Motif ID: HLF.p2

Z-value: 0.999


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
HLF 3131 hepatic leukemia factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HLFchr17_+_50697319-0.401.2e-01Click!


Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_177106702 1.475 NM_004673
ANGPTL1
angiopoietin-like 1
chr20_+_4614796 1.421 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr6_+_97117144 1.301 NM_001170807
NM_020482
FHL5

four and a half LIM domains 5

chr1_+_11171967 1.103 NM_021146
ANGPTL7
angiopoietin-like 7
chr15_-_75259714 1.063 PEAK1
NKF3 kinase family member
chr12_+_29267863 1.061 NM_018099
FAR2
fatty acyl CoA reductase 2
chr19_-_53941835 1.000 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chrX_-_15530112 0.975 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr2_+_113119985 0.873 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr7_-_31347032 0.867 NM_022728
NEUROD6
neurogenic differentiation 6
chr16_+_70646008 0.855 NM_001126102
NM_005143
HP

haptoglobin

chrX_+_51562894 0.841 NM_001005332
MAGED1
melanoma antigen family D, 1
chrX_+_55666557 0.817 NM_198451
FOXR2
forkhead box R2
chr3_-_159872960 0.766 NM_020169
LXN
latexin
chr7_+_128136347 0.716 FAM71F1
family with sequence similarity 71, member F1
chr3_+_171167243 0.707 NM_003262
SEC62
SEC62 homolog (S. cerevisiae)
chr1_+_115373937 0.672 NM_000549
TSHB
thyroid stimulating hormone, beta
chr16_-_74214654 0.669 NM_012091
ADAT1
adenosine deaminase, tRNA-specific 1
chr7_-_129379947 0.650 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

chrX_+_41191630 0.645 NM_022567
NYX
nyctalopin
chr1_-_108536885 0.629 NM_213651
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr3_-_101077605 0.605 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr1_+_195123766 0.602 NM_006684
CFHR4
complement factor H-related 4
chr17_-_8602601 0.601 NM_001128076
SPDYE4
speedy homolog E4 (Xenopus laevis)
chr1_+_157067729 0.597 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr3_-_45858566 0.592 NM_020347
LZTFL1
leucine zipper transcription factor-like 1
chr21_-_30796278 0.584 NM_181611
KRTAP19-5
keratin associated protein 19-5
chr4_-_78216145 0.582 NM_006835
CCNI
cyclin I
chr12_+_56424930 0.579 NM_005981
TSPAN31
tetraspanin 31
chr3_-_155524898 0.577 NM_001114397
NM_020865
DHX36

DEAH (Asp-Glu-Ala-His) box polypeptide 36

chr10_-_95350949 0.573 NM_006744
RBP4
retinol binding protein 4, plasma
chr6_-_52217185 0.569 NM_052872
IL17F
interleukin 17F
chr20_+_23419765 0.561 NM_005492
CST8
cystatin 8 (cystatin-related epididymal specific)
chr7_-_143560850 0.556 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr18_+_52965290 0.541 BOD1P
biorientation of chromosomes in cell division 1 pseudogene
chr14_-_69333624 0.527 NM_003049
SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr9_-_6005602 0.516 NM_012416
RANBP6
RAN binding protein 6
chr21_-_30836051 0.516 NM_181612
KRTAP19-6
keratin associated protein 19-6
chr12_+_54132264 0.512 NM_054105
OR6C2
olfactory receptor, family 6, subfamily C, member 2
chr10_-_104587069 0.512 NM_000102
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr8_+_24354387 0.503 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr7_-_141604323 0.495 NM_001001317
TRYX3
trypsin X3
chr4_+_129021514 0.490 NM_001190801
PLK4
polo-like kinase 4
chr10_+_118295417 0.489 NM_000936
PNLIP
pancreatic lipase
chr10_-_98280299 0.486 TM9SF3
transmembrane 9 superfamily member 3
chr12_-_47031287 0.484 NM_001172682
ZNF641
zinc finger protein 641
chr4_+_88187215 0.483 AFF1
AF4/FMR2 family, member 1
chr12_-_119451303 0.480 NM_032314
COQ5
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
chr7_+_143511480 0.478 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chrX_-_134883500 0.471 MMGT1
membrane magnesium transporter 1
chr3_+_101019357 0.463 NM_032359
C3orf26
chromosome 3 open reading frame 26
chr18_+_74957475 0.455


