Motif ID: FOXL1.p2

Z-value: 1.619


Transcription factors associated with FOXL1.p2:

Gene SymbolEntrez IDGene Name
FOXL1 2300 forkhead box L1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXL1chr16_+_85169615-0.621.0e-02Click!


Activity profile for motif FOXL1.p2.

activity profile for motif FOXL1.p2


Sorted Z-values histogram for motif FOXL1.p2

Sorted Z-values for motif FOXL1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXL1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_55053398 3.706


chr8_+_50147455 2.535 NM_001007176
C8orf22
chromosome 8 open reading frame 22
chr8_-_62764839 2.278 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr15_-_23204887 2.158 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr20_+_11846536 2.067 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr13_+_75232797 1.957 NM_015842
LMO7
LIM domain 7
chr12_+_58369392 1.908 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr6_+_132901119 1.879 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr8_-_82522175 1.836 NM_002677
PMP2
peripheral myelin protein 2
chr3_-_87408301 1.829 NM_000306
NM_001122757
POU1F1

POU class 1 homeobox 1

chr1_-_214963279 1.811 NM_001438
ESRRG
estrogen-related receptor gamma
chr4_-_44348414 1.775 NM_182592
YIPF7
Yip1 domain family, member 7
chr6_+_127940011 1.767 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr9_-_21472311 1.719 NM_176891
IFNE
interferon, epsilon
chr1_+_74473672 1.689 NM_015978
TNNI3K
TNNI3 interacting kinase
chr7_-_108311872 1.623 NM_001024607
C7orf66
chromosome 7 open reading frame 66
chr11_-_13474101 1.592 NM_000315
PTH
parathyroid hormone
chr9_-_21156609 1.563 NM_002175
IFNA21
interferon, alpha 21
chr2_+_211129567 1.553 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr17_-_26648375 1.546 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr14_-_94669547 1.536 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr12_-_44877769 1.459 SLC38A1
solute carrier family 38, member 1
chrX_-_77801480 1.456 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr8_-_102005697 1.435 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr5_-_43326922 1.413 HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr9_-_21132143 1.387 NM_002177
IFNW1
interferon, omega 1
chr18_+_59733724 1.382 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr3_-_52688768 1.377 NM_018165
NM_181042
PBRM1

polybromo 1

chr15_-_68781662 1.370 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr18_-_49944986 1.353 MBD2
methyl-CpG binding domain protein 2
chr20_+_9406460 1.340 PLCB4
phospholipase C, beta 4
chr1_+_103898844 1.329 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr5_+_86712376 1.299


chr12_+_21417068 1.293 NM_000415
IAPP
islet amyloid polypeptide
chr6_-_116553918 1.291 NM_000493
COL10A1
collagen, type X, alpha 1
chr11_-_56137553 1.243 NM_001004740
OR5M1
olfactory receptor, family 5, subfamily M, member 1
chr19_+_39402167 1.240 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr9_-_21218132 1.238 NM_021268
IFNA17
interferon, alpha 17
chr2_+_183316574 1.233 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr11_+_33319680 1.228 HIPK3
homeodomain interacting protein kinase 3
chr5_+_179934143 1.227 CNOT6
CCR4-NOT transcription complex, subunit 6
chr14_-_105785639 1.227


chr3_-_115380539 1.227 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr6_-_64087806 1.219 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr5_-_27074407 1.213 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr3_+_162697289 1.207 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr7_-_113346284 1.197 NM_002711
PPP1R3A
protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr1_+_246635918 1.185 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr2_-_55090759 1.165 NM_007008
RTN4
reticulon 4
chr14_-_30927931 1.162 NM_015473
HEATR5A
HEAT repeat containing 5A
chr3_-_166278969 1.161 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr18_-_39111243 1.157 NM_020783
SYT4
synaptotagmin IV
chr1_-_156784518 1.148 NM_001005189
OR6Y1
olfactory receptor, family 6, subfamily Y, member 1
chr2_-_215998181 1.142 FN1
fibronectin 1
chr4_+_88748704 1.141 NM_014208
DSPP
dentin sialophosphoprotein
chr20_-_14266200 1.130 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr11_-_7775064 1.120 NM_153444
OR5P2
olfactory receptor, family 5, subfamily P, member 2
chr11_-_57883117 1.115 NM_001005489
OR5B17
olfactory receptor, family 5, subfamily B, member 17
chrX_-_57180782 1.110 NM_019003
SPIN2A
spindlin family, member 2A
chr9_+_21399132 1.102 NM_002170
IFNA8
interferon, alpha 8
chr12_+_63510481 1.072


