Motif ID: EGR1..3.p2

Z-value: 2.423


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR3chr8_-_22606653-0.411.1e-01Click!
EGR2chr10_-_64246129-0.292.8e-01Click!
EGR1chr5_+_1378290770.049.0e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_60663842 5.184 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr2_+_109112428 4.720 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr12_+_6907646 3.991 NM_001940
ATN1
atrophin 1
chr2_+_191222077 3.701 NM_005966
NAB1
NGFI-A binding protein 1 (EGR1 binding protein 1)
chr3_-_88190737 3.522 NM_001008390
NM_003663
CGGBP1

CGG triplet repeat binding protein 1

chr12_+_50271283 3.197 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr13_+_19430906 3.044 NM_001190965
ZMYM2
zinc finger, MYM-type 2
chr5_+_139473873 2.793 NM_005859
PURA
purine-rich element binding protein A
chr22_+_49459935 2.652 NM_001080420
SHANK3
SH3 and multiple ankyrin repeat domains 3
chr13_+_19430881 2.541 ZMYM2
zinc finger, MYM-type 2
chr8_+_16929116 2.524 NM_181723
EFHA2
EF-hand domain family, member A2
chr14_+_70444191 2.475 PCNX
pecanex homolog (Drosophila)
chr13_+_19430788 2.286 NM_003453
NM_197968
NM_001190964
ZMYM2


zinc finger, MYM-type 2


chr17_+_2443652 2.284 NM_000430
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr21_+_16024241 2.150 NM_013396
USP25
ubiquitin specific peptidase 25
chr6_+_36272506 2.131 NM_015695
BRPF3
bromodomain and PHD finger containing, 3
chr17_+_11864841 2.055 NM_003010
MAP2K4
mitogen-activated protein kinase kinase 4
chr10_+_98582005 1.962 NM_001170765
NM_001170766
LCOR

ligand dependent nuclear receptor corepressor

chr17_+_2443983 1.914 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr19_+_57492236 1.903 NM_144684
ZNF480
zinc finger protein 480
chr5_+_122875691 1.877 NM_001031812
NM_001044722
NM_001044723
NM_004384
CSNK1G3



casein kinase 1, gamma 3



chr12_+_19484044 1.861 AEBP2
AE binding protein 2
chr12_+_26003218 1.817 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr2_+_104838177 1.770 NM_006236
POU3F3
POU class 3 homeobox 3
chr10_-_128884411 1.751 NM_001039762
FAM196A
family with sequence similarity 196, member A
chr8_+_94998258 1.747 NM_018444
NM_001161780
NM_001161779
NM_001161781
PDP1



pyruvate dehyrogenase phosphatase catalytic subunit 1



chr2_+_235525355 1.723 NM_014521
SH3BP4
SH3-domain binding protein 4
chr13_-_40533072 1.705 ELF1
E74-like factor 1 (ets domain transcription factor)
chr6_-_151754337 1.701 NM_020861
ZBTB2
zinc finger and BTB domain containing 2
chr10_+_49184658 1.700 MAPK8
mitogen-activated protein kinase 8
chr6_-_36272951 1.700


chr10_+_89613399 1.688 PTEN
phosphatase and tensin homolog
chr13_+_75108450 1.656 LMO7
LIM domain 7
chr10_+_93160066 1.611 NM_173497
NM_182765
HECTD2

HECT domain containing 2

chr4_+_38545741 1.535 NM_138389
FAM114A1
family with sequence similarity 114, member A1
chr11_+_113815317 1.534 NM_015523
REXO2
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
chr16_+_51722285 1.526 CHD9
chromodomain helicase DNA binding protein 9
chr4_+_108965167 1.521 NM_001136258
SGMS2
sphingomyelin synthase 2
chr12_+_6745947 1.519 PTMS
parathymosin
chr12_+_104248769 1.515 C12orf75
chromosome 12 open reading frame 75
chr15_+_65145248 1.513 NM_005902
SMAD3
SMAD family member 3
chr10_-_108914277 1.512 NM_001013031
NM_052918
SORCS1

