Motif ID: JUN.p2

Z-value: 1.848


Transcription factors associated with JUN.p2:

Gene SymbolEntrez IDGene Name
JUN 3725 jun oncogene
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
JUNBchr19_+_127632950.411.1e-01Click!
JUNchr1_-_590222750.283.0e-01Click!
JUNDchr19_-_182530480.146.1e-01Click!


Activity profile for motif JUN.p2.

activity profile for motif JUN.p2


Sorted Z-values histogram for motif JUN.p2

Sorted Z-values for motif JUN.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of JUN.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_26368969 5.502 NM_015871
ZNF593
zinc finger protein 593
chr21_-_43671355 4.916 NM_173354
SIK1
salt-inducible kinase 1
chr22_+_20101661 4.399 NM_015094
HIC2
hypermethylated in cancer 2
chr19_+_50663089 3.473 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr12_+_52665196 3.277 NM_017409
HOXC10
homeobox C10
chr6_+_43319199 3.194 NM_032538
TTBK1
tau tubulin kinase 1
chr7_-_100595552 2.838 NM_003378
VGF
VGF nerve growth factor inducible
chr8_+_23442331 2.654 SLC25A37
solute carrier family 25, member 37
chr1_+_29435534 2.515 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chr8_-_142446546 2.464 NM_005293
GPR20
G protein-coupled receptor 20
chr7_-_129379947 2.434 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

chr10_+_134060681 2.413 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr8_+_23442413 2.262 SLC25A37
solute carrier family 25, member 37
chr11_-_2149591 2.246 NM_000360
NM_199292
NM_199293
TH


tyrosine hydroxylase


chr3_+_42165740 2.241 TRAK1
trafficking protein, kinesin binding 1
chr7_+_116447499 2.116 ST7
suppression of tumorigenicity 7
chr19_+_16048266 2.029 TPM4
tropomyosin 4
chr19_+_16048315 2.021 TPM4
tropomyosin 4
chr21_-_42303517 1.955 NM_001098402
NM_001098403
NM_020727
ZNF295


zinc finger protein 295


chr7_+_142346724 1.894 NM_178829
C7orf34
chromosome 7 open reading frame 34
chr9_+_139152595 1.892 GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr19_+_16048306 1.892 TPM4
tropomyosin 4
chr19_+_1892184 1.888 CSNK1G2
casein kinase 1, gamma 2
chr1_+_1104939 1.839 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr19_+_1892157 1.807 NM_001319
CSNK1G2
casein kinase 1, gamma 2
chr18_+_22060383 1.796 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr5_-_176760242 1.794 NM_001029886
PFN3
profilin 3
chr11_+_72765044 1.763 NM_152222
RELT
RELT tumor necrosis factor receptor
chr1_+_27591738 1.739 NM_005281
GPR3
G protein-coupled receptor 3
chr8_+_23442307 1.737 NM_016612
SLC25A37
solute carrier family 25, member 37
chr7_+_116447527 1.711 ST7
suppression of tumorigenicity 7
chr19_-_55671273 1.702 FAM71E1
family with sequence similarity 71, member E1
chr1_+_201541269 1.695 NM_006763
BTG2
BTG family, member 2
chr6_+_108593907 1.687 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr1_+_201541241 1.682 BTG2
BTG family, member 2
chr22_+_18499354 1.668 NM_001185024
NM_013373
ZDHHC8

zinc finger, DHHC-type containing 8

chr17_+_24095135 1.651 NM_004295
TRAF4
TNF receptor-associated factor 4
chr10_+_35524835 1.642 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr11_-_1549719 1.637 NM_004420
DUSP8
dual specificity phosphatase 8
chr7_+_5598964 1.620 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr11_-_118693021 1.620 NM_006500
MCAM
melanoma cell adhesion molecule
chr9_-_126573349 1.615 NM_001489
NM_033334
NR6A1

nuclear receptor subfamily 6, group A, member 1

chr19_+_54067489 1.584 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr1_+_226394605 1.576 GUK1
guanylate kinase 1
chr19_+_54067450 1.575 NM_014330
PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr19_+_18584666 1.568 NM_012109
TMEM59L
transmembrane protein 59-like
chr11_-_69228286 1.567 NM_005117
FGF19
fibroblast growth factor 19
chr16_-_3008162 1.566 NM_021195
CLDN6
claudin 6
chr3_+_188222337 1.557 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr7_+_5598979 1.550 NM_003088
FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr6_+_26312758 1.539 NM_003545
HIST1H4E
histone cluster 1, H4e
chr22_+_17539198 1.514


