
NTSR1
neurotensin receptor 1 (high affinity)
chr1_+_93070186 0.843 RPL5
ribosomal protein L5
chr9_+_6403139 0.835 NM_152896
UHRF2
ubiquitin-like with PHD and ring finger domains 2
chr16_+_66676833 0.833 NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr10_+_104667991 0.827 NM_017649
NM_199076
NM_199077
CNNM2


cyclin M2


chr20_+_56900116 0.826 NM_001077488
GNAS
GNAS complex locus
chr18_-_33399601 0.823 CELF4
CUGBP, Elav-like family member 4
chr1_+_1360765 0.821 NM_022834
NM_199121
VWA1

von Willebrand factor A domain containing 1

chr10_+_124758391 0.820 NM_001609
ACADSB
acyl-CoA dehydrogenase, short/branched chain
chr16_+_28741908 0.820 NM_007245
NM_145714
NM_148414
NM_148415
NM_148416
ATXN2L




ataxin 2-like




chr4_+_158361185 0.819 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr20_+_34523231 0.815 NM_001042486
DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr5_+_154115046 0.811 LARP1
La ribonucleoprotein domain family, member 1
chr17_+_76623540 0.811 NM_001144888
NM_006340
NM_017450
NM_017451
BAIAP2



BAI1-associated protein 2



chr14_+_23653745 0.810 NM_001163484
DCAF11
DDB1 and CUL4 associated factor 11
chr19_+_8292374 0.802 NM_001031
RPS28
ribosomal protein S28
chr17_+_18027538 0.795 NM_017758
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr1_+_225194622 0.794 ADCK3
aarF domain containing kinase 3
chr17_+_77453363 0.792 NM_148896
NPB
neuropeptide B
chr3_+_151013126 0.790 NM_007282
NM_183381
RNF13

ring finger protein 13

chr17_+_77289804 0.787 SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr6_+_108987703 0.785 NM_201559
FOXO3
forkhead box O3
chr15_+_50098700 0.785 NM_002748
MAPK6
mitogen-activated protein kinase 6
chr18_+_75724655 0.785 NM_012283
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr19_+_1358604 0.783 DAZAP1
DAZ associated protein 1
chr19_+_44589283 0.783 ZFP36
zinc finger protein 36, C3H type, homolog (mouse)
chr14_+_38805622 0.777 CTAGE5
CTAGE family, member 5
chr14_-_22634134 0.777 ACIN1
apoptotic chromatin condensation inducer 1
chr2_-_73313823 0.773 NM_032319
C2orf7
chromosome 2 open reading frame 7
chr20_-_33335919 0.769 NM_181468
EIF6
eukaryotic translation initiation factor 6
chr14_-_73296387 0.768 C14orf43
chromosome 14 open reading frame 43
chr14_+_99775032 0.764 YY1
YY1 transcription factor
chr2_+_135392857 0.761 NM_001241
NM_058241
CCNT2