sortilin-related VPS10 domain containing receptor 1

chr19_+_16296734 1.487 KLF2
Kruppel-like factor 2 (lung)
chr12_+_6745835 1.484 PTMS
parathymosin
chr9_+_115678365 1.482 NM_133374
ZNF618
zinc finger protein 618
chr14_+_51188289 1.480 NM_152330
FRMD6
FERM domain containing 6
chr3_+_58452560 1.472 NM_001128214
KCTD6
potassium channel tetramerisation domain containing 6
chr14_+_44622916 1.459 NM_017922
PRPF39
PRP39 pre-mRNA processing factor 39 homolog (S. cerevisiae)
chr19_+_49943773 1.441 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr10_+_89613071 1.437 NM_000314
PTEN
phosphatase and tensin homolog
chr9_+_130354490 1.424 NM_001130438
NM_001195532
NM_003127
SPTAN1


spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)


chr9_+_127549437 1.401 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr2_+_54536780 1.387 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr7_+_39956480 1.378 NM_003718
NM_031267
CDK13

cyclin-dependent kinase 13

chr3_+_73128629 1.374 PPP4R2
protein phosphatase 4, regulatory subunit 2
chrX_-_152592450 1.371 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr2_+_181553333 1.362 NM_182678
NM_006357
UBE2E3

ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)

chr2_+_135392879 1.355 CCNT2
cyclin T2
chr12_+_6745729 1.350 NM_002824
PTMS
parathymosin
chr13_+_77170470 1.347 NM_001040153
SLAIN1
SLAIN motif family, member 1
chr7_+_39956633 1.335 CDK13
cyclin-dependent kinase 13
chr10_+_35665614 1.333 NM_145012
CCNY
cyclin Y
chr2_-_210744158 1.324 NM_152519
C2orf67
chromosome 2 open reading frame 67
chr3_+_73128667 1.323 PPP4R2
protein phosphatase 4, regulatory subunit 2
chr2_+_135392857 1.314 NM_001241
NM_058241
CCNT2

cyclin T2

chr10_+_116571485 1.305 NM_001135051
NM_020940
FAM160B1

family with sequence similarity 160, member B1

chr14_+_85069217 1.302


chr10_-_89613173 1.297 NM_001126049
KLLN
killin, p53-regulated DNA replication inhibitor
chr6_+_167970334 1.295 NM_001040000
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr1_+_78126787 1.277 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr10_+_111757867 1.275 ADD3
adducin 3 (gamma)
chr13_+_96884316 1.244 NM_021033
RAP2A
RAP2A, member of RAS oncogene family
chr1_+_67168470 1.242 NM_001077701
NM_001077704
MIER1

mesoderm induction early response 1 homolog (Xenopus laevis)

chr13_+_96884682 1.238 RAP2A
RAP2A, member of RAS oncogene family
chr14_+_59785739 1.236 PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr8_+_26204997 1.232 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr10_+_93160033 1.222


chr14_-_99016917 1.217 SETD3
SET domain containing 3
chr3_+_73128771 1.210 NM_174907
PPP4R2
protein phosphatase 4, regulatory subunit 2
chr1_-_9111674 1.206 NM_024980
GPR157
G protein-coupled receptor 157
chr21_+_16024157 1.200 USP25
ubiquitin specific peptidase 25
chr14_+_89934358 1.196 NM_001166106
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr4_+_3046034 1.195 NM_002111
HTT
huntingtin
chr3_-_15875932 1.194 NM_015199
ANKRD28
ankyrin repeat domain 28
chr2_+_149119029 1.184 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr19_+_16296632 1.183 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr14_-_99016866 1.177 SETD3
SET domain containing 3
chr1_+_70459686 1.170 SRSF11
serine/arginine-rich splicing factor 11
chr1_+_35507145 1.150 NM_005095
ZMYM4
zinc finger, MYM-type 4
chr14_-_99016833 1.146 SETD3
SET domain containing 3
chr11_-_94603857 1.137 NM_144665
SESN3
sestrin 3
chr4_+_48038259 1.127 NM_020846
SLAIN2
SLAIN motif family, member 2
chr12_+_129388543 1.123 PIWIL1
piwi-like 1 (Drosophila)
chr14_+_59786047 1.122 PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr6_+_89848229 1.120 PNRC1
proline-rich nuclear receptor coactivator 1
chr12_+_19483578 1.117 NM_001114176
NM_153207
AEBP2

