Motif ID: ALX1.p2

Z-value: 1.429


Transcription factors associated with ALX1.p2:

Gene SymbolEntrez IDGene Name
ALX1 8092 ALX homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ALX1chr12_+_841980150.495.6e-02Click!


Activity profile for motif ALX1.p2.

activity profile for motif ALX1.p2


Sorted Z-values histogram for motif ALX1.p2

Sorted Z-values for motif ALX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_76800525 1.962 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr3_+_63238854 1.785 NM_001130003
SYNPR
synaptoporin
chrX_-_21686079 1.627 NM_014332
SMPX
small muscle protein, X-linked
chr1_+_115373937 1.624 NM_000549
TSHB
thyroid stimulating hormone, beta
chr4_+_70928718 1.618 NM_000200
HTN3
histatin 3
chr9_-_21207303 1.589 NM_002173
IFNA16
interferon, alpha 16
chr8_-_15140162 1.507 NM_139167
SGCZ
sarcoglycan, zeta
chrX_+_66705407 1.486 NM_001011645
AR
androgen receptor
chr11_-_123695302 1.371 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr2_-_47969350 1.363 NM_025133
FBXO11
F-box protein 11
chr8_-_131483395 1.297 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr1_+_156991133 1.274 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chr12_-_11354620 1.260 NM_002723
PRB4
proline-rich protein BstNI subfamily 4
chr9_-_28709302 1.249 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr1_+_74473672 1.238 NM_015978
TNNI3K
TNNI3 interacting kinase
chr9_-_21192201 1.234 NM_021057
IFNA7
interferon, alpha 7
chr18_-_49944986 1.165 MBD2
methyl-CpG binding domain protein 2
chrX_+_51562894 1.148 NM_001005332
MAGED1
melanoma antigen family D, 1
chr9_-_21340885 1.077 NM_021002
IFNA6
interferon, alpha 6
chr4_+_43185 1.055 NM_182524
ZNF595
ZNF718
zinc finger protein 595
zinc finger protein 718
chr3_-_27473248 1.043 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr3_+_52212969 1.033 ALAS1
aminolevulinate, delta-, synthase 1
chr11_-_5212168 1.030 NM_000519
HBD
hemoglobin, delta
chr9_-_21358005 1.021 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr9_-_106401514 1.005 NM_001004482
OR13C5
olfactory receptor, family 13, subfamily C, member 5
chr2_-_218516950 1.001 NM_022648
TNS1
tensin 1
chr20_+_56912146 0.991 GNAS
GNAS complex locus
chrX_-_74921704 0.991 NM_138703
MAGEE2
melanoma antigen family E, 2
chr21_+_30929425 0.977 NM_181616
KRTAP20-2
keratin associated protein 20-2
chr1_-_156635879 0.971 NM_001004475
OR10T2
olfactory receptor, family 10, subfamily T, member 2
chr6_-_88917600 0.950 NM_001160260
CNR1
cannabinoid receptor 1 (brain)
chr12_-_9651748 0.945 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chrX_+_114734074 0.943 NM_001136025
NM_001172335
PLS3

plastin 3

chr4_+_71096830 0.941 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr11_-_51269023 0.927 NM_001005272
OR4A5
olfactory receptor, family 4, subfamily A, member 5
chr11_+_55362802 0.924 NM_001005496
OR5D16
olfactory receptor, family 5, subfamily D, member 16
chr1_-_35143570 0.924 NM_001080418
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chr4_-_21308415 0.924 NM_001035003
KCNIP4
Kv channel interacting protein 4
chr8_-_12220195 0.923 NM_001195257
NM_001037804
LOC100133267
DEFB130
defensin, beta 130-like
defensin, beta 130
chr12_-_11399776 0.923 NM_005039
NM_199353
NM_199354
PRB1


proline-rich protein BstNI subfamily 1


chr1_-_21288259 0.913 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr1_+_63022359 0.880 NM_032852
NM_178221
ATG4C