chrX_-_77037563 0.438 NM_032121
MAGT1
magnesium transporter 1
chr2_-_158008763 0.433 NM_004288
CYTIP
cytohesin 1 interacting protein
chr6_+_131936057 0.433 NM_000045
ARG1
arginase, liver
chr7_+_143646150 0.421 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr12_-_21649019 0.418 NM_021957
GYS2
glycogen synthase 2 (liver)
chr4_+_129021465 0.407 NM_001190799
NM_014264
PLK4

polo-like kinase 4

chr2_+_108360798 0.406 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr2_-_133895795 0.404 NCKAP5
NCK-associated protein 5
chr1_-_102234959 0.401 OLFM3
olfactomedin 3
chr12_-_108989882 0.398 NM_207435
C12orf76
chromosome 12 open reading frame 76
chr1_-_114925734 0.389 NM_005872
BCAS2
breast carcinoma amplified sequence 2
chr1_+_157167965 0.388 NM_152501
NM_198928
NM_198929
NM_198930
PYHIN1



pyrin and HIN domain family, member 1



chr6_-_30151526 0.388 NM_170769
NM_025236
RNF39

ring finger protein 39

chr4_+_71235259 0.388 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr5_-_147266257 0.386 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr11_-_13474101 0.385 NM_000315
PTH
parathyroid hormone
chr6_-_90081655 0.385 NM_002043
GABRR2
gamma-aminobutyric acid (GABA) receptor, rho 2
chr7_-_37923040 0.382 NM_003014
SFRP4
secreted frizzled-related protein 4
chr12_+_54080480 0.381 NM_001005518
OR6C65
olfactory receptor, family 6, subfamily C, member 65
chr15_+_60838053 0.380 TLN2
talin 2
chr12_-_9651748 0.379 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr11_-_121492010 0.378 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr5_+_96023926 0.378 CAST
calpastatin
chr1_+_227506751 0.378 NM_006542
SPHAR
S-phase response (cyclin related)
chr19_-_45611110 0.374 NM_020956
NM_181882
PRX

periaxin

chr9_-_103237851 0.366 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr21_-_30855478 0.366 NM_181614
KRTAP19-7
keratin associated protein 19-7
chr9_-_98421894 0.362 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr1_-_201162938 0.362 KLHL12
kelch-like 12 (Drosophila)
chr4_+_75449720 0.362 NM_001432
EREG
epiregulin
chr4_+_1864306 0.356 NM_007331
NM_133330
NM_133331
NM_133335
WHSC1



Wolf-Hirschhorn syndrome candidate 1



chr12_-_86947276 0.354 NM_152589
C12orf50
chromosome 12 open reading frame 50
chr1_+_7767300 0.353 NM_016831
PER3
period homolog 3 (Drosophila)
chr4_+_70896236 0.353 NM_001009181
NM_003154
STATH

statherin

chr12_-_51360439 0.349 NM_006121
KRT1
keratin 1
chr6_-_119512035 0.344 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr19_+_53951155 0.344 NM_019113
FGF21
fibroblast growth factor 21
chr21_+_43903803 0.342 NM_015056
RRP1B
ribosomal RNA processing 1 homolog B (S. cerevisiae)
chr9_-_70780574 0.342


chr8_-_66863841 0.337 NM_002603
PDE7A
phosphodiesterase 7A
chr13_+_47948586 0.337 RB1
retinoblastoma 1
chr19_-_58462729 0.330 NM_173857
VN1R4
vomeronasal 1 receptor 4
chr2_-_162072492 0.329 AHCTF1P1
AT hook containing transcription factor 1 pseudogene 1
chr7_-_44992729 0.328 C7orf40
chromosome 7 open reading frame 40
chr1_-_152867007 0.328 ADAR
adenosine deaminase, RNA-specific
chr12_-_103846186 0.326 NM_032148
SLC41A2
solute carrier family 41, member 2
chr10_+_85994788 0.325 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr19_-_53305825 0.324 NM_001159322
NM_001159323
NM_003706
PLA2G4C