AE binding protein 2

chr4_+_77391876 1.106 NM_001136570
FAM47E
family with sequence similarity 47, member E
chr2_+_181553613 1.094 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr16_+_68157611 1.092 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr7_+_33135376 1.090 NM_001033604
NM_001033605
NM_014451
NM_198428
BBS9



Bardet-Biedl syndrome 9



chr10_+_102749597 1.085 LZTS2
leucine zipper, putative tumor suppressor 2
chr1_+_26895108 1.079 NM_006015
NM_139135
ARID1A

AT rich interactive domain 1A (SWI-like)

chr2_+_203901160 1.073 NM_005759
ABI2
abl-interactor 2
chr11_+_12355600 1.071 NM_018222
PARVA
parvin, alpha
chr6_+_21701942 1.062 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr12_+_19484387 1.052 AEBP2
AE binding protein 2
chr14_-_60022487 1.048 NM_174978
C14orf39
chromosome 14 open reading frame 39
chr15_+_36332258 1.047 NM_152594
SPRED1
sprouty-related, EVH1 domain containing 1
chr3_+_50687675 1.038 NM_004947
DOCK3
dedicator of cytokinesis 3
chr10_+_89613347 1.035 PTEN
phosphatase and tensin homolog
chr5_-_59225377 1.021 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_109203412 1.018 NM_001135765
NM_001681
NM_170665
ATP2A2


ATPase, Ca++ transporting, cardiac muscle, slow twitch 2


chr1_-_240754620 1.017 NM_152666
PLD5
phospholipase D family, member 5
chr7_+_77005287 1.017 NM_001131008
NM_001131009
PTPN12

protein tyrosine phosphatase, non-receptor type 12

chr12_+_104248520 1.013 NM_001145199
C12orf75
chromosome 12 open reading frame 75
chr1_+_70459592 1.011 SRSF11
serine/arginine-rich splicing factor 11
chr8_+_59628281 1.007 NM_001007067
NM_001007068
NM_001007069
NM_001007070
NM_005625
SDCBP




syndecan binding protein (syntenin)




chr6_+_99389300 1.006 NM_005604
POU3F2
POU class 3 homeobox 2
chr10_+_94598204 1.004 NM_019053
EXOC6
exocyst complex component 6
chr3_+_180348818 0.999 NM_006218
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr20_+_13150417 0.999 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr6_+_149680747 0.999 TAB2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr5_+_102622305 0.997 NM_033211
C5orf30
chromosome 5 open reading frame 30
chr1_+_181259317 0.995


chr13_+_113193395 0.994 TMCO3
transmembrane and coiled-coil domains 3
chr6_-_94185780 0.994 NM_004440
EPHA7
EPH receptor A7
chr10_+_23768203 0.992 NM_001145373
OTUD1
OTU domain containing 1
chr15_-_71712605 0.989 NPTN
neuroplastin
chr1_+_183281173 0.978 NM_007212
RNF2
ring finger protein 2
chr4_-_35922288 0.977 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_+_37862398 0.974


chr14_-_99016959 0.966 NM_032233
NM_199123
SETD3

SET domain containing 3

chr10_-_102663070 0.958


chr2_+_206847658 0.958 NM_020923
ZDBF2
zinc finger, DBF-type containing 2
chr17_+_44927591 0.957 NM_002507
NGFR
nerve growth factor receptor
chr17_+_57909979 0.956 NM_001112707
NM_006852
TLK2

tousled-like kinase 2

chr2_+_228045121 0.954 NM_001135187
NM_001135188
NM_001135189
NM_004504
AGFG1



ArfGAP with FG repeats 1



chr10_+_35665403 0.952 CCNY
cyclin Y
chr1_-_99242765 0.952 NM_001010861
NM_001037317
LPPR5

