Motif ID: HMGA1,2.p2

Z-value: 3.780


Transcription factors associated with HMGA1,2.p2:

Gene SymbolEntrez IDGene Name
HMGA1 3159 high mobility group AT-hook 1
HMGA2 8091 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HMGA1chr6_+_34313347-0.731.4e-03Click!
HMGA2chr12_+_645048350.224.2e-01Click!


Activity profile for motif HMGA1,2.p2.

activity profile for motif HMGA1,2.p2


Sorted Z-values histogram for motif HMGA1,2.p2

Sorted Z-values for motif HMGA1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_215967442 6.417 FN1
fibronectin 1
chr2_-_47969350 5.688 NM_025133
FBXO11
F-box protein 11
chr3_-_114176401 5.270 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr13_-_45577144 4.847 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr2_+_228064531 4.591 AGFG1
ArfGAP with FG repeats 1
chr21_-_26345294 4.449


chr9_-_21218132 4.381 NM_021268
IFNA17
interferon, alpha 17
chr3_-_56784634 4.301 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr13_+_107753764 4.208


chr9_-_106407728 4.174 NM_001004481
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chr9_-_21132143 4.044 NM_002177
IFNW1
interferon, omega 1
chr5_-_58607673 3.910 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_16397617 3.798 NM_145764
MGST1
microsomal glutathione S-transferase 1
chr6_+_153113624 3.591 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr4_+_176076083 3.510 NM_001130703
NM_001130704
NM_001130705
NM_014269
ADAM29



ADAM metallopeptidase domain 29



chr12_-_66905802 3.431 NM_018402
IL26
interleukin 26
chr2_+_108751033 3.402 RANBP2
RAN binding protein 2
chr1_-_21310462 3.381 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr18_-_65766068 3.275 CD226
CD226 molecule
chr11_+_55776251 3.218 NM_001004747
OR5T3
olfactory receptor, family 5, subfamily T, member 3
chr11_-_5835507 3.179 NM_001005168
OR52E8
olfactory receptor, family 52, subfamily E, member 8
chr11_+_55799604 3.150 NM_001004745
OR5T1
olfactory receptor, family 5, subfamily T, member 1
chr12_+_63090008 3.138 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr8_-_93099040 3.127 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_-_79899748 3.111 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr5_+_161427225 3.046 NM_000816
NM_198903
NM_198904
GABRG2


gamma-aminobutyric acid (GABA) A receptor, gamma 2


chr10_+_129237602 2.966 NM_001030013
NPS
neuropeptide S
chr14_-_57133361 2.933 NM_001080455
SLC35F4
solute carrier family 35, member F4
chr2_-_99412694 2.921 REV1
REV1 homolog (S. cerevisiae)
chr1_-_150353179 2.904 NM_007113
TCHH
trichohyalin
chr4_+_71054492 2.875 NM_214711
C4orf40
chromosome 4 open reading frame 40
chr13_+_42253685 2.856 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr6_-_132987106 2.853 NM_001033080
TAAR2
trace amine associated receptor 2
chr1_-_245988330 2.844 NM_012353
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr7_+_90176647 2.839 NM_012395
CDK14
cyclin-dependent kinase 14
chr5_+_57823017 2.801 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr4_-_70861301 2.779 NM_001891
CSN2
casein beta
chr2_-_95846109 2.754 LOC150759
hypothetical LOC150759
chr15_-_23204887 2.753 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr12_+_29267863 2.731 NM_018099
FAR2
fatty acyl CoA reductase 2
chr4_+_69716298 2.676 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr9_+_74956601 2.673 ANXA1
annexin A1
chr9_-_21192201 2.650 NM_021057
IFNA7
interferon, alpha 7
chr14_-_94677807 2.642 NM_030621
DICER1
dicer 1, ribonuclease type III
chr8_-_13018123 2.635 NM_001164271
DLC1
deleted in liver cancer 1
chr2_-_188086612 2.628 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr7_+_80145461 2.618 CD36
CD36 molecule (thrombospondin receptor)
chr6_+_97117144 2.602 NM_001170807
NM_020482
FHL5

four and a half LIM domains 5

chr1_+_195123766 2.598 NM_006684
CFHR4
complement factor H-related 4
chr3_-_131081910 2.592 NM_001017395
TMCC1
transmembrane and coiled-coil domain family 1
chr8_+_24297742 2.586 NM_001145271
NM_001145272
NM_014479
ADAMDEC1


