Motif ID: IKZF2.p2

Z-value: 2.341


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF2chr2_-_2137232980.836.7e-05Click!


Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_32698892 2.912 NM_001159996
NRG1
neuregulin 1
chr4_-_153523113 2.630 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr11_+_101488380 2.619 NM_001195045
YAP1
Yes-associated protein 1
chr3_+_99465777 2.590 NM_001005479
OR5H6
olfactory receptor, family 5, subfamily H, member 6
chr6_+_127940011 2.455 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr14_-_105862080 2.444 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr14_-_106064887 2.266 LOC100126583
IGHV3-48
IGHA1
IGHM
hypothetical LOC100126583
immunoglobulin heavy variable 3-48
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant mu
chr14_+_38719462 2.240 PNN
pinin, desmosome associated protein
chr7_+_93388951 2.183 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr1_+_150852910 2.100 NM_178433
LCE3B
late cornified envelope 3B
chr2_+_228386800 2.005 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr6_-_109795925 1.967 CD164
CD164 molecule, sialomucin
chr14_+_38720085 1.957 PNN
pinin, desmosome associated protein
chr6_+_153113624 1.953 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr7_+_17304707 1.902 NM_001621
AHR
aryl hydrocarbon receptor
chr14_+_31615959 1.846 ARHGAP5
Rho GTPase activating protein 5
chr2_-_215967442 1.838 FN1
fibronectin 1
chr9_-_106401514 1.832 NM_001004482
OR13C5
olfactory receptor, family 13, subfamily C, member 5
chr14_+_64001969 1.826 NM_004857
AKAP5
A kinase (PRKA) anchor protein 5
chr4_+_95595419 1.756 PDLIM5
PDZ and LIM domain 5
chr11_-_95715976 1.679 NM_032427
MAML2
mastermind-like 2 (Drosophila)
chr4_+_124540114 1.673 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr2_-_210888010 1.665 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr14_+_31615922 1.657 ARHGAP5
Rho GTPase activating protein 5
chr13_+_81162030 1.640


chr5_-_146441184 1.639 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr14_-_20969706 1.605 NM_001170629
CHD8
chromodomain helicase DNA binding protein 8
chr12_-_11178109 1.593 NM_001097643
TAS2R30
taste receptor, type 2, member 30
chr6_+_88024152 1.591 ZNF292
zinc finger protein 292
chr14_-_94669547 1.569 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr18_+_27281729 1.549 NM_001944
DSG3
desmoglein 3
chr5_+_27508139 1.533 LOC643401
hypothetical protein LOC643401
chr6_-_127882192 1.532 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chr2_+_191009265 1.532 MFSD6
major facilitator superfamily domain containing 6
chr14_-_105589467 1.528 LOC100126583
IGHA1
IGHG1
IGHG2
IGHM
hypothetical LOC100126583
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant mu
chr2_-_225073357 1.519 CUL3
cullin 3
chr6_+_129245978 1.515 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr9_+_12764988 1.508 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr9_-_21375258 1.495 NM_000605
IFNA2
interferon, alpha 2
chr10_+_112669353 1.495 SHOC2
soc-2 suppressor of clear homolog (C. elegans)
chr10_+_90336489 1.489 NM_001010939
LIPJ
lipase, family member J
chr14_-_106193403 1.484 IGKV3-20
immunoglobulin kappa variable 3-20
chr14_+_22059212 1.474


chr7_+_80145461 1.467 CD36
CD36 molecule (thrombospondin receptor)
chr11_+_27019084 1.450 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr3_+_186563529 1.447 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr2_-_40593074 1.438 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr2_+_114390975 1.425 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr10_+_112669349 1.384 SHOC2
soc-2 suppressor of clear homolog (C. elegans)
chr17_-_36451189 1.380 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr1_-_246503738 1.379 NM_001004695
OR2T33
olfactory receptor, family 2, subfamily T, member 33
chr1_-_246554492 1.360 NM_001004691
OR2M7
olfactory receptor, family 2, subfamily M, member 7
chr17_-_26648375 1.360 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr7_-_22518200 1.352 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr12_-_51153788 1.351 NM_173086
KRT6C
keratin 6C
chr6_-_68655708 1.349


