Motif ID: MSX1,2.p2

Z-value: 0.656


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MSX2chr5_+_174084137-0.126.6e-01Click!
MSX1chr4_+_49122720.087.7e-01Click!


Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_135263737 0.977 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chrX_-_11194015 0.827 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chrX_+_99726445 0.788 NM_022144
TNMD
tenomodulin
chrX_-_133620103 0.764 NM_021796
PLAC1
placenta-specific 1
chr6_+_16237264 0.722 NM_013262
MYLIP
myosin regulatory light chain interacting protein
chrX_-_19598912 0.718 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr11_+_101693403 0.673 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr3_-_127810087 0.620 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr2_-_180135559 0.617 NM_001113398
ZNF385B
zinc finger protein 385B
chr5_+_169713458 0.534 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr11_+_7574992 0.472 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chrX_-_15530112 0.468 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr3_-_139315011 0.458 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr19_+_6723801 0.452


chr11_-_83071084 0.446 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr1_+_151456683 0.438 NM_001195571
PRR9
proline rich 9
chr1_+_203106600 0.432 NFASC
neurofascin
chr3_+_187866464 0.427 NM_000412
HRG
histidine-rich glycoprotein
chr1_+_31654998 0.420 NM_001199038
SERINC2
serine incorporator 2
chr7_-_13992351 0.391 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr6_+_16237300 0.387 MYLIP
myosin regulatory light chain interacting protein
chr7_-_96471544 0.387 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr14_-_64479198 0.379 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr4_-_77176163 0.353 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr15_-_41381744 0.351 NM_052955
TGM7
transglutaminase 7
chr21_-_36774257 0.339 NM_001146079
NM_144492
CLDN14

claudin 14

chr14_-_93324518 0.335 NM_178013
PRIMA1
proline rich membrane anchor 1
chr19_+_40895669 0.322 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr12_-_89922888 0.317 NM_004950
EPYC
epiphycan
chr6_+_50894397 0.313 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr1_+_31655607 0.306 NM_001199037
SERINC2
serine incorporator 2
chr12_-_89922875 0.304 EPYC
epiphycan
chr6_-_154719560 0.302 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr19_+_6723705 0.302 NM_005428
VAV1
vav 1 guanine nucleotide exchange factor
chr1_-_229071957 0.295 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr5_-_148738980 0.291 NM_014443
IL17B
interleukin 17B
chr12_-_50871953 0.282 NM_001081492
NM_182507
KRT80

keratin 80

chr2_+_28572441 0.281 NM_001170585
NM_153021
PLB1

phospholipase B1

chr10_-_44794146 0.257 NM_007021
C10orf10
chromosome 10 open reading frame 10
chrX_-_131089552 0.247 NM_194277
FRMD7
FERM domain containing 7
chr10_-_50269912 0.235 NM_001080520
DRGX
dorsal root ganglia homeobox
chr17_-_19592178 0.221 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr19_-_40696393 0.208 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr3_-_152585226 0.207 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr4_+_89115862 0.207 SPP1
secreted phosphoprotein 1
chr9_-_96395828 0.206 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr3_+_157321030 0.197 NM_172160
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr1_-_108032645 0.195 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr21_+_42492867 0.190 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr4_-_41579325 0.189


chr4_+_74566325 0.188 NM_001133
AFM
afamin
chr22_+_38652555 0.187 GRAP2
GRB2-related adaptor protein 2
chr10_+_7785360 0.183 ITIH2
inter-alpha (globulin) inhibitor H2
chr11_-_85074848 0.177 NM_152723
CCDC89
coiled-coil domain containing 89
chr9_+_134843918 0.176 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr13_-_98708549 0.175 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chrX_+_12834659 0.171 NM_138636
TLR8
toll-like receptor 8
chr2_+_113542017 0.170 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr10_+_85944383 0.169 NM_001171971
NM_033100
CDHR1

cadherin-related family member 1

chr20_-_48686832 0.163 NM_080829
FAM65C
family with sequence similarity 65, member C
chr5_+_176726918 0.161 RGS14
regulator of G-protein signaling 14
chr10_+_124310170 0.161 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chrX_+_16874651 0.157 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr8_-_38127489 0.156 NM_000349
STAR
steroidogenic acute regulatory protein
chr3_+_46591048 0.154 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chrX_+_38096679 0.153 NM_000531
OTC
ornithine carbamoyltransferase
chr8_+_24354387 0.153 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr2_-_237987553 0.152 COL6A3
collagen, type VI, alpha 3
chr1_+_151596953 0.150 NM_002965
S100A9
S100 calcium binding protein A9
chr1_+_31823097 0.149 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr9_-_126309510 0.149 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chrX_+_128966844 0.149 NM_021946
BCORL1
BCL6 corepressor-like 1
chrX_+_28515479 0.147 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr2_-_237987579 0.146 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr5_+_140509803 0.146 NM_018939
PCDHB6
protocadherin beta 6
chr7_+_5609416 0.146 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr7_+_77307382 0.145 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr4_+_89115825 0.144 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr17_-_25685175 0.142 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr2_-_237987554 0.142 COL6A3
collagen, type VI, alpha 3
chr7_+_132588359 0.139 NM_001037126
NM_021807
EXOC4

