Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.419


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF7chr5_+_133479196-0.523.9e-02Click!
TCF7L1chr2_+_85213884-0.361.7e-01Click!
LEF1chr4_-_109307325-0.234.0e-01Click!
TCF7L2chr10_+_1147007750.048.8e-01Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_21229975 2.841 NM_002172
IFNA14
interferon, alpha 14
chr6_-_127882192 2.011 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chr8_+_32698892 1.909 NM_001159996
NRG1
neuregulin 1
chrX_-_105169370 1.625 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr3_+_125296217 1.599 NM_001024660
NM_003947
KALRN

kalirin, RhoGEF kinase

chr8_-_6901661 1.466 NM_021010
DEFA5
defensin, alpha 5, Paneth cell-specific
chr12_+_19173669 1.229 NM_001143821
NM_001190860
NM_019012
PLEKHA5


pleckstrin homology domain containing, family A member 5


chr13_+_23042722 1.177 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr6_-_128263868 1.165 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr13_+_75108450 1.156 LMO7
LIM domain 7
chr7_+_80069439 1.150 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr18_-_24011349 1.133 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr9_-_35640852 1.125 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr8_-_16903911 1.118 NM_019851
FGF20
fibroblast growth factor 20
chr5_-_114543632 1.092 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr13_-_71339313 1.086 NM_004392
NM_080759
NM_080760
DACH1


dachshund homolog 1 (Drosophila)


chr14_-_20572783 1.085 NM_001012264
RNASE13
ribonuclease, RNase A family, 13 (non-active)
chr8_-_120033240 1.055 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr9_+_71009746 1.053 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr5_-_58370693 1.042 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr6_-_128883125 1.003 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr17_+_24742068 0.999 NM_020791
TAOK1
TAO kinase 1
chr10_+_53744043 0.992 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr12_+_8958397 0.978 NM_004426
PHC1
polyhomeotic homolog 1 (Drosophila)
chr17_+_16886491 0.974 NM_015134
NM_201274
MPRIP

myosin phosphatase Rho interacting protein

chr14_+_20306425 0.968 NM_022360
EDDM3B
epididymal protein 3B
chr12_+_15366712 0.964 NM_002848
NM_030667
PTPRO

protein tyrosine phosphatase, receptor type, O

chr4_+_42590038 0.954 NM_001080476
GRXCR1
glutaredoxin, cysteine rich 1
chr5_-_100266769 0.943 NM_175052
NM_005668
ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chr15_+_64481270 0.941 MAP2K1
mitogen-activated protein kinase kinase 1
chr17_-_35273947 0.931 NM_012481
NM_183228
NM_183229
NM_183230
NM_183231
NM_183232
IKZF3





IKAROS family zinc finger 3 (Aiolos)





chr2_-_231697999 0.928 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr3_-_191650291 0.925 NM_207316
TMEM207
transmembrane protein 207
chr14_+_74299748 0.913 NM_019589
YLPM1
YLP motif containing 1
chr4_+_113372287 0.900 NM_001128426
NM_018569
AP1AR

adaptor-related protein complex 1 associated regulatory protein

chr6_-_151754337 0.900 NM_020861
ZBTB2
zinc finger and BTB domain containing 2
chr1_+_93686154 0.898 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr9_-_21340885 0.897 NM_021002
IFNA6
interferon, alpha 6
chr21_-_26294332 0.896 APP
amyloid beta (A4) precursor protein
chr9_-_99746923 0.896 NM_018437
HEMGN
hemogen
chr1_+_221168388 0.887 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr8_-_143958234 0.883 NM_000497
NM_001026213
CYP11B1

cytochrome P450, family 11, subfamily B, polypeptide 1

chr7_-_19778928 0.876 NM_152774
TMEM196
transmembrane protein 196
chr7_+_90176647 0.872 NM_012395
CDK14
cyclin-dependent kinase 14
chr9_+_17568952 0.865 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr18_-_55136673 0.842 NM_181654
CPLX4
complexin 4
chr17_-_61253122 0.822 NM_001037325
CCDC46
coiled-coil domain containing 46
chr3_-_87408301 0.813 NM_000306
NM_001122757
POU1F1