lipid phosphate phosphatase-related protein type 5

chr8_+_59628352 0.949 SDCBP
syndecan binding protein (syntenin)
chr12_-_123023052 0.946 NM_025140
CCDC92
coiled-coil domain containing 92
chr15_+_71131877 0.942 NM_001172623
NM_001172624
NM_002499
NEO1


neogenin 1


chr6_+_89847183 0.939 PNRC1
proline-rich nuclear receptor coactivator 1
chr13_-_113192986 0.932 NM_001014283
DCUN1D2
DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)
chr18_+_12397894 0.928 NM_001142405
NM_006553
SLMO1

slowmo homolog 1 (Drosophila)

chr9_-_85622366 0.928 NM_001135953
NM_025211
GKAP1

G kinase anchoring protein 1

chr7_+_79602023 0.926 NM_002069
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr6_+_76368462 0.922 SENP6
SUMO1/sentrin specific peptidase 6
chrX_-_152591936 0.919 NM_001135740
PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr8_+_55533047 0.917 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr2_+_27504987 0.915 NRBP1
nuclear receptor binding protein 1
chr2_+_85051687 0.914 NM_020122
KCMF1
potassium channel modulatory factor 1
chr20_-_48980858 0.911 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr4_-_38342824 0.910 FLJ13197
hypothetical FLJ13197
chr15_+_37660568 0.904 NM_003246
THBS1
thrombospondin 1
chr4_+_81406765 0.903 NM_004464
NM_033143
FGF5

fibroblast growth factor 5

chr13_+_40533622 0.899 NM_007187
WBP4
WW domain binding protein 4 (formin binding protein 21)
chr7_-_130069399 0.897 NM_138693
KLF14
Kruppel-like factor 14
chr17_+_44340852 0.895 UBE2Z
ubiquitin-conjugating enzyme E2Z
chr12_+_55769189 0.891 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr11_+_117812282 0.888 NM_001197104
NM_005933
MLL

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

chr3_+_23822481 0.887 UBE2E1
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
chr14_-_64416307 0.880 SPTB
spectrin, beta, erythrocytic
chr15_-_71712711 0.867 NM_001161363
NM_001161364
NM_012428
NM_017455
NPTN



neuroplastin



chr14_+_66777578 0.866 NM_022474
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr2_+_192251105 0.863 NM_001031716
OBFC2A
oligonucleotide/oligosaccharide-binding fold containing 2A
chr3_+_171558143 0.858 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr17_+_5126275 0.853 NM_001083585
NM_004703
RABEP1

rabaptin, RAB GTPase binding effector protein 1

chr17_+_64020120 0.853 NM_002734
NM_212472
PRKAR1A

protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

chr10_+_171410 0.851 ZMYND11
zinc finger, MYND-type containing 11
chr17_+_44340828 0.851 UBE2Z
ubiquitin-conjugating enzyme E2Z
chr3_-_24511456 0.846 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr5_-_114660139 0.844 NM_001040440
CCDC112
coiled-coil domain containing 112
chr12_+_102982365 0.841 NM_013320
HCFC2
host cell factor C2
chr8_-_75396016 0.841 NM_020647
JPH1
junctophilin 1
chr6_-_110607496 0.835 WASF1
WAS protein family, member 1
chr7_+_35807369 0.832 SEPT7
septin 7
chr17_+_46151918 0.830 NM_006107
NM_016424
LUC7L3

