Motif ID: ESRRA.p2

Z-value: 1.368


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESRRAchr11_+_638296160.097.3e-01Click!


Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_540849 3.122 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr19_+_1358531 1.892 NM_018959
NM_170711
DAZAP1

DAZ associated protein 1

chr19_+_1358664 1.711 DAZAP1
DAZ associated protein 1
chr1_+_29086206 1.579 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr19_+_1358604 1.475 DAZAP1
DAZ associated protein 1
chr15_+_38520594 1.409 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr1_+_29086156 1.401 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr5_+_271447 1.397 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr12_+_131577229 1.389 NM_001142641
FBRSL1
fibrosin-like 1
chr5_+_271428 1.351 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr19_+_1358750 1.346 DAZAP1
DAZ associated protein 1
chr19_+_59796858 1.345 NM_006863
LILRA1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
chr5_+_271441 1.344 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr6_+_39124534 1.254 NM_002062
GLP1R
glucagon-like peptide 1 receptor
chr1_+_151147646 1.230 NM_005547
IVL
involucrin
chr5_+_271355 1.227 NM_004168
SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr6_+_34314545 1.209 NM_145905
HMGA1
high mobility group AT-hook 1
chr10_+_44726635 1.183 NM_001123376
TMEM72
transmembrane protein 72
chr5_+_38481392 1.111 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr19_-_4468715 1.109 NM_001080400
PLIN4
perilipin 4
chr1_+_55237193 1.097 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr1_-_19089971 1.087 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr6_+_44076281 1.077 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr22_+_29151651 1.073 NM_001003704
NM_016498
MTFP1

mitochondrial fission process 1

chr11_-_64284762 1.049 NM_001164716
NM_005609
PYGM

phosphorylase, glycogen, muscle

chr1_+_29011240 1.045 NM_000911
OPRD1
opioid receptor, delta 1
chr22_-_24088523 1.029 NM_182492
LRP5L
low density lipoprotein receptor-related protein 5-like
chr22_+_22703107 1.020 NM_001144931
LOC391322
D-dopachrome tautomerase-like
chr17_-_70367479 1.017 NM_000835
GRIN2C
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
chr10_+_80777248 0.987 PPIF
peptidylprolyl isomerase F
chr8_+_145221973 0.963 CYC1
cytochrome c-1
chr10_+_80777265 0.945 PPIF
peptidylprolyl isomerase F
chr16_-_65510230 0.943 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr1_+_15955719 0.939 FBLIM1
filamin binding LIM protein 1
chr7_+_45580704 0.917 ADCY1
adenylate cyclase 1 (brain)
chr17_+_7549138 0.916 NM_001406
EFNB3
ephrin-B3
chr1_+_29113589 0.912 NM_001166006
EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr16_-_73842884 0.906 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr16_+_55456619 0.903 NM_000339
NM_001126107
NM_001126108
SLC12A3


solute carrier family 12 (sodium/chloride transporters), member 3


chr14_-_104507862 0.902 AHNAK2
AHNAK nucleoprotein 2
chr7_+_45580606 0.897 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr11_-_780103 0.891 NM_016564
CEND1
cell cycle exit and neuronal differentiation 1
chr19_+_45807909 0.842


chrX_+_69371229 0.832 NM_001013579
AWAT1
acyl-CoA wax alcohol acyltransferase 1
chr22_+_38903825 0.831 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr9_-_116190038 0.827 AKNA
AT-hook transcription factor
chr11_-_780065 0.818 CEND1
cell cycle exit and neuronal differentiation 1
chr3_+_130730171 0.813 NM_000539
RHO
rhodopsin
chr15_+_41597097 0.801 NM_002373
MAP1A
microtubule-associated protein 1A
chr7_+_97679501 0.798 NM_177455
BHLHA15
basic helix-loop-helix family, member a15
chr7_-_158304062 0.792 ESYT2
extended synaptotagmin-like protein 2
chr15_+_62991106 0.780 NM_182703
ANKDD1A
ankyrin repeat and death domain containing 1A
chr5_-_271235 0.760 NM_145265
CCDC127
coiled-coil domain containing 127
chr2_-_128792515 0.750 NM_004807
HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chr1_-_150065176 0.727 NM_001001523
RORC
RAR-related orphan receptor C
chr7_+_116238309 0.723 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr19_+_1199548 0.716 NM_177401
MIDN
midnolin
chr11_+_65815940 0.706 NM_153266
TMEM151A
transmembrane protein 151A
chr2_+_119905812 0.698 NM_183240
TMEM37
transmembrane protein 37
chr6_+_37081387 0.698 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr11_+_65140207 0.693 NM_032223
PCNXL3
pecanex-like 3 (Drosophila)
chr12_+_6846955 0.686 TPI1
triosephosphate isomerase 1
chr12_+_6846844 0.686 NM_001159287
NM_000365
TPI1

triosephosphate isomerase 1

chr8_-_139995417 0.683 NM_152888
COL22A1
collagen, type XXII, alpha 1
chr19_+_3136860 0.676 NM_020170
NCLN
nicalin
chr1_+_151655623 0.671 NM_176823
S100A7A
S100 calcium binding protein A7A
chr1_+_226337425 0.648 NM_001024227
NM_001024228
ARF1