POU class 1 homeobox 1

chr18_-_24010944 0.796 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr7_+_90177082 0.793 CDK14
cyclin-dependent kinase 14
chrX_-_108611940 0.788 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr11_-_6633427 0.782 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr9_+_90193058 0.780 NM_006717
SPIN1
spindlin 1
chr14_+_19655405 0.767 NM_001004715
OR4K17
olfactory receptor, family 4, subfamily K, member 17
chr17_-_36760581 0.763 NM_004138
KRT33A
keratin 33A
chr14_+_56927014 0.757 NM_001011713
NAA30
N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr12_+_117067214 0.756 PEBP1
phosphatidylethanolamine binding protein 1
chr4_-_122213018 0.749 NM_024574
C4orf31
chromosome 4 open reading frame 31
chr11_+_101488380 0.749 NM_001195045
YAP1
Yes-associated protein 1
chr3_-_79899748 0.741 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr3_-_181237210 0.741 NM_016559
PEX5L
peroxisomal biogenesis factor 5-like
chr3_-_166278969 0.739 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr11_+_22646229 0.738 NM_177553
GAS2
growth arrest-specific 2
chr17_-_10313600 0.733 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr10_+_114144512 0.723 ACSL5
acyl-CoA synthetase long-chain family member 5
chr12_+_26096757 0.719 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr14_+_56927066 0.718 NAA30
N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr13_+_96884316 0.717 NM_021033
RAP2A
RAP2A, member of RAS oncogene family
chr2_+_104838177 0.716 NM_006236
POU3F3
POU class 3 homeobox 3
chr2_-_207739815 0.715 KLF7
Kruppel-like factor 7 (ubiquitous)
chr9_+_90193807 0.711 SPIN1
spindlin 1
chr4_+_78172966 0.711 SEPT11
septin 11
chr15_+_30694982 0.702 NM_014783
NM_199357
ARHGAP11A

Rho GTPase activating protein 11A

chr17_+_54997667 0.701 NM_001166301
NM_024612
DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

chr14_-_91111135 0.695 NM_001080113
C14orf184
chromosome 14 open reading frame 184
chr14_+_20283938 0.694 NM_006683
EDDM3A
epididymal protein 3A
chr12_+_7348194 0.680 NM_001080454
ACSM4
acyl-CoA synthetase medium-chain family member 4
chr12_-_88573949 0.677 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr2_+_187163232 0.666 ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr5_+_147775652 0.654 FBXO38
F-box protein 38
chr13_-_45087859 0.653 NM_182542
FAM194B
family with sequence similarity 194, member B
chr4_+_71330797 0.645 NM_001145006
MUC7
mucin 7, secreted
chr9_-_21295311 0.644 NM_002169
IFNA5
interferon, alpha 5
chr1_+_84402962 0.643 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_195179533 0.635 NM_005666
CFHR2
complement factor H-related 2
chr20_-_43440290 0.626 NM_014477
TP53TG5
TP53 target 5
chr2_-_95846109 0.621 LOC150759
hypothetical LOC150759
chr3_+_99484421 0.620 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chr15_-_53667800 0.619 PYGO1
pygopus homolog 1 (Drosophila)
chr20_+_11846536 0.615 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr5_+_34720368 0.602 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chrX_+_69404879 0.597 NM_004312
ARR3
arrestin 3, retinal (X-arrestin)
chr4_+_15292363 0.595 NM_001145191
FAM200B
family with sequence similarity 200, member B
chr4_+_15292500 0.594 FAM200B
family with sequence similarity 200, member B
chr19_-_2901583 0.586


chr11_-_35235325 0.585 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr9_-_73715666 0.577 FAM108B1
family with sequence similarity 108, member B1
chr18_+_59521173 0.564 NM_080475
SERPINB11
serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)
chr6_+_144649142 0.564 UTRN
utrophin
chr4_+_146622154 0.563 NM_005900
SMAD1
SMAD family member 1
chr14_-_57688560 0.563 NM_001001872
C14orf37
chromosome 14 open reading frame 37
chr11_+_58631190 0.560 NM_001142703
NM_001142704
NM_198947
FAM111B


