Motif ID: HAND1,2.p2

Z-value: 1.700


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HAND1chr5_-_1538380130.302.6e-01Click!
HAND2chr4_-_174687104-0.155.7e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_142270634 2.431 EPHB6
EPH receptor B6
chr19_+_55614006 2.426 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr1_+_557269 1.933


chr1_+_556968 1.925


chr12_+_119617060 1.918


chr2_+_204440753 1.697 NM_001037631
NM_005214
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr12_-_55917134 1.619 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr19_+_458475 1.505 NM_033513
C19orf20
chromosome 19 open reading frame 20
chr11_-_72063059 1.437 NM_002599
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr22_+_23333610 1.421 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr7_+_99654806 1.411 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr17_+_45617676 1.394


chr19_+_60279032 1.393 NM_133180
EPS8L1
EPS8-like 1
chr1_+_200358594 1.327 NM_004767
GPR37L1
G protein-coupled receptor 37 like 1
chrX_+_49718954 1.293 NM_000084
CLCN5
chloride channel 5
chr7_+_5609416 1.271 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr3_+_46894239 1.215 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr11_-_117305277 1.211 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr13_-_45640679 1.173 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr11_+_359723 1.164 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr6_+_37081387 1.154 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chrX_+_50044279 1.150 NM_033031
NM_033670
CCNB3

cyclin B3

chr1_-_199348316 1.144 NM_000069
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr19_-_4468715 1.142 NM_001080400
PLIN4
perilipin 4
chr1_+_159943385 1.128 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr14_-_105392671 1.117


chr10_-_76529253 1.110 NM_016364
DUSP13
dual specificity phosphatase 13
chr7_-_1562272 1.078 NM_001097620
TMEM184A
transmembrane protein 184A
chr3_+_150675117 1.066 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr19_-_60360768 1.058 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr19_+_750281 1.052 PTBP1
polypyrimidine tract binding protein 1
chr10_-_75080784 1.023 NM_024875
SYNPO2L
synaptopodin 2-like
chr1_-_53972464 1.019 NM_147193
GLIS1
GLIS family zinc finger 1
chrX_+_128741562 1.012 NM_018990
SASH3
SAM and SH3 domain containing 3
chr14_+_103675194 0.998 KIF26A
kinesin family member 26A
chr9_+_137577805 0.996 NM_014582
OBP2A
odorant binding protein 2A
chr19_-_47261761 0.993 NM_002088
GRIK5
glutamate receptor, ionotropic, kainate 5
chr2_+_218954995 0.971 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr12_-_52016270 0.967 NM_001173467
SP7
Sp7 transcription factor
chr20_+_57729659 0.962 NM_183244
NM_183246
PHACTR3

phosphatase and actin regulator 3

chrX_+_128741578 0.960 SASH3
SAM and SH3 domain containing 3
chrX_+_106030049 0.959 NM_001171092
CLDN2
claudin 2
chr19_-_60740246 0.956 NM_001101401
SBK2
SH3-binding domain kinase family, member 2
chrX_+_35974973 0.955 NM_173695
CXorf59
chromosome X open reading frame 59
chr5_+_148766632 0.941 LOC728264
hypothetical LOC728264
chr14_+_75058591 0.923 BATF
basic leucine zipper transcription factor, ATF-like
chr7_+_100037817 0.921 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr1_+_226404037 0.913 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr11_+_64737886 0.905 NM_001004326
SLC22A20
solute carrier family 22, member 20
chr3_-_14558591 0.895 NM_001080423
GRIP2
glutamate receptor interacting protein 2
chr10_-_5035967 0.883 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr17_+_7269658 0.881 NM_175734
C17orf74
chromosome 17 open reading frame 74
chr7_+_75977680 0.874 NM_030570
NM_182684
UPK3B

uroplakin 3B

chr13_+_112860968 0.869 NM_003891
PROZ
protein Z, vitamin K-dependent plasma glycoprotein
chr16_+_56286212 0.868 NM_032269
CCDC135
coiled-coil domain containing 135
chr11_+_2279932 0.865 TSPAN32
tetraspanin 32
chr7_+_73248308 0.864 EIF4H
eukaryotic translation initiation factor 4H
chr16_-_20246309 0.861 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr14_+_75058518 0.858 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr3_+_196933422 0.857 NM_152673
MUC20
mucin 20, cell surface associated
chr6_-_33822659 0.854 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chrX_-_63362227 0.850 NM_130388
ASB12
ankyrin repeat and SOCS box containing 12
chr6_-_30760413 0.849 KIAA1949
KIAA1949
chrX_+_69589081 0.847 DLG3
discs, large homolog 3 (Drosophila)
chr16_+_29582065 0.838 SPN
sialophorin
chr1_+_228949752 0.833 NM_006615
NM_016452
CAPN9