cyclin T2

chr5_-_139761182 0.759



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.16 2.83e-20 GO:0009987 cellular process
1.39 1.08e-19 GO:0044260 cellular macromolecule metabolic process
1.68 1.12e-19 GO:0010467 gene expression
1.30 2.76e-19 GO:0044237 cellular metabolic process
1.52 2.11e-18 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.45 5.51e-17 GO:0034641 cellular nitrogen compound metabolic process
1.64 5.98e-16 GO:0016070 RNA metabolic process
1.43 1.02e-15 GO:0006807 nitrogen compound metabolic process
1.55 2.11e-15 GO:0090304 nucleic acid metabolic process
1.32 3.18e-15 GO:0043170 macromolecule metabolic process
1.26 1.98e-14 GO:0044238 primary metabolic process
1.23 3.43e-14 GO:0008152 metabolic process
1.38 2.89e-12 GO:0060255 regulation of macromolecule metabolic process
1.22 1.07e-11 GO:0050794 regulation of cellular process
1.95 1.21e-11 GO:0051254 positive regulation of RNA metabolic process
1.88 1.47e-11 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.93 2.78e-11 GO:0010628 positive regulation of gene expression
1.75 3.15e-11 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.97 3.38e-11 GO:0045893 positive regulation of transcription, DNA-dependent
1.85 4.40e-11 GO:0051173 positive regulation of nitrogen compound metabolic process
1.54 6.73e-11 GO:0009059 macromolecule biosynthetic process
1.55 8.55e-11 GO:0034645 cellular macromolecule biosynthetic process
1.67 1.67e-10 GO:0010604 positive regulation of macromolecule metabolic process
1.63 1.72e-10 GO:0009893 positive regulation of metabolic process
1.32 1.84e-10 GO:0019222 regulation of metabolic process
1.72 6.25e-10 GO:0032774 RNA biosynthetic process
1.19 6.39e-10 GO:0050789 regulation of biological process
1.41 6.57e-10 GO:0009058 biosynthetic process
1.83 7.95e-10 GO:0010557 positive regulation of macromolecule biosynthetic process
1.77 9.53e-10 GO:0031328 positive regulation of cellular biosynthetic process
1.42 9.60e-10 GO:0044249 cellular biosynthetic process
1.76 9.72e-10 GO:0009891 positive regulation of biosynthetic process
2.06 1.09e-09 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.33 1.12e-09 GO:0080090 regulation of primary metabolic process
1.32 1.54e-09 GO:0031323 regulation of cellular metabolic process
1.63 1.72e-09 GO:0031325 positive regulation of cellular metabolic process
1.55 1.89e-09 GO:0007399 nervous system development
1.33 2.02e-09 GO:0007275 multicellular organismal development
1.18 2.11e-09 GO:0065007 biological regulation
1.39 7.43e-09 GO:0010468 regulation of gene expression
1.30 1.02e-08 GO:0032502 developmental process
1.37 1.28e-08 GO:0009889 regulation of biosynthetic process
1.37 1.51e-08 GO:0031326 regulation of cellular biosynthetic process
1.71 1.72e-08 GO:0006351 transcription, DNA-dependent
1.39 2.89e-08 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.38 6.53e-08 GO:0010556 regulation of macromolecule biosynthetic process
1.34 2.35e-07 GO:0048731 system development
1.79 2.36e-07 GO:0006396 RNA processing
1.38 3.16e-07 GO:0051252 regulation of RNA metabolic process
1.30 8.89e-07 GO:0048856 anatomical structure development
1.33 1.10e-06 GO:0048518 positive regulation of biological process
1.35 1.13e-06 GO:0048522 positive regulation of cellular process
1.33 2.35e-06 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.37 3.54e-06 GO:0048523 negative regulation of cellular process
1.58 3.76e-06 GO:0009892 negative regulation of metabolic process
1.37 3.82e-06 GO:0006355 regulation of transcription, DNA-dependent
1.34 5.21e-06 GO:0044267 cellular protein metabolic process
1.35 5.88e-06 GO:0048519 negative regulation of biological process
1.57 2.36e-05 GO:0010605 negative regulation of macromolecule metabolic process
1.57 2.57e-05 GO:0022008 neurogenesis
1.30 2.95e-05 GO:0051171 regulation of nitrogen compound metabolic process
1.57 3.21e-05 GO:0031324 negative regulation of cellular metabolic process
1.75 3.74e-05 GO:0051253 negative regulation of RNA metabolic process
1.65 4.82e-05 GO:0009890 negative regulation of biosynthetic process
1.58 4.86e-05 GO:0048699 generation of neurons
1.75 5.10e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.35 6.07e-05 GO:0030154 cell differentiation
1.70 6.83e-05 GO:0010629 negative regulation of gene expression
1.69 7.16e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.64 9.28e-05 GO:0031327 negative regulation of cellular biosynthetic process
1.67 1.11e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.30 1.33e-04 GO:0035270 endocrine system development
1.67 1.44e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.74 1.71e-04 GO:0007417 central nervous system development
1.62 1.83e-04 GO:0009790 embryo development
1.63 1.89e-04 GO:0045595 regulation of cell differentiation
1.64 2.01e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.33 2.87e-04 GO:0048869 cellular developmental process
1.29 2.92e-04 GO:0071842 cellular component organization at cellular level
1.28 3.27e-04 GO:0071841 cellular component organization or biogenesis at cellular level
1.92 4.18e-04 GO:0060284 regulation of cell development
1.52 4.40e-04 GO:0050793 regulation of developmental process
