Motif ID: ATF4.p2

Z-value: 1.213


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF4chr22_+_38246509-0.107.2e-01Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_1892157 2.283 NM_001319
 CSNK1G2
casein kinase 1, gamma 2
chr19_+_1892184 2.212 CSNK1G2
casein kinase 1, gamma 2
chr20_+_33667160 1.716 NM_003116
 SPAG4
sperm associated antigen 4
chr6_+_26312758 1.577 NM_003545
 HIST1H4E
histone cluster 1, H4e
chr17_+_38831874 1.440 NM_001661
 ARL4D
ADP-ribosylation factor-like 4D
chr22_+_20101661 1.432 NM_015094
 HIC2
hypermethylated in cancer 2
chr3_+_38181972 1.258 NM_005109
 OXSR1
oxidative-stress responsive 1
chr16_-_3008162 1.216 NM_021195
 CLDN6
claudin 6
chr1_-_243092581 1.195 HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr22_+_19601619 1.170 NM_005207
 CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr19_+_16048306 1.164 TPM4
tropomyosin 4
chr22_+_36927884 1.155 NM_001161572
NM_001161574
NM_012323
 MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr8_+_23442331 1.146 SLC25A37
solute carrier family 25, member 37
chr8_+_98857190 1.125 LAPTM4B
lysosomal protein transmembrane 4 beta
chr4_-_8493327 1.105 NM_001101667
NM_003501
 ACOX3

acyl-CoA oxidase 3, pristanoyl

chr2_+_108702338 1.101 NM_006267
 RANBP2
RAN binding protein 2
chr1_+_29435534 1.100 NM_001195001
NM_005704
NM_133177
NM_133178
 PTPRU



protein tyrosine phosphatase, receptor type, U



chr8_+_23442307 1.092 NM_016612
 SLC25A37
solute carrier family 25, member 37
chr8_+_23442413 1.087 SLC25A37
solute carrier family 25, member 37
chr22_+_19601721 1.073 CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
18.51 1.68e-02 GO:0070584 mitochondrion morphogenesis
2.98 3.54e-02 GO:0050657 nucleic acid transport
2.98 3.54e-02 GO:0050658 RNA transport
2.98 3.54e-02 GO:0051236 establishment of RNA localization
2.84 2.85e-02 GO:0006333 chromatin assembly or disassembly
2.17 2.62e-02 GO:0009150 purine ribonucleotide metabolic process
2.16 2.37e-02 GO:0009259 ribonucleotide metabolic process
1.98 3.89e-02 GO:0072521 purine-containing compound metabolic process
1.97 1.85e-02 GO:0006325 chromatin organization
1.88 4.57e-02 GO:0006753 nucleoside phosphate metabolic process
1.88 4.57e-02 GO:0009117 nucleotide metabolic process
1.84 1.50e-02 GO:0051276 chromosome organization
1.63 3.99e-03 GO:0044248 cellular catabolic process
1.60 9.14e-10 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.58 4.32e-05 GO:0010467 gene expression
1.57 1.79e-06 GO:0090304 nucleic acid metabolic process
1.54 8.12e-10 GO:0034641 cellular nitrogen compound metabolic process
1.52 3.19e-09 GO:0006807 nitrogen compound metabolic process
1.52 2.11e-03 GO:0016070 RNA metabolic process
1.52 1.68e-02 GO:0009056 catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
1.97 1.09e-03 GO:0005730 nucleolus
1.96 4.02e-04 GO:0005694 chromosome
1.96 2.93e-03 GO:0044427 chromosomal part
1.73 7.26e-10 GO:0031981 nuclear lumen
1.70 5.59e-06 GO:0005654 nucleoplasm
1.69 5.56e-11 GO:0044428 nuclear part
1.64 8.55e-10 GO:0070013 intracellular organelle lumen
1.62 2.68e-09 GO:0043233 organelle lumen
1.61 3.29e-09 GO:0031974 membrane-enclosed lumen
1.39 2.42e-12 GO:0044446 intracellular organelle part
1.38 5.18e-12 GO:0044422 organelle part
1.36 2.44e-02 GO:0031090 organelle membrane
1.33 1.17e-08 GO:0005634 nucleus
1.33 6.21e-03 GO:0043228 non-membrane-bounded organelle
1.33 6.21e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.26 1.56e-13 GO:0043231 intracellular membrane-bounded organelle
1.26 2.05e-13 GO:0043227 membrane-bounded organelle
1.21 4.31e-11 GO:0043229 intracellular organelle
1.21 6.65e-11 GO:0043226 organelle
1.19 2.21e-13 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
2.40 1.10e-02 GO:0003924 GTPase activity
1.83 2.84e-04 GO:0017111 nucleoside-triphosphatase activity
1.79 5.57e-04 GO:0016462 pyrophosphatase activity
1.78 6.46e-04 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.78 7.48e-04 GO:0016817 hydrolase activity, acting on acid anhydrides
1.54 3.76e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.51 1.03e-04 GO:0032553 ribonucleotide binding
1.51 1.03e-04 GO:0032555 purine ribonucleotide binding
1.51 2.23e-03 GO:0005524 ATP binding
1.50 1.44e-04 GO:0017076 purine nucleotide binding
1.50 2.78e-03 GO:0032559 adenyl ribonucleotide binding
1.49 3.59e-03 GO:0030554 adenyl nucleotide binding
1.47 5.15e-05 GO:0000166 nucleotide binding
1.33 6.30e-04 GO:0003676 nucleic acid binding
1.28 6.23e-10 GO:0005515 protein binding
1.23 1.60e-03 GO:0003824 catalytic activity
1.15 4.61e-09 GO:0005488 binding