Motif ID: IKZF1.p2

Z-value: 0.832


Transcription factors associated with IKZF1.p2:

Gene SymbolEntrez IDGene Name
IKZF1 10320 IKAROS family zinc finger 1 (Ikaros)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF1chr7_+_503188010.097.5e-01Click!


Activity profile for motif IKZF1.p2.

activity profile for motif IKZF1.p2


Sorted Z-values histogram for motif IKZF1.p2

Sorted Z-values for motif IKZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_118259684 0.812 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chrX_-_53327473 0.683 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr15_+_38923470 0.683 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr19_+_43447262 0.682 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_43447078 0.665 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_43446937 0.648 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr5_-_95044415 0.629 NM_031952
SPATA9
spermatogenesis associated 9
chr12_+_50913274 0.543 KRT7
keratin 7
chr1_+_39229474 0.541 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr11_+_10439253 0.534 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr11_+_63883192 0.520 NM_001006944
NM_003942
RPS6KA4

ribosomal protein S6 kinase, 90kDa, polypeptide 4

chrX_-_111809929 0.493 NM_178175
LHFPL1
lipoma HMGIC fusion partner-like 1
chr1_+_117253882 0.475 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr16_-_87244896 0.462 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr4_-_75083160 0.453 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chrX_-_133620103 0.440 NM_021796
PLAC1
placenta-specific 1
chr14_-_68424653 0.427 ACTN1
actinin, alpha 1
chr12_+_50913220 0.426 NM_005556
KRT7
keratin 7
chr11_+_35922106 0.423 NM_174902
LDLRAD3
low density lipoprotein receptor class A domain containing 3
chr1_+_35020425 0.409 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr22_+_38720881 0.398 NM_138435
FAM83F
family with sequence similarity 83, member F
chr10_+_102881050 0.397 NM_001195517
NM_005521
TLX1

T-cell leukemia homeobox 1

chrX_+_102356659 0.395 NM_001080425
NM_001127688
BEX4

brain expressed, X-linked 4

chr18_+_59295123 0.382 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr17_-_8220709 0.382 KRBA2
KRAB-A domain containing 2
chr2_+_3620296 0.374 NM_024027
NM_199235
COLEC11

collectin sub-family member 11

chr19_-_50963942 0.374


chr10_-_102880892 0.369 NM_001085398
TLX1NB
TLX1 neighbor
chr3_-_150286812 0.369 NM_003071
NM_139048
HLTF

helicase-like transcription factor

chr17_-_1478859 0.369 NM_152346
SLC43A2
solute carrier family 43, member 2
chrX_-_111970662 0.368 NM_133265
AMOT
angiomotin
chr5_+_180514548 0.364 NM_206880
OR2V2
olfactory receptor, family 2, subfamily V, member 2
chr8_+_32905027 0.360


chr5_-_160044844 0.356 ATP10B
ATPase, class V, type 10B
chr12_-_51585004 0.354 NM_002273
KRT8
keratin 8
chr8_-_37916803 0.346 NM_152413
GOT1L1
glutamic-oxaloacetic transaminase 1-like 1
chr17_+_69781980 0.343 NM_001172810
NM_023036
DNAI2

dynein, axonemal, intermediate chain 2

chr3_+_99350859 0.339 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr12_-_53044495 0.339 NM_020370
GPR84
G protein-coupled receptor 84
chr8_-_143848225 0.338 NM_177458
LYNX1
Ly6/neurotoxin 1
chr1_+_31814672 0.337 NM_022164
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr9_-_125732005 0.328 NM_020946
NM_024820
DENND1A