calpain 9

chr15_+_72687765 0.831 NM_003992
CLK3
CDC-like kinase 3
chr3_-_48576204 0.815 NM_033199
UCN2
urocortin 2
chr13_+_30207690 0.805 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr11_-_119504726 0.804 TRIM29
tripartite motif containing 29
chr11_+_2279812 0.797 NM_139022
TSPAN32
tetraspanin 32
chr3_-_13359746 0.795 NUP210
nucleoporin 210kDa
chr7_+_50106227 0.789 NM_001161834
C7orf72
chromosome 7 open reading frame 72
chr11_+_118332217 0.783 NM_006760
UPK2
uroplakin 2
chr14_-_105845570 0.782 IGHA1
immunoglobulin heavy constant alpha 1
chr1_+_17404206 0.776 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr1_+_16131633 0.766


chrX_+_152454773 0.746 NM_001001344
NM_021949
ATP2B3

ATPase, Ca++ transporting, plasma membrane 3

chr17_-_36346240 0.746 KRT23
keratin 23 (histone deacetylase inducible)
chr10_-_70846573 0.733 NM_001057
TACR2
tachykinin receptor 2
chr22_+_21053972 0.731


chr9_+_94776538 0.727 NM_033086
FGD3
FYVE, RhoGEF and PH domain containing 3
chr6_+_37030186 0.724 NM_153370
PI16
peptidase inhibitor 16
chr11_+_118463906 0.724 NM_001024382
HMBS
hydroxymethylbilane synthase
chrX_+_150635162 0.721 NM_033085
FATE1
fetal and adult testis expressed 1
chr6_-_31196174 0.718 NM_001264
CDSN
corneodesmosin
chr22_-_16127520 0.717 CECR3
cat eye syndrome chromosome region, candidate 3
chr1_+_28134090 0.712 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr6_+_16251260 0.711 MYLIP
myosin regulatory light chain interacting protein
chr19_+_10404110 0.711 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr19_-_54212158 0.710 NM_000894
LHB
luteinizing hormone beta polypeptide
chr12_-_120725210 0.709 LOC338799
hypothetical LOC338799
chr10_-_121286034 0.705 NM_002925
RGS10
regulator of G-protein signaling 10
chr11_-_2279642 0.704 NM_001142946
C11orf21
chromosome 11 open reading frame 21
chr8_-_19584373 0.703 NM_018371
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr11_-_33139449 0.697 NM_001033505
NM_001033506
NM_001326
CSTF3


cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa


chr6_+_167445284 0.692 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr10_+_82287637 0.689 NM_207372
SH2D4B
SH2 domain containing 4B
chr16_+_82885821 0.688 NM_021197
WFDC1
WAP four-disulfide core domain 1
chrX_-_69396241 0.681 NM_002565
P2RY4
pyrimidinergic receptor P2Y, G-protein coupled, 4
chr19_+_17047569 0.678 NM_001130065
NM_004145
MYO9B

myosin IXB

chr7_+_101978777 0.675 NM_001166339
NM_001031618
SPDYE2L
SPDYE2
WBSCR19-like protein 3
speedy homolog E2 (Xenopus laevis)
chr17_+_71235324 0.674 ITGB4
integrin, beta 4
chr12_-_52015696 0.671 NM_152860
SP7
Sp7 transcription factor
chr11_+_2439241 0.662 NM_181798
KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr1_-_29322993 0.660 NM_001003682
TMEM200B
transmembrane protein 200B
chrX_-_106033202 0.655 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr6_-_133161318 0.646 NM_052831
C6orf192
chromosome 6 open reading frame 192
chr14_-_64508547 0.636 NM_198686
RAB15
RAB15, member RAS onocogene family
chr11_+_66927976 0.634 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr17_-_76897590 0.633 NM_178519
C17orf55
chromosome 17 open reading frame 55
chr16_+_12053555 0.630 NM_001080530
SNX29
sorting nexin 29
chr17_+_35038276 0.622 NM_181505
PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr1_+_32433605 0.612 TXLNA
taxilin alpha
chr1_+_199519202 0.612 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr16_+_28413421 0.611 NM_018690
APOBR
apolipoprotein B receptor
chr3_+_150675169 0.611 TM4SF4
transmembrane 4 L six family member 4
chrX_-_100759562 0.608 NM_001009584
NM_001184768
NM_019007
ARMCX6