ATG4 autophagy related 4 homolog C (S. cerevisiae)

chr3_-_38810504 0.866 NM_006514
SCN10A
sodium channel, voltage-gated, type X, alpha subunit
chr1_-_157014048 0.863 NM_001005278
OR6N2
olfactory receptor, family 6, subfamily N, member 2
chr9_+_5221401 0.846 NM_002195
INSL4
insulin-like 4 (placenta)
chr5_+_134331494 0.839 NM_178019
CATSPER3
cation channel, sperm associated 3
chr11_-_55128424 0.838 NM_001004700
OR4C11
olfactory receptor, family 4, subfamily C, member 11
chr19_-_63556632 0.827 NM_130786
A1BG
alpha-1-B glycoprotein
chr17_-_32730804 0.821 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr11_+_88550687 0.809 NM_000372
TYR
tyrosinase (oculocutaneous albinism IA)
chr8_-_111056099 0.798 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr12_-_11030777 0.782 NM_176890
TAS2R50
taste receptor, type 2, member 50
chr1_+_54132447 0.781 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr7_+_63305015 0.768 NM_001159524
ZNF735
zinc finger protein 735
chr9_-_21218132 0.765 NM_021268
IFNA17
interferon, alpha 17
chr4_-_457839 0.756 ABCA11P
ATP-binding cassette, sub-family A (ABC1), member 11 (pseudogene)
chr4_+_70950747 0.754 NM_002159
HTN1
histatin 1
chr15_+_100175888 0.751 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr6_-_25982418 0.750 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr4_-_69218909 0.744 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr14_+_100365390 0.728 MEG3
maternally expressed 3 (non-protein coding)
chr22_-_15682555 0.716 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr7_+_115650240 0.712 NM_152829
TES
testis derived transcript (3 LIM domains)
chr4_-_75083160 0.698 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr1_-_245988330 0.696 NM_012353
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr21_-_30583702 0.685 NM_001128598
KRTAP25-1
keratin associated protein 25-1
chr7_-_81237162 0.677 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr5_+_57823017 0.668 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr10_+_90414125 0.666 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr1_-_180908639 0.664 NM_001102450
NM_033345
RGS8

regulator of G-protein signaling 8

chr6_+_53043729 0.655 NM_012347
FBXO9
F-box protein 9
chr3_+_28406990 0.648 NM_001040432
ZCWPW2
zinc finger, CW type with PWWP domain 2
chr14_+_73153300 0.641 NM_001037162
ACOT6
acyl-CoA thioesterase 6
chr10_-_98326435 0.628 TM9SF3
transmembrane 9 superfamily member 3
chr1_+_221168388 0.622 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr10_-_27097782 0.617 ABI1
abl-interactor 1
chr1_-_177106702 0.599 NM_004673
ANGPTL1
angiopoietin-like 1
chr12_+_20739555 0.599 NM_001145945
NM_001145946
NM_001145944
NM_017435
SLCO1C1



solute carrier organic anion transporter family, member 1C1



chr1_+_39694849 0.598 MACF1
microtubule-actin crosslinking factor 1
chrX_-_6156655 0.597 NM_181332
NLGN4X
neuroligin 4, X-linked
chr4_+_70831387 0.593 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr3_-_69120188 0.593 C3orf64
chromosome 3 open reading frame 64
chr3_-_17716515 0.589 NM_001134381
TBC1D5
TBC1 domain family, member 5
chr14_-_105997732 0.589 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_-_120462705 0.588 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr17_+_58440629 0.587 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr9_+_124416768 0.579 NM_012364
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chrX_+_90977115 0.577 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr5_+_140762551 0.575 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr21_-_44899003 0.573 NM_198698
KRTAP12-4
keratin associated protein 12-4
chr1_-_89364273 0.569 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr1_+_195010552 0.569 NM_001166624
NM_021023
CFHR3

complement factor H-related 3

chr9_-_106407728 0.568 NM_001004481
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chrX_-_23835868 0.563 NM_024122
APOO
apolipoprotein O
chrX_-_111809929 0.563 NM_178175
LHFPL1
lipoma HMGIC fusion partner-like 1
chrX_+_140810117 0.560 NM_177456
MAGEC3
melanoma antigen family C, 3
chr5_+_140709907 0.557 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr17_-_18207416 0.557 NM_004169
NM_148918
SHMT1

serine hydroxymethyltransferase 1 (soluble)