ADAM-like, decysin 1


chr21_+_30929425 2.573 NM_181616
KRTAP20-2
keratin associated protein 20-2
chr16_-_70339666 2.562 AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chr11_-_22838547 2.550 NM_001195637
LOC100500938
hypothetical LOC100500938
chr12_-_78831821 2.525 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory (inhibitor) subunit 12A
chr15_+_100175888 2.525 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr3_+_189425886 2.501 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr10_+_124141808 2.460 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr3_-_121117647 2.454 GSK3B
glycogen synthase kinase 3 beta
chr18_+_30544193 2.439 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr12_+_8557402 2.375 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr5_-_43326922 2.368 HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr12_+_76749199 2.354 NM_014903
NAV3
neuron navigator 3
chr1_-_151352587 2.327 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr5_+_175444454 2.323 NM_001079529
FAM153B
family with sequence similarity 153, member B
chr10_+_24537725 2.321 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr11_+_26310253 2.316 NM_031418
ANO3
anoctamin 3
chr5_+_166644420 2.303 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr6_-_127882192 2.287 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chr3_+_39346200 2.286 NM_005201
CCR8
chemokine (C-C motif) receptor 8
chr18_+_50139168 2.280 NM_173529
C18orf54
chromosome 18 open reading frame 54
chr10_+_115514567 2.243 NM_182601
C10orf81
chromosome 10 open reading frame 81
chr5_-_77880731 2.229 LHFPL2
lipoma HMGIC fusion partner-like 2
chr20_+_9406460 2.228 PLCB4
phospholipase C, beta 4
chr11_-_6005546 2.227 NM_001001917
OR56A1
olfactory receptor, family 56, subfamily A, member 1
chr1_-_196776697 2.223 NM_133262
NM_133326
ATP6V1G3

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

chrX_+_118598325 2.210 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr14_-_62638336 2.201 NM_172376
KCNH5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr11_-_55460451 2.185 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr4_+_157044296 2.183 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr3_-_193928038 2.178 NM_004113
FGF12
fibroblast growth factor 12
chr15_-_23201740 2.176 NM_130838
UBE3A
ubiquitin protein ligase E3A
chr9_-_21295311 2.175 NM_002169
IFNA5
interferon, alpha 5
chr11_-_55128424 2.156 NM_001004700
OR4C11
olfactory receptor, family 4, subfamily C, member 11
chr2_+_108230082 2.153 NM_001008743
SULT1C3
sulfotransferase family, cytosolic, 1C, member 3
chr8_+_118216517 2.151 NM_001172814
NM_173851
SLC30A8

solute carrier family 30 (zinc transporter), member 8

chr4_+_70896236 2.146 NM_001009181
NM_003154
STATH

statherin

chr9_-_103185621 2.145 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr11_-_4827013 2.133 NM_001004758
OR51S1
olfactory receptor, family 51, subfamily S, member 1
chr18_-_29882555 2.124 NM_001198549
NOL4
nucleolar protein 4
chr18_+_59733724 2.120 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr9_+_111927601 2.101 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr6_+_127940011 2.098 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr9_+_6318348 2.094 NM_001001874
NM_001001875
NM_033516
TPD52L3


tumor protein D52-like 3


chr2_+_203901160 2.090 NM_005759
ABI2
abl-interactor 2
chr13_-_35686665 2.089 NM_017826
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr9_-_14900992 2.089 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr5_+_179065282 2.035 CANX
calnexin
chr7_+_90177082 2.031 CDK14
cyclin-dependent kinase 14
chr4_+_91375204 2.028 NM_207491
FAM190A
family with sequence similarity 190, member A
chr11_-_62753574 2.027 NM_199352
SLC22A25
solute carrier family 22, member 25
chr19_+_41418723 2.024 ZNF146
zinc finger protein 146
chr13_+_108046500 2.019 NM_015011
MYO16
myosin XVI
chr21_-_30908093 2.012 NM_181602
KRTAP6-1
keratin associated protein 6-1
chr11_-_121492010 1.997 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr3_+_171112053 1.991 NM_182610
SAMD7
sterile alpha motif domain containing 7
chr8_+_107529327 1.985 NM_001198532
OXR1
oxidation resistance 1
chr12_+_46802695 1.983 NM_001166687
NM_001166688
PFKM