chr1_+_226394589 1.510 GUK1
guanylate kinase 1
chr19_+_1704661 1.487 NM_001080488
ONECUT3
one cut homeobox 3
chr12_-_51734434 1.479 LOC283335
hypothetical LOC283335
chr7_+_30140868 1.476 NM_152793
C7orf41
chromosome 7 open reading frame 41
chr9_-_139473606 1.466 NM_001130969
NM_001130970
NM_001130971
NM_001178064
NM_015537
NELF




nasal embryonic LHRH factor




chr1_+_226394626 1.464 GUK1
guanylate kinase 1
chr19_+_48912053 1.460 NM_019612
IRGC
immunity-related GTPase family, cinema
chr7_-_104696678 1.446 NM_182691
SRPK2
SRSF protein kinase 2
chr5_-_172130766 1.441 NM_004417
DUSP1
dual specificity phosphatase 1
chr19_+_54067491 1.441 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr5_+_174084137 1.435 NM_002449
MSX2
msh homeobox 2
chr19_+_47593137 1.434


chr1_+_226394638 1.407 GUK1
guanylate kinase 1
chr1_+_226394545 1.406 NM_000858
NM_001159390
GUK1

guanylate kinase 1

chr11_-_65094319 1.397 LOC254100
hypothetical protein LOC254100
chr7_+_1239078 1.391 NM_001080461
UNCX
UNC homeobox
chr6_-_15356865 1.377


chr10_-_64246129 1.369 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr6_+_15357013 1.367 JARID2
jumonji, AT rich interactive domain 2
chr5_+_118993152 1.358 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr5_-_1935764 1.353 NM_016358
IRX4
iroquois homeobox 4
chr1_-_1274618 1.334 DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr21_-_38792173 1.292 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr9_+_131291144 1.273


chr10_+_35524060 1.262 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr1_+_110456584 1.259 NM_203412
UBL4B
ubiquitin-like 4B
chr19_+_17047569 1.254 NM_001130065
NM_004145
MYO9B

myosin IXB

chr2_+_232165818 1.251 NM_152614
C2orf57
chromosome 2 open reading frame 57
chr1_-_149955870 1.245 NM_007185
CELF3
CUGBP, Elav-like family member 3
chr11_-_68537243 1.230 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr7_-_140270749 1.230 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr2_+_10969513 1.228 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr5_-_175897430 1.224 RNF44
ring finger protein 44
chr3_+_42165829 1.224 TRAK1
trafficking protein, kinesin binding 1
chr19_+_55671594 1.221 C19orf63
chromosome 19 open reading frame 63
chr2_+_30307900 1.221 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr3_-_188946168 1.219 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr19_+_55671468 1.207 NM_175063
NM_206538
C19orf63

chromosome 19 open reading frame 63

chr7_+_128099581 1.207 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr8_-_145983457 1.201 NM_030580
ZNF34
zinc finger protein 34
chrX_-_148857299 1.187 NM_001013845
CXorf40B
chromosome X open reading frame 40B
chr22_+_20326572 1.185 SDF2L1
stromal cell-derived factor 2-like 1
chr19_+_55671600 1.184 C19orf63
chromosome 19 open reading frame 63
chr11_+_76491532 1.184 NM_006189
OMP
olfactory marker protein
chr19_+_13124870 1.180 IER2
immediate early response 2
chr19_-_52308848 1.168 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr19_+_55671584 1.167 C19orf63
chromosome 19 open reading frame 63
chr4_-_4300821 1.161 NM_032927
TMEM128
transmembrane protein 128
chr1_+_29086206 1.159 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr9_-_34387786 1.157 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr8_-_142586487 1.156 NM_207414
FLJ43860
FLJ43860 protein
chr3_-_155524898 1.154 NM_001114397
NM_020865
DHX36