exocyst complex component 4

chr12_-_51457371 0.138 NM_015848
KRT76
keratin 76
chr4_+_89115892 0.137 SPP1
secreted phosphoprotein 1
chr19_+_50863341 0.135 NM_000164
GIPR
gastric inhibitory polypeptide receptor
chr1_+_15637521 0.134 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr16_-_74056083 0.134 NM_145254
TMEM170A
transmembrane protein 170A
chr9_-_110658030 0.134 NM_006686
ACTL7B
actin-like 7B
chrX_-_24600661 0.132 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr10_-_74384485 0.131 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr1_+_32438788 0.131 NM_024296
CCDC28B
coiled-coil domain containing 28B
chr1_+_150029798 0.129


chr12_+_49634048 0.126 NM_001109619
HIGD1C
HIG1 hypoxia inducible domain family, member 1C
chr2_+_233633348 0.123 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr3_-_194579207 0.123 NM_198505
ATP13A5
ATPase type 13A5
chr4_-_89963177 0.121 NM_001015045
FAM13A
family with sequence similarity 13, member A
chrX_+_123062143 0.121 STAG2
stromal antigen 2
chr12_-_69837831 0.120 TSPAN8
tetraspanin 8
chr3_+_16191159 0.119 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr12_+_53809731 0.118 NM_001005243
OR9K2
olfactory receptor, family 9, subfamily K, member 2
chr19_+_53016910 0.118 NM_000554
CRX
cone-rod homeobox
chr9_+_110664366 0.117 NM_006687
ACTL7A
actin-like 7A
chr1_-_240679380 0.116 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr8_-_30826074 0.115 NM_031271
TEX15
testis expressed 15
chr1_+_226352179 0.114 ARF1
ADP-ribosylation factor 1
chr3_+_52803823 0.113 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chrX_-_110542040 0.113 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr7_+_111850367 0.112 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr3_-_150578148 0.112 TM4SF1
transmembrane 4 L six family member 1
chrX_+_54963953 0.112 NM_001039705
NM_016157
NM_177556
TRO


trophinin


chr7_+_116238309 0.109 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr22_-_24107543 0.108 NM_001135772
LRP5L
low density lipoprotein receptor-related protein 5-like
chr2_+_233029076 0.108 NM_001631
ALPI
alkaline phosphatase, intestinal
chr19_-_14030970 0.107 NM_001145028
PALM3
paralemmin 3
chr17_-_36113502 0.107 NM_019016
KRT24
keratin 24
chr2_-_237987509 0.106 COL6A3
collagen, type VI, alpha 3
chr10_+_7785331 0.106 ITIH2
inter-alpha (globulin) inhibitor H2
chr11_-_59140192 0.105 NM_002556
OSBP
oxysterol binding protein
chrX_-_43717864 0.105 NM_000266
NDP
Norrie disease (pseudoglioma)
chr16_-_11918019 0.104 NM_001130007
GSPT1
G1 to S phase transition 1
chr8_-_27171814 0.103 NM_030795
STMN4
stathmin-like 4
chr21_-_30836051 0.102 NM_181612
KRTAP19-6
keratin associated protein 19-6
chr7_+_136203938 0.100 NM_001006627
NM_001006630
CHRM2

cholinergic receptor, muscarinic 2

chr11_-_6746763 0.100 NM_001004490
OR2AG2
olfactory receptor, family 2, subfamily AG, member 2
chr2_-_237987545 0.099 COL6A3
collagen, type VI, alpha 3
chr1_-_19058741 0.098 NM_152232
TAS1R2
taste receptor, type 1, member 2
chr9_+_1040367 0.098 DMRT2
doublesex and mab-3 related transcription factor 2
chrX_+_16578201 0.096 NM_004057
S100G
S100 calcium binding protein G
chr15_-_68128924 0.096 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr1_+_110683580 0.093 RBM15
RNA binding motif protein 15
chrX_+_30171768 0.092 NM_002363
NM_177415
MAGEB1

melanoma antigen family B, 1

chr3_-_188903038 0.091 NM_001004312
RTP2
receptor (chemosensory) transporter protein 2
chr22_+_38903825 0.091 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr3_-_150578207 0.091 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr18_-_5286013 0.090 NM_001143823
NM_003409
ZFP161

zinc finger protein 161 homolog (mouse)

chr9_+_135491305 0.090 NM_000787
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr13_-_93929719 0.090 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr17_-_61655915 0.089 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chrX_+_119621771 0.089 NM_014060
MCTS1
malignant T cell amplified sequence 1
chr11_+_130745580 0.089 NM_001048209
NTM
neurotrimin
chr22_+_38296703 0.088 NM_001003406
NM_021096
CACNA1I

