Motif ID: HIF1A.p2

Z-value: 1.011


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIF1Achr14_+_61231795-0.097.3e-01Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_97016027 1.633 NM_001122646
 FAM178B
family with sequence similarity 178, member B
chr5_+_78568094 1.151


chr11_+_18372689 1.104 LDHA
lactate dehydrogenase A
chr17_+_77780177 1.094 NM_004207
 SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr7_+_156624424 1.086 UBE3C
ubiquitin protein ligase E3C
chr20_+_30410447 1.075 ASXL1
additional sex combs like 1 (Drosophila)
chr13_-_43259032 1.036 NM_017993
 ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr7_+_156624392 1.034 NM_014671
 UBE3C
ubiquitin protein ligase E3C
chr11_+_18372687 1.027 LDHA
lactate dehydrogenase A
chr11_+_18372493 1.024 NM_001135239
NM_001165415
NM_001165416
NM_005566
 LDHA



lactate dehydrogenase A



chr11_+_18372708 0.997 LDHA
lactate dehydrogenase A
chr2_-_74915722 0.924


chr7_+_156624370 0.876 UBE3C
ubiquitin protein ligase E3C
chr20_+_41519947 0.847 SRSF6
serine/arginine-rich splicing factor 6
chr20_+_41519882 0.818 NM_006275
 SRSF6
serine/arginine-rich splicing factor 6
chr10_+_104394185 0.809 NM_030912
 TRIM8
tripartite motif containing 8
chr1_+_109963982 0.804 AMPD2
adenosine monophosphate deaminase 2
chr8_+_49083522 0.783 NM_003350
 UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr17_+_52517529 0.758 NM_003488
 AKAP1
A kinase (PRKA) anchor protein 1
chr12_+_68923043 0.714 NM_014515
 CNOT2
CCR4-NOT transcription complex, subunit 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
1.53 9.43e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.50 1.16e-02 GO:0009892 negative regulation of metabolic process
1.38 2.23e-04 GO:0048523 negative regulation of cellular process
1.38 1.98e-03 GO:0010467 gene expression
1.37 7.85e-05 GO:0048519 negative regulation of biological process
1.36 7.04e-05 GO:0044267 cellular protein metabolic process
1.36 6.19e-03 GO:0006464 protein modification process
1.36 1.61e-02 GO:0016070 RNA metabolic process
1.35 2.36e-04 GO:0044249 cellular biosynthetic process
1.35 2.64e-02 GO:0009059 macromolecule biosynthetic process
1.35 2.78e-02 GO:0034645 cellular macromolecule biosynthetic process
1.34 1.82e-10 GO:0044260 cellular macromolecule metabolic process
1.34 3.44e-04 GO:0009058 biosynthetic process
1.34 2.48e-03 GO:0090304 nucleic acid metabolic process
1.34 9.95e-03 GO:0043412 macromolecule modification
1.33 8.43e-05 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.31 7.48e-05 GO:0034641 cellular nitrogen compound metabolic process
1.30 1.64e-14 GO:0044237 cellular metabolic process
1.30 1.06e-04 GO:0006807 nitrogen compound metabolic process
1.27 2.07e-07 GO:0043170 macromolecule metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
2.49 4.72e-02 GO:0001726 ruffle
2.20 1.80e-02 GO:0031965 nuclear membrane
2.16 1.51e-04 GO:0005635 nuclear envelope
2.04 2.65e-02 GO:0031252 cell leading edge
1.57 2.16e-03 GO:0031967 organelle envelope
1.56 2.62e-03 GO:0031975 envelope
1.45 4.32e-08 GO:0044428 nuclear part
1.43 4.09e-05 GO:0012505 endomembrane system
1.38 1.76e-05 GO:0031090 organelle membrane
1.37 1.04e-05 GO:0070013 intracellular organelle lumen
1.37 2.89e-04 GO:0031981 nuclear lumen
1.36 1.84e-05 GO:0043233 organelle lumen
1.36 2.36e-05 GO:0031974 membrane-enclosed lumen
1.35 2.40e-04 GO:0005829 cytosol
1.27 3.46e-10 GO:0005634 nucleus
1.27 3.52e-10 GO:0044446 intracellular organelle part
1.26 1.26e-09 GO:0044422 organelle part
1.22 4.93e-16 GO:0043231 intracellular membrane-bounded organelle
1.22 7.24e-16 GO:0043227 membrane-bounded organelle
1.22 1.44e-07 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
1.36 1.93e-03 GO:0016740 transferase activity
1.29 6.65e-03 GO:0000166 nucleotide binding
1.22 1.49e-10 GO:0005515 protein binding
1.21 2.75e-02 GO:0003676 nucleic acid binding
1.18 1.82e-03 GO:0003824 catalytic activity
1.10 2.32e-07 GO:0005488 binding