family with sequence similarity 111, member B


chr11_-_89181390 0.559 NM_020358
TRIM49
tripartite motif containing 49
chr1_-_118529303 0.556 NM_206996
SPAG17
sperm associated antigen 17
chr4_-_40911212 0.554 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr13_+_75232797 0.553 NM_015842
LMO7
LIM domain 7
chr8_+_18072250 0.548 NM_001160179
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr3_+_39346200 0.544 NM_005201
CCR8
chemokine (C-C motif) receptor 8
chr20_+_20296744 0.543 NM_002196
INSM1
insulinoma-associated 1
chr1_+_145479805 0.541 NM_004326
BCL9
B-cell CLL/lymphoma 9
chr18_+_59295123 0.541 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr14_-_72563497 0.540 NM_021260
ZFYVE1
zinc finger, FYVE domain containing 1
chr14_-_22521544 0.529 NM_032876
JUB
jub, ajuba homolog (Xenopus laevis)
chr10_+_90552466 0.525 NM_001128215
LIPM
lipase, family member M
chr9_+_124551839 0.522 NM_001004453
OR1L6
olfactory receptor, family 1, subfamily L, member 6
chr7_-_122627235 0.522 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr3_-_114643008 0.522 NM_001164496
NM_018338
WDR52

WD repeat domain 52

chr12_+_1608672 0.521 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chr6_+_134315940 0.520 NM_004865
TBPL1
TBP-like 1
chr2_+_185171682 0.519 ZNF804A
zinc finger protein 804A
chr6_-_52736231 0.512 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr14_-_57688669 0.512 C14orf37
chromosome 14 open reading frame 37
chr2_-_165768798 0.510 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr4_-_10295412 0.505 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr12_+_32151351 0.503 NM_001003398
NM_001714
BICD1

bicaudal D homolog 1 (Drosophila)

chr11_-_13474101 0.502 NM_000315
PTH
parathyroid hormone
chr5_+_149526533 0.498 NM_001804
CDX1
caudal type homeobox 1
chr9_-_14858974 0.497 FREM1
FRAS1 related extracellular matrix 1
chr4_+_69996780 0.496 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr9_-_16717887 0.496 BNC2
basonuclin 2
chr11_-_121492010 0.496 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr6_-_11887265 0.495 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr4_-_85638410 0.495 NM_006168
NKX6-1
NK6 homeobox 1
chr3_+_134239860 0.492 NM_001136469
NM_023943
TMEM108

transmembrane protein 108

chr5_-_70621688 0.488 SMA4
glucuronidase, beta pseudogene
chr8_-_25338472 0.485 NM_000825
NM_001083111
GNRH1

gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

chr4_+_109761170 0.483 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr9_-_106420305 0.480 NM_001001956
OR13C9
olfactory receptor, family 13, subfamily C, member 9
chr3_+_122109716 0.479 NM_014980
STXBP5L
syntaxin binding protein 5-like
chr18_-_29412148 0.478


chr12_-_47868563 0.474 TUBA1A
tubulin, alpha 1a
chr11_-_62753574 0.473 NM_199352
SLC22A25
solute carrier family 22, member 25
chr2_+_190981257 0.473 NM_017694
MFSD6
major facilitator superfamily domain containing 6
chr9_-_70345549 0.471 NM_153237
C9orf71
chromosome 9 open reading frame 71
chr2_+_54537842 0.468 SPTBN1
spectrin, beta, non-erythrocytic 1
chr5_-_39430180 0.467 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr1_-_175400665 0.466 ASTN1
astrotactin 1
chr1_+_195055483 0.463 NM_002113
CFHR1
complement factor H-related 1
chrX_-_32083506 0.462 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr16_-_18720192 0.460 NM_015161
ARL6IP1
ADP-ribosylation factor-like 6 interacting protein 1
chr12_-_22378833 0.458 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr7_-_19151509 0.457 NM_152898
FERD3L
Fer3-like (Drosophila)
chr15_+_34659047 0.453 NM_001130010
C15orf41
chromosome 15 open reading frame 41
chr15_+_38923470 0.453 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr1_+_156716290 0.452 NM_001004472
OR10R2
olfactory receptor, family 10, subfamily R, member 2
chr9_+_115265827 0.446 NM_017790
RGS3
regulator of G-protein signaling 3
chr2_-_136311219 0.445 NM_002299
LCT
lactase
chr5_+_140215778 0.444 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr19_-_58157832 0.441 NM_001031665
ZNF816-ZNF321
ZNF816
ZNF816-ZNF321 readthrough
zinc finger protein 816
chr4_-_120462705 0.440 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chrX_+_106050261 0.440 NM_020384
CLDN2
claudin 2
chr22_-_30885200 0.439 NM_001010859
C22orf42
chromosome 22 open reading frame 42
chr11_+_100367929 0.439 NM_032021
TMEM133
transmembrane protein 133
chr13_-_71338558 0.438 DACH1
dachshund homolog 1 (Drosophila)
chr11_+_62813947 0.438 NM_001039752
SLC22A10
solute carrier family 22, member 10
chrX_-_106248674 0.435 RBM41
RNA binding motif protein 41
chr5_-_159759620 0.432 NM_022090
C5orf54
chromosome 5 open reading frame 54
chr13_-_98708549 0.431 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr7_+_110518297 0.431 NM_001099658
NM_001099660
NM_018334
LRRN3


