Motif ID: EWSR1-FLI1.p2

Z-value: 0.896


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EWSR1chr22_+_279983670.505.1e-02Click!
FLI1chr11_+_1280693400.476.7e-02Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_2443983 1.531 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr17_+_2443652 1.123 NM_000430
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr18_+_44319365 0.739 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr19_-_1966628 0.730 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr10_+_23424383 0.713 NM_012228
MSRB2
methionine sulfoxide reductase B2
chr17_-_70901303 0.709 GRB2
growth factor receptor-bound protein 2
chr8_+_30361485 0.691 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr12_+_44409762 0.678 NM_152641
ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr3_-_193928038 0.669 NM_004113
FGF12
fibroblast growth factor 12
chr4_-_86106567 0.645 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr2_+_37425240 0.636 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr11_+_101485946 0.635 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr10_+_114700775 0.624 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr4_+_120029426 0.607 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr2_+_79593567 0.593 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr2_-_21106291 0.593 APOB
apolipoprotein B (including Ag(x) antigen)
chr16_-_48960186 0.593 NM_001173984
NM_013263
BRD7

bromodomain containing 7

chr19_-_55763091 0.564 NM_001080457
LRRC4B
leucine rich repeat containing 4B
chr1_+_221955876 0.552 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr1_-_180297372 0.540 NM_001009992
ZNF648
zinc finger protein 648
chr13_+_113193395 0.535 TMCO3
transmembrane and coiled-coil domains 3
chr2_-_26395420 0.517 NM_001145168
NM_001145169
GPR113

G protein-coupled receptor 113

chr19_-_52243721 0.510 NM_017854
TMEM160
transmembrane protein 160
chr14_-_53493198 0.509 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr2_-_218551786 0.500 TNS1
tensin 1
chr4_-_39044300 0.483 NM_002913
RFC1
replication factor C (activator 1) 1, 145kDa
chr14_+_69415880 0.480 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chr12_+_55808514 0.470 NM_002332
LRP1
low density lipoprotein receptor-related protein 1
chr7_-_127458231 0.470 NM_022143
LRRC4
leucine rich repeat containing 4
chr20_-_48741481 0.470


chr4_+_183302105 0.465 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr12_+_14409875 0.463 NM_018179
ATF7IP
activating transcription factor 7 interacting protein
chr12_+_44409743 0.445 ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr12_+_105692466 0.428 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr12_+_55808696 0.426 LRP1
low density lipoprotein receptor-related protein 1
chrX_+_56606686 0.412 NM_013444
UBQLN2
ubiquilin 2
chr3_-_42282665 0.411 NM_000729
CCK
cholecystokinin
chr5_+_152850276 0.407 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr10_-_14412813 0.387 NM_018027
FRMD4A
FERM domain containing 4A
chr10_+_106004457 0.382 NM_001191002
NM_004832
GSTO1

glutathione S-transferase omega 1

chr11_-_65244718 0.375 NM_032193
RNASEH2C
ribonuclease H2, subunit C
chr3_-_166397142 0.373 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr13_-_32678142 0.361 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr11_-_117628211 0.359 NM_198275
MPZL3
myelin protein zero-like 3
chr5_-_81082699 0.355 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr4_+_77391876 0.348 NM_001136570
FAM47E
family with sequence similarity 47, member E
chr12_+_88627601 0.338 LOC338758
hypothetical LOC338758
chr18_-_5620629 0.337 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr9_+_35528890 0.329 RUSC2
RUN and SH3 domain containing 2
chrX_-_49851743 0.328 NM_139289
AKAP4
A kinase (PRKA) anchor protein 4
chr2_+_113533155 0.316 NM_012275
IL1F5
interleukin 1 family, member 5 (delta)
chr13_+_28131279 0.315 POMP
proteasome maturation protein
chr17_-_31146660 0.314 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chr12_-_79855580 0.313 LIN7A
lin-7 homolog A (C. elegans)
chr3_-_193609531 0.313 NM_021032
FGF12
fibroblast growth factor 12
chr1_-_93030538 0.312 NM_005665
EVI5
ecotropic viral integration site 5
chr9_-_83494198 0.310 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr11_-_66897584 0.308 NM_013246
CLCF1
cardiotrophin-like cytokine factor 1
chr3_+_171558215 0.305 SKIL
SKI-like oncogene
chr12_-_79855618 0.302 NM_004664
LIN7A
lin-7 homolog A (C. elegans)
chr3_+_171558188 0.299 SKIL
SKI-like oncogene
chr3_-_48446405 0.295 NM_001130082
PLXNB1
plexin B1
chr13_-_74953873 0.294 NM_014832
TBC1D4
TBC1 domain family, member 4
chr9_-_106705867 0.287 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr13_+_28131140 0.283 NM_015932
POMP
proteasome maturation protein
chr3_+_77171938 0.275 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr3_-_58497913 0.273 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr6_-_53638464 0.272 NM_001003760
KLHL31
kelch-like 31 (Drosophila)
chr2_-_128155829 0.269 NM_001161404
LIMS2
LIM and senescent cell antigen-like domains 2
chr19_-_9098625 0.263 NM_001001958
OR7G3
olfactory receptor, family 7, subfamily G, member 3
chr6_-_132314004 0.261 NM_001901
CTGF
connective tissue growth factor
chr10_-_102017327 0.260 NM_018294
CWF19L1
CWF19-like 1, cell cycle control (S. pombe)
chr9_-_103397023 0.255 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr3_+_171558143 0.253 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr11_+_71605466 0.253 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr3_-_133236447 0.249 NM_130808
CPNE4
copine IV
chr13_+_113193308 0.248 NM_017905
TMCO3
transmembrane and coiled-coil domains 3
chr4_+_151218862 0.247 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr3_-_109292444 0.246 NM_001777
NM_198793
CD47

CD47 molecule

chr14_-_93665678 0.245 NM_032036
IFI27L2
interferon, alpha-inducible protein 27-like 2
chr2_-_191580567 0.240 STAT1
signal transducer and activator of transcription 1, 91kDa
chr2_+_79593679 0.239 CTNNA2
catenin (cadherin-associated protein), alpha 2
chrX_+_84385649 0.237 NM_021998
ZNF711
zinc finger protein 711
chr2_-_25418856 0.236 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr1_-_72521079 0.230


chr7_+_143043871 0.229 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr14_-_93665668 0.224 IFI27L2
interferon, alpha-inducible protein 27-like 2
chr1_+_200429740 0.219 NM_001017403
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr16_-_69277355 0.218 NM_138383
MTSS1L
metastasis suppressor 1-like
chr2_-_25418819 0.217 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr4_-_44145580 0.217 NM_198353
KCTD8
potassium channel tetramerisation domain containing 8
chr9_-_106705780 0.216 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr1_-_171442937 0.216 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr4_+_166519392 0.215 NM_001873
CPE
carboxypeptidase E
chr11_-_65244486 0.215 RNASEH2C
ribonuclease H2, subunit C
chr8_+_104222052 0.207 NM_001024372
NM_024812
BAALC

brain and acute leukemia, cytoplasmic

chr11_-_122571198 0.207 NM_024769
CLMP
CXADR-like membrane protein
chr2_+_182464910 0.206 SSFA2
sperm specific antigen 2
chr1_-_236120844 0.204 NM_021186
ZP4
zona pellucida glycoprotein 4
chr17_-_10574370 0.204 NM_001004313
TMEM220
transmembrane protein 220
chrX_+_2994852 0.202 NM_004042
ARSF
arylsulfatase F
chrX_-_85189194 0.195 NM_000390
NM_001145414
CHM

choroideremia (Rab escort protein 1)

chr9_+_114552871 0.194 NM_001012994
SNX30
sorting nexin family member 30
chr1_+_165865953 0.194 NM_052862
RCSD1
RCSD domain containing 1
chr11_+_10480891 0.193 AMPD3
adenosine monophosphate deaminase 3
chr11_-_122571046 0.191 CLMP
CXADR-like membrane protein
chr14_+_59782222 0.188 NM_177952
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr8_-_22606653 0.188 NM_004430
EGR3
early growth response 3
chr19_-_60783996 0.187 NM_152600
ZNF579
zinc finger protein 579
chr9_+_33807168 0.183 NM_017811
UBE2R2
ubiquitin-conjugating enzyme E2R 2
chr6_+_26491302 0.182 NM_001197238
NM_001197239
NM_001197240
NM_006995
NM_181531
NM_001197237
BTN2A2





butyrophilin, subfamily 2, member A2





chr1_-_223907283 0.180 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr20_+_2792688 0.175 NM_002836
PTPRA
VPS16
protein tyrosine phosphatase, receptor type, A
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr18_+_54682261 0.174 ZNF532
zinc finger protein 532
chr5_+_65258139 0.172 NM_001006600
NM_018695
ERBB2IP

erbb2 interacting protein

chr1_+_242691295 0.172 NM_001130957
NM_173807
C1orf101

chromosome 1 open reading frame 101

chr12_-_13139848 0.168 NM_031289
NM_153823
GSG1

germ cell associated 1

chr10_+_104211134 0.167 TMEM180
transmembrane protein 180
chr1_-_224993498 0.165 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chrX_+_138060 0.165 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr17_-_34607257 0.163 NM_000723
NM_199247
NM_199248
CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chr14_+_31616196 0.161 NM_001030055
NM_001173
ARHGAP5

Rho GTPase activating protein 5

chr1_+_185064654 0.160 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr3_-_65999548 0.158 NM_001033057
NM_004742
NM_015520
MAGI1


membrane associated guanylate kinase, WW and PDZ domain containing 1


chr10_+_114699953 0.158 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr3_-_56477404 0.154 NM_015576
ERC2
ELKS/RAB6-interacting/CAST family member 2
chr5_-_148422799 0.150 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr20_+_6696744 0.147 NM_001200
BMP2
bone morphogenetic protein 2
chr17_-_11841413 0.146 NM_144680
ZNF18
zinc finger protein 18
chr10_+_75211810 0.140 NM_203298
CHCHD1
coiled-coil-helix-coiled-coil-helix domain containing 1
chr3_-_188936941 0.138 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr5_-_146869613 0.134 DPYSL3
dihydropyrimidinase-like 3
chr9_-_69669550 0.134 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr8_-_22982435 0.133 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr12_-_54869511 0.132 SMARCC2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
chr9_+_34169023 0.131 UBAP1
ubiquitin associated protein 1
chr10_+_104211148 0.130 NM_024789
TMEM180
transmembrane protein 180
chr11_+_9642226 0.128 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr1_+_87153025 0.128 HS2ST1
heparan sulfate 2-O-sulfotransferase 1
chr19_-_11355882 0.126 NM_000121
EPOR
erythropoietin receptor
chr5_-_137117770 0.125 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr17_+_582406 0.125 NM_024792
FAM57A
family with sequence similarity 57, member A
chr20_-_47238082 0.125 STAU1
staufen, RNA binding protein, homolog 1 (Drosophila)
chr5_-_141981083 0.124 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr12_+_54947293 0.120 NM_001099337
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr9_+_34169036 0.119 UBAP1
ubiquitin associated protein 1
chr18_-_44189625 0.118 ZBTB7C
zinc finger and BTB domain containing 7C
chr1_-_150276114 0.116 NM_005620
S100A11
S100 calcium binding protein A11
chr6_-_46091238 0.116 NM_016929
CLIC5
chloride intracellular channel 5
chr9_+_33807213 0.115 UBE2R2
ubiquitin-conjugating enzyme E2R 2
chr15_-_77085056 0.114 NM_153815
RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr4_-_96689137 0.114 UNC5C
unc-5 homolog C (C. elegans)
chr10_-_35143900 0.113 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr1_+_109036431 0.113 NM_018061
PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chrX_-_148394570 0.112 NM_000202
NM_001166550
NM_006123
IDS


iduronate 2-sulfatase


chr7_-_94123308 0.112 SGCE
sarcoglycan, epsilon
chr12_+_107797985 0.112 NM_001917
DAO
D-amino-acid oxidase
chr1_+_165866127 0.111 RCSD1
RCSD domain containing 1
chr1_-_150276091 0.111 S100A11
S100 calcium binding protein A11
chr16_-_69277194 0.111 MTSS1L
metastasis suppressor 1-like
chr9_+_34169047 0.110 UBAP1
ubiquitin associated protein 1
chr9_-_129679760 0.110 NM_000476
AK1
adenylate kinase 1
chr1_-_72520735 0.110 NM_173808
NEGR1
neuronal growth regulator 1
chr12_-_54869568 0.110 NM_001130420
NM_003075
NM_139067
SMARCC2


SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2


chr2_-_24161033 0.109 NM_147184
NM_004881
TP53I3

tumor protein p53 inducible protein 3

chr5_-_137117539 0.109 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr7_-_99411573 0.109 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr6_+_117044334 0.109 NM_001010892
NM_001161664
RSPH4A

radial spoke head 4 homolog A (Chlamydomonas)

chr17_-_60483278 0.108


chr5_-_137117932 0.108 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr17_+_45488356 0.107 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr5_-_137117936 0.107 NM_006805
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr20_-_47238310 0.107 NM_001037328
NM_004602
NM_017452
NM_017453
NM_017454
STAU1




staufen, RNA binding protein, homolog 1 (Drosophila)




chr11_-_93223315 0.105 NM_001144871
C11orf90
chromosome 11 open reading frame 90
chr3_-_129852182 0.105 RPN1
ribophorin I
chr5_-_64100239 0.104 NM_173829
SREK1IP1
SREK1-interacting protein 1
chr5_-_137117873 0.104 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr19_+_60487345 0.103 NM_032430
BRSK1
BR serine/threonine kinase 1
chr11_+_9642182 0.103 SWAP70
SWAP switching B-cell complex 70kDa subunit
chrX_+_122923236 0.103 NM_001042750
NM_001042751
NM_006603
STAG2


stromal antigen 2


chr1_-_150276064 0.102 S100A11
S100 calcium binding protein A11
chr14_-_63079492 0.102 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr9_+_34169002 0.102 NM_001171201
NM_001171202
NM_001171203
NM_001171204
NM_016525
UBAP1




ubiquitin associated protein 1




chr2_-_114230666 0.101 NM_025181
SLC35F5
solute carrier family 35, member F5
chr16_-_24876357 0.101 ARHGAP17
Rho GTPase activating protein 17
chr20_+_41621119 0.097 SGK2
serum/glucocorticoid regulated kinase 2
chr12_-_1573591 0.096 NM_152441
FBXL14
F-box and leucine-rich repeat protein 14
chr17_-_71385651 0.096 TRIM47
tripartite motif containing 47
chr14_-_63079299 0.096 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr1_-_68071635 0.093 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr9_+_34169058 0.091 UBAP1
ubiquitin associated protein 1
chrX_+_24077649 0.089 NM_001178086
NM_001178095
NM_001178084
NM_001178085
NM_003410
ZFX




zinc finger protein, X-linked




chr3_-_15875932 0.089 NM_015199
ANKRD28
ankyrin repeat domain 28
chr11_-_66898223 0.088 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr1_-_48235148 0.088 NM_001194986
LOC388630
UPF0632 protein A
chr17_-_60483169 0.087 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr5_-_64100176 0.086 SREK1IP1
SREK1-interacting protein 1
chr12_-_9651748 0.085 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr3_+_143925545 0.083


chr5_-_101659864 0.083 NM_180991
SLCO4C1
solute carrier organic anion transporter family, member 4C1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.46 1.49e-05 GO:0000904 cell morphogenesis involved in differentiation
3.65 1.74e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
3.64 3.57e-05 GO:0007409 axonogenesis
3.05 4.64e-05 GO:0032989 cellular component morphogenesis
3.11 4.88e-05 GO:0000902 cell morphogenesis
3.01 6.37e-05 GO:0030030 cell projection organization
3.31 6.97e-05 GO:0048858 cell projection morphogenesis
3.28 8.33e-05 GO:0032990 cell part morphogenesis
3.45 1.00e-04 GO:0048812 neuron projection morphogenesis
3.25 1.76e-04 GO:0031175 neuron projection development
2.61 1.83e-04 GO:0048699 generation of neurons
2.77 4.00e-04 GO:0030182 neuron differentiation
1.96 4.11e-04 GO:0048583 regulation of response to stimulus
2.46 7.55e-04 GO:0022008 neurogenesis
2.92 8.79e-04 GO:0048666 neuron development
2.03 2.44e-03 GO:0007399 nervous system development
1.98 9.66e-03 GO:0009966 regulation of signal transduction
1.92 1.67e-02 GO:0009653 anatomical structure morphogenesis
2.88 1.91e-02 GO:0051094 positive regulation of developmental process
1.73 2.87e-02 GO:0048869 cellular developmental process
2.16 4.46e-02 GO:0048468 cell development
1.49 4.79e-02 GO:0023052 signaling
3.10 4.89e-02 GO:0007411 axon guidance
1.71 4.99e-02 GO:0030154 cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.92 4.29e-03 GO:0043005 neuron projection
2.19 6.24e-03 GO:0042995 cell projection
2.37 1.96e-02 GO:0030054 cell junction

Nothing significant found in function category.