chr9_-_16717887 1.071 BNC2
basonuclin 2
chr4_+_53975597 1.064 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr7_-_81237162 1.034 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr4_+_146250978 1.032 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr17_+_58440629 1.029 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chrX_+_37750778 1.026 NM_001163335
NM_138780
SYTL5

synaptotagmin-like 5

chr5_+_65408500 1.017 ERBB2IP
erbb2 interacting protein
chr1_-_102235377 1.000 NM_058170
OLFM3
olfactomedin 3
chr1_-_150328153 0.964 NM_001008536
TCHHL1
trichohyalin-like 1
chr1_-_246869181 0.950 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr20_+_9236446 0.944 NM_000933
PLCB4
phospholipase C, beta 4
chr2_-_99412694 0.933 REV1
REV1 homolog (S. cerevisiae)
chr1_-_188713324 0.928 NM_199051
FAM5C
family with sequence similarity 5, member C
chr2_+_214984705 0.928 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr3_+_137224266 0.925 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr9_+_5646582 0.919 NM_020829
KIAA1432
KIAA1432
chrX_-_76700873 0.904 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr19_-_43608641 0.883 NM_001146202
NM_001146203
NM_001146204
NM_001146205
NM_001146206
NM_001146207
NM_170604
RASGRP4






RAS guanyl releasing protein 4






chr12_-_18134319 0.879 NM_024730
RERGL
RERG/RAS-like
chrX_+_41468351 0.878 NM_080817
GPR82
G protein-coupled receptor 82
chr9_+_124551839 0.877 NM_001004453
OR1L6
olfactory receptor, family 1, subfamily L, member 6
chr4_+_119174947 0.875 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr1_+_190811479 0.872 NM_002922
RGS1
regulator of G-protein signaling 1
chr1_+_151240846 0.872 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr12_+_28301399 0.869 NM_018318
CCDC91
coiled-coil domain containing 91
chr15_+_47502666 0.866 NM_002009
FGF7
fibroblast growth factor 7
chr6_+_50894397 0.861 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr6_-_132987106 0.858 NM_001033080
TAAR2
trace amine associated receptor 2
chr9_-_106401514 0.857 NM_001004482
OR13C5
olfactory receptor, family 13, subfamily C, member 5
chr5_+_161045235 0.854 NM_000811
GABRA6
gamma-aminobutyric acid (GABA) A receptor, alpha 6
chr6_-_133008834 0.852 NM_138327
TAAR1
trace amine associated receptor 1
chr12_+_79362256 0.850 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr8_+_104900591 0.847 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr5_+_147529488 0.845 NM_001001325
SPINK14
serine peptidase inhibitor, Kazal type 14 (putative)
chr4_+_70831387 0.844 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr9_-_13240313 0.838 NM_003829
MPDZ
multiple PDZ domain protein
chr3_-_109958723 0.830 NM_032579
RETNLB
resistin like beta
chr12_-_89976261 0.828 NM_007035
KERA
keratocan
chr2_-_210726539 0.801 C2orf67
chromosome 2 open reading frame 67
chr11_-_5766621 0.795 NM_001001913
OR52N1
olfactory receptor, family 52, subfamily N, member 1
chr7_+_93862137 0.793 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr4_+_73123712 0.790 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr6_+_54281161 0.790 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr3_-_69381995 0.789 FRMD4B
FERM domain containing 4B
chr5_+_140757787 0.784 NM_018925
NM_032099
PCDHGB5

protocadherin gamma subfamily B, 5

chr2_-_127817143 0.776 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr12_-_44919818 0.773 SLC38A1
solute carrier family 38, member 1
chrX_-_140614227 0.770 NM_145665
NM_032417
SPANXE
SPANXD
SPANXA2
SPANX family, member E
SPANX family, member D
SPANX family, member A2
chr7_+_80145461 0.768 CD36
CD36 molecule (thrombospondin receptor)
chr14_+_71065794 0.767 NM_015556
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr18_-_65766068 0.762 CD226
CD226 molecule
chr4_+_70896236 0.754 NM_001009181
NM_003154
STATH