LUC7-like 3 (S. cerevisiae)

chr1_+_35507197 0.827 ZMYM4
zinc finger, MYM-type 4
chr3_+_148610516 0.824 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr13_+_113193308 0.817 NM_017905
TMCO3
transmembrane and coiled-coil domains 3
chr13_+_31318828 0.812 EEF1DP3
eukaryotic translation elongation factor 1 delta pseudogene 3
chr9_+_102229283 0.811 NM_001198807
NM_080655
NM_001198805
C9orf30


chromosome 9 open reading frame 30


chr2_+_181553783 0.811 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr8_-_144313053 0.810 LY6H
lymphocyte antigen 6 complex, locus H
chr12_-_123023312 0.805 CCDC92
coiled-coil domain containing 92
chr6_+_37895570 0.799 ZFAND3
zinc finger, AN1-type domain 3
chr11_-_16992524 0.796 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr18_+_12298189 0.796 TUBB6
tubulin, beta 6
chr14_+_32478209 0.790 NM_001164749
NM_001165893
NM_022123
NM_173159
NPAS3



neuronal PAS domain protein 3



chr4_+_89147821 0.790 NM_000297
PKD2
polycystic kidney disease 2 (autosomal dominant)
chr1_+_93686154 0.788 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr17_+_64020155 0.788 PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr1_+_13948448 0.788 NM_001007257
PRDM2
PR domain containing 2, with ZNF domain
chr6_+_76367944 0.786 SENP6
SUMO1/sentrin specific peptidase 6
chr7_+_35807139 0.785 NM_001011553
NM_001788
SEPT7