chrX_-_2896285 0.557 ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr12_-_11313907 0.553 NM_006249
PRB3
proline-rich protein BstNI subfamily 3
chr9_-_21156609 0.552 NM_002175
IFNA21
interferon, alpha 21
chrX_-_33267646 0.552 NM_000109
DMD
dystrophin
chr11_-_64459910 0.546 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr6_+_110608284 0.542 NM_015891
CDC40
cell division cycle 40 homolog (S. cerevisiae)
chr5_+_121493113 0.541 NM_207317
ZNF474
zinc finger protein 474
chr1_-_155788775 0.540 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr5_+_76470829 0.531


chr15_+_36014748 0.530 NM_152453
TMCO5A
transmembrane and coiled-coil domains 5A
chr11_-_59707074 0.529 NM_022349
NM_152851
NM_152852
MS4A6A


membrane-spanning 4-domains, subfamily A, member 6A


chr16_-_70763849 0.526 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr12_-_11075272 0.525 NM_176885
TAS2R31
taste receptor, type 2, member 31
chr5_-_43432969 0.524 CCL28
chemokine (C-C motif) ligand 28
chr11_-_104274606 0.515 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chrX_+_154764136 0.513 NM_001145149
NM_001185183
NM_005638
VAMP7


vesicle-associated membrane protein 7


chr5_+_147775652 0.508 FBXO38
F-box protein 38
chr5_+_147562531 0.505 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr8_+_7821268 0.500 NM_001193630
LOC100132396
zinc finger protein 705D-like
chr8_-_86477585 0.496 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr18_+_28023984 0.495 NM_005925
MEP1B
meprin A, beta
chr12_+_29267863 0.494 NM_018099
FAR2
fatty acyl CoA reductase 2
chr3_+_129124591 0.492 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr3_-_161584137 0.486 NM_001190242
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chr4_-_164754106 0.486 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr11_+_55629094 0.486 NM_001005200
OR8H2
olfactory receptor, family 8, subfamily H, member 2
chr11_-_16454493 0.482 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr5_+_140200995 0.480 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr10_-_48426868 0.478 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr19_+_21056792 0.477 NM_182515
ZNF714
zinc finger protein 714
chrX_+_77889861 0.477 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr5_+_81636921 0.473 NM_001017971
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr6_-_66346417 0.473 NM_198283
EYS
eyes shut homolog (Drosophila)
chr12_-_11439752 0.470 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chrX_-_131089552 0.470 NM_194277
FRMD7
FERM domain containing 7
chr10_-_42183441 0.468 LOC283027
hypothetical protein LOC283027
chrX_+_105298953 0.465 NM_001171020
NM_152423
MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr4_-_72868598 0.462 NM_000583
GC
group-specific component (vitamin D binding protein)
chr19_+_41872141 0.460 NM_152603
ZNF567
zinc finger protein 567
chr12_-_11041740 0.457 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr4_+_53975597 0.456 FIP1L1
FIP1 like 1 (S. cerevisiae)
chrX_-_19898302 0.455 NM_198279
CXorf23
chromosome X open reading frame 23
chr12_+_100512877 0.453 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr3_+_150028130 0.449 NM_001871
CPB1
carboxypeptidase B1 (tissue)
chr12_+_54172413 0.448 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr12_-_21818881 0.446 NM_004982
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr18_-_28247186 0.445


chr19_-_23661779 0.444 NM_138330
ZNF675
zinc finger protein 675
chr12_+_54106304 0.440 NM_001005183
OR6C76
olfactory receptor, family 6, subfamily C, member 76
chr3_+_35658852 0.438 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr4_+_71283383 0.434 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr9_-_27287106 0.433 NM_001161585
NM_020641
C9orf11

chromosome 9 open reading frame 11

chr12_+_16391795 0.433 NM_020300
NM_145791
MGST1

microsomal glutathione S-transferase 1

chr3_-_197726587 0.431 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr6_-_2696152 0.431 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr9_+_6231677 0.429 NM_033439
IL33
interleukin 33
chr12_+_26017954 0.427 NM_001164747
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr14_-_105785639 0.427


