Motif ID: HIC1.p2

Z-value: 2.432


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_19051040.844.4e-05Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_1704661 3.945 NM_001080488
 ONECUT3
one cut homeobox 3
chr8_+_145461356 3.519 NM_001008271
NM_001080514
 SCXA
SCXB
scleraxis homolog A (mouse)
scleraxis homolog B (mouse)
chr14_+_105012106 3.344 NM_001312
 CRIP2
cysteine-rich protein 2
chr14_+_104226769 3.232 NM_001031714
NM_022489
NM_032714
 INF2


inverted formin, FH2 and WH2 domain containing


chr11_+_359723 2.753 NM_178537
 B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr16_+_162845 2.391 NM_000517
 HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr16_+_2510323 2.357 NM_001145815
NM_015944
 AMDHD2

amidohydrolase domain containing 2

chr19_+_540849 2.339 NM_001194
 HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr2_+_241586927 2.304 NM_001080437
 SNED1
sushi, nidogen and EGF-like domains 1
chr16_+_11669736 2.281 NM_003498
 SNN
stannin
chr7_+_154943466 2.251 NM_001427
 EN2
engrailed homeobox 2
chr7_-_44331544 2.121 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
 CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr10_+_112247614 2.058 NM_004419
 DUSP5
dual specificity phosphatase 5
chr1_+_2149993 2.057 NM_003036
 SKI
v-ski sarcoma viral oncogene homolog (avian)
chr1_+_234372454 2.003 NM_003272
 GPR137B
G protein-coupled receptor 137B
chr14_+_104402626 1.992 NM_001112726
NM_015005
 KIAA0284

KIAA0284

chr19_+_1236766 1.979 NM_001405
 EFNA2
ephrin-A2
chr2_+_238200922 1.965 NM_001137550
 LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr2_+_232281491 1.896 PTMA
prothymosin, alpha
chr9_+_17568952 1.892 NM_003026
 SH3GL2
SH3-domain GRB2-like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 169 entries
enrichment   p-value GO term description
2.71 6.74e-05 GO:0001843 neural tube closure
2.64 1.57e-04 GO:0060606 tube closure
2.57 3.46e-04 GO:0014020 primary neural tube formation
2.39 7.42e-04 GO:0001841 neural tube formation
2.25 9.05e-04 GO:0001838 embryonic epithelial tube formation
2.21 1.57e-03 GO:0072175 epithelial tube formation
2.20 2.80e-05 GO:0021915 neural tube development
2.13 2.98e-04 GO:0021953 central nervous system neuron differentiation
2.11 8.46e-04 GO:0016331 morphogenesis of embryonic epithelium
2.11 7.33e-03 GO:0035148 tube formation
2.09 2.75e-02 GO:0050768 negative regulation of neurogenesis
2.05 7.03e-04 GO:0060828 regulation of canonical Wnt receptor signaling pathway
2.01 2.18e-02 GO:0001657 ureteric bud development
1.98 1.94e-03 GO:0030326 embryonic limb morphogenesis
1.98 1.94e-03 GO:0035113 embryonic appendage morphogenesis
1.98 2.51e-02 GO:0010721 negative regulation of cell development
1.97 9.39e-07 GO:0060562 epithelial tube morphogenesis
1.94 5.97e-04 GO:0048736 appendage development
1.94 5.97e-04 GO:0060173 limb development
1.90 3.01e-03 GO:0035107 appendage morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
1.58 8.79e-08 GO:0045202 synapse
1.58 8.60e-03 GO:0044297 cell body
1.58 1.12e-02 GO:0043025 neuronal cell body
1.55 6.66e-05 GO:0044456 synapse part
1.50 4.92e-03 GO:0005667 transcription factor complex
1.43 9.79e-04 GO:0043005 neuron projection
1.35 9.00e-04 GO:0030054 cell junction
1.20 1.20e-02 GO:0005654 nucleoplasm
1.18 1.06e-03 GO:0005829 cytosol
1.17 1.51e-02 GO:0031981 nuclear lumen
1.14 4.84e-02 GO:0044459 plasma membrane part
1.11 1.79e-05 GO:0005634 nucleus
1.09 1.47e-07 GO:0005737 cytoplasm
1.09 1.76e-03 GO:0044444 cytoplasmic part
1.08 1.45e-13 GO:0044424 intracellular part
1.08 7.29e-13 GO:0005622 intracellular
1.08 1.34e-06 GO:0043227 membrane-bounded organelle
1.08 1.92e-06 GO:0043231 intracellular membrane-bounded organelle
1.07 8.80e-07 GO:0043226 organelle
1.07 1.65e-06 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
1.95 1.79e-03 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
1.93 8.53e-04 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
1.87 6.19e-03 GO:0003704 specific RNA polymerase II transcription factor activity
1.85 3.79e-03 GO:0016566 specific transcriptional repressor activity
1.81 3.90e-07 GO:0010843 promoter binding
1.79 1.39e-02 GO:0005249 voltage-gated potassium channel activity
1.78 8.28e-07 GO:0000975 regulatory region DNA binding
1.78 8.28e-07 GO:0001067 regulatory region nucleic acid binding
1.78 8.28e-07 GO:0044212 transcription regulatory region DNA binding
1.76 5.01e-04 GO:0022843 voltage-gated cation channel activity
1.71 5.67e-05 GO:0005244 voltage-gated ion channel activity
1.71 5.67e-05 GO:0022832 voltage-gated channel activity
1.71 1.04e-02 GO:0005267 potassium channel activity
1.66 6.03e-08 GO:0016563 transcription activator activity
1.54 1.60e-03 GO:0005096 GTPase activator activity
1.51 7.81e-07 GO:0030695 GTPase regulator activity
1.49 1.12e-02 GO:0003702 RNA polymerase II transcription factor activity
1.48 1.12e-14 GO:0030528 transcription regulator activity
1.48 4.36e-06 GO:0060589 nucleoside-triphosphatase regulator activity
1.47 3.28e-03 GO:0016564 transcription repressor activity