DENN/MADD domain containing 1A

chr14_+_61653827 0.326 FLJ43390
hypothetical LOC646113
chr1_-_50661716 0.326 NM_032110
DMRTA2
DMRT-like family A2
chr1_+_31814709 0.325 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr2_+_27225362 0.325 NM_175769
TCF23
transcription factor 23
chr1_+_156701895 0.325 NM_001004473
OR10K1
olfactory receptor, family 10, subfamily K, member 1
chrX_-_119593646 0.321 NM_003588
CUL4B
cullin 4B
chr8_+_125532223 0.317 NM_017956
TRMT12
tRNA methyltransferase 12 homolog (S. cerevisiae)
chrX_-_48661226 0.314 NM_006875
PIM2
pim-2 oncogene
chr12_-_53064565 0.314 ZNF385A
zinc finger protein 385A
chr21_-_44899003 0.311 NM_198698
KRTAP12-4
keratin associated protein 12-4
chr7_+_47661366 0.304 NM_001123065
C7orf65
chromosome 7 open reading frame 65
chr11_+_13940489 0.303 NM_006108
SPON1
spondin 1, extracellular matrix protein
chr2_-_39040981 0.303 LOC375196
hypothetical LOC375196
chr1_-_151855413 0.302 NM_020672
S100A14
S100 calcium binding protein A14
chr1_-_158306570 0.300 NM_002241
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr13_-_49597776 0.295 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr1_+_246718487 0.294 NM_001004697
OR2T5
olfactory receptor, family 2, subfamily T, member 5
chr7_-_19123765 0.293 TWIST1
twist homolog 1 (Drosophila)
chr5_-_131591380 0.291 NM_001017974
NM_001142598
NM_001142599
P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr15_-_39593285 0.291 NM_001135685
NM_002344
NM_206961
LTK


leukocyte receptor tyrosine kinase


chr14_-_53977785 0.288 NM_005776
CNIH
cornichon homolog (Drosophila)
chr11_+_65740789 0.284 PACS1
phosphofurin acidic cluster sorting protein 1
chr17_+_38247493 0.281 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr7_-_19123787 0.279 NM_000474
TWIST1
twist homolog 1 (Drosophila)
chr11_+_47236072 0.279 NM_001130101
NM_005693
NR1H3

nuclear receptor subfamily 1, group H, member 3

chr10_-_105427898 0.275 SH3PXD2A
SH3 and PX domains 2A
chr11_+_66952462 0.272 NM_003952
RPS6KB2
ribosomal protein S6 kinase, 70kDa, polypeptide 2
chr5_-_137695337 0.268 NM_001790
NM_022809
CDC25C

cell division cycle 25 homolog C (S. pombe)

chrX_+_41078353 0.265 DDX3X
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
chr15_-_89338728 0.264 NM_003981
NM_199413
NM_199414
PRC1


protein regulator of cytokinesis 1


chr1_+_31814712 0.263 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr13_-_37341859 0.263 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr19_+_9132367 0.262


chr19_-_5929286 0.261 NM_003624
NM_007320
NM_007322
RANBP3


RAN binding protein 3


chr12_-_42231990 0.261 NM_025003
ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr10_+_118295417 0.260 NM_000936
PNLIP
pancreatic lipase
chr1_+_174698929 0.257 NM_020318
NM_021936
PAPPA2

pappalysin 2

chr3_+_115149234 0.256 NM_173570
ZDHHC23
zinc finger, DHHC-type containing 23
chr3_-_185218311 0.254 NM_001023587
NM_005688
ABCC5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

chr5_+_14541523 0.253 TRIO
triple functional domain (PTPRF interacting)
chr4_-_56107725 0.252 NM_004898
CLOCK
clock homolog (mouse)
chr17_-_7434113 0.252 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chrX_+_73440749 0.249 NM_203303
ZCCHC13
zinc finger, CCHC domain containing 13
chr15_+_69626594 0.248 THSD4
thrombospondin, type I, domain containing 4
chr10_-_6144119 0.247 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr19_-_60320592 0.247 NM_017607
PPP1R12C
protein phosphatase 1, regulatory (inhibitor) subunit 12C
chr1_+_27062215 0.245 NM_006142
SFN
stratifin
chr19_+_60580015 0.244 NM_139172
TMEM190
transmembrane protein 190
chr11_+_13940715 0.243 SPON1
spondin 1, extracellular matrix protein
chr19_+_10388448 0.243 PDE4A
phosphodiesterase 4A, cAMP-specific
chr20_+_36408237 0.243 NM_004139
LBP
lipopolysaccharide binding protein
chr18_+_46340400 0.240 NM_002747
MAPK4
mitogen-activated protein kinase 4
chr12_+_109424387 0.239 NM_152442
RAD9B
RAD9 homolog B (S. pombe)
chr11_+_63463009 0.238 NM_024771
NAA40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr14_+_102659464 0.238 TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr17_+_45527507 0.238 NM_002611
PDK2
pyruvate dehydrogenase kinase, isozyme 2
chr1_-_150653351 0.237 NM_016190
CRNN
cornulin
chr12_+_1799693 0.234 NM_001039029
NM_001163925
NM_001163926
LRTM2


