Motif ID: HES1.p2

Z-value: 2.039


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HES1chr3_+_195336631,
chr3_+_195336625		-0.342.0e-01Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_11819364 5.139 NM_181443
 BTBD3
BTB (POZ) domain containing 3
chr2_+_113119985 2.354 NM_005415
 SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr12_+_8741746 2.353 NM_020734
 RIMKLB
ribosomal modification protein rimK-like family member B
chr2_+_46779827 2.302 NM_144949
 SOCS5
suppressor of cytokine signaling 5
chr14_+_61231795 2.152 NM_001530
NM_181054
 HIF1A

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

chr2_+_182464910 2.089 SSFA2
sperm specific antigen 2
chr3_-_88190737 2.078 NM_001008390
NM_003663
 CGGBP1

CGG triplet repeat binding protein 1

chr3_+_112273464 1.925 NM_015480
 PVRL3
poliovirus receptor-related 3
chr7_+_93977267 1.897 CASD1
CAS1 domain containing 1
chr17_+_43082273 1.874 NM_002265
 KPNB1
karyopherin (importin) beta 1
chr22_+_39817733 1.848 EP300
E1A binding protein p300
chr2_+_181553613 1.824 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr2_-_225615556 1.761 NM_014689
 DOCK10
dedicator of cytokinesis 10
chr2_+_85619802 1.754 MAT2A
methionine adenosyltransferase II, alpha
chr5_+_63497408 1.743 NM_001113561
NM_178532
 RNF180

ring finger protein 180

chr2_+_182464713 1.729 NM_001130445
NM_006751
 SSFA2

sperm specific antigen 2

chr8_-_12657339 1.709 NM_152271
 LONRF1
LON peptidase N-terminal domain and ring finger 1
chr3_+_180348818 1.535 NM_006218
 PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr8_+_59069522 1.532 NM_147189
 FAM110B
family with sequence similarity 110, member B
chr7_+_24579239 1.453 NM_016447
 MPP6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 37 entries
enrichment   p-value GO term description
2.35 2.98e-02 GO:0007173 epidermal growth factor receptor signaling pathway
1.96 1.43e-03 GO:0016569 covalent chromatin modification
1.96 1.91e-03 GO:0016570 histone modification
1.93 3.12e-08 GO:0016568 chromatin modification
1.80 5.48e-04 GO:0032446 protein modification by small protein conjugation
1.78 2.91e-03 GO:0016567 protein ubiquitination
1.76 3.96e-07 GO:0006325 chromatin organization
1.66 6.65e-03 GO:0070647 protein modification by small protein conjugation or removal
1.63 2.75e-06 GO:0051276 chromosome organization
1.62 1.49e-02 GO:0018193 peptidyl-amino acid modification
1.47 4.36e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.42 3.50e-10 GO:0006464 protein modification process
1.40 1.05e-07 GO:0006996 organelle organization
1.38 1.11e-08 GO:0043412 macromolecule modification
1.35 5.31e-10 GO:0044267 cellular protein metabolic process
1.34 2.63e-02 GO:0006793 phosphorus metabolic process
1.34 2.63e-02 GO:0006796 phosphate metabolic process
1.32 2.82e-02 GO:0044248 cellular catabolic process
1.29 7.35e-15 GO:0044260 cellular macromolecule metabolic process
1.29 2.95e-07 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
1.85 3.73e-02 GO:0031301 integral to organelle membrane
1.84 1.37e-02 GO:0031300 intrinsic to organelle membrane
1.78 1.30e-02 GO:0031252 cell leading edge
1.73 5.52e-03 GO:0005813 centrosome
1.55 1.62e-02 GO:0005815 microtubule organizing center
1.45 1.72e-02 GO:0005730 nucleolus
1.40 1.12e-11 GO:0005829 cytosol
1.32 9.23e-08 GO:0044428 nuclear part
1.31 6.50e-06 GO:0031981 nuclear lumen
1.30 1.94e-03 GO:0005739 mitochondrion
1.29 2.22e-06 GO:0070013 intracellular organelle lumen
1.29 5.58e-03 GO:0005654 nucleoplasm
1.28 1.87e-06 GO:0031974 membrane-enclosed lumen
1.28 3.62e-06 GO:0043233 organelle lumen
1.26 4.09e-03 GO:0012505 endomembrane system
1.23 4.62e-16 GO:0044444 cytoplasmic part
1.23 9.36e-14 GO:0005634 nucleus
1.22 6.65e-27 GO:0005737 cytoplasm
1.22 1.64e-04 GO:0043228 non-membrane-bounded organelle
1.22 1.64e-04 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
1.87 7.01e-03 GO:0000287 magnesium ion binding
1.77 9.22e-05 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.76 5.14e-03 GO:0004842 ubiquitin-protein ligase activity
1.75 7.93e-04 GO:0016881 acid-amino acid ligase activity
1.74 4.24e-03 GO:0019787 small conjugating protein ligase activity
1.69 1.07e-02 GO:0016791 phosphatase activity
1.67 6.20e-06 GO:0016874 ligase activity
1.53 2.35e-06 GO:0019899 enzyme binding
1.37 2.75e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.32 7.58e-06 GO:0016740 transferase activity
1.31 2.78e-04 GO:0032559 adenyl ribonucleotide binding
1.30 3.25e-04 GO:0030554 adenyl nucleotide binding
1.30 4.13e-04 GO:0005524 ATP binding
1.29 5.81e-05 GO:0032553 ribonucleotide binding
1.29 5.81e-05 GO:0032555 purine ribonucleotide binding
1.29 7.95e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.28 5.46e-06 GO:0000166 nucleotide binding
1.28 7.61e-05 GO:0017076 purine nucleotide binding
1.21 2.07e-10 GO:0003824 catalytic activity
1.18 9.61e-14 GO:0005515 protein binding