septin 7

chr2_+_181554048 0.784 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr4_-_71789843 0.783 LOC641510
hypothetical LOC641510
chr10_+_102662675 0.781 FAM178A
family with sequence similarity 178, member A
chr12_+_55769153 0.780 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.26 2.30e-16 GO:0044260 cellular macromolecule metabolic process
1.11 6.01e-15 GO:0009987 cellular process
1.17 7.60e-14 GO:0050794 regulation of cellular process
1.18 2.89e-13 GO:0044237 cellular metabolic process
1.39 1.07e-12 GO:0006464 protein modification process
1.16 2.05e-12 GO:0050789 regulation of biological process
1.21 6.37e-12 GO:0043170 macromolecule metabolic process
1.36 2.24e-11 GO:0043412 macromolecule modification
1.14 3.33e-11 GO:0065007 biological regulation
1.41 7.34e-11 GO:0007399 nervous system development
1.23 9.94e-11 GO:0019222 regulation of metabolic process
1.24 7.41e-10 GO:0031323 regulation of cellular metabolic process
1.29 1.46e-09 GO:0044267 cellular protein metabolic process
1.37 2.10e-09 GO:0023051 regulation of signaling
1.24 2.47e-09 GO:0060255 regulation of macromolecule metabolic process
1.29 7.30e-09 GO:0048519 negative regulation of biological process
1.74 7.63e-09 GO:0007409 axonogenesis
1.15 1.08e-08 GO:0044238 primary metabolic process
1.67 1.34e-08 GO:0048858 cell projection morphogenesis
1.71 1.43e-08 GO:0048812 neuron projection morphogenesis
1.72 1.52e-08 GO:0048667 cell morphogenesis involved in neuron differentiation
1.22 2.17e-08 GO:0080090 regulation of primary metabolic process
1.30 2.59e-08 GO:0048523 negative regulation of cellular process
1.66 2.93e-08 GO:0032990 cell part morphogenesis
1.13 3.00e-08 GO:0008152 metabolic process
1.58 3.05e-08 GO:0030030 cell projection organization
1.65 5.37e-08 GO:0000904 cell morphogenesis involved in differentiation
1.26 5.60e-08 GO:0071842 cellular component organization at cellular level
1.47 6.44e-08 GO:0022008 neurogenesis
1.36 7.64e-08 GO:0009653 anatomical structure morphogenesis
1.26 1.06e-07 GO:0010468 regulation of gene expression
1.36 1.45e-07 GO:0009966 regulation of signal transduction
1.64 1.74e-07 GO:0031175 neuron projection development
1.57 2.20e-07 GO:0000902 cell morphogenesis
1.78 2.33e-07 GO:0007411 axon guidance
1.47 3.70e-07 GO:0048699 generation of neurons
1.54 6.84e-07 GO:0032989 cellular component morphogenesis
1.21 8.14e-07 GO:0016043 cellular component organization
1.28 8.59e-07 GO:0030154 cell differentiation
1.43 8.76e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.28 1.27e-06 GO:0048869 cellular developmental process
1.24 1.60e-06 GO:0071841 cellular component organization or biogenesis at cellular level
1.25 2.50e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.23 2.63e-06 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.21 6.48e-06 GO:0019538 protein metabolic process
1.20 7.13e-06 GO:0071840 cellular component organization or biogenesis
1.25 7.90e-06 GO:0051252 regulation of RNA metabolic process
1.41 7.94e-06 GO:0048468 cell development
1.18 9.81e-06 GO:0032502 developmental process
1.53 1.29e-05 GO:0048666 neuron development
1.24 1.35e-05 GO:0048522 positive regulation of cellular process
1.23 1.92e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.44 2.59e-05 GO:0016192 vesicle-mediated transport
1.22 3.87e-05 GO:0031326 regulation of cellular biosynthetic process
1.21 5.36e-05 GO:0009889 regulation of biosynthetic process
1.66 5.71e-05 GO:0070647 protein modification by small protein conjugation or removal
1.32 8.24e-05 GO:0051641 cellular localization
1.18 8.68e-05 GO:0007275 multicellular organismal development
1.24 9.64e-05 GO:0006355 regulation of transcription, DNA-dependent
1.33 9.71e-05 GO:0031325 positive regulation of cellular metabolic process
1.34 1.25e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.38 1.40e-04 GO:0050793 regulation of developmental process
1.70 1.59e-04 GO:0032446 protein modification by small protein conjugation
1.41 1.85e-04 GO:0046907 intracellular transport
1.46 2.40e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.47 2.71e-04 GO:0010629 negative regulation of gene expression
1.41 2.82e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.31 3.15e-04 GO:0009893 positive regulation of metabolic process
1.26 3.23e-04 GO:0016070 RNA metabolic process
1.43 3.52e-04 GO:0010628 positive regulation of gene expression
1.35 4.05e-04 GO:0032268 regulation of cellular protein metabolic process
1.34 4.21e-04 GO:0010646 regulation of cell communication
1.43 4.56e-04 GO:0051254 positive regulation of RNA metabolic process
1.20 5.23e-04 GO:0048518 positive regulation of biological process
1.20 5.31e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.32 6.85e-04 GO:0051649 establishment of localization in cell
1.39 7.81e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.18 8.29e-04 GO:0048856 anatomical structure development
1.37 9.41e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.16 1.11e-03 GO:0023052 signaling
1.41 1.18e-03 GO:0030182 neuron differentiation
1.46 1.48e-03 GO:0051253 negative regulation of RNA metabolic process
1.36 1.56e-03 GO:0009891 positive regulation of biosynthetic process
1.39 1.92e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.49 2.60e-03 GO:0061024 membrane organization
1.17 2.61e-03 GO:0006807 nitrogen compound metabolic process
2.07 2.63e-03 GO:0040029 regulation of gene expression, epigenetic
1.18 2.92e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.32 2.95e-03 GO:0006793 phosphorus metabolic process
1.32 2.95e-03 GO:0006796 phosphate metabolic process