chr9_+_112470871 1.341 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr5_-_147191428 1.340 NM_003122
SPINK1
serine peptidase inhibitor, Kazal type 1
chr1_-_150564302 1.337 NM_002016
FLG
filaggrin
chr7_+_94135384 1.333 PEG10
paternally expressed 10
chr20_-_17589122 1.324 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr17_-_36376663 1.320 NM_213656
KRT39
keratin 39
chr18_+_30544193 1.317 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr9_-_72673753 1.312 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr14_-_31026901 1.299 NM_001197184
GPR33
G protein-coupled receptor 33 (gene/pseudogene)
chr11_-_89248832 1.297 NM_001164397
TRIM64B
tripartite motif containing 64B
chr9_-_21358005 1.263 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr14_+_74353417 1.259 YLPM1
YLP motif containing 1
chr5_-_86739683 1.257 CCNH
cyclin H
chr5_-_147191334 1.253 SPINK1
serine peptidase inhibitor, Kazal type 1
chr10_+_63092724 1.251 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr14_+_55148488 1.249 KTN1
kinectin 1 (kinesin receptor)
chr6_+_53043729 1.249 NM_012347
FBXO9
F-box protein 9
chr11_-_5178505 1.238 NM_001004760
OR51V1
olfactory receptor, family 51, subfamily V, member 1
chr13_+_49658016 1.234


chr10_-_98280299 1.210 TM9SF3
transmembrane 9 superfamily member 3
chr13_-_32678142 1.208 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr6_+_64414389 1.201 NM_015153
PHF3
PHD finger protein 3
chr12_-_11075272 1.195 NM_176885
TAS2R31
taste receptor, type 2, member 31
chr1_+_39569396 1.195 NM_033044
MACF1
microtubule-actin crosslinking factor 1
chr14_-_106184988 1.194 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr11_+_56187713 1.190 NM_001004730
OR5AR1
olfactory receptor, family 5, subfamily AR, member 1
chr1_+_93317374 1.187 NM_001164391
NM_001164392
NM_001164393
NM_007358
MTF2



metal response element binding transcription factor 2



chr2_+_192251105 1.186 NM_001031716
OBFC2A
oligonucleotide/oligosaccharide-binding fold containing 2A
chr7_+_111879348 1.184 NM_001197079
IFRD1
interferon-related developmental regulator 1
chr11_+_89341319 1.184 NM_001136486
TRIM64
tripartite motif containing 64
chr9_+_122890394 1.178 NM_007018
CEP110
centrosomal protein 110kDa
chr1_+_157067729 1.174 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr10_-_113933457 1.172 NM_020918
GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr10_-_121592020 1.171 MCMBP
minichromosome maintenance complex binding protein
chr14_+_22059174 1.169


chr14_-_105763152 1.168 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG3
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr10_+_86121526 1.161 FAM190B
family with sequence similarity 190, member B
chr5_+_65476418 1.161 NM_139168
SREK1
splicing regulatory glutamine/lysine-rich protein 1
chr22_+_29696662 1.160


chr4_-_122357104 1.159 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr12_-_11041740 1.155 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr4_-_120462705 1.155 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr5_+_140160966 1.155 NM_018906
NM_031497
PCDHA3

