Motif ID: HMX1.p2

Z-value: 1.770


Transcription factors associated with HMX1.p2:

Gene SymbolEntrez IDGene Name
HMX1 3166 H6 family homeobox 1



Activity profile for motif HMX1.p2.

activity profile for motif HMX1.p2


Sorted Z-values histogram for motif HMX1.p2

Sorted Z-values for motif HMX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_21442663 2.453 NM_002509
NKX2-2
NK2 homeobox 2
chr8_+_32525269 2.415 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr10_-_99521701 2.318 NM_003015
SFRP5
secreted frizzled-related protein 5
chr3_+_57969127 2.061 NM_001164317
NM_001164318
NM_001164319
NM_001457
FLNB



filamin B, beta



chr10_+_94811010 2.026 NM_183374
CYP26C1
cytochrome P450, family 26, subfamily C, polypeptide 1
chrX_+_48915127 1.946 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr11_+_268569 1.830 NM_138329
NLRP6
NLR family, pyrin domain containing 6
chr19_+_590878 1.771 NM_020637
FGF22
fibroblast growth factor 22
chr19_+_43447078 1.641 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr15_-_75694674 1.597 LINGO1
leucine rich repeat and Ig domain containing 1
chr12_+_4253143 1.587 NM_001759
CCND2
cyclin D2
chr10_+_103882776 1.585 NM_015062
PPRC1
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr7_+_5609416 1.544 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr19_+_43446937 1.477 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr19_+_43447262 1.433 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr20_+_2581177 1.377 NM_006392
NOP56
NOP56 ribonucleoprotein homolog (yeast)
chr22_-_35011703 1.363 MYH9
myosin, heavy chain 9, non-muscle
chr5_+_148186348 1.358 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr20_-_538909 1.243 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr1_+_151917674 1.225 NM_000906
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr16_+_87232501 1.186 NM_013278
IL17C
interleukin 17C
chrX_+_40367761 1.178 NM_001195522
LOC347411
brain protein 44-like protein 2
chr22_+_28032950 1.167 NM_006478
NM_152236
NM_152237
GAS2L1


growth arrest-specific 2 like 1


chr11_-_407324 1.150 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr17_+_1906262 1.135 NM_001098202
HIC1
hypermethylated in cancer 1
chr1_+_234372454 1.128 NM_003272
GPR137B
G protein-coupled receptor 137B
chr7_+_72486044 1.121 NM_003508
FZD9
frizzled homolog 9 (Drosophila)
chr11_+_66381451 1.118 NM_024036
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr6_+_33697023 1.104 NM_002224
ITPR3
inositol 1,4,5-triphosphate receptor, type 3
chr10_+_83625049 1.099 NM_001010848
NM_001165972
NRG3

neuregulin 3

chr7_-_719268 1.094 NM_001164761
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr9_+_134843918 1.085 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr16_-_85099941 1.073 LOC400550
hypothetical LOC400550
chr22_+_36384647 1.070 NM_020315
PDXP
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr10_+_72102563 1.017 NM_080722
NM_139155
ADAMTS14

ADAM metallopeptidase with thrombospondin type 1 motif, 14

chr17_-_72045218 1.007 NM_134268
CYGB
cytoglobin
chr12_+_93066370 0.997 NM_005761
PLXNC1
plexin C1
chr2_+_242146791 0.989 NM_032515
BOK
BCL2-related ovarian killer
chr19_-_54857003 0.985 IRF3
interferon regulatory factor 3
chrX_+_13497614 0.976 NM_001167890
NM_015507
EGFL6