statherin

chr21_-_30614477 0.751 NM_203405
KRTAP26-1
keratin associated protein 26-1
chr5_+_139869819 0.744


chr11_-_19180092 0.743 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr6_-_123999640 0.742 NM_006073
TRDN
triadin
chr17_-_60439764 0.731 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr11_+_36546138 0.723 NM_000448
RAG1
recombination activating gene 1
chr7_+_134114701 0.717 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr6_+_27400518 0.715 NM_032030
FKSG83
FKSG83
chr1_-_246554492 0.712 NM_001004691
OR2M7
olfactory receptor, family 2, subfamily M, member 7
chr4_-_123596921 0.707 NM_000586
IL2
interleukin 2
chr1_-_166779825 0.704 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr1_-_157003095 0.703 NM_001005185
OR6N1
olfactory receptor, family 6, subfamily N, member 1
chr12_-_10853940 0.701 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr4_-_157006827 0.701 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr4_-_64957595 0.700 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr3_+_35658852 0.695 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr9_+_42707229 0.690 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr7_+_134114912 0.688 CALD1
caldesmon 1
chrX_+_55666557 0.685 NM_198451
FOXR2
forkhead box R2
chr4_+_42590038 0.685 NM_001080476
GRXCR1
glutaredoxin, cysteine rich 1
chr3_-_78749633 0.683 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chrX_-_33139349 0.683 NM_004006
DMD
dystrophin
chr7_-_107230867 0.682 NM_000111
SLC26A3
solute carrier family 26, member 3
chr5_+_76470829 0.680


chr2_+_85619797 0.675 NM_005911
MAT2A
methionine adenosyltransferase II, alpha
chr1_+_245818284 0.675 NM_001001915
OR2G2
olfactory receptor, family 2, subfamily G, member 2
chr12_-_66905802 0.674 NM_018402
IL26
interleukin 26
chr18_+_50409387 0.671 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr5_-_146441184 0.669 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr2_+_228064531 0.668 AGFG1
ArfGAP with FG repeats 1
chr2_+_227900471 0.666 NM_020194
MFF
mitochondrial fission factor
chr11_-_55987452 0.665 NM_001004743
OR5M9
olfactory receptor, family 5, subfamily M, member 9
chr11_-_6148131 0.664 NM_001004052
OR52B2
olfactory receptor, family 52, subfamily B, member 2
chr7_+_110518297 0.660 NM_001099658
NM_001099660
NM_018334
LRRN3


leucine rich repeat neuronal 3


chr5_+_180726874 0.659 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr11_+_88550687 0.658 NM_000372
TYR
tyrosinase (oculocutaneous albinism IA)
chr3_+_150028130 0.656 NM_001871
CPB1
carboxypeptidase B1 (tissue)
chr3_-_99236520 0.654 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr7_+_113853790 0.651 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr4_-_21308415 0.651 NM_001035003
KCNIP4
Kv channel interacting protein 4
chr3_-_174341653 0.643 NM_031955
SPATA16
spermatogenesis associated 16
chr18_+_64616296 0.640 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr12_+_54045161 0.639 NM_001005497
OR6C75
olfactory receptor, family 6, subfamily C, member 75
chr10_-_121592020 0.638 MCMBP
minichromosome maintenance complex binding protein
chr4_+_71261066 0.638 NM_012390
SMR3B
SMR3A
submaxillary gland androgen regulated protein 3B
submaxillary gland androgen regulated protein 3A
chr15_+_46271158 0.637 NM_001145668
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
chr4_+_71096830 0.635 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr21_-_31049566 0.633 NM_181619
KRTAP21-1
keratin associated protein 21-1
chr3_+_190372456 0.633 NM_198485
TPRG1
tumor protein p63 regulated 1
chr2_+_166137091 0.626 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr14_+_20319049 0.625 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chrX_-_138114846 0.618 NM_001139498
NM_001139500
NM_001139501
FGF13


