Motif ID: EGR1..3.p2

Z-value: 2.423


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR3chr8_-_22606653-0.411.1e-01Click!
EGR2chr10_-_64246129-0.292.8e-01Click!
EGR1chr5_+_1378290770.049.0e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_60663842 5.184 NM_020928
 ZSWIM6
zinc finger, SWIM-type containing 6
chr2_+_109112428 4.720 NM_001099289
 SH3RF3
SH3 domain containing ring finger 3
chr12_+_6907646 3.991 NM_001940
 ATN1
atrophin 1
chr2_+_191222077 3.701 NM_005966
 NAB1
NGFI-A binding protein 1 (EGR1 binding protein 1)
chr3_-_88190737 3.522 NM_001008390
NM_003663
 CGGBP1

CGG triplet repeat binding protein 1

chr12_+_50271283 3.197 NM_014191
 SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr13_+_19430906 3.044 NM_001190965
 ZMYM2
zinc finger, MYM-type 2
chr5_+_139473873 2.793 NM_005859
 PURA
purine-rich element binding protein A
chr22_+_49459935 2.652 NM_001080420
 SHANK3
SH3 and multiple ankyrin repeat domains 3
chr13_+_19430881 2.541 ZMYM2
zinc finger, MYM-type 2
chr8_+_16929116 2.524 NM_181723
 EFHA2
EF-hand domain family, member A2
chr14_+_70444191 2.475 PCNX
pecanex homolog (Drosophila)
chr13_+_19430788 2.286 NM_003453
NM_197968
NM_001190964
 ZMYM2


zinc finger, MYM-type 2


chr17_+_2443652 2.284 NM_000430
 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr21_+_16024241 2.150 NM_013396
 USP25
ubiquitin specific peptidase 25
chr6_+_36272506 2.131 NM_015695
 BRPF3
bromodomain and PHD finger containing, 3
chr17_+_11864841 2.055 NM_003010
 MAP2K4
mitogen-activated protein kinase kinase 4
chr10_+_98582005 1.962 NM_001170765
NM_001170766
 LCOR

ligand dependent nuclear receptor corepressor

chr17_+_2443983 1.914 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr19_+_57492236 1.903 NM_144684
 ZNF480
zinc finger protein 480

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 138 entries
enrichment   p-value GO term description
3.30 4.18e-02 GO:0008333 endosome to lysosome transport
2.19 3.74e-02 GO:0016458 gene silencing
2.18 9.85e-03 GO:0007173 epidermal growth factor receptor signaling pathway
2.07 2.63e-03 GO:0040029 regulation of gene expression, epigenetic
1.86 6.37e-03 GO:0006184 GTP catabolic process
1.78 2.33e-07 GO:0007411 axon guidance
1.74 7.63e-09 GO:0007409 axonogenesis
1.72 1.52e-08 GO:0048667 cell morphogenesis involved in neuron differentiation
1.71 1.43e-08 GO:0048812 neuron projection morphogenesis
1.70 1.59e-04 GO:0032446 protein modification by small protein conjugation
1.67 1.34e-08 GO:0048858 cell projection morphogenesis
1.66 2.93e-08 GO:0032990 cell part morphogenesis
1.66 5.71e-05 GO:0070647 protein modification by small protein conjugation or removal
1.65 5.37e-08 GO:0000904 cell morphogenesis involved in differentiation
1.65 4.92e-03 GO:0030036 actin cytoskeleton organization
1.64 1.74e-07 GO:0031175 neuron projection development
1.63 3.58e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.62 1.65e-02 GO:0072523 purine-containing compound catabolic process
1.62 2.17e-02 GO:0006195 purine nucleotide catabolic process
1.61 1.31e-02 GO:0016567 protein ubiquitination

Gene overrepresentation in compartment category:

Showing 1 to 20 of 61 entries
enrichment   p-value GO term description
2.65 2.04e-02 GO:0000932 cytoplasmic mRNA processing body
2.64 3.71e-05 GO:0035770 RNA granule
2.63 1.31e-02 GO:0042641 actomyosin
2.36 6.31e-06 GO:0030027 lamellipodium
2.20 7.37e-05 GO:0016585 chromatin remodeling complex
2.12 1.21e-02 GO:0030117 membrane coat
2.12 1.21e-02 GO:0048475 coated membrane
2.08 4.16e-03 GO:0014069 postsynaptic density
2.01 4.34e-04 GO:0030055 cell-substrate junction
1.97 5.40e-07 GO:0031252 cell leading edge
1.95 2.90e-05 GO:0005912 adherens junction
1.95 2.66e-03 GO:0005924 cell-substrate adherens junction
1.95 4.40e-03 GO:0005925 focal adhesion
1.85 2.89e-02 GO:0019717 synaptosome
1.82 3.28e-04 GO:0070161 anchoring junction
1.81 5.71e-03 GO:0005938 cell cortex
1.75 2.84e-03 GO:0030136 clathrin-coated vesicle
1.68 2.65e-03 GO:0030135 coated vesicle
1.66 4.19e-04 GO:0005667 transcription factor complex
1.62 1.33e-02 GO:0005911 cell-cell junction

Gene overrepresentation in function category:

Showing 1 to 20 of 37 entries
enrichment   p-value GO term description
3.95 2.79e-02 GO:0070411 I-SMAD binding
2.47 6.77e-03 GO:0046332 SMAD binding
2.10 4.66e-02 GO:0019902 phosphatase binding
1.70 5.04e-05 GO:0016881 acid-amino acid ligase activity
1.70 2.72e-04 GO:0019787 small conjugating protein ligase activity
1.70 1.81e-02 GO:0004721 phosphoprotein phosphatase activity
1.68 2.24e-05 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.63 7.01e-03 GO:0004842 ubiquitin-protein ligase activity
1.59 4.96e-02 GO:0010843 promoter binding
1.57 7.34e-04 GO:0016563 transcription activator activity
1.57 1.91e-03 GO:0008134 transcription factor binding
1.55 2.06e-02 GO:0003702 RNA polymerase II transcription factor activity
1.54 4.24e-05 GO:0019904 protein domain specific binding
1.45 3.07e-03 GO:0016874 ligase activity
1.41 4.26e-05 GO:0019899 enzyme binding
1.41 1.20e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.41 1.22e-02 GO:0030695 GTPase regulator activity
1.39 8.35e-07 GO:0030528 transcription regulator activity
1.39 7.44e-03 GO:0008092 cytoskeletal protein binding
1.33 2.33e-02 GO:0043565 sequence-specific DNA binding