armadillo repeat containing, X-linked 6


chr13_+_30207668 0.606 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr7_-_100630912 0.602 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr6_-_39390073 0.601 NM_031460
NM_001135111
KCNK17

potassium channel, subfamily K, member 17

chr21_+_41616590 0.600 FAM3B
family with sequence similarity 3, member B
chr21_-_42644138 0.600 NM_005423
TFF2
trefoil factor 2
chr19_+_5865192 0.600 NM_004058
NM_080590
CAPS

calcyphosine

chr9_-_35744271 0.599 NM_001044264
MSMP
microseminoprotein, prostate associated
chrX_+_130505630 0.595 NM_001004486
OR13H1
olfactory receptor, family 13, subfamily H, member 1
chr10_+_118946989 0.591 NM_181840
KCNK18
potassium channel, subfamily K, member 18
chr15_+_67393795 0.590 NM_001104554
PAQR5
progestin and adipoQ receptor family member V
chr1_+_46418786 0.588 TSPAN1
tetraspanin 1
chr12_-_108755588 0.585 NM_021625
TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr1_-_203868622 0.570 NM_001973
NM_021795
ELK4

ELK4, ETS-domain protein (SRF accessory protein 1)

chr17_+_14145051 0.570 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr5_+_36644187 0.566 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_152560179 0.557 NM_080429
AQP10
aquaporin 10
chr2_+_128119908 0.555 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr21_+_43024936 0.550 PDE9A
phosphodiesterase 9A
chr3_+_196933481 0.548 MUC20
mucin 20, cell surface associated
chr9_-_131555111 0.548 NM_004878
PTGES
prostaglandin E synthase
chr5_+_38439399 0.546 NM_182798
NM_182799
EGFLAM

EGF-like, fibronectin type III and laminin G domains

chr19_+_11510578 0.543 NM_001299
CNN1
calponin 1, basic, smooth muscle
chrX_+_150653873 0.542 NM_005140
CNGA2
cyclic nucleotide gated channel alpha 2
chr7_-_142293382 0.535 NM_018646
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chrX_-_10605726 0.535 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr11_+_1420250 0.535 BRSK2
BR serine/threonine kinase 2
chrX_+_129363575 0.534 NM_016024
RBMX2
RNA binding motif protein, X-linked 2
chr7_-_150385912 0.529 NM_001164410
NM_004935
CDK5

cyclin-dependent kinase 5

chr16_+_639278 0.528 NM_145294
WDR90
WD repeat domain 90
chr19_+_60879802 0.527 NM_001130071
EPN1
epsin 1
chr6_-_86407875 0.525 NM_001159675
NM_001159676
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr1_-_110949867 0.524 NM_004974
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr16_+_55612125 0.523 NLRC5
NLR family, CARD domain containing 5
chr19_+_10424581 0.521 NM_006202
PDE4A
phosphodiesterase 4A, cAMP-specific
chr12_+_1799693 0.520 NM_001039029
NM_001163925
NM_001163926
LRTM2


leucine-rich repeats and transmembrane domains 2


chr20_-_48686832 0.520 NM_080829
FAM65C
family with sequence similarity 65, member C
chr5_+_150008030 0.515 SYNPO
synaptopodin
chr17_-_9864048 0.515 GAS7
growth arrest-specific 7
chr17_-_37590910 0.515 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr1_+_148511806 0.513 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr9_+_135389698 0.511 NM_014694
ADAMTSL2
ADAMTS-like 2
chr1_+_26358097 0.511 NM_024869
GRRP1
glycine/arginine rich protein 1
chr11_-_64283945 0.504 PYGM
phosphorylase, glycogen, muscle
chr14_-_105163301 0.502 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr17_+_71232370 0.501 NM_001005619
ITGB4
integrin, beta 4
chr19_+_40511909 0.498 NM_001185099
NM_001185100
NM_001185101
NM_001771
CD22