fibroblast growth factor 13


chr3_-_121445831 0.617 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr17_+_32807040 0.617 NM_173625
C17orf78
chromosome 17 open reading frame 78
chr1_+_69998445 0.614 NM_020794
LRRC7
leucine rich repeat containing 7
chr16_+_14187965 0.612 MKL2
MKL/myocardin-like 2
chr10_-_98280299 0.611 TM9SF3
transmembrane 9 superfamily member 3
chr1_-_148936123 0.611 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr1_+_81544432 0.610 LPHN2
latrophilin 2
chr4_+_71283383 0.605 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr14_-_105681377 0.604 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_-_207291364 0.602 NM_001093730
DYTN
dystrotelin
chr5_-_58688428 0.599 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr21_-_30796278 0.598 NM_181611
KRTAP19-5
keratin associated protein 19-5
chr4_+_157044296 0.596 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr2_-_63518589 0.595 NM_001042692
WDPCP
WD repeat containing planar cell polarity effector
chr3_-_194755281 0.594 NM_032279
ATP13A4
ATPase type 13A4
chr4_+_86615275 0.593 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr8_-_66863841 0.592 NM_002603
PDE7A
phosphodiesterase 7A
chr12_-_9252227 0.589 NM_002864
PZP
pregnancy-zone protein
chr4_-_80466177 0.588 NM_032693
NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr11_-_6005546 0.586 NM_001001917
OR56A1
olfactory receptor, family 56, subfamily A, member 1
chr9_+_74956494 0.586 NM_000700
ANXA1
annexin A1
chr4_+_74825138 0.585 NM_000584
IL8
interleukin 8
chr2_-_210876560 0.582 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr13_-_45577144 0.577 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr14_+_18447521 0.575 NM_001013354
OR11H12
olfactory receptor, family 11, subfamily H, member 12
chr14_-_106330781 0.574 IGHV5-78
immunoglobulin heavy variable 5-78 pseudogene
chr3_+_171183203 0.574 SEC62
SEC62 homolog (S. cerevisiae)
chr1_+_62835759 0.574 NM_014495
ANGPTL3
angiopoietin-like 3
chrX_-_53646332 0.571 HUWE1
HECT, UBA and WWE domain containing 1
chr9_-_21067804 0.571 NM_002176
IFNB1
interferon, beta 1, fibroblast
chr7_+_80069439 0.571 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr9_+_124477135 0.570 NM_001005234
OR1L3
olfactory receptor, family 1, subfamily L, member 3
chr11_-_84311867 0.568 DLG2
discs, large homolog 2 (Drosophila)
chr13_-_47899043 0.567 NM_001162497
LPAR6
lysophosphatidic acid receptor 6
chr15_+_64481270 0.555 MAP2K1
mitogen-activated protein kinase kinase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.79 5.23e-53 GO:0007608 sensory perception of smell
4.41 7.75e-50 GO:0007606 sensory perception of chemical stimulus
3.17 7.45e-41 GO:0007600 sensory perception
2.45 5.56e-34 GO:0050877 neurological system process
2.23 4.03e-32 GO:0003008 system process
1.45 7.10e-19 GO:0032501 multicellular organismal process
1.31 2.65e-11 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.49 6.94e-18 GO:0071944 cell periphery
1.49 9.09e-18 GO:0005886 plasma membrane
1.53 2.37e-08 GO:0005576 extracellular region
1.72 1.00e-06 GO:0044421 extracellular region part
1.74 3.25e-05 GO:0005615 extracellular space
1.20 5.20e-05 GO:0044425 membrane part
1.22 1.47e-04 GO:0016021 integral to membrane
1.21 2.27e-04 GO:0031224 intrinsic to membrane
1.15 1.28e-03 GO:0016020 membrane
2.33 1.95e-03 GO:0045111 intermediate filament cytoskeleton
2.44 2.10e-03 GO:0005882 intermediate filament
1.98 4.15e-03 GO:0005578 proteinaceous extracellular matrix
1.87 6.50e-03 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.98 1.45e-55 GO:0004984 olfactory receptor activity
3.13 1.01e-41 GO:0004930 G-protein coupled receptor activity
2.39 2.41e-30 GO:0004888 transmembrane receptor activity
2.01 4.06e-23 GO:0004872 receptor activity
1.85 2.56e-21 GO:0004871 signal transducer activity
1.85 2.56e-21 GO:0060089 molecular transducer activity
2.40 8.21e-04 GO:0005125 cytokine activity
10.55 1.70e-03 GO:0005132 interferon-alpha/beta receptor binding
1.53 4.77e-03 GO:0005102 receptor binding