Motif ID: CRX.p2

Z-value: 1.735


Transcription factors associated with CRX.p2:

Gene SymbolEntrez IDGene Name
CRX 1406 cone-rod homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CRXchr19_+_530169100.039.3e-01Click!


Activity profile for motif CRX.p2.

activity profile for motif CRX.p2


Sorted Z-values histogram for motif CRX.p2

Sorted Z-values for motif CRX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CRX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_69371229 1.914 NM_001013579
AWAT1
acyl-CoA wax alcohol acyltransferase 1
chr10_-_62431203 1.768 RHOBTB1
Rho-related BTB domain containing 1
chr1_-_166779825 1.738 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr9_-_103237851 1.432 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr8_-_18710575 1.420 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr22_+_21094094 1.413


chrX_+_55666557 1.406 NM_198451
FOXR2
forkhead box R2
chrX_-_131401319 1.373 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chrX_-_53646332 1.361 HUWE1
HECT, UBA and WWE domain containing 1
chrX_-_83644054 1.313 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr1_+_166812466 1.281 NM_002995
XCL1
chemokine (C motif) ligand 1
chrX_+_110074124 1.279 NM_001128166
NM_001128167
PAK3

p21 protein (Cdc42/Rac)-activated kinase 3

chr9_-_112010233 1.230 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr14_+_85069217 1.217


chr7_-_99115454 1.213 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr5_-_134290789 1.208


chr12_+_70618892 1.165 NM_173353
TPH2
tryptophan hydroxylase 2
chr2_-_158008763 1.162 NM_004288
CYTIP
cytohesin 1 interacting protein
chr12_+_26017954 1.144 NM_001164747
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chrX_-_70248022 1.139 NM_000206
IL2RG
interleukin 2 receptor, gamma
chrX_+_69404879 1.135 NM_004312
ARR3
arrestin 3, retinal (X-arrestin)
chrX_+_110252960 1.134 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chrX_+_38096679 1.130 NM_000531
OTC
ornithine carbamoyltransferase
chr1_+_246635918 1.108 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chrX_-_129347101 1.105 NM_178471
GPR119
G protein-coupled receptor 119
chr11_-_19038803 1.097 NM_054030
MRGPRX2
MAS-related GPR, member X2
chr21_+_30690165 1.069 NM_181599
KRTAP13-1
keratin associated protein 13-1
chr2_-_55090759 1.053 NM_007008
RTN4
reticulon 4
chr9_-_99740243 1.045 NM_197978
HEMGN
hemogen
chr3_-_15538164 1.002 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chr22_+_21370394 0.989 IGL@
immunoglobulin lambda locus
chr1_+_159032551 0.985 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chrX_+_17563333 0.955 NM_001136024
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr7_+_129057152 0.943 NM_001040110
NRF1
nuclear respiratory factor 1
chr10_-_46039941 0.928 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr11_-_1563056 0.926 NM_001005922
KRTAP5-1
keratin associated protein 5-1
chr3_-_47909001 0.924 MAP4
microtubule-associated protein 4
chr16_-_46823682 0.921 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr1_+_207823667 0.916 NM_020439
CAMK1G
calcium/calmodulin-dependent protein kinase IG
chrX_+_100220491 0.902 NM_021637
TMEM35
transmembrane protein 35
chr1_+_39569396 0.901 NM_033044
MACF1
microtubule-actin crosslinking factor 1
chr12_+_10015274 0.888 NM_138337
NM_201623
CLEC12A

C-type lectin domain family 12, member A

chr19_+_41872141 0.882 NM_152603
ZNF567
zinc finger protein 567
chr15_-_88023576 0.879 NM_001145311
NM_002666
PLIN1

perilipin 1

chr1_-_246869181 0.874 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr13_-_102209422 0.865 NM_001146197
C13orf40
chromosome 13 open reading frame 40
chr6_-_144427340 0.842 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr1_+_81544432 0.831 LPHN2
latrophilin 2
chr8_-_7207899 0.809 NM_001164457
ZNF705G
zinc finger protein 705G
chr15_-_73818013 0.809


chr15_+_79213660 0.803 NM_173528
C15orf26
chromosome 15 open reading frame 26
chr22_-_36305883 0.788 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr18_+_31488530 0.784 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr4_+_56731117 0.783 NM_020722
KIAA1211
KIAA1211
chr15_-_50270856 0.783 NM_016194
GNB5
guanine nucleotide binding protein (G protein), beta 5
chrX_-_24600661 0.780 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chrX_+_144710557 0.767 NM_001144006
NM_001144008
NM_001144009
NM_001144010
SLITRK2



