Motif ID: LHX3,4.p2

Z-value: 0.827


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
LHX3 8022 LIM homeobox 3
LHX4 89884 LIM homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
LHX4chr1_+_178466064-0.476.4e-02Click!
LHX3chr9_-_138234707-0.273.2e-01Click!


Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_52697160 1.185 HOXC5
HOXC6
homeobox C5
homeobox C6
chr13_-_45323757 0.995 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr7_-_122627235 0.961 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr8_-_62764839 0.956 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr6_-_66346417 0.948 NM_198283
EYS
eyes shut homolog (Drosophila)
chr8_-_131483395 0.914 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr10_-_33264491 0.868 NM_033668
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr22_-_38619739 0.859 NM_152512
ENTHD1
ENTH domain containing 1
chr12_+_52696908 0.846 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr10_+_102212787 0.813 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr8_+_32905027 0.728


chr1_+_157526127 0.712 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr15_+_92700167 0.701 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr9_-_137671206 0.699 NM_182974
GLT6D1
glycosyltransferase 6 domain containing 1
chr9_+_4829763 0.696 RCL1
RNA terminal phosphate cyclase-like 1
chr15_+_46271158 0.675 NM_001145668
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
chr12_-_88573949 0.663 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr4_+_71054492 0.662 NM_214711
C4orf40
chromosome 4 open reading frame 40
chr18_+_59733724 0.662 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr3_-_69212192 0.656 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr12_-_10870134 0.638 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr10_+_685887 0.636 C10orf108
chromosome 10 open reading frame 108
chr21_-_35153664 0.632 RUNX1
runt-related transcription factor 1
chr4_-_116254381 0.621 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr5_+_166644420 0.607 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr3_-_54937001 0.604 NM_020678
LRTM1
leucine-rich repeats and transmembrane domains 1
chr5_-_88155360 0.589 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr20_-_18425811 0.578 NM_006606
RBBP9
retinoblastoma binding protein 9
chr4_-_120462705 0.573 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr11_+_33306652 0.567 HIPK3
homeodomain interacting protein kinase 3
chr14_+_74968589 0.550 NM_001135049
JDP2
Jun dimerization protein 2
chr10_+_63478974 0.543 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr11_+_22646229 0.538 NM_177553
GAS2
growth arrest-specific 2
chr5_-_160044844 0.537 ATP10B
ATPase, class V, type 10B
chr9_+_12683385 0.528 NM_000550
TYRP1
tyrosinase-related protein 1
chr11_-_117628211 0.526 NM_198275
MPZL3
myelin protein zero-like 3
chr3_-_166278969 0.522 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr3_+_99334230 0.506 NM_001005338
OR5H1
olfactory receptor, family 5, subfamily H, member 1
chr11_+_26310253 0.503 NM_031418
ANO3
anoctamin 3
chr10_+_129237602 0.501 NM_001030013
NPS
neuropeptide S
chr11_-_30910074 0.499 NM_020869
DCDC5
doublecortin domain containing 5
chr14_+_100365390 0.491 MEG3
maternally expressed 3 (non-protein coding)
chr4_+_68995761 0.484 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr16_-_3783475 0.478 CREBBP
CREB binding protein
chr7_-_87180499 0.466 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr15_+_32048380 0.465 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr21_-_26345294 0.460