ADP-ribosylation factor 1

chr14_-_105245959 0.648 IGHA1
immunoglobulin heavy constant alpha 1
chr19_-_60360768 0.645 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr11_-_18704294 0.643 NM_173588
IGSF22
immunoglobulin superfamily, member 22
chr22_+_48740432 0.634 PIM3
pim-3 oncogene
chr3_-_42719322 0.630 NM_020707
HHATL
hedgehog acyltransferase-like
chr9_+_37640996 0.629 NM_014907
FRMPD1
FERM and PDZ domain containing 1
chrX_+_48505097 0.616 NM_001080489
GLOD5
glyoxalase domain containing 5
chr8_+_145221924 0.616 NM_001916
CYC1
cytochrome c-1
chr9_-_130006309 0.616 NM_001131015
NM_012127
CIZ1

CDKN1A interacting zinc finger protein 1

chr22_+_18485145 0.612 RANBP1
RAN binding protein 1
chr20_+_39402834 0.612 NM_022896
LPIN3
lipin 3
chr14_+_99220349 0.609 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr8_+_145221966 0.599 CYC1
cytochrome c-1
chr8_-_145099963 0.595 NM_201379
PLEC
plectin
chr16_-_65984836 0.595 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr12_+_103677388 0.593 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr12_+_121233615 0.593 NM_001098519
LRRC43
leucine rich repeat containing 43
chr11_+_65815911 0.587 TMEM151A
transmembrane protein 151A
chr14_+_104523660 0.583 NM_174891
C14orf79
chromosome 14 open reading frame 79
chr15_+_73281288 0.582 C15orf39
chromosome 15 open reading frame 39
chr1_+_38032045 0.580 NM_001031740
NM_001113482
MANEAL

mannosidase, endo-alpha-like

chr17_-_34014390 0.577 SRCIN1
SRC kinase signaling inhibitor 1
chr20_-_61600834 0.564 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chrX_-_13744933 0.564 GPM6B
glycoprotein M6B
chr7_+_138859213 0.560 NM_001080511
CLEC2L
C-type lectin domain family 2, member L
chr9_-_129719031 0.553 NM_175039
NM_175040
ST6GALNAC4

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

chr17_-_70430839 0.549 NM_173477
USH1G
Usher syndrome 1G (autosomal recessive)
chr19_-_54250808 0.548 NM_033142
CGB7
chorionic gonadotropin, beta polypeptide 7
chr19_+_2200112 0.545 NM_000479
AMH
anti-Mullerian hormone
chr17_-_31332568 0.545 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr19_+_7734034 0.545 NM_001144904
NM_001144905
NM_001144906
NM_001144907
NM_001144908
NM_001144909
NM_001144910
NM_001144911
NM_014257
CLEC4M








C-type lectin domain family 4, member M








chr22_+_18485095 0.541 RANBP1
RAN binding protein 1
chr3_+_180805266 0.538 NM_002492
NDUFB5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr22_+_18485076 0.536 RANBP1
RAN binding protein 1
chr1_-_1679940 0.535 NM_001198995
NADK
NAD kinase
chr10_+_80777234 0.535 PPIF
peptidylprolyl isomerase F
chr15_+_73281286 0.533 C15orf39
chromosome 15 open reading frame 39
chr16_+_658081 0.530 NM_138769
RHOT2
ras homolog gene family, member T2
chr2_-_128149112 0.530 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr9_+_130005429 0.528 NM_001005336
NM_004408
DNM1

dynamin 1

chr9_+_130005489 0.527 DNM1
dynamin 1
chr10_+_75427853 0.527 NM_003373
NM_014000
VCL

vinculin

chr10_+_80777199 0.526 NM_005729
PPIF
peptidylprolyl isomerase F
chr9_+_130005487 0.525 DNM1
dynamin 1
chr17_-_8756524 0.524 NM_014308
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chr6_-_2785682 0.520 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr22_+_18484810 0.512 NM_002882
RANBP1
RAN binding protein 1
chr15_+_73281249 0.510 NM_015492
C15orf39
chromosome 15 open reading frame 39
chr3_-_180805104 0.510 NM_020409
NM_177988
MRPL47