SLIT and NTRK-like family, member 2



chr13_+_42034871 0.761 NM_033012
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr5_-_36027100 0.760 NM_152404
UGT3A1
UDP glycosyltransferase 3 family, polypeptide A1
chr9_+_4829763 0.760 RCL1
RNA terminal phosphate cyclase-like 1
chr1_-_156635879 0.755 NM_001004475
OR10T2
olfactory receptor, family 10, subfamily T, member 2
chrX_-_106248674 0.753 RBM41
RNA binding motif protein 41
chr3_-_99236520 0.747 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr11_-_6148131 0.744 NM_001004052
OR52B2
olfactory receptor, family 52, subfamily B, member 2
chr13_-_32658215 0.733 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr4_-_159863889 0.732 NM_005038
PPID
peptidylprolyl isomerase D
chr1_-_47428310 0.729 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr8_-_82522175 0.727 NM_002677
PMP2
peripheral myelin protein 2
chr17_+_35718948 0.724 NM_000964
RARA
retinoic acid receptor, alpha
chr5_-_34020445 0.723 NM_001012509
NM_016180
SLC45A2

solute carrier family 45, member 2

chr17_+_65612589 0.723 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr6_-_52217185 0.722 NM_052872
IL17F
interleukin 17F
chrX_+_18618965 0.721 NM_006240
NM_152224
NM_152226
PPEF1


protein phosphatase, EF-hand calcium binding domain 1


chrX_-_111809929 0.720 NM_178175
LHFPL1
lipoma HMGIC fusion partner-like 1
chr3_-_48015264 0.717 MAP4
microtubule-associated protein 4
chr2_-_180580024 0.711 NM_020943
CWC22
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr6_-_138935359 0.702 NM_020464
NHSL1
NHS-like 1
chr17_+_3065661 0.701 NM_014565
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr11_+_69176391 0.697 CCND1
cyclin D1
chr14_+_69993969 0.697 NM_003813
ADAM21
ADAM metallopeptidase domain 21
chr4_+_187307320 0.696 NM_001006655
FAM149A
family with sequence similarity 149, member A
chr9_+_115678365 0.694 NM_133374
ZNF618
zinc finger protein 618
chr12_+_55201854 0.691 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr12_+_29267863 0.688 NM_018099
FAR2
fatty acyl CoA reductase 2
chr10_+_95838801 0.684 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr4_-_40631397 0.670 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr1_-_156056456 0.669 NM_001159397
NM_001159398
NM_052938
FCRL1


Fc receptor-like 1


chr11_-_48330574 0.668 NM_001005513
OR4C45
olfactory receptor, family 4, subfamily C, member 45
chr11_+_113280727 0.661 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr8_-_8788149 0.660 NM_004225
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr12_-_88573949 0.659 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr18_+_59733724 0.656 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr4_+_110968594 0.654 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr18_+_50049846 0.654 NM_007195
POLI
polymerase (DNA directed) iota
chr1_-_47428190 0.651 PDZK1IP1
PDZK1 interacting protein 1
chr4_+_114190233 0.646 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr12_-_4358968 0.635 NM_020638
FGF23
fibroblast growth factor 23
chr12_-_11066436 0.630 NM_176888
TAS2R19
taste receptor, type 2, member 19
chr3_-_113701073 0.627 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chr15_-_75364387 0.620 NM_024776
PEAK1
NKF3 kinase family member
chr8_+_32698892 0.619 NM_001159996
NRG1
neuregulin 1
chr19_+_23091616 0.619 ZNF730
zinc finger protein 730
chrX_-_111953009 0.618 NM_001113490
AMOT
angiomotin
chr1_+_119712918 0.614 NM_001005783
NM_016527
HAO2

hydroxyacid oxidase 2 (long chain)

chr12_-_68291208 0.612 NM_201550
LRRC10
leucine rich repeat containing 10
chrX_-_106248706 0.608 NM_001171080
NM_018301
RBM41

