Motif ID: ATF5_CREB3.p2

Z-value: 2.562


Transcription factors associated with ATF5_CREB3.p2:

Gene SymbolEntrez IDGene Name
ATF5 22809 activating transcription factor 5
CREB3 10488 cAMP responsive element binding protein 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CREB3chr9_+_357222070.793.0e-04Click!
ATF5chr19_+_55123770-0.322.3e-01Click!


Activity profile for motif ATF5_CREB3.p2.

activity profile for motif ATF5_CREB3.p2


Sorted Z-values histogram for motif ATF5_CREB3.p2

Sorted Z-values for motif ATF5_CREB3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF5_CREB3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_12652427 4.743 NM_021961
 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr6_+_64340408 4.326 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr6_+_64339869 4.233 NM_003463
 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr6_+_64340388 4.232 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr10_-_113933457 4.097 NM_020918
 GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr2_-_156897286 3.750 NM_006186
 NR4A2
nuclear receptor subfamily 4, group A, member 2
chr17_+_64020120 3.134 NM_002734
NM_212472
 PRKAR1A

protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

chr8_+_64243741 3.089 YTHDF3
YTH domain family, member 3
chr17_+_64020155 3.027 PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr8_+_64243662 3.000 NM_152758
 YTHDF3
YTH domain family, member 3
chr5_+_56505412 2.995 NM_022913
 GPBP1
GC-rich promoter binding protein 1
chr12_+_70435176 2.953 RAB21
RAB21, member RAS oncogene family
chr5_+_56505608 2.918 GPBP1
GC-rich promoter binding protein 1
chr17_+_64020159 2.849 PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr12_+_22669352 2.847 ETNK1
ethanolamine kinase 1
chr2_+_28469275 2.838 NM_005253
 FOSL2
FOS-like antigen 2
chr6_+_89848229 2.798 PNRC1
proline-rich nuclear receptor coactivator 1
chr17_+_8279860 2.737 NM_001025579
NM_030808
 NDEL1

nudE nuclear distribution gene E homolog (A. nidulans)-like 1

chr2_+_28469172 2.724 FOSL2
FOS-like antigen 2
chr17_+_55051818 2.719 NM_004859
 CLTC
clathrin, heavy chain (Hc)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 38 entries
enrichment   p-value GO term description
3.61 3.63e-02 GO:0006888 ER to Golgi vesicle-mediated transport
1.69 1.65e-05 GO:0046907 intracellular transport
1.62 8.94e-05 GO:0006351 transcription, DNA-dependent
1.57 2.67e-02 GO:0006396 RNA processing
1.55 4.97e-10 GO:0010467 gene expression
1.55 4.22e-05 GO:0051649 establishment of localization in cell
1.54 6.02e-06 GO:0051641 cellular localization
1.54 7.30e-04 GO:0032774 RNA biosynthetic process
1.53 4.34e-08 GO:0009059 macromolecule biosynthetic process
1.52 6.79e-08 GO:0034645 cellular macromolecule biosynthetic process
1.52 6.73e-03 GO:0045184 establishment of protein localization
1.49 2.17e-02 GO:0015031 protein transport
1.48 7.30e-07 GO:0016070 RNA metabolic process
1.43 1.10e-08 GO:0044267 cellular protein metabolic process
1.43 2.56e-02 GO:0008104 protein localization
1.41 5.31e-18 GO:0044260 cellular macromolecule metabolic process
1.41 1.42e-06 GO:0090304 nucleic acid metabolic process
1.40 7.31e-07 GO:0044249 cellular biosynthetic process
1.40 9.59e-03 GO:0033036 macromolecule localization
1.39 7.79e-07 GO:0009058 biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
2.39 3.23e-03 GO:0016607 nuclear speck
1.72 1.99e-02 GO:0005815 microtubule organizing center
1.65 7.21e-05 GO:0015630 microtubule cytoskeleton
1.53 3.22e-03 GO:0044451 nucleoplasm part
1.48 1.49e-08 GO:0031981 nuclear lumen
1.47 2.78e-05 GO:0005654 nucleoplasm
1.45 4.31e-09 GO:0044428 nuclear part
1.43 1.03e-08 GO:0043233 organelle lumen
1.43 1.08e-08 GO:0070013 intracellular organelle lumen
1.42 1.70e-08 GO:0031974 membrane-enclosed lumen
1.39 1.43e-02 GO:0005783 endoplasmic reticulum
1.39 3.79e-02 GO:0005794 Golgi apparatus
1.28 7.43e-13 GO:0044422 organelle part
1.28 1.15e-12 GO:0044446 intracellular organelle part
1.26 3.71e-02 GO:0005829 cytosol
1.23 3.04e-08 GO:0005634 nucleus
1.21 3.48e-16 GO:0043227 membrane-bounded organelle
1.21 5.79e-16 GO:0043231 intracellular membrane-bounded organelle
1.20 1.72e-06 GO:0044444 cytoplasmic part
1.20 4.73e-02 GO:0043234 protein complex

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
1.57 2.17e-04 GO:0003723 RNA binding
1.41 3.79e-06 GO:0035639 purine ribonucleoside triphosphate binding
1.41 4.49e-06 GO:0032553 ribonucleotide binding
1.41 4.49e-06 GO:0032555 purine ribonucleotide binding
1.41 4.82e-06 GO:0017076 purine nucleotide binding
1.38 1.01e-03 GO:0030554 adenyl nucleotide binding
1.38 1.04e-03 GO:0032559 adenyl ribonucleotide binding
1.38 1.26e-03 GO:0005524 ATP binding
1.37 1.98e-06 GO:0000166 nucleotide binding
1.25 5.28e-04 GO:0003676 nucleic acid binding
1.22 6.19e-12 GO:0005515 protein binding
1.12 3.18e-10 GO:0005488 binding