mitochondrial ribosomal protein L47

chr1_+_32530294 0.507 NM_004964
HDAC1
histone deacetylase 1
chr1_+_243384868 0.503 NM_018012
KIF26B
kinesin family member 26B
chr7_+_97748959 0.502 BRI3
brain protein I3
chr4_+_7096123 0.502 TADA2B
transcriptional adaptor 2B
chr1_+_32530298 0.500 HDAC1
histone deacetylase 1
chr1_+_32530289 0.495 HDAC1
histone deacetylase 1
chr1_+_9338531 0.484


chr19_+_44308224 0.484 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr19_+_17923110 0.480 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr12_+_119360274 0.476 NM_004373
COX6A1
cytochrome c oxidase subunit VIa polypeptide 1
chr14_-_102045849 0.474 NM_152326
ANKRD9
ankyrin repeat domain 9
chr4_+_7245218 0.473 NM_020777
SORCS2
sortilin-related VPS10 domain containing receptor 2
chr3_+_9720509 0.472 NM_153635
CPNE9
copine family member IX
chr10_-_97190885 0.471 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr16_+_66464492 0.469 NM_014329
EDC4
enhancer of mRNA decapping 4
chr15_-_38417564 0.468 C15orf52
chromosome 15 open reading frame 52
chr19_+_4134350 0.461 NM_133475
ANKRD24
ankyrin repeat domain 24
chr19_+_59866217 0.450 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr3_-_51971915 0.447 NM_033010
PCBP4
poly(rC) binding protein 4
chrX_-_53002900 0.447 NM_014138
FAM156A
family with sequence similarity 156, member A
chr13_+_112349358 0.446 NM_207440
C13orf35
chromosome 13 open reading frame 35
chr22_+_28032950 0.445 NM_006478
NM_152236
NM_152237
GAS2L1


growth arrest-specific 2 like 1


chr22_+_18485068 0.435 RANBP1
RAN binding protein 1
chr14_+_69021149 0.433 NM_001161498
UPF0639
UPF0639 protein
chr7_-_100630912 0.427 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr13_+_97856148 0.426


chr16_+_4370879 0.422 VASN
vasorin
chr7_+_150413814 0.418 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr1_-_13263334 0.418 NM_001012276
PRAMEF8
PRAMEF7
PRAME family member 8
PRAME family member 7
chr19_+_54238913 0.417 NM_033043
CGB
CGB5
chorionic gonadotropin, beta polypeptide
chorionic gonadotropin, beta polypeptide 5
chr19_-_1464187 0.413 NM_213604
ADAMTSL5
ADAMTS-like 5
chr16_+_658158 0.413 RHOT2
ras homolog gene family, member T2
chr14_-_102045749 0.409 ANKRD9
ankyrin repeat domain 9
chr11_+_67554653 0.409 NM_002496
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr1_-_33110668 0.405 NM_001171941
FNDC5
fibronectin type III domain containing 5
chr4_-_40212670 0.405 NM_019027
RBM47
RNA binding motif protein 47
chr19_+_59297953 0.403 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr16_+_30844707 0.402 FBXL19
F-box and leucine-rich repeat protein 19
chr2_-_172675873 0.401 DLX2
distal-less homeobox 2
chr2_-_27339278 0.401 NM_003459
SLC30A3
solute carrier family 30 (zinc transporter), member 3
chr17_+_45008473 0.401 NXPH3
neurexophilin 3
chr17_+_45778381 0.398 NM_022167
XYLT2
xylosyltransferase II
chr19_+_38867273 0.398 NM_022467
CHST8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr19_-_12028126 0.394 NM_001080404
ZNF878
zinc finger protein 878
chr11_+_43920385 0.394 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr16_-_2663375 0.391


chr19_+_2279679 0.390 SPPL2B
signal peptide peptidase-like 2B
chr22_+_35586950 0.388 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr1_+_20269239 0.388 NM_000929
PLA2G5
phospholipase A2, group V
chr15_-_76210611 0.386 NM_006383
CIB2
calcium and integrin binding family member 2
chr5_+_176807931 0.386 NM_001174102
PRR7
proline rich 7 (synaptic)
chr20_-_45848684 0.385 NM_001161841
NM_198596
SULF2

sulfatase 2

chr16_+_2528022 0.384 PDPK1
3-phosphoinositide dependent protein kinase-1
chr4_-_1827475 0.382 NM_012318
LETM1
leucine zipper-EF-hand containing transmembrane protein 1
chr11_+_1817294 0.381 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr20_-_1922393 0.380 NM_001190900
PDYN
prodynorphin
chr20_-_3696344 0.378 NM_001039140
C20orf27
chromosome 20 open reading frame 27
chr19_+_2279685 0.378 SPPL2B
signal peptide peptidase-like 2B
chrX_-_44087778 0.378 NM_025184
EFHC2
EF-hand domain (C-terminal) containing 2
chr1_+_17719405 0.377 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr11_-_75769514 0.374 NM_004705
PRKRIR
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
chr1_+_234625338 0.372 NM_080738
EDARADD
EDAR-associated death domain
chr16_+_4614820 0.372 NM_001142289
NM_001142290
NM_001142291
NM_015246
MGRN1