RNA binding motif protein 41

chrX_+_135558001 0.605 NM_000074
CD40LG
CD40 ligand
chr12_-_131816604 0.603 ANKLE2
ankyrin repeat and LEM domain containing 2
chr6_+_163904564 0.602 QKI
quaking homolog, KH domain RNA binding (mouse)
chr9_-_70345549 0.601 NM_153237
C9orf71
chromosome 9 open reading frame 71
chr22_-_35011703 0.599 MYH9
myosin, heavy chain 9, non-muscle
chr11_+_114054409 0.593 NM_182495
FAM55B
family with sequence similarity 55, member B
chr14_-_54948290 0.592 NM_014924
ATG14
ATG14 autophagy related 14 homolog (S. cerevisiae)
chrX_-_63362227 0.589 NM_130388
ASB12
ankyrin repeat and SOCS box containing 12
chr1_+_234748187 0.583 NM_201545
LGALS8
lectin, galactoside-binding, soluble, 8
chr11_-_117628211 0.581 NM_198275
MPZL3
myelin protein zero-like 3
chr6_-_133008834 0.578 NM_138327
TAAR1
trace amine associated receptor 1
chrX_-_57180782 0.567 NM_019003
SPIN2A
spindlin family, member 2A
chr9_-_74757735 0.566 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr5_-_74568458 0.565 NM_001164443
ANKRD31
ankyrin repeat domain 31
chr3_+_185377430 0.562 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr1_+_154386358 0.561 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr4_-_123596921 0.560 NM_000586
IL2
interleukin 2
chr6_-_132952517 0.554 NM_003967
TAAR5
trace amine associated receptor 5
chrX_+_142794838 0.551 NM_001012989
UBE2NL
ubiquitin-conjugating enzyme E2N-like
chr1_-_53380709 0.550 NM_006671
SLC1A7
solute carrier family 1 (glutamate transporter), member 7
chr10_-_101831579 0.550 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr3_+_125586241 0.550 KALRN
kalirin, RhoGEF kinase
chr15_+_60838053 0.548 TLN2
talin 2
chr21_+_37377116 0.544 NM_003316
TTC3
tetratricopeptide repeat domain 3
chr3_-_47073910 0.544 SETD2
SET domain containing 2
chr3_-_54937001 0.539 NM_020678
LRTM1
leucine-rich repeats and transmembrane domains 1
chr21_-_30791298 0.537 NM_181610
KRTAP19-4
keratin associated protein 19-4
chr18_+_27281729 0.534 NM_001944
DSG3
desmoglein 3
chr5_+_161045235 0.534 NM_000811
GABRA6
gamma-aminobutyric acid (GABA) A receptor, alpha 6
chr1_-_26266571 0.531 NM_032588
TRIM63
tripartite motif containing 63
chr2_-_65013070 0.530 LOC400958
hypothetical LOC400958
chr15_+_57691272 0.530 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr8_-_67253234 0.525 NM_000756
CRH
corticotropin releasing hormone
chr1_+_158426908 0.524 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr11_-_127962662 0.524 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr7_-_132371208 0.522 EEF1G
eukaryotic translation elongation factor 1 gamma
chr5_-_159672060 0.516 NM_024565
CCNJL
cyclin J-like
chr1_+_143326315 0.515 NM_001037675
NBPF10
NBPF9
NBPF8
neuroblastoma breakpoint family, member 10
neuroblastoma breakpoint family, member 9
neuroblastoma breakpoint family, member 8
chr1_+_116744992 0.513 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chrX_+_111005934 0.512 NM_001195576
NM_001195578
LOC100329135

hypothetical LOC100329135

chr12_-_89976261 0.505 NM_007035
KERA
keratocan
chr1_-_154041393 0.505 GON4L
gon-4-like (C. elegans)
chr3_+_103029523 0.503 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr19_-_13910167 0.502 NM_024825
PODNL1
podocan-like 1
chr17_+_45527507 0.501 NM_002611
PDK2
pyruvate dehydrogenase kinase, isozyme 2
chrX_-_110542040 0.498 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr6_+_57290357 0.495 NM_000947
PRIM2
primase, DNA, polypeptide 2 (58kDa)
chrX_-_106033202 0.493 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr11_+_123945102 0.492 NM_001005194
OR8A1
olfactory receptor, family 8, subfamily A, member 1
chr9_-_35640852 0.492 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr5_-_95794416 0.491 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr1_-_246045653 0.488 NM_001001966
OR14A16
olfactory receptor, family 14, subfamily A, member 16
chr9_+_96561750 0.488 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr21_+_30937053 0.487 NM_001128077
KRTAP20-3
keratin associated protein 20-3
chr7_+_111850367 0.487 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr17_+_31195760 0.485 TAF15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chr11_+_66499323 0.485 NM_001136485
C11orf86
chromosome 11 open reading frame 86
chr11_-_57947358 0.484 NM_001005566
OR5B2
olfactory receptor, family 5, subfamily B, member 2
chr3_+_101316463 0.483 NM_001167924
C3orf26
chromosome 3 open reading frame 26
chr1_+_150948146 0.481 NM_178356
LCE4A
late cornified envelope 4A
chr12_-_10870134 0.481 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr10_-_82039158 0.479 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr12_+_54172413 0.478 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr7_+_57513824 0.477 NM_001159279
ZNF716
zinc finger protein 716
chr9_+_107249897 0.474 NM_001145313
NM_031919
NM_207647
FSD1L