DEAH (Asp-Glu-Ala-His) box polypeptide 36

chr1_+_1207351 1.153 NM_001130413
NM_002978
SCNN1D

sodium channel, nonvoltage-gated 1, delta

chr7_-_158314945 1.150 ESYT2
extended synaptotagmin-like protein 2
chr15_+_29406335 1.139 NM_015995
KLF13
Kruppel-like factor 13
chr19_+_40541327 1.132 NM_005304
FFAR3
free fatty acid receptor 3
chr1_+_19843261 1.129 NM_005380
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr12_+_52634950 1.124 NM_173860
HOXC12
homeobox C12
chr19_-_54231884 1.119 NM_033377
CGB1
CGB2
chorionic gonadotropin, beta polypeptide 1
chorionic gonadotropin, beta polypeptide 2
chr4_-_8481085 1.106 ACOX3
acyl-CoA oxidase 3, pristanoyl
chr19_+_40716153 1.105 NM_014364
GAPDHS
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr11_+_72765318 1.086 NM_032871
RELT
RELT tumor necrosis factor receptor
chr6_+_139497933 1.085 NM_016217
HECA
headcase homolog (Drosophila)
chr9_+_138341752 1.080 NM_001145638
NM_015597
GPSM1

G-protein signaling modulator 1

chr19_+_16048047 1.073 NM_003290
TPM4
tropomyosin 4
chr9_-_139473433 1.070 NELF
nasal embryonic LHRH factor
chr9_+_131291224 1.065 LOC100506190
hypothetical LOC100506190
chr22_+_20326541 1.058 NM_022044
SDF2L1
stromal cell-derived factor 2-like 1
chr11_-_33139449 1.047 NM_001033505
NM_001033506
NM_001326
CSTF3


cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa


chr1_+_29086156 1.046 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr1_-_20916789 1.044 NM_001122819
NM_020816
KIF17

kinesin family member 17

chr1_+_36409277 1.042 MAP7D1
MAP7 domain containing 1
chr9_-_139473569 1.036 NELF
nasal embryonic LHRH factor
chr11_+_18676857 1.033 TMEM86A
transmembrane protein 86A
chr3_+_158026769 1.028 NM_001004316
NM_001193283
LEKR1

leucine, glutamate and lysine rich 1

chr22_+_20326591 1.014 SDF2L1
stromal cell-derived factor 2-like 1
chr22_+_20326615 1.009 SDF2L1
stromal cell-derived factor 2-like 1
chr19_+_53801811 1.008 NM_133498
SPACA4
sperm acrosome associated 4
chr20_+_19863716 1.008 RIN2
Ras and Rab interactor 2
chr10_+_99069007 0.998 NM_005479
FRAT1
frequently rearranged in advanced T-cell lymphomas
chr12_+_120635021 0.992 NM_001080825
TMEM120B
transmembrane protein 120B
chr5_+_139907366 0.984 NM_003732
EIF4EBP3
eukaryotic translation initiation factor 4E binding protein 3
chr19_-_50779924 0.981 NM_001017989
NM_025136
OPA3

optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)

chr12_-_31368347 0.978 FAM60A
family with sequence similarity 60, member A
chr15_+_74416129 0.978 ISL2
ISL LIM homeobox 2
chr9_+_132990760 0.968 NM_005085
NUP214
nucleoporin 214kDa
chr7_+_100111712 0.966 GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr16_+_84204424 0.965 NM_014615
KIAA0182
KIAA0182
chr9_-_98421894 0.964 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr7_-_5534252 0.962 ACTB
actin, beta
chr2_+_74635354 0.961 DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr4_+_3220564 0.955 NM_001042690
C4orf44
chromosome 4 open reading frame 44
chr3_+_50272648 0.942


chr1_-_226357552 0.941 NM_024319
C1orf35
chromosome 1 open reading frame 35
chr19_-_55671814 0.937 NM_138411
FAM71E1
family with sequence similarity 71, member E1
chr19_-_48791967 0.935 NM_001007561
IRGQ
immunity-related GTPase family, Q
chr19_-_50779914 0.926 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr5_+_137829065 0.926 EGR1
early growth response 1
chr16_-_78192111 0.916 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr21_-_34820916 0.911 NM_203418
RCAN1
regulator of calcineurin 1
chr16_+_4325142 0.910 GLIS2
GLIS family zinc finger 2
chr19_+_53016910 0.910 NM_000554
CRX
cone-rod homeobox
chr5_+_137701122 0.906 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr2_+_96790298 0.905 NM_020184
CNNM4
cyclin M4
chr2_-_74634569 0.905 NM_032603
LOXL3
lysyl oxidase-like 3
chr19_+_13124889 0.901 IER2
immediate early response 2
chr1_-_20685314 0.901 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr1_+_242281175 0.900 NM_205768
ZNF238
zinc finger protein 238
chr19_+_50196526 0.894 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr13_+_110771015 0.887 NM_152324
C13orf16
chromosome 13 open reading frame 16
chr19_-_53941835 0.884 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chr9_+_101623957 0.882 NM_006981
NM_173199
NR4A3

