Motif ID: IRF1,2,7.p3

Z-value: 1.875


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF7chr11_-_605649-0.552.7e-02Click!
IRF2chr4_-_185632610-0.097.4e-01Click!
IRF1chr5_-_1318543250.087.7e-01Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_111900650 2.933 NM_001032731
NM_002535
NM_016817
 OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr15_+_42790951 2.645 NM_004048
 B2M
beta-2-microglobulin
chr10_+_91082218 2.623 NM_001031683
 IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_+_78858675 2.534 NM_006820
 IFI44L
interferon-induced protein 44-like
chr10_+_91142301 2.310 NM_001548
 IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr1_+_157246305 2.037 NM_005531
 IFI16
interferon, gamma-inducible protein 16
chr15_-_42790805 1.967


chr14_+_34521945 1.695 SRP54
signal recognition particle 54kDa
chr4_+_144654526 1.561


chr9_+_21399132 1.455 NM_002170
 IFNA8
interferon, alpha 8
chr6_-_138231006 1.444


chr10_+_91051685 1.436 NM_001547
 IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr7_+_10979978 1.420 NM_014660
 PHF14
PHD finger protein 14
chr20_-_45410033 1.355 ZMYND8
zinc finger, MYND-type containing 8
chr19_+_17377502 1.340 LOC100507535
hypothetical LOC100507535
chr10_+_91077581 1.316 NM_001549
 IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr19_-_17377383 1.283 NM_004335
 BST2
bone marrow stromal cell antigen 2
chr6_+_87921980 1.164 NM_015021
 ZNF292
zinc finger protein 292
chr11_-_63087430 1.154 NM_017878
 HRASLS2
HRAS-like suppressor 2
chr1_+_157167965 1.151 NM_152501
NM_198928
NM_198929
NM_198930
 PYHIN1



pyrin and HIN domain family, member 1




Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 54 entries
enrichment   p-value GO term description
11.33 4.33e-02 GO:0019883 antigen processing and presentation of endogenous antigen
6.68 2.31e-02 GO:0070534 protein K63-linked ubiquitination
5.54 3.46e-08 GO:0034340 response to type I interferon
5.38 1.95e-07 GO:0060337 type I interferon-mediated signaling pathway
5.38 1.95e-07 GO:0071357 cellular response to type I interferon
5.29 2.12e-02 GO:0032480 negative regulation of type I interferon production
4.43 2.19e-02 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
3.79 7.14e-03 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
3.71 1.18e-08 GO:0009615 response to virus
3.69 6.85e-04 GO:0030330 DNA damage response, signal transduction by p53 class mediator
3.64 4.76e-02 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
3.64 4.76e-02 GO:0072395 signal transduction involved in cell cycle checkpoint
3.64 4.76e-02 GO:0072401 signal transduction involved in DNA integrity checkpoint
3.64 4.76e-02 GO:0072404 signal transduction involved in G1/S transition checkpoint
3.64 4.76e-02 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
3.64 4.76e-02 GO:0072422 signal transduction involved in DNA damage checkpoint
3.64 4.76e-02 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
3.64 4.76e-02 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
3.63 1.32e-02 GO:0051352 negative regulation of ligase activity
3.63 1.32e-02 GO:0051444 negative regulation of ubiquitin-protein ligase activity

Gene overrepresentation in compartment category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
3.28 4.95e-02 GO:0000502 proteasome complex

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
15.87 8.95e-03 GO:0047023 androsterone dehydrogenase activity
2.56 1.65e-04 GO:0004842 ubiquitin-protein ligase activity
2.42 6.78e-04 GO:0019787 small conjugating protein ligase activity
2.24 2.10e-03 GO:0016881 acid-amino acid ligase activity
2.13 4.16e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.78 4.96e-02 GO:0008289 lipid binding