calcium channel, voltage-dependent, T type, alpha 1I subunit

chr4_+_89115923 0.087 SPP1
secreted phosphoprotein 1
chr3_+_69895310 0.086 NM_001184967
MITF
microphthalmia-associated transcription factor
chr12_+_111713931 0.085 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chr4_+_71372422 0.085 NM_152291
MUC7
mucin 7, secreted
chr12_-_13139848 0.085 NM_031289
NM_153823
GSG1

germ cell associated 1

chr3_+_69895651 0.084 NM_006722
MITF
microphthalmia-associated transcription factor
chrX_-_129347101 0.084 NM_178471
GPR119
G protein-coupled receptor 119
chr1_-_51660328 0.083 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr11_+_122901543 0.082 GRAMD1B
GRAM domain containing 1B
chr1_-_167969802 0.081 NM_000450
SELE
selectin E
chr9_+_1040333 0.080 NM_006557
NM_001130865
DMRT2

doublesex and mab-3 related transcription factor 2

chr19_-_60150676 0.079 NM_001127255
NM_139176
NM_206828
NLRP7


NLR family, pyrin domain containing 7


chr4_+_15038726 0.079 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr14_-_49543987 0.079 NM_001012706
C14orf182
chromosome 14 open reading frame 182
chr6_+_12622286 0.079


chr16_-_3025542 0.079 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr3_+_9919511 0.078 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr11_+_61473931 0.078 NM_001139443
NM_004183
BEST1

bestrophin 1

chr12_+_48630790 0.077 NM_000486
AQP2
aquaporin 2 (collecting duct)
chr9_+_130942029 0.077 PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr10_-_119124727 0.077 NM_173791
PDZD8
PDZ domain containing 8
chr10_+_7785347 0.076 ITIH2
inter-alpha (globulin) inhibitor H2
chr5_+_68703036 0.076 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr11_+_15090545 0.075 NM_001031853
INSC
inscuteable homolog (Drosophila)
chrX_+_144716619 0.075 NM_004709
CXorf1
chromosome X open reading frame 1
chr11_+_6823458 0.073 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr5_+_59819761 0.072 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr8_-_27171852 0.071 STMN4
stathmin-like 4
chr10_+_124020810 0.071 NM_144587
BTBD16
BTB (POZ) domain containing 16
chr7_+_21434818 0.071


chr8_-_15140162 0.070 NM_139167
SGCZ
sarcoglycan, zeta
chr4_+_155703581 0.069 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr12_-_112058403 0.069 NM_001193520
NM_004658
RASAL1

RAS protein activator like 1 (GAP1 like)

chr1_+_119851348 0.069 NM_000862
HSD3B1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chrX_-_19898302 0.068 NM_198279
CXorf23
chromosome X open reading frame 23
chr12_+_14429499 0.068 ATF7IP
activating transcription factor 7 interacting protein
chr6_-_31938572 0.067 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr2_-_56266408 0.067 LOC100129434
hypothetical LOC100129434
chr6_-_76022565 0.066 TMEM30A
transmembrane protein 30A
chrX_+_103181171 0.066 NM_001164416
H2BFM
H2B histone family, member M
chr17_-_15495534 0.065 TRIM16
tripartite motif containing 16
chr15_+_90197884 0.065 NM_001145044
NM_013272
SLCO3A1

solute carrier organic anion transporter family, member 3A1

chr12_+_108038774 0.065 ACACB
acetyl-CoA carboxylase beta
chrX_+_119621933 0.064 MCTS1
malignant T cell amplified sequence 1
chr14_+_20595820 0.064 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr10_-_74384569 0.063 PLA2G12B
phospholipase A2, group XIIB
chrX_+_153310171 0.062 NM_001183
ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr3_+_185300660 0.062 NM_182589
HTR3E
5-hydroxytryptamine (serotonin) receptor 3, family member E
chr12_+_49605010 0.062 METTL7A
methyltransferase like 7A
chr8_-_49996353 0.061 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr7_+_30704125 0.060 INMT
indolethylamine N-methyltransferase
chr1_-_205012348 0.059 NM_000572
IL10
interleukin 10
chr1_+_29086206 0.059 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr3_+_9919295 0.059 NM_153483
IL17RE
interleukin 17 receptor E
chr11_-_64484184 0.058 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr4_-_159311959 0.057 FAM198B
family with sequence similarity 198, member B
chr10_+_115501202 0.057 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr7_-_16471817 0.057 NM_015464
SOSTDC1
sclerostin domain containing 1
chr18_+_75388522 0.056 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr10_+_7785290 0.056 ITIH2
inter-alpha (globulin) inhibitor H2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.48 2.16e-03 GO:0071944 cell periphery
1.44 1.07e-02 GO:0005886 plasma membrane

Nothing significant found in function category.