phospholipase A2, group IVC (cytosolic, calcium-independent)


chr1_-_1580266 0.319 CDK11A
CDK11B
cyclin-dependent kinase 11A
cyclin-dependent kinase 11B
chr9_-_68552337 0.319 NM_001085457
CBWD5
CBWD3
CBWD1
CBWD6
COBW domain containing 5
COBW domain containing 3
COBW domain containing 1
COBW domain containing 6
chr11_+_113280727 0.317 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr5_+_147695314 0.316 NM_001040433
SPINK9
serine peptidase inhibitor, Kazal type 9
chr9_-_90456824 0.315 NM_001100111
LOC286238
hypothetical protein LOC286238
chr12_+_54106304 0.312 NM_001005183
OR6C76
olfactory receptor, family 6, subfamily C, member 76
chr4_+_119174947 0.311 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr1_-_201162991 0.311 NM_021633
KLHL12
kelch-like 12 (Drosophila)
chr10_+_74323344 0.311 NM_152635
OIT3
oncoprotein induced transcript 3
chr7_-_143597313 0.311 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr21_-_43903755 0.309 NM_007031
HSF2BP
heat shock transcription factor 2 binding protein
chr2_+_68548173 0.308 NM_173545
APLF
aprataxin and PNKP like factor
chr21_+_30937053 0.308 NM_001128077
KRTAP20-3
keratin associated protein 20-3
chr11_-_4675524 0.306 NM_030774
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chr4_-_104338924 0.301 NM_001813
CENPE
centromere protein E, 312kDa
chr1_-_205210567 0.301 NM_001122979
NM_001170631
NM_032029
FCAMR


Fc receptor, IgA, IgM, high affinity


chr11_+_93394025 0.299 NM_001098672
HEPHL1
hephaestin-like 1
chr11_-_19038803 0.297 NM_054030
MRGPRX2
MAS-related GPR, member X2
chr6_-_132987106 0.297 NM_001033080
TAAR2
trace amine associated receptor 2
chrX_+_123062143 0.297 STAG2
stromal antigen 2
chr2_-_27215781 0.296 NM_178553
C2orf53
chromosome 2 open reading frame 53
chr4_+_41395493 0.295 LIMCH1
LIM and calponin homology domains 1
chr1_+_166414706 0.294 NM_001031800
NM_152902
TIPRL

TIP41, TOR signaling pathway regulator-like (S. cerevisiae)

chr3_+_62279707 0.294 C3orf14
chromosome 3 open reading frame 14
chr17_+_31455332 0.291 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr17_-_36559579 0.290 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr2_+_190710730 0.290 NM_001042521
C2orf88
chromosome 2 open reading frame 88
chr6_-_30188845 0.288 NM_007028
TRIM31
tripartite motif containing 31
chr13_-_45577144 0.287 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr7_+_115650240 0.287 NM_152829
TES
testis derived transcript (3 LIM domains)
chr3_-_58175437 0.287 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr12_-_4624536 0.287 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr9_+_128764324 0.285 NM_001190728
RALGPS1
Ral GEF with PH domain and SH3 binding motif 1
chr4_+_146820805 0.284 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr10_-_82039158 0.284 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr6_+_7347878 0.283 NM_153005
RIOK1
RIO kinase 1 (yeast)
chr1_+_151081953 0.279 NM_001128600
LCE6A
late cornified envelope 6A
chr9_+_15542871 0.277 NM_173550
C9orf93
chromosome 9 open reading frame 93
chr10_-_52315436 0.277 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr15_-_75364387 0.276 NM_024776
PEAK1
NKF3 kinase family member
chr15_+_56217686 0.275 NM_020980
AQP9
aquaporin 9
chr1_+_166414839 0.275 TIPRL
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
chr13_+_110653407 0.272 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr9_-_19023183 0.271 NM_153707
FAM154A
family with sequence similarity 154, member A
chr17_+_41728273 0.270 NM_014834
LRRC37A
leucine rich repeat containing 37A
chr4_+_71096830 0.269 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr1_-_202449659 0.267 NM_198447
GOLT1A
golgi transport 1A
chr18_+_59705918 0.266 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr12_-_6852709 0.266 NM_001146316
NM_032641
SPSB2