protocadherin alpha 3

chr18_+_3443771 1.150 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr19_+_41419165 1.141 ZNF146
zinc finger protein 146
chr3_+_180348818 1.140 NM_006218
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr21_+_30937053 1.136 NM_001128077
KRTAP20-3
keratin associated protein 20-3
chr5_-_101862447 1.124 NM_173488
SLCO6A1
solute carrier organic anion transporter family, member 6A1
chr13_+_19430881 1.120 ZMYM2
zinc finger, MYM-type 2
chr13_-_101852028 1.113 NM_175929
FGF14
fibroblast growth factor 14
chr14_+_98247702 1.108 NM_182560
C14orf177
chromosome 14 open reading frame 177
chr5_+_43645018 1.104 NNT
nicotinamide nucleotide transhydrogenase
chr11_+_33306652 1.103 HIPK3
homeodomain interacting protein kinase 3
chr1_-_115070413 1.103 CSDE1
cold shock domain containing E1, RNA-binding
chr2_-_231697999 1.094 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr12_-_12182641 1.086 LRP6
low density lipoprotein receptor-related protein 6
chrX_+_56772391 1.086 LOC550643
hypothetical LOC550643
chr11_+_11820096 1.085 USP47
ubiquitin specific peptidase 47
chr21_-_26294332 1.084 APP
amyloid beta (A4) precursor protein
chr1_-_196776697 1.078 NM_133262
NM_133326
ATP6V1G3

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

chr11_-_6005546 1.078 NM_001001917
OR56A1
olfactory receptor, family 56, subfamily A, member 1
chr4_-_101658094 1.070 NM_001159694
NM_016242
EMCN

endomucin

chr5_-_151764857 1.068 NM_020167
NMUR2
neuromedin U receptor 2
chr6_-_11887265 1.068 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr9_+_124416768 1.063 NM_012364
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr4_+_144654526 1.062


chr10_+_112669267 1.061 NM_007373
SHOC2
soc-2 suppressor of clear homolog (C. elegans)
chr17_+_36642240 1.060 NM_031962
KRTAP9-9
KRTAP9-3
keratin associated protein 9-9
keratin associated protein 9-3
chr13_+_48448950 1.060 FNDC3A
fibronectin type III domain containing 3A
chr14_-_20694023 1.058 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr22_-_39189369 1.047 MKL1
megakaryoblastic leukemia (translocation) 1
chr18_-_35634247 1.045 LOC647946
hypothetical LOC647946
chr13_+_48448912 1.042 FNDC3A
fibronectin type III domain containing 3A
chr12_+_58369392 1.042 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr1_-_246823691 1.040 NM_001004693
OR2T10
olfactory receptor, family 2, subfamily T, member 10
chr9_+_74956494 1.035 NM_000700
ANXA1
annexin A1
chr13_+_48582389 1.034 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr7_-_14847479 1.032 NM_004080
NM_145695
DGKB

diacylglycerol kinase, beta 90kDa

chr3_-_52688768 1.030 NM_018165
NM_181042
PBRM1

polybromo 1

chr12_+_77963563 1.022 NM_001135806
SYT1
synaptotagmin I
chr2_-_21079145 1.017 APOB
apolipoprotein B (including Ag(x) antigen)
chr6_+_132901119 1.016 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr10_+_129237602 1.016 NM_001030013
NPS
neuropeptide S
chr3_+_73193499 1.012 NM_018029
EBLN2
endogenous Borna-like N element-2
chr21_-_30720100 1.007 NM_181622
KRTAP13-3
keratin associated protein 13-3
chr8_-_82522175 1.007 NM_002677
PMP2
peripheral myelin protein 2
chr10_+_106003941 1.006 NM_001191003
GSTO1
glutathione S-transferase omega 1
chr17_+_23394062 1.005 NLK
nemo-like kinase
chr7_+_93862137 1.005 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr13_+_48448628 1.001 FNDC3A
fibronectin type III domain containing 3A
chr6_-_128883125 1.001 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr6_-_26343139 0.994 NM_005320
HIST1H1D
histone cluster 1, H1d
chr17_-_3142625 0.993 NM_002550
OR3A1
olfactory receptor, family 3, subfamily A, member 1
chr21_-_26345294 0.990


chr9_-_114814286 0.988 NM_001101338
ZNF883
zinc finger protein 883
chr3_-_71715431 0.986 NM_001012505
NM_032682
FOXP1

forkhead box P1

chr2_-_213723298 0.986 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr9_-_28709302 0.985 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr12_-_88573949 0.978 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr10_+_96433240 0.973 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr10_-_98311813 0.972 TM9SF3
transmembrane 9 superfamily member 3
chr14_-_105785639 0.971


chr1_-_21310462 0.962 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr16_+_31105579 0.959


