Motif ID: E2F1..5.p2

Z-value: 2.234


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F3chr6_+_205100190.504.9e-02Click!
E2F4chr16_+_65783599-0.505.0e-02Click!
E2F1chr20_-_317378150.485.8e-02Click!
E2F5chr8_+_862871610.467.3e-02Click!
E2F2chr1_-_23729871-0.175.2e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_120378052 2.915 NM_019071
NM_198267
 ING3

inhibitor of growth family, member 3

chr10_+_62208256 2.545 CDK1
cyclin-dependent kinase 1
chr10_+_62208094 2.536 NM_001170406
NM_001170407
NM_001786
NM_033379
 CDK1



cyclin-dependent kinase 1



chr2_+_173927783 2.156 NM_031942
NM_145810
 CDCA7

cell division cycle associated 7

chr10_+_96295511 1.952 NM_018063
 HELLS
helicase, lymphoid-specific
chr1_+_143920424 1.787 NM_203458
 NOTCH2NL
notch 2 N-terminal like
chr7_+_93977267 1.605 CASD1
CAS1 domain containing 1
chr6_+_20510019 1.595 NM_001949
 E2F3
E2F transcription factor 3
chr11_+_86426518 1.594 NM_001168724
NM_022918
 TMEM135

transmembrane protein 135

chr1_+_26671548 1.552 HMGN2
high-mobility group nucleosomal binding domain 2
chr5_+_139473873 1.482 NM_005859
 PURA
purine-rich element binding protein A
chrX_+_44617346 1.476 NM_021140
 KDM6A
lysine (K)-specific demethylase 6A
chr2_+_48395271 1.464 NM_002158
 FOXN2
forkhead box N2
chr1_+_113734997 1.423 NM_001142782
NM_152900
 MAGI3

membrane associated guanylate kinase, WW and PDZ domain containing 3

chr5_+_56505608 1.419 GPBP1
GC-rich promoter binding protein 1
chr1_+_210848726 1.395 ATF3
activating transcription factor 3
chr1_+_210848763 1.345 ATF3
activating transcription factor 3
chr15_+_97923655 1.303 NM_001130926
NM_001130927
NM_001171894
NM_005587
 MEF2A



myocyte enhancer factor 2A



chr13_+_97426713 1.293 IPO5
importin 5
chr1_+_6767968 1.260 NM_001195563
NM_015215
 CAMTA1

calmodulin binding transcription activator 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 88 entries
enrichment   p-value GO term description
6.32 2.00e-03 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
6.32 7.31e-03 GO:0007062 sister chromatid cohesion
4.37 7.09e-12 GO:0065004 protein-DNA complex assembly
4.26 5.37e-10 GO:0031497 chromatin assembly
4.25 8.51e-12 GO:0071824 protein-DNA complex subunit organization
4.21 3.91e-09 GO:0006334 nucleosome assembly
4.10 3.97e-02 GO:0051318 G1 phase
3.93 1.48e-08 GO:0034728 nucleosome organization
3.69 3.36e-10 GO:0006333 chromatin assembly or disassembly
3.46 8.86e-08 GO:0006323 DNA packaging
3.41 1.21e-02 GO:0031124 mRNA 3'-end processing
3.22 1.26e-07 GO:0071103 DNA conformation change
2.89 4.63e-02 GO:0006402 mRNA catabolic process
2.79 7.17e-06 GO:0006260 DNA replication
2.76 9.41e-03 GO:0051320 S phase
2.73 7.67e-04 GO:0000082 G1/S transition of mitotic cell cycle
2.69 2.29e-02 GO:0000084 S phase of mitotic cell cycle
2.57 3.36e-02 GO:0050657 nucleic acid transport
2.57 3.36e-02 GO:0050658 RNA transport
2.57 3.36e-02 GO:0051236 establishment of RNA localization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 46 entries
enrichment   p-value GO term description
4.49 2.99e-07 GO:0000786 nucleosome
3.78 7.05e-08 GO:0032993 protein-DNA complex
3.45 4.64e-02 GO:0000792 heterochromatin
3.36 1.74e-15 GO:0000785 chromatin
3.28 2.32e-02 GO:0034708 methyltransferase complex
3.28 2.32e-02 GO:0035097 histone methyltransferase complex
2.78 2.38e-02 GO:0000790 nuclear chromatin
2.72 4.95e-02 GO:0071013 catalytic step 2 spliceosome
2.65 3.46e-16 GO:0044427 chromosomal part
2.53 2.93e-06 GO:0016604 nuclear body
2.51 1.17e-16 GO:0005694 chromosome
2.38 1.58e-02 GO:0005681 spliceosomal complex
2.38 3.05e-02 GO:0016607 nuclear speck
2.34 1.06e-02 GO:0031965 nuclear membrane
2.31 4.91e-05 GO:0005635 nuclear envelope
2.31 3.67e-03 GO:0044454 nuclear chromosome part
2.30 2.02e-02 GO:0000775 chromosome, centromeric region
2.23 1.19e-03 GO:0000228 nuclear chromosome
2.04 9.23e-11 GO:0044451 nucleoplasm part
2.03 6.43e-21 GO:0005654 nucleoplasm

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
3.89 1.84e-02 GO:0019205 nucleobase, nucleoside, nucleotide kinase activity
1.60 8.30e-04 GO:0003723 RNA binding
1.53 4.66e-11 GO:0003677 DNA binding
1.51 4.29e-16 GO:0003676 nucleic acid binding
1.46 4.25e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.45 1.30e-07 GO:0000166 nucleotide binding
1.43 3.74e-04 GO:0030554 adenyl nucleotide binding
1.43 4.22e-04 GO:0032559 adenyl ribonucleotide binding
1.42 1.04e-03 GO:0005524 ATP binding
1.39 2.08e-04 GO:0017076 purine nucleotide binding
1.39 3.35e-04 GO:0032553 ribonucleotide binding
1.39 3.35e-04 GO:0032555 purine ribonucleotide binding
1.38 6.00e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.27 8.52e-16 GO:0005515 protein binding
1.15 2.43e-16 GO:0005488 binding