splA/ryanodine receptor domain and SOCS box containing 2

chr22_-_15682555 0.263 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr6_+_17501589 0.261 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr12_+_63510481 0.259


chr5_-_58918031 0.258 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr8_+_110621485 0.258 NM_004215
EBAG9
estrogen receptor binding site associated, antigen, 9
chr11_-_6870306 0.256 NM_003700
OR2D2
olfactory receptor, family 2, subfamily D, member 2
chr11_-_57947358 0.255 NM_001005566
OR5B2
olfactory receptor, family 5, subfamily B, member 2
chr10_+_95838801 0.254 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr19_-_57082907 0.253 NM_001135590
NM_032679
ZNF577

zinc finger protein 577

chr5_-_56814310 0.252 NM_001017992
ACTBL2
actin, beta-like 2
chr14_+_20007377 0.252 NM_000270
PNP
purine nucleoside phosphorylase
chr11_-_6418705 0.252 NM_000613
HPX
hemopexin
chr5_+_96023627 0.251 NM_001042440
CAST
calpastatin
chr18_+_53967544 0.250 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr1_-_158883666 0.244 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr5_-_139992621 0.244 NM_000591
CD14
CD14 molecule
chr7_+_89870707 0.244 CLDN12
claudin 12
chr1_+_7766966 0.243 PER3
period homolog 3 (Drosophila)
chr17_-_23965305 0.243 NM_001174103
SGK494
uncharacterized serine/threonine-protein kinase SgK494
chrX_-_117135330 0.243 NM_001168301
KLHL13
kelch-like 13 (Drosophila)
chrX_+_65152004 0.242


chr7_-_15568099 0.241 NM_001004320
AGMO
alkylglycerol monooxygenase
chr3_+_187917791 0.239 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr9_-_21472311 0.232 NM_176891
IFNE
interferon, epsilon
chr7_+_89870647 0.231 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr11_-_116168316 0.230 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr5_+_112877251 0.230 NM_022828
YTHDC2
YTH domain containing 2
chrX_+_12903145 0.229 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chrX_-_72351348 0.229 NAP1L2
nucleosome assembly protein 1-like 2
chrX_+_102078855 0.229 NM_001031834
RAB40AL
RAB40A, member RAS oncogene family-like
chr6_+_150731720 0.229 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr10_+_114033403 0.228 NM_058222
TECTB
tectorin beta
chr1_+_36409277 0.226 MAP7D1
MAP7 domain containing 1
chr12_-_44919818 0.226 SLC38A1
solute carrier family 38, member 1
chrX_-_148476903 0.225 NM_005365
NM_001080790
MAGEA9
MAGEA9B
melanoma antigen family A, 9
melanoma antigen family A, 9B
chr12_-_121946635 0.225 NM_024667
VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr1_-_67039518 0.223 NM_005478
INSL5
insulin-like 5
chr3_+_142525744 0.221 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr21_-_26345294 0.220


chrX_-_138875342 0.219 NM_001013403
CXorf66
chromosome X open reading frame 66
chr1_+_239882202 0.218 NM_144625
WDR64
WD repeat domain 64
chr10_+_118340460 0.218 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chr11_-_71429747 0.217 NUMA1
nuclear mitotic apparatus protein 1
chr15_-_40628202 0.217 LRRC57
leucine rich repeat containing 57
chr10_+_18669619 0.216 NM_201590
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr1_-_152867070 0.216 NM_001025107
ADAR
adenosine deaminase, RNA-specific
chr10_+_5228756 0.216 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr17_-_36792161 0.214 NM_021013
KRT34
keratin 34
chr5_+_96023479 0.214 NM_001190442
CAST
calpastatin
chr11_-_55684368 0.214 NM_001004058
OR8K5
olfactory receptor, family 8, subfamily K, member 5
chr6_-_22410993 0.214 NM_001163558
PRL
prolactin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.17 2.33e-02 GO:0007608 sensory perception of smell
2.05 4.88e-02 GO:0007606 sensory perception of chemical stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
23.52 2.25e-02 GO:0033150 cytoskeletal calyx
1.69 3.65e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.27 1.82e-03 GO:0004984 olfactory receptor activity