leucine-rich repeats and transmembrane domains 2


chr13_-_77390907 0.234 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr4_-_122304925 0.233 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chrX_-_74292800 0.232 NM_004299
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr18_-_72857951 0.231 MBP
myelin basic protein
chr19_+_447453 0.231 NM_130760
NM_130762
MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr16_-_65510230 0.230 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr1_+_3378030 0.228 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr19_-_14771947 0.228 NM_198944
OR7C1
olfactory receptor, family 7, subfamily C, member 1
chr1_+_33124658 0.227 NM_002143
HPCA
hippocalcin
chr2_-_11727705 0.227 NM_012344
NTSR2
neurotensin receptor 2
chr3_-_47299259 0.224 NM_001134878
NM_022342
NM_182902
KIF9


kinesin family member 9


chr19_+_51493486 0.224 NM_022462
HIF3A
hypoxia inducible factor 3, alpha subunit
chrX_-_30505804 0.224 NM_025159
CXorf21
chromosome X open reading frame 21
chr8_+_105421226 0.223 NM_030788
TM7SF4
transmembrane 7 superfamily member 4
chr17_-_42532605 0.223


chr8_-_145881968 0.223 ARHGAP39
Rho GTPase activating protein 39
chr5_-_55326358 0.222 NM_001190981
NM_002184
NM_175767
IL6ST


interleukin 6 signal transducer (gp130, oncostatin M receptor)


chr20_+_55569542 0.222 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr21_+_39117064 0.221 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr19_-_10807866 0.220 NM_006858
TMED1
transmembrane emp24 protein transport domain containing 1
chr10_+_118340460 0.220 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chr10_+_103901922 0.220 NM_004741
NOLC1
nucleolar and coiled-body phosphoprotein 1
chr3_+_46423682 0.220 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr15_-_41409979 0.219 NM_014793
LCMT2
leucine carboxyl methyltransferase 2
chr8_+_73612179 0.219 NM_004770
KCNB2
potassium voltage-gated channel, Shab-related subfamily, member 2
chr1_+_93830106 0.217 LOC100129046
hypothetical LOC100129046
chr22_-_36212160 0.217 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr10_+_104145421 0.217 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chrX_+_100532594 0.217 NM_021029
RPL36A
ribosomal protein L36a
chr14_+_64240902 0.216 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr11_+_817584 0.216 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr12_-_56445653 0.215 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr3_-_69212192 0.214 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr19_+_10597167 0.213 NM_020428
SLC44A2
solute carrier family 44, member 2
chr1_+_6767968 0.213 NM_001195563
NM_015215
CAMTA1

calmodulin binding transcription activator 1

chr3_-_171786468 0.211 NM_020949
SLC7A14
solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
chr11_-_10672079 0.210 NM_001100163
NM_130385
MRVI1

murine retrovirus integration site 1 homolog

chr7_+_48095464 0.210 UPP1
uridine phosphorylase 1
chr9_-_89939719 0.208 NM_001166137
FAM75C2
family with sequence similarity 75, member C2
chrX_-_19918958 0.207 LOC729609
hypothetical LOC729609
chr9_+_86473273 0.207 NM_001018064
NM_006180
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr5_-_178984192 0.205 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr14_+_104244998 0.205 INF2
inverted formin, FH2 and WH2 domain containing
chrX_+_21302317 0.204 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr1_+_885763 0.204 NM_198317
KLHL17
kelch-like 17 (Drosophila)
chr15_+_67532176 0.203 NM_001003
NM_213725
RPLP1

ribosomal protein, large, P1

chr8_-_79880095 0.201 NM_000880
IL7
interleukin 7
chr6_+_154373323 0.200 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chrX_-_71709335 0.200 HDAC8
histone deacetylase 8
chr6_-_17814596 0.199 NM_005124
NUP153
nucleoporin 153kDa
chr2_-_192767494 0.199 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr15_-_38908197 0.199 NM_001130143
NM_017726
PPP1R14D