chr12_-_9651748 0.456 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr4_+_78651929 0.455 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr4_-_100492854 0.455 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr3_-_114047479 0.449 NM_001008784
CD200R1L
CD200 receptor 1-like
chr7_-_86526880 0.446 NM_001142749
KIAA1324L
KIAA1324-like
chr4_+_119174947 0.438 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr5_+_127012611 0.433 NM_001048252
CTXN3
cortexin 3
chr1_+_156991133 0.432 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chr7_+_18296569 0.429 HDAC9
histone deacetylase 9
chr14_-_60185659 0.427 NM_005982
SIX1
SIX homeobox 1
chr14_+_100365162 0.426 MEG3
maternally expressed 3 (non-protein coding)
chr3_-_121117647 0.421 GSK3B
glycogen synthase kinase 3 beta
chr5_-_16795336 0.419 MYO10
myosin X
chr1_-_92725017 0.418 NM_005263
GFI1
growth factor independent 1 transcription repressor
chr1_+_81544432 0.409 LPHN2
latrophilin 2
chr14_-_46882144 0.407 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr15_+_100175888 0.406 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr5_+_147672181 0.398 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr12_+_8557402 0.394 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr6_+_53043729 0.393 NM_012347
FBXO9
F-box protein 9
chr13_+_52500830 0.390 NM_006418
OLFM4
olfactomedin 4
chr3_-_99236520 0.385 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr4_-_46605980 0.385 NM_130902
COX7B2
cytochrome c oxidase subunit VIIb2
chr17_-_38087366 0.384 NM_016602
CCR10
chemokine (C-C motif) receptor 10
chr12_-_15757114 0.378 EPS8
epidermal growth factor receptor pathway substrate 8
chr4_+_71330797 0.377 NM_001145006
MUC7
mucin 7, secreted
chr9_-_14076901 0.374 NFIB
nuclear factor I/B
chr1_+_144198658 0.371 LIX1L
Lix1 homolog (mouse)-like
chr3_+_73193499 0.368 NM_018029
EBLN2
endogenous Borna-like N element-2
chr10_-_45131061 0.366 NM_001004297
OR13A1
olfactory receptor, family 13, subfamily A, member 1
chr10_+_126620681 0.366 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr11_-_6005546 0.366 NM_001001917
OR56A1
olfactory receptor, family 56, subfamily A, member 1
chr19_-_21985560 0.365 NM_007153
ZNF208
zinc finger protein 208
chr13_+_47948586 0.363 RB1
retinoblastoma 1
chr11_-_20138445 0.362 NM_001029865
DBX1
developing brain homeobox 1
chr4_-_20594645 0.361 KCNIP4
Kv channel interacting protein 4
chr3_-_131081910 0.361 NM_001017395
TMCC1
transmembrane and coiled-coil domain family 1
chr11_-_102081654 0.360 NM_022122
MMP27
matrix metallopeptidase 27
chrX_-_102418329 0.357 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr3_-_101316038 0.356 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr4_+_88748704 0.356 NM_014208
DSPP
dentin sialophosphoprotein
chr2_+_216695062 0.356 XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr14_-_94669547 0.355 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr1_-_245942679 0.354 NM_001005286
OR6F1
olfactory receptor, family 6, subfamily F, member 1
chr3_-_18455207 0.353 NM_001131010
SATB1
SATB homeobox 1
chr1_-_58920315 0.351


chr11_+_55351270 0.350 NM_001004739
OR5L2
olfactory receptor, family 5, subfamily L, member 2
chr17_-_1195096 0.349 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr6_+_55300225 0.348 NM_207410
GFRAL
GDNF family receptor alpha like
chr12_-_23628774 0.341 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr6_-_56615544 0.340 NM_001723
NM_015548
DST

dystonin

chr14_+_28311740 0.340 C14orf23
chromosome 14 open reading frame 23
chr14_+_66901237 0.333 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr2_-_224574860 0.330 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr7_+_94135384 0.329 PEG10
paternally expressed 10
chr2_-_55053398 0.327