EGF-like-domain, multiple 6

chr17_-_76064842 0.971 NM_002522
NPTX1
neuronal pentraxin I
chr14_+_22845851 0.968 NM_004050
BCL2L2-PABPN1
BCL2L2
BCL2L2-PABPN1 read-through transcript
BCL2-like 2
chr2_-_233060774 0.966 NM_004826
ECEL1
endothelin converting enzyme-like 1
chr7_-_19151509 0.964 NM_152898
FERD3L
Fer3-like (Drosophila)
chr2_-_241408296 0.959 NM_004321
KIF1A
kinesin family member 1A
chr1_+_1557419 0.943 NM_006983
MMP23B
matrix metallopeptidase 23B
chr16_+_3002457 0.926 NM_020982
CLDN9
claudin 9
chr14_+_41146513 0.906 NM_152447
LRFN5
leucine rich repeat and fibronectin type III domain containing 5
chr12_+_4300607 0.882 NM_020375
C12orf5
chromosome 12 open reading frame 5
chr14_-_88328848 0.842 NM_183387
EML5
echinoderm microtubule associated protein like 5
chr2_+_218833982 0.834 NM_001077191
NM_001077194
NM_170699
GPBAR1


G protein-coupled bile acid receptor 1


chr8_+_32623792 0.831 NM_013959
NRG1
neuregulin 1
chr12_-_47679459 0.816 DDN
dendrin
chr16_-_1763036 0.809 NM_023936
MRPS34
mitochondrial ribosomal protein S34
chr11_+_66381077 0.799 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr19_+_58733144 0.796 NM_001079906
ZNF331
zinc finger protein 331
chr4_-_2390050 0.793 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr21_-_26345294 0.791


chr16_-_65751263 0.780 TRADD
TNFRSF1A-associated via death domain
chr2_+_109729176 0.772 NM_023016
ANKRD57
ankyrin repeat domain 57
chr17_+_71229191 0.769 ITGB4
integrin, beta 4
chr16_-_65751305 0.761 NM_003789
TRADD
TNFRSF1A-associated via death domain
chr3_-_129777618 0.761 NM_007354
C3orf27
chromosome 3 open reading frame 27
chr17_-_77635703 0.754 FASN
fatty acid synthase
chr14_-_104705753 0.753 JAG2
jagged 2
chr14_+_101097440 0.752 NM_001362
DIO3
deiodinase, iodothyronine, type III
chr9_-_26882713 0.749 NM_001167575
NM_024828
C9orf82

chromosome 9 open reading frame 82

chr14_+_73775927 0.746 NM_182894
VSX2
visual system homeobox 2
chr10_+_126140330 0.743 NM_001167880
NM_022126
LHPP

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

chr17_-_15185623 0.737 NM_031898
TEKT3
tektin 3
chr4_-_142273881 0.732 NM_020724
RNF150
ring finger protein 150
chr14_+_100270222 0.730 DLK1
delta-like 1 homolog (Drosophila)
chr19_+_2240996 0.715


chr11_-_45264193 0.711 NM_020826
SYT13
synaptotagmin XIII
chr4_+_2390469 0.710 NM_001193282
LOC402160
hypothetical protein LOC402160
chr17_+_21220260 0.709 NM_021012
KCNJ12
potassium inwardly-rectifying channel, subfamily J, member 12
chr8_+_31616809 0.707 NM_013962
NRG1
neuregulin 1
chr18_-_45975163 0.702 NM_001080467
MYO5B
myosin VB
chr4_+_75529716 0.700 NM_001657
AREG
amphiregulin
chr17_+_19255083 0.696 NM_007148
RNF112
ring finger protein 112
chr1_-_215377718 0.693 NM_001134285
ESRRG
estrogen-related receptor gamma
chrX_-_100332933 0.691 YWHAQP8
YWHAQ pseudogene 8
chr7_-_719102 0.687 NM_001164762
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr18_+_48120539 0.685 NM_005215
DCC
deleted in colorectal carcinoma
chr1_+_39229474 0.675 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr18_-_55091596 0.675 NM_013435
RAX
retina and anterior neural fold homeobox
chr22_+_35777561 0.672 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chr19_+_4445291 0.665 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr3_+_127743868 0.658 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr8_+_120497732 0.651 NM_002514
NOV
nephroblastoma overexpressed gene
chr3_+_122109716 0.650 NM_014980
STXBP5L
syntaxin binding protein 5-like
chrX_-_131918905 0.648 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr20_+_20296744 0.648 NM_002196
INSM1
insulinoma-associated 1
chr2_+_171381317 0.645 NM_000817
NM_013445
GAD1