leucine rich repeat neuronal 3


chrX_-_131918905 0.429 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr11_-_88962426 0.424 NM_001143837
NOX4
NADPH oxidase 4
chr1_+_168381811 0.424 NM_001136107
METTL11B
methyltransferase like 11B
chr12_+_22669352 0.423 ETNK1
ethanolamine kinase 1
chr11_+_55899675 0.422 NM_001005204
NM_001013356
OR8U1
OR8U8
olfactory receptor, family 8, subfamily U, member 1
olfactory receptor, family 8, subfamily U, member 8
chr10_+_28918672 0.420 WAC
WW domain containing adaptor with coiled-coil
chr6_+_131190237 0.420 NM_001195597
LOC285733
hypothetical LOC285733
chr13_+_95541093 0.420 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr15_+_45797977 0.419 NM_020858
NM_024966
NM_153616
NM_153617
NM_153618
NM_153619
SEMA6D





sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D





chr13_+_96884682 0.419 RAP2A
RAP2A, member of RAS oncogene family
chr15_-_80125514 0.419 MEX3B
mex-3 homolog B (C. elegans)
chr3_+_142569988 0.410 ZBTB38
zinc finger and BTB domain containing 38
chr3_-_188870799 0.409 NM_001048
SST
somatostatin
chr9_-_74169649 0.409 NM_001102420
NM_001102421
NM_006007
ZFAND5


zinc finger, AN1-type domain 5


chr1_+_195213289 0.409 NM_030787
CFHR5
complement factor H-related 5
chr8_+_94999167 0.408 NM_001161778
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr2_+_204509698 0.408 NM_012092
ICOS
inducible T-cell co-stimulator
chr6_+_83130673 0.408 NM_001166392
TPBG
trophoblast glycoprotein
chr2_+_101680594 0.408 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr6_+_88111289 0.407 NM_001010868
C6orf163
chromosome 6 open reading frame 163
chrX_+_128867757 0.406 NM_001166221
NM_006649
UTP14A

UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)

chrX_+_135057202 0.406 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr1_-_156056456 0.405 NM_001159397
NM_001159398
NM_052938
FCRL1


Fc receptor-like 1


chr6_+_64339869 0.405 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_+_195010552 0.405 NM_001166624
NM_021023
CFHR3

complement factor H-related 3

chr2_+_112996053 0.404 TTL
tubulin tyrosine ligase
chr19_-_49523747 0.403 ZFP112
zinc finger protein 112 homolog (mouse)
chr5_-_34020445 0.399 NM_001012509
NM_016180
SLC45A2

solute carrier family 45, member 2

chr17_-_36376663 0.399 NM_213656
KRT39
keratin 39
chr7_+_29200636 0.398 NM_004067
CHN2
chimerin (chimaerin) 2
chr14_-_19553191 0.396 NM_001004712
OR4K14
olfactory receptor, family 4, subfamily K, member 14

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.75 2.83e-02 GO:0007608 sensory perception of smell
1.70 3.69e-02 GO:0007606 sensory perception of chemical stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.09 2.80e-02 GO:0005882 intermediate filament

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.84 1.51e-03 GO:0004984 olfactory receptor activity