chr12_+_7348194 0.955 NM_001080454
ACSM4
acyl-CoA synthetase medium-chain family member 4
chr8_+_120289735 0.952 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr4_+_25931745 0.944 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr13_+_23042722 0.943 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr11_+_55776251 0.941 NM_001004747
OR5T3
olfactory receptor, family 5, subfamily T, member 3
chr1_-_246869181 0.926 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr10_+_102285690 0.924 HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr2_-_189363075 0.924 NM_052952
DIRC1
disrupted in renal carcinoma 1
chr1_+_42934910 0.923 YBX1
Y box binding protein 1
chr17_+_12564330 0.921 NM_001146313
MYOCD
myocardin
chr11_+_113815317 0.920 NM_015523
REXO2
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
chr9_-_14900992 0.920 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr17_+_36636404 0.920 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr7_+_91762227 0.916


chr5_+_140235114 0.914 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr18_-_46600295 0.914 NM_001127175
NM_001127176
NM_031939
MRO


maestro


chr10_-_112668679 0.913 NM_001195306
BBIP1
BBSome interacting protein 1
chr9_+_70046658 0.913 NM_201453
CBWD5
CBWD3
CBWD1
CBWD6
COBW domain containing 5
COBW domain containing 3
COBW domain containing 1
COBW domain containing 6
chr9_+_108665168 0.912 NM_021224
ZNF462
zinc finger protein 462
chr2_-_49235059 0.906 NM_000145
NM_181446
FSHR

follicle stimulating hormone receptor

chr9_-_21192201 0.905 NM_021057
IFNA7
interferon, alpha 7
chr7_-_18033970 0.905 NM_175886
PRPS1L1
phosphoribosyl pyrophosphate synthetase 1-like 1
chr17_+_23393744 0.903 NM_016231
NLK
nemo-like kinase
chr14_+_85066265 0.903 FLRT2
fibronectin leucine rich transmembrane protein 2
chr16_+_10430225 0.893 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr11_+_55297489 0.888 NM_001001967
OR5D13
olfactory receptor, family 5, subfamily D, member 13
chr7_-_122627235 0.886 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr15_-_75259714 0.882 PEAK1
NKF3 kinase family member
chr14_-_22549168 0.882 NM_001130706
NM_001130708
NM_021944
C14orf93


chromosome 14 open reading frame 93


chr1_-_171838802 0.882 NM_178527
SLC9A11
solute carrier family 9, member 11
chr4_+_71054492 0.873 NM_214711
C4orf40
chromosome 4 open reading frame 40
chr1_+_40399618 0.871 NM_012421
RLF
rearranged L-myc fusion
chr8_-_17812151 0.869


chr20_-_33783409 0.868 RBM39
RNA binding motif protein 39
chr11_+_109468734 0.865 ZC3H12C
zinc finger CCCH-type containing 12C
chr1_+_40399642 0.862 RLF
rearranged L-myc fusion
chr4_+_74520796 0.862 NM_001134
AFP
alpha-fetoprotein
chr2_-_210876560 0.861 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr19_+_41418723 0.856 ZNF146
zinc finger protein 146
chr11_-_62753574 0.854 NM_199352
SLC22A25
solute carrier family 22, member 25

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.57 1.60e-28 GO:0007606 sensory perception of chemical stimulus
2.66 5.95e-28 GO:0007608 sensory perception of smell
1.85 8.02e-16 GO:0007600 sensory perception
1.58 7.04e-13 GO:0050877 neurological system process
1.46 2.32e-10 GO:0003008 system process
1.15 2.35e-05 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 5.06e-04 GO:0071944 cell periphery
1.17 5.94e-04 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.73 2.35e-29 GO:0004984 olfactory receptor activity
1.84 1.32e-16 GO:0004930 G-protein coupled receptor activity
1.53 1.92e-10 GO:0004888 transmembrane receptor activity
1.40 4.44e-08 GO:0004872 receptor activity
1.32 3.43e-06 GO:0004871 signal transducer activity
1.32 3.43e-06 GO:0060089 molecular transducer activity