phosphofructokinase, muscle

chr5_-_41297296 1.965 NM_001115131
C6
complement component 6
chr1_+_146827470 1.958 NM_173638
NBPF15
neuroblastoma breakpoint family, member 15
chr12_+_9871343 1.957 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr13_+_51933228 1.947 CKAP2
cytoskeleton associated protein 2
chr2_-_210888010 1.940 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr14_-_105681377 1.937 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_+_54080480 1.928 NM_001005518
OR6C65
olfactory receptor, family 6, subfamily C, member 65
chr6_-_64087806 1.911 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr11_-_5110383 1.910 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chr11_-_57728228 1.908 NM_001004459
OR1S2
olfactory receptor, family 1, subfamily S, member 2
chr4_+_71298187 1.908 NM_021225
PROL1
proline rich, lacrimal 1
chr9_-_95255694 1.896 NM_198841
FAM120AOS
family with sequence similarity 120A opposite strand
chr4_-_70115037 1.885 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr9_+_74956614 1.855 ANXA1
annexin A1
chr8_-_12220195 1.853 NM_001195257
NM_001037804
LOC100133267
DEFB130
defensin, beta 130-like
defensin, beta 130
chr9_+_124477135 1.841 NM_001005234
OR1L3
olfactory receptor, family 1, subfamily L, member 3
chr10_+_118177371 1.839 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr4_+_114190233 1.838 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr9_-_103187082 1.834 NM_001701
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr1_-_203320153 1.820 NM_203376
TMEM81
transmembrane protein 81
chr4_+_87070449 1.819 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr1_+_63022359 1.806 NM_032852
NM_178221
ATG4C

ATG4 autophagy related 4 homolog C (S. cerevisiae)

chr8_-_18710575 1.789 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr1_-_246823691 1.776 NM_001004693
OR2T10
olfactory receptor, family 2, subfamily T, member 10
chr8_-_114458557 1.775 NM_198124
CSMD3
CUB and Sushi multiple domains 3
chr1_-_151296611 1.774 NM_005988
SPRR2A
small proline-rich protein 2A
chr14_+_31100330 1.772 NM_025152
NUBPL
nucleotide binding protein-like
chr8_+_50987149 1.764 NM_018967
SNTG1
syntrophin, gamma 1
chr8_-_30121741 1.760 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr2_-_215951161 1.756 FN1
fibronectin 1
chr8_-_102005697 1.752 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr2_-_158008763 1.751 NM_004288
CYTIP
cytohesin 1 interacting protein
chr3_+_115099007 1.746 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr12_+_10015274 1.737 NM_138337
NM_201623
CLEC12A

C-type lectin domain family 12, member A

chr11_-_5130174 1.736 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr13_+_81162030 1.731


chr2_+_190710730 1.728 NM_001042521
C2orf88
chromosome 2 open reading frame 88
chr15_+_49988882 1.726 TMOD3
tropomodulin 3 (ubiquitous)
chr9_+_21399132 1.709 NM_002170
IFNA8
interferon, alpha 8
chr2_+_114390975 1.702 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr6_-_53638464 1.698 NM_001003760
KLHL31
kelch-like 31 (Drosophila)
chr12_+_32546243 1.696 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr11_-_104399104 1.683 NM_001136109
NM_001136110
NM_001136112
NM_004347
CASP5



caspase 5, apoptosis-related cysteine peptidase



chr9_+_74956494 1.679 NM_000700
ANXA1
annexin A1
chr5_+_102493155 1.678 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr21_-_30614477 1.657 NM_203405
KRTAP26-1
keratin associated protein 26-1
chr1_+_185064654 1.653 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr9_-_89939719 1.651 NM_001166137
FAM75C2
family with sequence similarity 75, member C2
chr4_+_71126376 1.650 NM_152997
C4orf7
chromosome 4 open reading frame 7
chr14_+_67238355 1.643 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr8_-_62764839 1.643 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr4_+_53975597 1.638 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr2_+_159533329 1.638 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr6_+_64344307 1.612 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr2_-_55090759 1.608 NM_007008
RTN4
reticulon 4
chr5_-_160211623 1.603 NM_025153
ATP10B
ATPase, class V, type 10B
chr12_-_10846435 1.602 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr10_-_127559841 1.600 NM_018180
DHX32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr3_-_152173475 1.598 NM_001195794
NM_174878
CLRN1

clarin 1

chr12_+_18305740 1.594 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr4_-_191185390 1.592 NM_001005217
FRG2B
FRG2
FSHD region gene 2 family, member B
FSHD region gene 2
chr1_+_149165438 1.582 NM_001145415
NM_012432
SETDB1

SET domain, bifurcated 1

chr20_-_33783409 1.578 RBM39
RNA binding motif protein 39
chr9_+_78305368 1.576 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chrX_-_131401319 1.574 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr8_-_17797127 1.570 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr4_+_159350850 1.568 NM_018342
TMEM144
transmembrane protein 144
chr3_-_25654659 1.568 TOP2B
topoisomerase (DNA) II beta 180kDa
chr3_-_107070400 1.567 NM_170662
CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr11_-_5819702 1.564 NM_001005167
OR52E6
olfactory receptor, family 52, subfamily E, member 6
chr3_-_191650291 1.555 NM_207316
TMEM207
transmembrane protein 207
chr10_+_5228756 1.549 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr11_-_123182266 1.548 NM_001005325
OR6M1
olfactory receptor, family 6, subfamily M, member 1
chr7_+_28441758 1.537 NM_004904
CREB5
cAMP responsive element binding protein 5
chr4_-_104240413 1.536 NM_020139
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr8_+_36760999 1.529 NM_001031836
KCNU1
potassium channel, subfamily U, member 1
chr14_-_30927931 1.528 NM_015473
HEATR5A
HEAT repeat containing 5A
chr19_-_7009644 1.526 NM_001164425
MBD3L3
methyl-CpG-binding domain protein 3-like 3-like
chr4_+_71283383 1.522 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr3_-_167037946 1.518 NM_000055
BCHE
butyrylcholinesterase
chrX_+_105298953 1.518 NM_001171020
NM_152423
MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr4_+_146820805 1.514 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr7_+_104539548 1.509 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr20_+_12937616 1.508 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr12_+_53927248 1.498 NM_001005490
OR6C74
olfactory receptor, family 6, subfamily C, member 74
chr18_-_49944986 1.496 MBD2
methyl-CpG binding domain protein 2
chr3_-_99236520 1.496 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr22_-_39189369 1.495 MKL1
megakaryoblastic leukemia (translocation) 1
chr4_-_21155376 1.483 NM_001035004
KCNIP4
Kv channel interacting protein 4
chr13_-_32678142 1.481 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr3_+_98641143 1.478 NM_173655
EPHA6
EPH receptor A6
chr13_+_48178620 1.478 NM_020377
CYSLTR2
cysteinyl leukotriene receptor 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.16 3.16e-52 GO:0007608 sensory perception of smell
3.02 6.86e-52 GO:0007606 sensory perception of chemical stimulus
2.16 7.15e-33 GO:0007600 sensory perception
1.68 8.28e-20 GO:0050877 neurological system process
1.55 5.21e-17 GO:0003008 system process
1.14 3.22e-03 GO:0032501 multicellular organismal process
1.11 1.41e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.23 3.42e-09 GO:0071944 cell periphery
1.23 6.09e-09 GO:0005886 plasma membrane
1.10 7.03e-03 GO:0044425 membrane part
1.11 1.76e-02 GO:0016021 integral to membrane
1.11 2.87e-02 GO:0031224 intrinsic to membrane
1.08 3.34e-02 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.28 2.02e-55 GO:0004984 olfactory receptor activity
2.18 4.59e-36 GO:0004930 G-protein coupled receptor activity
1.76 1.56e-24 GO:0004888 transmembrane receptor activity
1.54 1.55e-17 GO:0004872 receptor activity
1.42 3.72e-13 GO:0004871 signal transducer activity
1.42 3.72e-13 GO:0060089 molecular transducer activity
5.67 1.21e-02 GO:0005132 interferon-alpha/beta receptor binding
1.38 2.90e-02 GO:0005509 calcium ion binding