Motif ID: KLF4.p3

Z-value: 1.595


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF4chr9_-_1092905280.233.9e-01Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_129962292 3.660 NM_024112
 C9orf16
chromosome 9 open reading frame 16
chr12_+_110328126 3.306 NM_005475
 SH2B3
SH2B adaptor protein 3
chr1_+_32992131 3.191


chr9_+_132961723 2.549 AIF1L
allograft inflammatory factor 1-like
chr22_+_21817512 2.354 NM_004914
 RAB36
RAB36, member RAS oncogene family
chr22_+_21742727 2.296 GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr1_-_1840564 2.171 NM_178545
 TMEM52
transmembrane protein 52
chr7_-_158073121 2.045 NM_002847
NM_130842
NM_130843
 PTPRN2


protein tyrosine phosphatase, receptor type, N polypeptide 2


chr21_+_44699796 2.025 NM_030891
 LRRC3
leucine rich repeat containing 3
chr22_-_17546296 1.852 NM_005984
 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr22_+_21742364 1.832 NM_002073
 GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr5_+_176006993 1.642 NM_001006616
NM_012171
NM_130465
 TSPAN17


tetraspanin 17


chr1_-_32574185 1.627 NM_023009
 MARCKSL1
MARCKS-like 1
chr9_+_138680064 1.598 EGFL7
EGF-like-domain, multiple 7
chr19_+_40958206 1.584 NM_001172630
NM_052948
 ARHGAP33

Rho GTPase activating protein 33

chr10_+_75427853 1.556 NM_003373
NM_014000
 VCL

vinculin

chr22_-_17546276 1.554 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr22_-_17489912 1.515 NM_001173533
NM_001173534
NM_001184781
NM_005137
 DGCR2



DiGeorge syndrome critical region gene 2



chr22_-_17545872 1.513 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr22_+_18081968 1.508 NM_002688
 SEPT5
septin 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 41 entries
enrichment   p-value GO term description
1.63 3.97e-02 GO:0007173 epidermal growth factor receptor signaling pathway
1.27 3.24e-03 GO:0051253 negative regulation of RNA metabolic process
1.26 6.03e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.24 1.01e-02 GO:0010629 negative regulation of gene expression
1.24 4.58e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.22 4.39e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.21 5.66e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.21 2.56e-03 GO:0008219 cell death
1.20 3.37e-03 GO:0022008 neurogenesis
1.20 4.99e-03 GO:0016265 death
1.20 9.12e-03 GO:0048699 generation of neurons
1.16 2.95e-05 GO:0006464 protein modification process
1.16 1.06e-03 GO:0009653 anatomical structure morphogenesis
1.16 1.59e-03 GO:0007399 nervous system development
1.15 1.87e-04 GO:0043412 macromolecule modification
1.15 2.19e-03 GO:0023051 regulation of signaling
1.14 4.07e-05 GO:0044267 cellular protein metabolic process
1.14 4.14e-04 GO:0048523 negative regulation of cellular process
1.13 8.13e-04 GO:0048522 positive regulation of cellular process
1.13 1.14e-03 GO:0048519 negative regulation of biological process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 37 entries
enrichment   p-value GO term description
1.55 1.47e-02 GO:0008021 synaptic vesicle
1.54 4.73e-03 GO:0005925 focal adhesion
1.48 2.01e-02 GO:0030055 cell-substrate junction
1.47 4.45e-02 GO:0005924 cell-substrate adherens junction
1.41 9.95e-03 GO:0030136 clathrin-coated vesicle
1.38 2.70e-02 GO:0070161 anchoring junction
1.31 6.76e-03 GO:0044456 synapse part
1.30 5.71e-04 GO:0045202 synapse
1.23 1.81e-03 GO:0030054 cell junction
1.20 2.05e-06 GO:0005654 nucleoplasm
1.20 4.94e-03 GO:0031410 cytoplasmic vesicle
1.20 6.11e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.19 8.27e-03 GO:0031988 membrane-bounded vesicle
1.18 1.75e-02 GO:0031982 vesicle
1.17 1.14e-06 GO:0031981 nuclear lumen
1.16 4.09e-05 GO:0012505 endomembrane system
1.16 1.28e-02 GO:0005794 Golgi apparatus
1.15 2.99e-06 GO:0005829 cytosol
1.15 5.31e-06 GO:0044428 nuclear part
1.14 2.88e-05 GO:0070013 intracellular organelle lumen

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
1.56 4.22e-02 GO:0019199 transmembrane receptor protein kinase activity
1.31 8.64e-03 GO:0016564 transcription repressor activity
1.28 1.14e-02 GO:0000988 protein binding transcription factor activity
1.28 1.14e-02 GO:0000989 transcription factor binding transcription factor activity
1.27 1.47e-02 GO:0003712 transcription cofactor activity
1.24 4.30e-02 GO:0019904 protein domain specific binding
1.23 1.32e-02 GO:0008092 cytoskeletal protein binding
1.22 1.07e-03 GO:0019899 enzyme binding
1.20 3.33e-02 GO:0043565 sequence-specific DNA binding
1.17 7.86e-03 GO:0001071 nucleic acid binding transcription factor activity
1.17 7.86e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.17 1.46e-02 GO:0030528 transcription regulator activity
1.12 8.93e-24 GO:0005515 protein binding
1.12 2.97e-02 GO:0016740 transferase activity
1.06 6.30e-17 GO:0005488 binding