mahogunin, ring finger 1



chr19_-_1463997 0.371 ADAMTSL5
ADAMTS-like 5
chr16_+_2528001 0.370 PDPK1
3-phosphoinositide dependent protein kinase-1
chr6_+_36773605 0.370 RAB44
RAB44, member RAS oncogene family
chr1_-_13484119 0.366 NM_001012276
PRAMEF8
PRAMEF7
PRAME family member 8
PRAME family member 7
chr17_+_77289775 0.365 NM_012140
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr9_-_137992967 0.364 NM_016172
UBAC1
UBA domain containing 1
chr22_+_18485057 0.363 RANBP1
RAN binding protein 1
chr8_-_131098015 0.360 FAM49B
family with sequence similarity 49, member B
chr16_+_2527952 0.359 NM_002613
NM_031268
PDPK1

3-phosphoinositide dependent protein kinase-1

chrX_+_152682772 0.359 NM_001163257
NM_005393
PLXNB3

plexin B3

chr17_+_35075124 0.357 NM_003673
TCAP
titin-cap (telethonin)
chr16_+_4614959 0.352 MGRN1
mahogunin, ring finger 1
chr19_+_62434188 0.352 NM_001015879
NM_003160
NM_001015878
AURKC


aurora kinase C


chr8_-_145090892 0.351 NM_201381
PLEC
plectin
chr17_-_45619038 0.347 COL1A1
collagen, type I, alpha 1
chr3_-_10003512 0.344 NM_018447
TMEM111
transmembrane protein 111
chr22_-_43040063 0.343 NM_001099294
KIAA1644
KIAA1644
chr1_-_202726068 0.343 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr11_+_111462821 0.342 SDHD
succinate dehydrogenase complex, subunit D, integral membrane protein
chr11_+_66381077 0.342 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr13_+_113587674 0.341 GAS6
growth arrest-specific 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.48 2.07e-06 GO:0006810 transport
2.55 3.98e-06 GO:0006091 generation of precursor metabolites and energy
3.95 5.65e-06 GO:0045333 cellular respiration
1.46 7.55e-06 GO:0051234 establishment of localization
4.40 1.38e-05 GO:0022904 respiratory electron transport chain
2.80 2.63e-05 GO:0015980 energy derivation by oxidation of organic compounds
1.89 3.44e-05 GO:0055114 oxidation-reduction process
3.61 7.27e-05 GO:0022900 electron transport chain
1.37 2.13e-04 GO:0051179 localization
2.15 8.00e-03 GO:0008610 lipid biosynthetic process
4.72 1.10e-02 GO:0006119 oxidative phosphorylation
4.82 2.19e-02 GO:0042773 ATP synthesis coupled electron transport
4.82 2.19e-02 GO:0042775 mitochondrial ATP synthesis coupled electron transport
5.21 2.61e-02 GO:0006941 striated muscle contraction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.54 2.46e-14 GO:0005743 mitochondrial inner membrane
3.31 2.98e-13 GO:0019866 organelle inner membrane
2.48 3.85e-12 GO:0044429 mitochondrial part
2.83 4.62e-12 GO:0005740 mitochondrial envelope
2.86 6.56e-12 GO:0031966 mitochondrial membrane
2.16 2.75e-08 GO:0031975 envelope
2.17 2.96e-08 GO:0031967 organelle envelope
1.74 7.87e-07 GO:0005739 mitochondrion
3.95 9.54e-07 GO:0044455 mitochondrial membrane part
4.96 9.34e-06 GO:0070469 respiratory chain
1.24 6.74e-05 GO:0044444 cytoplasmic part
4.74 1.19e-04 GO:0005746 mitochondrial respiratory chain
1.17 3.26e-04 GO:0005737 cytoplasm
1.17 1.05e-03 GO:0016020 membrane
3.16 2.61e-03 GO:0030016 myofibril
3.34 3.57e-03 GO:0030017 sarcomere
2.98 6.21e-03 GO:0043292 contractile fiber
3.07 6.68e-03 GO:0044449 contractile fiber part
1.38 8.57e-03 GO:0031090 organelle membrane
1.19 1.86e-02 GO:0044422 organelle part
1.17 3.10e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.20 7.04e-04 GO:0030246 carbohydrate binding
1.80 2.29e-03 GO:0016491 oxidoreductase activity
2.61 3.68e-03 GO:0005529 sugar binding