chr19_-_20011251 0.425 NM_033196
ZNF682
zinc finger protein 682
chr12_-_54150188 0.425 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr16_+_54072969 0.424 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr8_+_17866373 0.423 PCM1
pericentriolar material 1
chr14_+_20306425 0.422 NM_022360
EDDM3B
epididymal protein 3B
chr12_+_53809731 0.420 NM_001005243
OR9K2
olfactory receptor, family 9, subfamily K, member 2
chr1_+_78243181 0.418 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr4_-_45820686 0.417 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr18_+_45342398 0.414 NM_006033
LIPG
lipase, endothelial
chr4_-_69116839 0.412 NM_001077
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr3_-_52688768 0.410 NM_018165
NM_181042
PBRM1

polybromo 1

chr21_-_26867138 0.410 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr7_-_87068106 0.409 ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr12_-_94914133 0.405 NM_002108
HAL
histidine ammonia-lyase
chrX_+_102852492 0.403 NM_182541
TMEM31
transmembrane protein 31
chr21_+_30895276 0.402 NM_181620
KRTAP22-1
keratin associated protein 22-1
chr16_+_14201687 0.401 MKL2
MKL/myocardin-like 2
chr4_-_123761615 0.393 NM_021803
IL21
interleukin 21
chr5_+_140215778 0.391 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr19_-_21438525 0.391


chr5_-_37220702 0.385 C5orf42
chromosome 5 open reading frame 42
chrX_-_151370325 0.384 NM_000808
GABRA3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr3_-_113495763 0.383 NM_183061
SLC9A10
solute carrier family 9, member 10
chr7_+_20653490 0.383 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr7_-_130069399 0.383 NM_138693
KLF14
Kruppel-like factor 14
chr9_-_113130533 0.379 NM_205859
OR2K2
olfactory receptor, family 2, subfamily K, member 2
chr17_-_61655915 0.377 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr1_+_246578699 0.377 NM_001001918
OR14C36
olfactory receptor, family 14, subfamily C, member 36
chrX_-_102234606 0.375 NM_022052
NXF3
nuclear RNA export factor 3
chr8_-_125252884 0.374 C8orf78
chromosome 8 open reading frame 78
chr8_-_37876129 0.373 NM_001002814
NM_025151
RAB11FIP1

RAB11 family interacting protein 1 (class I)

chr13_-_59223074 0.372


chr19_-_53444733 0.369 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr18_-_54447168 0.369 NM_052947
ALPK2
alpha-kinase 2
chr19_-_22396915 0.367 NM_001098626
ZNF98
zinc finger protein 98
chr5_+_140723939 0.366 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr3_-_87408301 0.365 NM_000306
NM_001122757
POU1F1

POU class 1 homeobox 1

chr11_-_57947358 0.364 NM_001005566
OR5B2
olfactory receptor, family 5, subfamily B, member 2
chr5_-_39430180 0.363 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr1_-_42738535 0.363 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr7_+_77307382 0.362 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr4_+_71126376 0.361 NM_152997
C4orf7
chromosome 4 open reading frame 7
chr16_+_15503623 0.356 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr2_+_228064531 0.352 AGFG1
ArfGAP with FG repeats 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.76 3.75e-20 GO:0007606 sensory perception of chemical stimulus
3.92 1.11e-19 GO:0007608 sensory perception of smell
2.70 3.43e-15 GO:0007600 sensory perception
2.03 4.62e-10 GO:0050877 neurological system process
1.88 1.05e-09 GO:0003008 system process
6.67 7.58e-03 GO:0060338 regulation of type I interferon-mediated signaling pathway
3.06 4.06e-02 GO:0007156 homophilic cell adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.39 1.24e-06 GO:0005886 plasma membrane
1.39 1.84e-06 GO:0071944 cell periphery
1.30 1.97e-05 GO:0016021 integral to membrane
1.29 4.06e-05 GO:0031224 intrinsic to membrane
1.21 2.75e-03 GO:0044425 membrane part
1.44 4.43e-03 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.11 1.63e-21 GO:0004984 olfactory receptor activity
2.71 9.06e-17 GO:0004930 G-protein coupled receptor activity
2.18 1.95e-13 GO:0004888 transmembrane receptor activity
1.92 1.37e-11 GO:0004872 receptor activity
1.69 3.55e-08 GO:0004871 signal transducer activity
1.69 3.55e-08 GO:0060089 molecular transducer activity
16.67 8.95e-05 GO:0005132 interferon-alpha/beta receptor binding