chr3_+_101316463 0.324 NM_001167924
C3orf26
chromosome 3 open reading frame 26
chr6_+_55147029 0.324 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr6_-_152681171 0.321 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr10_+_57028755 0.319 NM_001190478
MTRNR2L5
MT-RNR2-like 5
chr8_+_9990471 0.313 NM_001135671
MSRA
methionine sulfoxide reductase A
chr12_+_52708460 0.312 NM_004503
HOXC6
homeobox C6
chr13_-_34948758 0.312 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr10_+_91142301 0.311 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr11_-_57883117 0.307 NM_001005489
OR5B17
olfactory receptor, family 5, subfamily B, member 17
chr4_-_80548378 0.307 NM_033214
GK2
glycerol kinase 2
chr3_+_152934393 0.307 NM_207365
AADACL2
arylacetamide deacetylase-like 2
chr12_+_9871343 0.303 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr19_-_53841064 0.300 NM_001217
CA11
carbonic anhydrase XI
chr21_-_26294332 0.299 APP
amyloid beta (A4) precursor protein
chr14_+_69307914 0.299 SRSF5
serine/arginine-rich splicing factor 5
chr3_-_79899748 0.298 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr10_+_17310475 0.294 VIM
vimentin
chrX_+_153186602 0.294 NM_001145934
TKTL1
transketolase-like 1
chr6_-_116799548 0.293 LOC100287467
hypothetical LOC100287467
chr18_-_49944986 0.291 MBD2
methyl-CpG binding domain protein 2
chr6_-_132952517 0.291 NM_003967
TAAR5
trace amine associated receptor 5
chr15_-_48345453 0.290 NM_002112
HDC
histidine decarboxylase
chr14_+_61532293 0.290 NM_031914
SYT16
synaptotagmin XVI
chr3_-_121065112 0.287


chr2_+_170074457 0.287 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr11_-_124478414 0.287 NM_001080546
TMEM218
transmembrane protein 218
chr5_-_160211623 0.286 NM_025153
ATP10B
ATPase, class V, type 10B
chr11_-_26550243 0.285 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr6_-_109795925 0.284 CD164
CD164 molecule, sialomucin
chr1_+_62835759 0.280 NM_014495
ANGPTL3
angiopoietin-like 3
chrX_+_56772391 0.276 LOC550643
hypothetical LOC550643
chr2_+_225973845 0.276 NM_020864
KIAA1486
KIAA1486
chrX_-_62697473 0.274 LOC92249
hypothetical LOC92249
chr1_-_150398327 0.273 NM_001122965
RPTN
repetin
chr3_-_71860958 0.273 NM_001134650
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr11_+_63282639 0.273 RTN3
reticulon 3
chr22_+_42726423 0.271 NM_001003828
PARVB
parvin, beta
chr8_-_91164100 0.271 NM_004929
CALB1
calbindin 1, 28kDa
chr22_-_15682555 0.270 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr9_-_21295311 0.269 NM_002169
IFNA5
interferon, alpha 5
chr5_-_58331515 0.269 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_230717850 0.269 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr2_+_183316574 0.268 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr13_+_77007809 0.266 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr1_-_188713324 0.265 NM_199051
FAM5C
family with sequence similarity 5, member C
chr3_-_159872960 0.265 NM_020169
LXN
latexin
chr10_-_48426868 0.264 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr1_-_214963279 0.263 NM_001438
ESRRG
estrogen-related receptor gamma
chr11_-_5766621 0.263 NM_001001913
OR52N1
olfactory receptor, family 52, subfamily N, member 1
chr10_-_50066386 0.262 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr14_+_28305922 0.262 NM_005249
FOXG1
forkhead box G1
chr5_-_145232723 0.261 NM_001080516
GRXCR2
glutaredoxin, cysteine rich 2
chr1_-_157014048 0.261 NM_001005278
OR6N2
olfactory receptor, family 6, subfamily N, member 2
chr9_-_74757735 0.261 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr6_-_144427340 0.260 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr18_+_64616296 0.260 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr4_-_87593306 0.260 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr3_+_103029523 0.258 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr4_+_5577783 0.257 NM_005750
C4orf6
chromosome 4 open reading frame 6
chr7_+_129057152 0.256 NM_001040110
NRF1
nuclear respiratory factor 1
chr11_-_89181390 0.256 NM_020358
TRIM49
tripartite motif containing 49
chr16_+_68284252 0.253 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr13_+_108046500 0.250 NM_015011
MYO16
myosin XVI
chr1_-_152394215 0.249 NM_001159484
NM_207308
NUP210L

