Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.419


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF7chr5_+_133479196-0.523.9e-02Click!
TCF7L1chr2_+_85213884-0.361.7e-01Click!
LEF1chr4_-_109307325-0.234.0e-01Click!
TCF7L2chr10_+_1147007750.048.8e-01Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_21229975 2.841 NM_002172
IFNA14
interferon, alpha 14
chr6_-_127882192 2.011 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chr8_+_32698892 1.909 NM_001159996
NRG1
neuregulin 1
chrX_-_105169370 1.625 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr3_+_125296217 1.599 NM_001024660
NM_003947
KALRN

kalirin, RhoGEF kinase

chr8_-_6901661 1.466 NM_021010
DEFA5
defensin, alpha 5, Paneth cell-specific
chr12_+_19173669 1.229 NM_001143821
NM_001190860
NM_019012
PLEKHA5


pleckstrin homology domain containing, family A member 5


chr13_+_23042722 1.177 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr6_-_128263868 1.165 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr13_+_75108450 1.156 LMO7
LIM domain 7
chr7_+_80069439 1.150 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr18_-_24011349 1.133 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr9_-_35640852 1.125 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr8_-_16903911 1.118 NM_019851
FGF20
fibroblast growth factor 20
chr5_-_114543632 1.092 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr13_-_71339313 1.086 NM_004392
NM_080759
NM_080760
DACH1


dachshund homolog 1 (Drosophila)


chr14_-_20572783 1.085 NM_001012264
RNASE13
ribonuclease, RNase A family, 13 (non-active)
chr8_-_120033240 1.055 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr9_+_71009746 1.053 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr5_-_58370693 1.042 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
1.75 2.83e-02 GO:0007608 sensory perception of smell
1.70 3.69e-02 GO:0007606 sensory perception of chemical stimulus

Gene overrepresentation in compartment category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
2.09 2.80e-02 GO:0005882 intermediate filament

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
1.84 1.51e-03 GO:0004984 olfactory receptor activity