nuclear receptor subfamily 4, group A, member 3

chr19_+_44591589 0.877


chr22_-_17512097 0.876 DGCR14
DiGeorge syndrome critical region gene 14
chr1_-_10677051 0.872 CASZ1
castor zinc finger 1
chr19_-_50779861 0.870 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr19_+_63747678 0.868 TRIM28
tripartite motif containing 28
chr9_-_129517740 0.860 NM_001002913
PTRH1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr11_+_67130898 0.859 NM_001166102
NM_007103
NDUFV1

NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa

chr1_+_242281199 0.859 ZNF238
zinc finger protein 238
chr19_-_55706156 0.852 NM_138334
JOSD2
Josephin domain containing 2
chr7_+_116238309 0.845 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr15_+_66658626 0.844 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr9_+_133154896 0.839 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr21_+_46369911 0.834 COL6A2
collagen, type VI, alpha 2
chr11_+_18676913 0.832 NM_153347
TMEM86A
transmembrane protein 86A
chr22_-_17512174 0.831 NM_022719
DGCR14
DiGeorge syndrome critical region gene 14
chr7_-_158314963 0.828 NM_020728
ESYT2
extended synaptotagmin-like protein 2
chr21_+_46369606 0.825 COL6A2
collagen, type VI, alpha 2
chr1_+_207944807 0.825 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr9_+_129900590 0.815 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr15_+_74416156 0.813 NM_145805
ISL2
ISL LIM homeobox 2
chr9_-_129517712 0.811 PTRH1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr17_-_75427644 0.791 NM_003655
CBX4
chromobox homolog 4
chr1_-_243092581 0.789 HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chrX_+_153325643 0.788 NM_004699
FAM50A
family with sequence similarity 50, member A
chr12_+_47658502 0.785 NM_005430
WNT1
wingless-type MMTV integration site family, member 1
chr3_-_188945921 0.784 BCL6
B-cell CLL/lymphoma 6
chr9_-_110658030 0.783 NM_006686
ACTL7B
actin-like 7B
chr10_-_64246080 0.781 EGR2
early growth response 2
chr22_+_18485145 0.776 RANBP1
RAN binding protein 1
chr19_+_60688349 0.776 NM_020378
NAT14
N-acetyltransferase 14 (GCN5-related, putative)
chr3_+_195688974 0.774 FLJ34208
hypothetical LOC401106
chr7_-_5534737 0.774 ACTB
actin, beta
chr5_+_159276317 0.771 NM_000679
ADRA1B
adrenergic, alpha-1B-, receptor
chr7_+_151284396 0.771 NM_145292
GALNTL5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
chr11_+_116575249 0.771 NM_001001522
NM_003186
TAGLN

transgelin

chr22_+_39404940 0.767 NM_005297
MCHR1
melanin-concentrating hormone receptor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.28 6.20e-04 GO:0031323 regulation of cellular metabolic process
1.32 2.89e-03 GO:0009889 regulation of biosynthetic process
1.31 3.62e-03 GO:0031326 regulation of cellular biosynthetic process
1.26 7.34e-03 GO:0080090 regulation of primary metabolic process
1.25 2.69e-02 GO:0060255 regulation of macromolecule metabolic process
1.31 2.79e-02 GO:0051252 regulation of RNA metabolic process
1.28 3.08e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.22 3.52e-02 GO:0019222 regulation of metabolic process
1.28 3.53e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.19 3.66e-02 GO:0043170 macromolecule metabolic process
1.29 4.54e-02 GO:0010556 regulation of macromolecule biosynthetic process
1.32 4.74e-02 GO:0048523 negative regulation of cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.20 1.27e-04 GO:0005634 nucleus
1.10 5.57e-03 GO:0043229 intracellular organelle
1.10 5.93e-03 GO:0043226 organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 5.18e-07 GO:0005515 protein binding
1.59 1.09e-04 GO:0030528 transcription regulator activity
1.59 1.23e-04 GO:0001071 nucleic acid binding transcription factor activity
1.59 1.23e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.08 7.72e-04 GO:0005488 binding
1.64 2.69e-03 GO:0043565 sequence-specific DNA binding
1.24 5.78e-03 GO:0003676 nucleic acid binding