glutamate decarboxylase 1 (brain, 67kDa)

chr15_-_75693309 0.645 LINGO1
leucine rich repeat and Ig domain containing 1
chr6_+_41714171 0.644 NM_005586
MDFI
MyoD family inhibitor
chr17_-_3651236 0.643 NM_002208
ITGAE
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
chr1_+_180836050 0.641


chr19_-_10202947 0.623 NM_004230
S1PR2
sphingosine-1-phosphate receptor 2
chr3_+_127118130 0.621 LOC100125556
family with sequence similarity 86, member A pseudogene
chr22_-_49063088 0.620 PLXNB2
plexin B2
chr12_-_42231990 0.612 NM_025003
ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr19_+_627346 0.609 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr2_-_122210873 0.607 NM_032390
MKI67IP
MKI67 (FHA domain) interacting nucleolar phosphoprotein
chr12_-_47651812 0.603 NM_003394
WNT10B
wingless-type MMTV integration site family, member 10B
chr4_-_109307325 0.602 NM_001166119
LEF1
lymphoid enhancer-binding factor 1
chr3_-_193928038 0.599 NM_004113
FGF12
fibroblast growth factor 12
chr4_-_21559471 0.598 NM_147182
KCNIP4
Kv channel interacting protein 4
chr20_+_2974659 0.597 NM_030811
MRPS26
mitochondrial ribosomal protein S26
chr10_-_135000464 0.593 NM_015722
CALY
calcyon neuron-specific vesicular protein
chr5_+_170779664 0.593 FGF18
fibroblast growth factor 18
chr15_-_38953628 0.591 NM_133639
RHOV
ras homolog gene family, member V
chr20_-_26137755 0.588 LOC284801
hypothetical protein LOC284801
chr7_+_30917939 0.583 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chr20_+_21231921 0.575 NM_012255
XRN2
5'-3' exoribonuclease 2
chr16_+_1763185 0.572 NM_001010865
EME2
essential meiotic endonuclease 1 homolog 2 (S. pombe)
chr11_+_63758550 0.571 NM_003377
VEGFB
vascular endothelial growth factor B
chr16_+_56259657 0.570 NM_170776
GPR97
G protein-coupled receptor 97
chr3_-_57088332 0.568 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr7_-_97719372 0.566 NM_015395
TECPR1
tectonin beta-propeller repeat containing 1
chr7_-_100009205 0.566 NM_001168682
SAP25
sin3A-binding protein 25
chr4_+_2031036 0.565 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr16_+_12902955 0.564 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr10_-_98470164 0.560 NM_152309
PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr8_-_26780665 0.556 ADRA1A
adrenergic, alpha-1A-, receptor
chr6_+_36754467 0.556 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr17_-_9635325 0.548 NM_001105571
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr20_+_30103642 0.546 NM_001172129
NM_001172130
NM_001172131
NM_001172132
NM_001172133
NM_002110
HCK





hemopoietic cell kinase





chr16_+_65754788 0.546 NM_001040667
NM_001538
HSF4

heat shock transcription factor 4

chr19_+_47056162 0.541 RPS19
ribosomal protein S19
chr2_+_176677479 0.541


chr20_+_60311469 0.535 ADRM1
adhesion regulating molecule 1
chr12_-_47679176 0.535 NM_015086
DDN
dendrin
chr16_+_2954217 0.535 NM_024507
NM_172229
KREMEN2

kringle containing transmembrane protein 2

chr11_+_66547391 0.534 NM_177963
SYT12
synaptotagmin XII
chrX_+_46656543 0.532 NM_001077445
NM_014735
PHF16