1.81 5.36e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.81 5.54e-04 GO:0006397 mRNA processing
1.74 5.86e-04 GO:0048646 anatomical structure formation involved in morphogenesis
1.62 6.27e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.75 6.70e-04 GO:0023057 negative regulation of signaling
1.24 6.87e-04 GO:0016043 cellular component organization
1.34 8.04e-04 GO:0048513 organ development
1.78 9.21e-04 GO:0009968 negative regulation of signal transduction
1.23 1.17e-03 GO:0071840 cellular component organization or biogenesis
1.82 1.33e-03 GO:0007420 brain development
1.49 1.34e-03 GO:0048468 cell development
1.55 1.42e-03 GO:2000026 regulation of multicellular organismal development
1.73 1.50e-03 GO:0010648 negative regulation of cell communication
2.29 2.27e-03 GO:0045165 cell fate commitment
1.78 2.30e-03 GO:0009792 embryo development ending in birth or egg hatching
1.65 2.35e-03 GO:0016071 mRNA metabolic process
2.78 2.44e-03 GO:0021915 neural tube development
1.87 2.83e-03 GO:0048729 tissue morphogenesis
2.20 3.24e-03 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
2.03 3.87e-03 GO:0043193 positive regulation of gene-specific transcription
1.24 4.48e-03 GO:0019538 protein metabolic process
1.80 5.11e-03 GO:0003006 developmental process involved in reproduction
1.84 5.30e-03 GO:0008380 RNA splicing
1.31 6.11e-03 GO:0006464 protein modification process
1.75 6.13e-03 GO:0043009 chordate embryonic development
2.12 6.85e-03 GO:0030900 forebrain development
1.75 7.97e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.30 8.04e-03 GO:0043412 macromolecule modification
1.96 9.39e-03 GO:0002009 morphogenesis of an epithelium
1.88 1.03e-02 GO:0045596 negative regulation of cell differentiation
1.20 1.05e-02 GO:0023052 signaling
1.73 1.23e-02 GO:0048598 embryonic morphogenesis
1.34 1.48e-02 GO:0009653 anatomical structure morphogenesis
1.32 1.59e-02 GO:0023051 regulation of signaling
1.40 1.85e-02 GO:0051246 regulation of protein metabolic process
1.65 2.19e-02 GO:0032583 regulation of gene-specific transcription
2.17 2.30e-02 GO:0031016 pancreas development
1.73 2.65e-02 GO:0007389 pattern specification process
1.89 2.77e-02 GO:0003002 regionalization
1.34 2.87e-02 GO:0009966 regulation of signal transduction
1.81 3.04e-02 GO:0010608 posttranscriptional regulation of gene expression
1.50 3.06e-02 GO:0030182 neuron differentiation
2.68 3.15e-02 GO:0048638 regulation of developmental growth
1.39 3.16e-02 GO:0010646 regulation of cell communication
1.98 3.31e-02 GO:0048732 gland development
1.74 3.77e-02 GO:0051093 negative regulation of developmental process
1.53 4.22e-02 GO:0009887 organ morphogenesis
3.52 4.24e-02 GO:0030850 prostate gland development
1.39 4.39e-02 GO:0032268 regulation of cellular protein metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 7.08e-25 GO:0005622 intracellular
1.16 7.26e-24 GO:0044424 intracellular part
1.21 3.43e-19 GO:0043231 intracellular membrane-bounded organelle
1.21 5.57e-19 GO:0043227 membrane-bounded organelle
1.18 3.40e-18 GO:0043226 organelle
1.18 3.69e-18 GO:0043229 intracellular organelle
1.53 3.41e-17 GO:0031974 membrane-enclosed lumen
1.54 3.52e-17 GO:0043233 organelle lumen
1.54 3.62e-17 GO:0070013 intracellular organelle lumen
1.29 5.86e-17 GO:0005634 nucleus
1.60 1.91e-16 GO:0031981 nuclear lumen
1.52 8.16e-15 GO:0044428 nuclear part
1.66 1.12e-13 GO:0005654 nucleoplasm
1.24 2.24e-11 GO:0044446 intracellular organelle part
1.24 7.80e-11 GO:0044422 organelle part
1.16 3.22e-09 GO:0005737 cytoplasm
1.68 4.42e-07 GO:0044451 nucleoplasm part
1.24 1.90e-05 GO:0032991 macromolecular complex
1.16 3.04e-05 GO:0044444 cytoplasmic part
1.05 3.11e-05 GO:0044464 cell part
1.05 3.24e-05 GO:0005623 cell
1.69 6.35e-05 GO:0030529 ribonucleoprotein complex
2.02 2.57e-04 GO:0016604 nuclear body
1.29 7.50e-04 GO:0005829 cytosol
2.24 4.04e-03 GO:0016607 nuclear speck
2.50 7.50e-03 GO:0000790 nuclear chromatin
1.43 2.02e-02 GO:0031988 membrane-bounded vesicle
1.52 2.98e-02 GO:0005730 nucleolus
1.19 3.47e-02 GO:0043234 protein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 3.60e-19 GO:0005488 binding
1.24 3.87e-18 GO:0005515 protein binding
1.39 2.27e-14 GO:0003676 nucleic acid binding
1.39 6.90e-09 GO:0000166 nucleotide binding
1.69 1.39e-08 GO:0003723 RNA binding
1.61 2.14e-08 GO:0030528 transcription regulator activity
1.56 9.20e-07 GO:0001071 nucleic acid binding transcription factor activity
1.56 9.20e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
2.01 2.58e-06 GO:0016563 transcription activator activity
1.66 4.02e-06 GO:0043565 sequence-specific DNA binding
1.31 2.01e-05 GO:0003677 DNA binding
1.33 2.11e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.79 3.27e-04 GO:0005525 GTP binding
1.32 4.22e-04 GO:0032553 ribonucleotide binding
1.32 4.22e-04 GO:0032555 purine ribonucleotide binding
1.31 6.85e-04 GO:0017076 purine nucleotide binding
1.74 1.12e-03 GO:0019001 guanyl nucleotide binding
1.74 1.12e-03 GO:0032561 guanyl ribonucleotide binding
3.02 1.35e-02 GO:0003743 translation initiation factor activity
2.05 2.07e-02 GO:0003714 transcription corepressor activity
1.68 3.50e-02 GO:0016564 transcription repressor activity