nucleoporin 210kDa-like

chr9_-_21340885 0.246 NM_021002
IFNA6
interferon, alpha 6
chr3_-_52269467 0.246 WDR82
WD repeat domain 82
chr1_-_143708467 0.242 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr18_+_31488530 0.241 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr8_+_36760999 0.241 NM_001031836
KCNU1
potassium channel, subfamily U, member 1
chr17_-_60439764 0.241 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr9_-_28709302 0.238 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr17_-_9635325 0.238 NM_001105571
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr18_+_28023984 0.237 NM_005925
MEP1B
meprin A, beta
chr14_+_95915774 0.236 NM_016472
C14orf129
chromosome 14 open reading frame 129
chr11_+_91724909 0.236 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr5_+_132237253 0.235 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chrX_-_55074125 0.233 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr19_+_21056792 0.230 NM_182515
ZNF714
zinc finger protein 714
chr12_+_8499788 0.229 NM_001007033
CLEC6A
C-type lectin domain family 6, member A
chr16_+_2749934 0.229


chr20_+_2892918 0.229 PTPRA
protein tyrosine phosphatase, receptor type, A
chr16_+_24696069 0.227 TNRC6A
trinucleotide repeat containing 6A
chr3_-_64186151 0.226 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chrX_+_55951280 0.225


chrX_-_142432884 0.225 NM_001009609
SPANXN3
SPANX family, member N3
chr20_+_23293020 0.225 NM_022482
GZF1
GDNF-inducible zinc finger protein 1
chr8_-_82536312 0.224 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr4_-_69116839 0.224 NM_001077
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr9_-_21375258 0.223 NM_000605
IFNA2
interferon, alpha 2
chr3_+_99288706 0.223 NM_054106
OR5AC2
olfactory receptor, family 5, subfamily AC, member 2
chr14_+_55148488 0.223 KTN1
kinectin 1 (kinesin receptor)
chr12_-_52281050 0.222 NM_001130059
ATF7
activating transcription factor 7
chr8_+_70541631 0.218 SULF1
sulfatase 1
chr21_-_18697829 0.217 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr3_+_174598937 0.216 NM_014932
NLGN1
neuroligin 1
chr19_+_9157269 0.215 NM_175883
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr7_+_90176647 0.215 NM_012395
CDK14
cyclin-dependent kinase 14

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.08 1.94e-12 GO:0007608 sensory perception of smell
2.89 1.03e-11 GO:0007606 sensory perception of chemical stimulus
1.77 1.20e-08 GO:0003008 system process
2.07 5.21e-07 GO:0007600 sensory perception
1.79 7.78e-07 GO:0050877 neurological system process
1.33 9.95e-07 GO:0032501 multicellular organismal process
1.22 3.68e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.42 3.08e-09 GO:0005886 plasma membrane
1.41 6.03e-09 GO:0071944 cell periphery
1.23 1.15e-03 GO:0016021 integral to membrane
1.21 4.95e-03 GO:0031224 intrinsic to membrane
1.16 6.26e-03 GO:0016020 membrane
1.19 7.02e-03 GO:0044425 membrane part
1.52 3.25e-02 GO:0044430 cytoskeletal part
1.41 4.58e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.18 1.72e-13 GO:0004984 olfactory receptor activity
2.29 1.47e-11 GO:0004930 G-protein coupled receptor activity
1.88 7.48e-09 GO:0004888 transmembrane receptor activity
1.64 2.09e-08 GO:0004871 signal transducer activity
1.64 2.09e-08 GO:0060089 molecular transducer activity
1.71 3.31e-08 GO:0004872 receptor activity