CD22 molecule



chr9_-_33455191 0.497 NOL6
nucleolar protein family 6 (RNA-associated)
chr22_+_38296703 0.487 NM_001003406
NM_021096
CACNA1I

calcium channel, voltage-dependent, T type, alpha 1I subunit

chr11_+_123315459 0.487 NM_001001965
OR4D5
olfactory receptor, family 4, subfamily D, member 5
chr1_-_154041393 0.484 GON4L
gon-4-like (C. elegans)
chr19_+_44838373 0.479 NM_001190441
LGALS16
beta-galactoside-binding lectin
chrX_+_46935035 0.478 NM_153280
UBA1
ubiquitin-like modifier activating enzyme 1
chr20_-_62052922 0.477 NM_001193379
UCKL1
uridine-cytidine kinase 1-like 1
chr19_-_59542197 0.477 NM_012276
LILRA4
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
chr12_-_108755565 0.476 TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr3_+_42675841 0.474 ZBTB47
zinc finger and BTB domain containing 47
chr15_+_38430517 0.472 NM_001145643
PHGR1
proline/histidine/glycine-rich 1
chr8_-_27906287 0.471 NM_173833
SCARA5
scavenger receptor class A, member 5 (putative)
chr17_+_20423628 0.468 NM_001190790
CDRT15L2
CMT1A duplicated region transcript 15-like 2
chr18_-_58946858 0.466 BCL2
B-cell CLL/lymphoma 2
chr5_+_149867866 0.466 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr14_-_87806913 0.463 NM_138318
KCNK10
potassium channel, subfamily K, member 10
chr11_-_70350292 0.462 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr22_-_21814208 0.459 NM_014433
RTDR1
rhabdoid tumor deletion region gene 1
chr17_-_9863929 0.459 GAS7
growth arrest-specific 7
chr17_+_70984173 0.457 KIAA0195
KIAA0195
chr7_+_102078007 0.456 NM_001166339
NM_001031618
SPDYE2L
SPDYE2
WBSCR19-like protein 3
speedy homolog E2 (Xenopus laevis)
chr7_-_150385867 0.452 CDK5
cyclin-dependent kinase 5
chr11_+_22316242 0.452 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr17_+_6288457 0.451 NM_001195228
NM_019013
FAM64A

family with sequence similarity 64, member A

chr10_+_72642274 0.449 NM_170744
UNC5B
unc-5 homolog B (C. elegans)
chr6_+_31016755 0.445 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr17_+_43263991 0.441 NM_033413
LRRC46
leucine rich repeat containing 46
chr20_+_36643251 0.439 NM_001018082
ADIG
adipogenin
chrX_+_37735013 0.438 NM_012274
CXorf27
chromosome X open reading frame 27
chr3_+_38322430 0.437 NM_004803
SLC22A14
solute carrier family 22, member 14
chr22_-_27787793 0.435 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr15_+_40484249 0.435 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr15_+_52092392 0.429 NM_001080534
UNC13C
unc-13 homolog C (C. elegans)
chr1_-_30977931 0.426 LAPTM5
lysosomal protein transmembrane 5
chr6_-_46997579 0.426 NM_001098518
GPR116
G protein-coupled receptor 116
chr12_-_50502474 0.425 NM_001013690
FIGNL2
fidgetin-like 2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.61 7.38e-09 GO:0005576 extracellular region
1.48 1.03e-05 GO:0044459 plasma membrane part
1.32 1.08e-05 GO:0005886 plasma membrane
1.31 2.07e-05 GO:0071944 cell periphery
1.61 1.60e-04 GO:0005887 integral to plasma membrane
1.21 1.97e-04 GO:0044425 membrane part
1.58 3.98e-04 GO:0031226 intrinsic to plasma membrane
1.63 6.61e-04 GO:0044421 extracellular region part
1.22 8.36e-04 GO:0031224 intrinsic to membrane
1.17 9.20e-04 GO:0016020 membrane
1.22 2.17e-03 GO:0016021 integral to membrane
1.64 8.91e-03 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.89 2.54e-02 GO:0048019 receptor antagonist activity
13.68 2.97e-02 GO:0032052 bile acid binding
7.33 4.23e-02 GO:0030547 receptor inhibitor activity