1.41 2.97e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.49 3.43e-03 GO:0016044 cellular membrane organization
1.24 4.12e-03 GO:0006996 organelle organization
1.31 4.12e-03 GO:0051246 regulation of protein metabolic process
1.23 4.38e-03 GO:0048583 regulation of response to stimulus
1.17 4.39e-03 GO:0034641 cellular nitrogen compound metabolic process
1.41 4.45e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.26 4.76e-03 GO:0065009 regulation of molecular function
1.65 4.92e-03 GO:0030036 actin cytoskeleton organization
1.37 5.21e-03 GO:2000026 regulation of multicellular organismal development
1.44 5.48e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.45 5.48e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.27 6.02e-03 GO:0035556 intracellular signal transduction
1.44 6.21e-03 GO:0016071 mRNA metabolic process
1.86 6.37e-03 GO:0006184 GTP catabolic process
1.29 7.85e-03 GO:0044248 cellular catabolic process
1.16 8.41e-03 GO:0007165 signal transduction
1.17 8.53e-03 GO:0048731 system development
1.38 8.95e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.60 9.41e-03 GO:0010608 posttranscriptional regulation of gene expression
1.37 9.62e-03 GO:0009890 negative regulation of biosynthetic process
2.18 9.85e-03 GO:0007173 epidermal growth factor receptor signaling pathway
1.38 9.98e-03 GO:0045595 regulation of cell differentiation
1.32 1.23e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.61 1.31e-02 GO:0016567 protein ubiquitination
1.38 1.35e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.20 1.36e-02 GO:0090304 nucleic acid metabolic process
1.49 1.65e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.62 1.65e-02 GO:0072523 purine-containing compound catabolic process
1.30 1.70e-02 GO:0009892 negative regulation of metabolic process
1.62 2.17e-02 GO:0006195 purine nucleotide catabolic process
1.30 2.31e-02 GO:0032879 regulation of localization
1.31 2.55e-02 GO:0006351 transcription, DNA-dependent
1.49 2.72e-02 GO:0016568 chromatin modification
1.41 3.12e-02 GO:0044265 cellular macromolecule catabolic process
1.32 3.22e-02 GO:0051128 regulation of cellular component organization
1.38 3.32e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.63 3.58e-02 GO:0048011 nerve growth factor receptor signaling pathway
2.19 3.74e-02 GO:0016458 gene silencing
1.49 4.02e-02 GO:0018193 peptidyl-amino acid modification
1.60 4.09e-02 GO:0006897 endocytosis
1.60 4.09e-02 GO:0010324 membrane invagination
3.30 4.18e-02 GO:0008333 endosome to lysosome transport
1.35 4.35e-02 GO:0019220 regulation of phosphate metabolic process
1.35 4.35e-02 GO:0051174 regulation of phosphorus metabolic process
1.25 4.63e-02 GO:0051239 regulation of multicellular organismal process
1.42 4.83e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.30 4.92e-02 GO:0031324 negative regulation of cellular metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 6.82e-45 GO:0005622 intracellular
1.16 1.75e-44 GO:0044424 intracellular part
1.16 6.77e-27 GO:0043229 intracellular organelle
1.16 7.55e-27 GO:0043226 organelle
1.19 2.24e-26 GO:0005737 cytoplasm
1.16 1.55e-20 GO:0043227 membrane-bounded organelle
1.16 1.63e-20 GO:0043231 intracellular membrane-bounded organelle
1.23 9.64e-20 GO:0005634 nucleus
1.17 1.74e-11 GO:0044444 cytoplasmic part
1.32 8.70e-11 GO:0005829 cytosol
1.05 1.56e-09 GO:0044464 cell part
1.05 1.68e-09 GO:0005623 cell
1.54 1.68e-07 GO:0030054 cell junction
1.22 2.45e-07 GO:0043234 protein complex
1.97 5.40e-07 GO:0031252 cell leading edge
1.14 7.90e-07 GO:0044446 intracellular organelle part
1.14 2.17e-06 GO:0044422 organelle part
1.25 2.26e-06 GO:0044428 nuclear part
1.32 3.30e-06 GO:0005654 nucleoplasm
1.27 6.15e-06 GO:0031981 nuclear lumen
2.36 6.31e-06 GO:0030027 lamellipodium
1.95 2.90e-05 GO:0005912 adherens junction
2.64 3.71e-05 GO:0035770 RNA granule
1.56 3.83e-05 GO:0045202 synapse
1.17 5.55e-05 GO:0032991 macromolecular complex
1.22 5.86e-05 GO:0070013 intracellular organelle lumen
2.20 7.37e-05 GO:0016585 chromatin remodeling complex
1.21 1.18e-04 GO:0031974 membrane-enclosed lumen
1.21 1.22e-04 GO:0043233 organelle lumen
1.26 2.43e-04 GO:0005856 cytoskeleton
1.82 3.28e-04 GO:0070161 anchoring junction
1.36 3.59e-04 GO:0031982 vesicle
1.37 3.92e-04 GO:0031410 cytoplasmic vesicle
1.66 4.19e-04 GO:0005667 transcription factor complex
2.01 4.34e-04 GO:0030055 cell-substrate junction
1.37 8.89e-04 GO:0044451 nucleoplasm part
1.18 9.27e-04 GO:0043228 non-membrane-bounded organelle
1.18 9.27e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.57 1.33e-03 GO:0015629 actin cytoskeleton
1.35 1.87e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.35 1.98e-03 GO:0031988 membrane-bounded vesicle
1.68 2.65e-03 GO:0030135 coated vesicle
1.95 2.66e-03 GO:0005924 cell-substrate adherens junction
1.75 2.84e-03 GO:0030136 clathrin-coated vesicle
1.31 3.09e-03 GO:0042995 cell projection
2.08 4.16e-03 GO:0014069 postsynaptic density
1.95 4.40e-03 GO:0005925 focal adhesion
1.22 5.29e-03 GO:0012505 endomembrane system
1.53 5.39e-03 GO:0044456 synapse part
1.81 5.71e-03 GO:0005938 cell cortex
2.12 1.21e-02 GO:0030117 membrane coat
2.12 1.21e-02 GO:0048475 coated membrane
2.63 1.31e-02 GO:0042641 actomyosin
1.62 1.33e-02 GO:0005911 cell-cell junction
2.65 2.04e-02 GO:0000932 cytoplasmic mRNA processing body
1.32 2.57e-02 GO:0015630 microtubule cytoskeleton
1.25 2.72e-02 GO:0044430 cytoskeletal part
1.85 2.89e-02 GO:0019717 synaptosome
1.54 3.31e-02 GO:0016323 basolateral plasma membrane
1.44 3.64e-02 GO:0005815 microtubule organizing center
1.58 4.70e-02 GO:0030425 dendrite

