Motif ID: GTF2I.p2

Z-value: 1.479


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2Ichr7_+_737099430.476.4e-02Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_138060 3.237 NM_018390
 PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr9_+_132961683 2.299 NM_001185095
NM_001185096
NM_031426
 AIF1L


allograft inflammatory factor 1-like


chr5_+_139008209 2.255 NM_016463
 CXXC5
CXXC finger protein 5
chr9_+_132961723 2.209 AIF1L
allograft inflammatory factor 1-like
chr16_+_84202515 2.115 NM_001134473
 KIAA0182
KIAA0182
chr5_+_139008667 1.812 CXXC5
CXXC finger protein 5
chr18_+_41659542 1.810 NM_213602
 SIGLEC15
sialic acid binding Ig-like lectin 15
chr17_+_7682355 1.590


chr5_+_36912595 1.473 NM_015384
NM_133433
 NIPBL

Nipped-B homolog (Drosophila)

chr16_-_71650034 1.451 NM_001164766
 ZFHX3
zinc finger homeobox 3
chr5_+_139008052 1.400 CXXC5
CXXC finger protein 5
chr6_+_149680747 1.331 TAB2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr7_+_5289079 1.310 NM_001040661
NM_153247
 SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr5_+_139008091 1.279 CXXC5
CXXC finger protein 5
chr5_-_36912487 1.210 LOC646719
hypothetical LOC646719
chr5_+_139008139 1.188 CXXC5
CXXC finger protein 5
chr17_-_34157962 1.185 NM_007144
 PCGF2
polycomb group ring finger 2
chr5_+_36912656 1.175 NIPBL
Nipped-B homolog (Drosophila)
chr1_+_224317044 1.148 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr1_+_224317030 1.145 H3F3A
H3 histone, family 3A

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 197 entries
enrichment   p-value GO term description
1.97 3.40e-02 GO:0051494 negative regulation of cytoskeleton organization
1.91 1.90e-02 GO:0022612 gland morphogenesis
1.75 1.48e-02 GO:0031098 stress-activated protein kinase signaling cascade
1.73 3.26e-02 GO:0032970 regulation of actin filament-based process
1.71 3.70e-02 GO:0000187 activation of MAPK activity
1.68 1.20e-03 GO:0070482 response to oxygen levels
1.65 8.14e-03 GO:0001666 response to hypoxia
1.63 7.05e-04 GO:0044087 regulation of cellular component biogenesis
1.61 1.24e-02 GO:0071902 positive regulation of protein serine/threonine kinase activity
1.59 3.27e-02 GO:0006936 muscle contraction
1.57 1.25e-05 GO:0033674 positive regulation of kinase activity
1.56 3.37e-02 GO:0003012 muscle system process
1.55 3.00e-05 GO:0051347 positive regulation of transferase activity
1.55 7.10e-05 GO:0045860 positive regulation of protein kinase activity
1.55 1.44e-04 GO:0001944 vasculature development
1.55 1.33e-03 GO:0000165 MAPKKK cascade
1.54 3.31e-05 GO:0071495 cellular response to endogenous stimulus
1.54 6.88e-04 GO:0001568 blood vessel development
1.54 5.44e-03 GO:0051129 negative regulation of cellular component organization
1.54 1.84e-02 GO:0043405 regulation of MAP kinase activity

Gene overrepresentation in compartment category:

Showing 1 to 20 of 36 entries
enrichment   p-value GO term description
2.60 3.92e-02 GO:0031519 PcG protein complex
1.89 8.82e-05 GO:0005925 focal adhesion
1.80 3.22e-06 GO:0005912 adherens junction
1.80 4.48e-04 GO:0030055 cell-substrate junction
1.80 6.92e-04 GO:0005924 cell-substrate adherens junction
1.71 2.42e-05 GO:0070161 anchoring junction
1.61 4.38e-04 GO:0030424 axon
1.53 7.25e-04 GO:0016323 basolateral plasma membrane
1.52 5.37e-05 GO:0015629 actin cytoskeleton
1.52 1.36e-02 GO:0031252 cell leading edge
1.48 3.60e-02 GO:0030425 dendrite
1.38 2.51e-03 GO:0043005 neuron projection
1.33 6.34e-04 GO:0030054 cell junction
1.28 2.23e-04 GO:0042995 cell projection
1.25 7.36e-03 GO:0031982 vesicle
1.25 1.44e-02 GO:0031988 membrane-bounded vesicle
1.24 3.95e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.23 1.41e-08 GO:0005829 cytosol
1.23 1.72e-04 GO:0005654 nucleoplasm
1.23 3.38e-02 GO:0031410 cytoplasmic vesicle

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
1.79 3.21e-02 GO:0031625 ubiquitin protein ligase binding
1.76 5.22e-03 GO:0005057 receptor signaling protein activity
1.44 1.57e-03 GO:0003779 actin binding
1.42 4.79e-03 GO:0016563 transcription activator activity
1.38 5.20e-10 GO:0001071 nucleic acid binding transcription factor activity
1.38 5.20e-10 GO:0003700 sequence-specific DNA binding transcription factor activity
1.38 9.87e-05 GO:0008092 cytoskeletal protein binding
1.37 3.99e-06 GO:0043565 sequence-specific DNA binding
1.37 2.81e-03 GO:0019904 protein domain specific binding
1.35 4.43e-06 GO:0019899 enzyme binding
1.32 4.22e-07 GO:0030528 transcription regulator activity
1.28 2.78e-02 GO:0004672 protein kinase activity
1.26 4.61e-04 GO:0005102 receptor binding
1.19 8.56e-33 GO:0005515 protein binding
1.07 8.90e-15 GO:0005488 binding