protein phosphatase 1, regulatory (inhibitor) subunit 14D

chrX_-_71709622 0.198 NM_001166418
NM_001166419
NM_001166420
NM_001166422
NM_001166448
NM_018486
HDAC8





histone deacetylase 8





chr14_+_64240996 0.198 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr1_-_153480980 0.197 NM_001005741
NM_001005742
NM_001171811
GBA


glucosidase, beta, acid


chr14_-_105623358 0.196 IGHA1
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_-_119826073 0.194 SPPL3
signal peptide peptidase 3
chr3_-_193609531 0.193 NM_021032
FGF12
fibroblast growth factor 12
chr16_-_695719 0.192 NM_153350
FBXL16
F-box and leucine-rich repeat protein 16
chr12_+_111980044 0.192 NM_004416
DTX1
deltex homolog 1 (Drosophila)
chrX_-_55037235 0.191 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr10_-_102036398 0.191 NM_173809
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr12_+_111408667 0.190


chr11_+_72658586 0.189 NM_176798
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr3_+_129117007 0.189 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr2_+_191009265 0.189 MFSD6
major facilitator superfamily domain containing 6
chr15_-_41000100 0.187 NM_173500
TTBK2
tau tubulin kinase 2
chr1_-_110108048 0.187 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr15_-_66511488 0.186 NM_001004439
ITGA11
integrin, alpha 11
chr5_+_79651545 0.186 NM_032567
SPZ1
spermatogenic leucine zipper 1
chr1_+_196153122 0.186 NM_020204
LHX9
LIM homeobox 9
chr19_+_50004134 0.185 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr12_-_14929991 0.185 NM_000900
NM_001190839
MGP

matrix Gla protein

chr6_-_142451487 0.184 NM_002511
NMBR
neuromedin B receptor
chr14_-_76958984 0.184 NM_138791
NM_001113475
C14orf148

chromosome 14 open reading frame 148

chr12_-_46786107 0.184 SENP1
SUMO1/sentrin specific peptidase 1
chr11_+_74788200 0.183 NM_001005
RPS3
ribosomal protein S3
chr1_-_109651140 0.182 NM_001010985
MYBPHL
myosin binding protein H-like
chr11_-_62203119 0.181 UBXN1
UBX domain protein 1
chr10_+_96295511 0.181 NM_018063
HELLS
helicase, lymphoid-specific
chr4_-_17392232 0.181 NM_015688
FAM184B
family with sequence similarity 184, member B
chr3_+_52504410 0.180 STAB1
stabilin 1
chr1_+_23990228 0.180 NM_007260
LYPLA2
lysophospholipase II
chr1_-_51560469 0.179 NM_001080494
TTC39A
tetratricopeptide repeat domain 39A
chr3_-_48729593 0.178 NM_001005909
NM_001005910
NM_001005911
NM_001146178
NM_001146179
NM_001190316
NM_001190317
NM_016291
IP6K2







inositol hexakisphosphate kinase 2







chr2_-_101291483 0.177 NM_173647
RNF149
ring finger protein 149
chr7_-_32897934 0.176 NM_015483
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr6_+_126112431 0.176 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr6_+_126112417 0.176 NM_012259
HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr3_-_185578621 0.175 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr3_-_69517913 0.173 FRMD4B
FERM domain containing 4B
chr17_+_37694007 0.173 STAT5A
signal transducer and activator of transcription 5A
chr19_+_51492136 0.173 NM_152795
HIF3A
hypoxia inducible factor 3, alpha subunit
chr19_-_19245022 0.172 NM_001001524
TM6SF2
transmembrane 6 superfamily member 2
chr19_+_54962083 0.172 AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr1_-_120413542 0.171 NOTCH2
notch 2
chr6_+_155453114 0.171 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr17_+_1892026 0.171 NM_080822
OVCA2
ovarian tumor suppressor candidate 2
chr7_-_103417198 0.169 NM_005045
NM_173054
RELN

reelin

chr3_-_130630021 0.169 NM_207307
C3orf25
chromosome 3 open reading frame 25

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.69 1.58e-02 GO:0005083 small GTPase regulator activity