Motif ID: EWSR1-FLI1.p2

Z-value: 0.896


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EWSR1chr22_+_279983670.505.1e-02Click!
FLI1chr11_+_1280693400.476.7e-02Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_2443983 1.531 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr17_+_2443652 1.123 NM_000430
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr18_+_44319365 0.739 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr19_-_1966628 0.730 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr10_+_23424383 0.713 NM_012228
MSRB2
methionine sulfoxide reductase B2
chr17_-_70901303 0.709 GRB2
growth factor receptor-bound protein 2
chr8_+_30361485 0.691 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr12_+_44409762 0.678 NM_152641
ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr3_-_193928038 0.669 NM_004113
FGF12
fibroblast growth factor 12
chr4_-_86106567 0.645 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr2_+_37425240 0.636 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr11_+_101485946 0.635 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr10_+_114700775 0.624 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr4_+_120029426 0.607 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr2_+_79593567 0.593 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr2_-_21106291 0.593 APOB
apolipoprotein B (including Ag(x) antigen)
chr16_-_48960186 0.593 NM_001173984
NM_013263
BRD7

bromodomain containing 7

chr19_-_55763091 0.564 NM_001080457
LRRC4B
leucine rich repeat containing 4B
chr1_+_221955876 0.552 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr1_-_180297372 0.540 NM_001009992
ZNF648
zinc finger protein 648

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
3.65 1.74e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
3.64 3.57e-05 GO:0007409 axonogenesis
3.46 1.49e-05 GO:0000904 cell morphogenesis involved in differentiation
3.45 1.00e-04 GO:0048812 neuron projection morphogenesis
3.31 6.97e-05 GO:0048858 cell projection morphogenesis
3.28 8.33e-05 GO:0032990 cell part morphogenesis
3.25 1.76e-04 GO:0031175 neuron projection development
3.11 4.88e-05 GO:0000902 cell morphogenesis
3.10 4.89e-02 GO:0007411 axon guidance
3.05 4.64e-05 GO:0032989 cellular component morphogenesis
3.01 6.37e-05 GO:0030030 cell projection organization
2.92 8.79e-04 GO:0048666 neuron development
2.88 1.91e-02 GO:0051094 positive regulation of developmental process
2.77 4.00e-04 GO:0030182 neuron differentiation
2.61 1.83e-04 GO:0048699 generation of neurons
2.46 7.55e-04 GO:0022008 neurogenesis
2.16 4.46e-02 GO:0048468 cell development
2.03 2.44e-03 GO:0007399 nervous system development
1.98 9.66e-03 GO:0009966 regulation of signal transduction
1.96 4.11e-04 GO:0048583 regulation of response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
2.92 4.29e-03 GO:0043005 neuron projection
2.37 1.96e-02 GO:0030054 cell junction
2.19 6.24e-03 GO:0042995 cell projection

Nothing significant found in function category.