PHD finger protein 16

chr13_-_75009941 0.532 NM_203495
NM_203497
COMMD6

COMM domain containing 6

chr12_-_15265490 0.532 NM_001190726
NM_032918
RERG

RAS-like, estrogen-regulated, growth inhibitor

chr9_-_138277467 0.526 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr2_+_242289983 0.526 NM_032329
ING5
inhibitor of growth family, member 5
chr9_-_10602722 0.525 NM_002839
PTPRD
protein tyrosine phosphatase, receptor type, D
chr14_+_61653827 0.524 FLJ43390
hypothetical LOC646113
chr17_+_58908152 0.521 NM_000789
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr19_+_47056102 0.520 RPS19
ribosomal protein S19
chr9_-_34554800 0.520 CNTFR
ciliary neurotrophic factor receptor
chr20_+_2224612 0.518 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chrX_-_111809929 0.518 NM_178175
LHFPL1
lipoma HMGIC fusion partner-like 1
chr5_+_156625629 0.518 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chrX_+_101853912 0.516 NM_001004051
NM_001184874
NM_001184875
NM_001184876
NM_138437
GPRASP2




G protein-coupled receptor associated sorting protein 2




chr14_+_20568184 0.515 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr3_+_50291521 0.514 NM_153215
C3orf45
chromosome 3 open reading frame 45
chr17_+_9489578 0.513 NM_153210
USP43
ubiquitin specific peptidase 43
chr9_-_23811477 0.512 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr1_-_45081190 0.511 NM_001166292
NM_003738
PTCH2

patched 2

chr10_+_106390848 0.511 NM_014978
SORCS3
sortilin-related VPS10 domain containing receptor 3
chr7_+_50314801 0.510 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr15_+_62230962 0.509 NM_024798
SNX22
sorting nexin 22
chr2_-_27469947 0.509 FTH1P3
ferritin, heavy polypeptide 1 pseudogene 3
chrX_-_152863251 0.509 NM_002910
RENBP
renin binding protein
chr19_+_40474867 0.508 NM_002361
NM_080600
MAG

myelin associated glycoprotein

chr5_-_172594691 0.507 NM_001166175
NM_001166176
NM_004387
NKX2-5


NK2 transcription factor related, locus 5 (Drosophila)


chr20_+_61655934 0.507


chr17_+_71229110 0.506 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr10_+_72826656 0.506 NM_001171930
NM_001171931
NM_001171932
NM_022124
NM_052836
CDH23




cadherin-related 23




chr12_-_47604930 0.506 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr19_+_40299058 0.504 FXYD3
FXYD domain containing ion transport regulator 3
chr4_+_81325447 0.503 NM_020226
PRDM8
PR domain containing 8
chr9_+_966963 0.501 NM_021240
DMRT3
doublesex and mab-3 related transcription factor 3
chr21_-_38954433 0.499 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr11_+_1367665 0.498 NM_003957
BRSK2
BR serine/threonine kinase 2
chr22_+_45537181 0.496 NM_014346
TBC1D22A
TBC1 domain family, member 22A
chr3_-_52839727 0.495 NM_001166449
NM_002218
ITIH4

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

chr15_+_87147667 0.494 NM_001135
NM_013227
ACAN

aggrecan

chr14_-_100104014 0.493 NM_001159531
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr16_-_87405817 0.492 NM_000485
NM_001030018
APRT

adenine phosphoribosyltransferase

chr2_-_219566364 0.492 NM_005209
NM_057093
NM_057094
CRYBA2


crystallin, beta A2


chr11_+_527521 0.492 NM_198075
LRRC56
leucine rich repeat containing 56
chrX_+_46318135 0.491 NM_019886
CHST7
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
chr1_-_194844061 0.489 NM_198503
KCNT2
potassium channel, subfamily T, member 2
chr1_-_194844299 0.489 KCNT2
potassium channel, subfamily T, member 2
chr1_+_35020425 0.489 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr19_+_62523636 0.488 NM_213598
ZNF543
zinc finger protein 543
chr9_-_135029096 0.487 NM_021996
GBGT1
RALGDS
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
ral guanine nucleotide dissociation stimulator
chr22_+_28446288 0.486 NM_182527
CABP7
calcium binding protein 7
chr1_+_154478574 0.483 NM_199173
BGLAP
bone gamma-carboxyglutamate (gla) protein
chrX_-_34585287 0.483 NM_031442
TMEM47
transmembrane protein 47
chr14_+_28306633 0.481 FOXG1
forkhead box G1
chr8_+_121206478 0.481 NM_021110
COL14A1
collagen, type XIV, alpha 1
chr19_+_52215982 0.479 NM_002517
NPAS1
neuronal PAS domain protein 1
chr11_+_69165065 0.479 CCND1
cyclin D1
chr5_-_88004891 0.477 LOC645323
hypothetical LOC645323
chr22_-_29272668 0.475 NM_001193336
LOC730005
SEC14-like (S. cerevisiae)
chr22_+_49128583 0.473 NM_014678
PPP6R2
protein phosphatase 6, regulatory subunit 2
chr9_+_139202874 0.472 NM_003731
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr17_-_37275142 0.465 NM_018143
KLHL11
kelch-like 11 (Drosophila)
chr16_-_47872973 0.464 CBLN1
cerebellin 1 precursor
chr15_+_81567327 0.461 NM_001144903
NM_023003
TM6SF1