fibronectin type III and SPRY domain containing 1-like


chr11_-_104274606 0.474 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr12_+_53809731 0.470 NM_001005243
OR9K2
olfactory receptor, family 9, subfamily K, member 2
chr1_-_158883666 0.468 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr10_-_75005421 0.465 NM_152586
USP54
ubiquitin specific peptidase 54
chr3_-_61703850 0.463


chr3_+_99484421 0.462 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chr11_+_93394025 0.462 NM_001098672
HEPHL1
hephaestin-like 1
chrX_+_99786044 0.461 SRPX2
sushi-repeat containing protein, X-linked 2
chrX_+_103181171 0.457 NM_001164416
H2BFM
H2B histone family, member M
chr1_-_204455269 0.456 NM_001007544
C1orf186
chromosome 1 open reading frame 186
chr8_-_110730183 0.456 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr5_-_16795336 0.456 MYO10
myosin X
chr3_-_194579207 0.455 NM_198505
ATP13A5
ATPase type 13A5
chr3_-_159872960 0.454 NM_020169
LXN
latexin
chrX_-_102234606 0.452 NM_022052
NXF3
nuclear RNA export factor 3
chr1_+_146843980 0.448 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr7_+_93373755 0.446 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chrX_-_77801480 0.446 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr5_-_22248630 0.445 CDH12
cadherin 12, type 2 (N-cadherin 2)
chrX_-_21586337 0.443 NM_153270
KLHL34
kelch-like 34 (Drosophila)
chr5_-_79322549 0.442 NM_001010891
NM_001167741
MTX3

metaxin 3

chr1_-_156923111 0.440 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr10_-_98280299 0.439 TM9SF3
transmembrane 9 superfamily member 3
chr10_-_15237351 0.439 LOC100192204
peptidylprolyl isomerase A pseudogene
chr10_+_118340460 0.438 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chr11_-_66877519 0.437 NM_021173
POLD4
polymerase (DNA-directed), delta 4
chr19_-_63177713 0.437 NM_152474
C19orf18
chromosome 19 open reading frame 18
chrX_-_109570113 0.436 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr8_+_118216517 0.434 NM_001172814
NM_173851
SLC30A8

solute carrier family 30 (zinc transporter), member 8


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.10 2.48e-15 GO:0007600 sensory perception
2.40 5.27e-13 GO:0007606 sensory perception of chemical stimulus
1.75 2.23e-12 GO:0050877 neurological system process
2.43 6.37e-12 GO:0007608 sensory perception of smell
1.62 6.00e-11 GO:0003008 system process
1.16 4.31e-03 GO:0050896 response to stimulus
1.17 3.63e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.22 1.55e-04 GO:0071944 cell periphery
1.22 2.48e-04 GO:0005886 plasma membrane
1.18 2.82e-04 GO:0031224 intrinsic to membrane
1.18 4.47e-04 GO:0016021 integral to membrane
1.15 7.14e-04 GO:0044425 membrane part
4.56 9.56e-03 GO:0001750 photoreceptor outer segment

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.52 2.58e-13 GO:0004984 olfactory receptor activity
1.89 8.04e-11 GO:0004930 G-protein coupled receptor activity
1.67 6.66e-10 GO:0004888 transmembrane receptor activity
1.54 6.97e-09 GO:0004872 receptor activity
1.47 1.78e-08 GO:0004871 signal transducer activity
1.47 1.78e-08 GO:0060089 molecular transducer activity