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.22 5.94e-28 GO:0005515 protein binding
1.12 3.75e-25 GO:0005488 binding
1.39 8.35e-07 GO:0030528 transcription regulator activity
1.25 1.09e-06 GO:0000166 nucleotide binding
1.68 2.24e-05 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.54 4.24e-05 GO:0019904 protein domain specific binding
1.41 4.26e-05 GO:0019899 enzyme binding
1.70 5.04e-05 GO:0016881 acid-amino acid ligase activity
1.17 1.31e-04 GO:0003676 nucleic acid binding
1.70 2.72e-04 GO:0019787 small conjugating protein ligase activity
1.57 7.34e-04 GO:0016563 transcription activator activity
1.22 8.26e-04 GO:0017076 purine nucleotide binding
1.22 1.02e-03 GO:0032553 ribonucleotide binding
1.22 1.02e-03 GO:0032555 purine ribonucleotide binding
1.21 1.51e-03 GO:0008270 zinc ion binding
1.57 1.91e-03 GO:0008134 transcription factor binding
1.14 2.00e-03 GO:0046872 metal ion binding
1.22 2.07e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.45 3.07e-03 GO:0016874 ligase activity
1.13 4.59e-03 GO:0043169 cation binding
1.13 5.60e-03 GO:0043167 ion binding
2.47 6.77e-03 GO:0046332 SMAD binding
1.63 7.01e-03 GO:0004842 ubiquitin-protein ligase activity
1.39 7.44e-03 GO:0008092 cytoskeletal protein binding
1.18 9.89e-03 GO:0003677 DNA binding
1.41 1.20e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.41 1.22e-02 GO:0030695 GTPase regulator activity
1.17 1.48e-02 GO:0046914 transition metal ion binding
1.70 1.81e-02 GO:0004721 phosphoprotein phosphatase activity
1.27 2.00e-02 GO:0001071 nucleic acid binding transcription factor activity
1.27 2.00e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.55 2.06e-02 GO:0003702 RNA polymerase II transcription factor activity
1.33 2.33e-02 GO:0043565 sequence-specific DNA binding
3.95 2.79e-02 GO:0070411 I-SMAD binding
1.29 3.06e-02 GO:0003723 RNA binding
2.10 4.66e-02 GO:0019902 phosphatase binding
1.59 4.96e-02 GO:0010843 promoter binding