transmembrane 6 superfamily member 1

chrX_-_139414890 0.460 NM_005634
SOX3
SRY (sex determining region Y)-box 3
chr16_-_47872880 0.460


chr1_-_2554288 0.458 NM_033467
MMEL1
membrane metallo-endopeptidase-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.57 1.96e-08 GO:0007399 nervous system development
1.37 8.63e-08 GO:0048731 system development
1.45 1.03e-07 GO:0030154 cell differentiation
1.33 1.35e-07 GO:0007275 multicellular organismal development
1.42 8.18e-07 GO:0048869 cellular developmental process
1.32 3.55e-06 GO:0048856 anatomical structure development
1.64 6.07e-06 GO:0022008 neurogenesis
1.28 6.28e-06 GO:0032502 developmental process
1.66 9.96e-06 GO:0048699 generation of neurons
1.62 2.30e-05 GO:0048468 cell development
1.44 3.00e-05 GO:0023051 regulation of signaling
1.61 4.06e-05 GO:0050793 regulation of developmental process
1.71 5.38e-05 GO:0045595 regulation of cell differentiation
1.66 7.78e-05 GO:2000026 regulation of multicellular organismal development
2.05 9.93e-05 GO:0060284 regulation of cell development
1.45 1.76e-04 GO:0009966 regulation of signal transduction
1.85 1.81e-04 GO:0051094 positive regulation of developmental process
2.30 2.30e-04 GO:0045664 regulation of neuron differentiation
1.38 2.96e-04 GO:0048583 regulation of response to stimulus
2.15 3.12e-04 GO:0050767 regulation of neurogenesis
1.37 4.40e-04 GO:0048513 organ development
2.06 4.62e-04 GO:0051960 regulation of nervous system development
1.73 2.11e-03 GO:0031175 neuron projection development
1.78 2.53e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.89 2.91e-03 GO:0045597 positive regulation of cell differentiation
1.72 3.32e-03 GO:0000904 cell morphogenesis involved in differentiation
1.75 4.96e-03 GO:0048812 neuron projection morphogenesis
1.46 5.33e-03 GO:0010646 regulation of cell communication
2.39 1.02e-02 GO:0042692 muscle cell differentiation
1.74 1.07e-02 GO:0007409 axonogenesis
2.96 1.11e-02 GO:0050770 regulation of axonogenesis
1.56 1.17e-02 GO:0030182 neuron differentiation
2.39 1.48e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.29 1.67e-02 GO:0048523 negative regulation of cellular process
2.37 1.77e-02 GO:0022604 regulation of cell morphogenesis
1.32 2.19e-02 GO:0007166 cell surface receptor linked signaling pathway
1.84 2.36e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.27 2.48e-02 GO:0048522 positive regulation of cellular process
1.81 2.56e-02 GO:0051093 negative regulation of developmental process
1.38 3.66e-02 GO:0051239 regulation of multicellular organismal process
1.55 4.81e-02 GO:0030030 cell projection organization
1.24 4.95e-02 GO:0048518 positive regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.33 5.94e-05 GO:0044459 plasma membrane part
1.19 3.28e-03 GO:0005886 plasma membrane
1.18 4.41e-03 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.40 3.98e-02 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity