Motif ID: MTF1.p2

Z-value: 2.425


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MTF1chr1_-_380978110.411.1e-01Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_1704661 4.896 NM_001080488
ONECUT3
one cut homeobox 3
chr16_-_87535106 3.214 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr20_-_60228665 2.964 NM_007232
HRH3
histamine receptor H3
chr14_+_105012106 2.944 NM_001312
CRIP2
cysteine-rich protein 2
chr17_+_72880967 2.651 SEPT9
septin 9
chr2_-_128792515 2.559 NM_004807
HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chr2_+_232281491 2.533 PTMA
prothymosin, alpha
chr2_+_120820140 2.518 NM_002193
INHBB
inhibin, beta B
chr6_+_41622267 2.341 FOXP4
forkhead box P4
chr2_+_241156776 2.286 NM_018226
RNPEPL1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr9_+_125813849 2.284 LHX2
LIM homeobox 2
chr12_+_130878870 2.097 NM_016155
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr16_+_1143738 2.006 CACNA1H
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr20_-_60484420 1.978 NM_080473
GATA5
GATA binding protein 5
chr12_+_55896844 1.939 NM_007224
NXPH4
neurexophilin 4
chr7_+_1239078 1.917 NM_001080461
UNCX
UNC homeobox
chr16_+_49139694 1.894 NM_033119
NKD1
naked cuticle homolog 1 (Drosophila)
chr1_-_6402467 1.866 NM_019089
HES2
hairy and enhancer of split 2 (Drosophila)
chr11_+_119887630 1.862 LOC100293636
GRIK4
hypothetical protein LOC100293636
glutamate receptor, ionotropic, kainate 4
chr1_+_2149993 1.803 NM_003036
SKI
v-ski sarcoma viral oncogene homolog (avian)
chr9_-_95757365 1.797 NM_021570
BARX1
BARX homeobox 1
chr10_-_103525646 1.768 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chr16_+_87765661 1.751 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr9_+_139892049 1.732 NM_000718
CACNA1B
calcium channel, voltage-dependent, N type, alpha 1B subunit
chr9_-_95757448 1.689 BARX1
BARX homeobox 1
chr20_-_60375695 1.666 NM_005560
LAMA5
laminin, alpha 5
chr20_-_55274497 1.649 BMP7
bone morphogenetic protein 7
chr16_+_12902955 1.643 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr5_+_133478252 1.558 NM_003202
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr8_+_145461356 1.533 NM_001008271
NM_001080514
SCXA
SCXB
scleraxis homolog A (mouse)
scleraxis homolog B (mouse)
chr19_+_951295 1.530 NM_138690
GRIN3B
glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
chr2_+_232281470 1.518 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr11_+_359723 1.509 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr1_-_3437834 1.508 MEGF6
multiple EGF-like-domains 6
chr17_+_26060617 1.495


chr16_+_55230078 1.484 NM_005946
MT1A
metallothionein 1A
chr4_+_3737872 1.481 ADRA2C
adrenergic, alpha-2C-, receptor
chr16_-_695719 1.471 NM_153350
FBXL16
F-box and leucine-rich repeat protein 16
chr15_+_29406335 1.452 NM_015995
KLF13
Kruppel-like factor 13
chr20_+_20296744 1.445 NM_002196
INSM1
insulinoma-associated 1
chr10_+_134060681 1.439 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr21_+_41719847 1.418 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr19_+_1358664 1.403 DAZAP1
DAZ associated protein 1
chr19_+_13090101 1.399 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr19_-_50963942 1.390


chr16_+_82559600 1.383 NM_019065
NECAB2
N-terminal EF-hand calcium binding protein 2
chr9_+_138726737 1.380 NM_152421
FAM69B
family with sequence similarity 69, member B
chr17_-_29930431 1.356 NM_207454
C17orf102
chromosome 17 open reading frame 102
chr3_+_53170254 1.354 NM_006254
NM_212539
PRKCD

protein kinase C, delta

chr4_-_1683712 1.345 NM_006527
SLBP
stem-loop binding protein
chr16_-_55259405 1.332 NM_005950
MT1G
metallothionein 1G
chr17_+_78630793 1.331 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chr21_+_42946719 1.327 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr14_-_104515738 1.313 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr12_+_131577229 1.304 NM_001142641
FBRSL1
fibrosin-like 1
chr14_+_99181232 1.300 NM_001127258
NM_032425
HHIPL1

HHIP-like 1

chr11_+_696103 1.300 NM_022772
EPS8L2
EPS8-like 2
chr9_-_94936319 1.299 NM_004148
NINJ1
ninjurin 1
chr20_-_38751289 1.293 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr20_+_60744268 1.281 SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr22_+_27931685 1.280 NM_133455
EMID1
EMI domain containing 1
chr10_+_6284845 1.275 NM_004566
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr20_+_60744231 1.275 NM_016354
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr17_+_24944605 1.275 NM_152345
ANKRD13B
ankyrin repeat domain 13B
chr2_+_219532590 1.266 NM_003936
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr6_+_36754433 1.264 NM_000389
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr11_+_65802221 1.261 NM_182553
CNIH2
cornichon homolog 2 (Drosophila)
chr20_-_55275078 1.246 NM_001719
BMP7
bone morphogenetic protein 7
chr3_+_50167424 1.244 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr6_+_36754467 1.243 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr20_+_60810610 1.242 NM_002531
NTSR1
neurotensin receptor 1 (high affinity)
chr19_+_590878 1.240 NM_020637
FGF22
fibroblast growth factor 22
chr2_+_241586927 1.238 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr19_+_1397268 1.237 APC2
adenomatosis polyposis coli 2
chr19_+_1236766 1.221 NM_001405
EFNA2
ephrin-A2
chr4_+_2031036 1.219 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr8_-_140784416 1.217 NM_016601
KCNK9
potassium channel, subfamily K, member 9
chr20_+_55399847 1.215 NM_017495
NM_183425
RBM38

RNA binding motif protein 38

chr16_+_4361775 1.209 NM_138440
VASN
vasorin
chr21_+_44560779 1.199 PFKL
phosphofructokinase, liver
chr11_+_67563030 1.192 NM_006019
TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
chr17_+_27617307 1.188 NM_138328
RHBDL3
rhomboid, veinlet-like 3 (Drosophila)
chr13_+_113587674 1.183 GAS6
growth arrest-specific 6
chr9_+_94987032 1.175 NM_006648
WNK2
WNK lysine deficient protein kinase 2
chr11_-_69343128 1.163 NM_005247
FGF3
fibroblast growth factor 3
chr5_+_176170041 1.154 NM_133369
UNC5A
unc-5 homolog A (C. elegans)
chr4_+_1764802 1.152 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr20_-_61600834 1.151 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr9_-_139042416 1.151 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr11_+_63758550 1.150 NM_003377
VEGFB
vascular endothelial growth factor B
chr1_+_153317887 1.138 NM_004952
EFNA3
ephrin-A3
chr4_+_3738093 1.132 NM_000683
ADRA2C
adrenergic, alpha-2C-, receptor
chr10_-_133971136 1.124 NM_173575
STK32C
serine/threonine kinase 32C
chr3_-_51976428 1.123 NM_020418
NM_001174100
NM_033008
PCBP4


poly(rC) binding protein 4


chr7_+_2525922 1.118 NM_001040167
NM_001040168
LFNG

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr17_+_73676219 1.118 NM_004710
SYNGR2
synaptogyrin 2
chr22_+_41836697 1.115 NM_001197
BIK
BCL2-interacting killer (apoptosis-inducing)
chr11_+_627268 1.110 NM_000797
DRD4
dopamine receptor D4
chr16_+_55249355 1.098 NM_005949
MT1F
metallothionein 1F
chr11_+_551449 1.097 NM_001143994
NM_003475
RASSF7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr3_-_48607596 1.096 NM_000094
COL7A1
collagen, type VII, alpha 1
chr16_-_772926 1.091 NM_001025190
MSLNL
mesothelin-like
chr10_+_50487146 1.078 NM_020984
CHAT
choline O-acetyltransferase
chr22_+_28446288 1.074 NM_182527
CABP7
calcium binding protein 7
chr17_+_70495318 1.069 NM_014603
CDR2L
cerebellar degeneration-related protein 2-like
chr16_+_1763185 1.068 NM_001010865
EME2
essential meiotic endonuclease 1 homolog 2 (S. pombe)
chr16_+_517834 1.062 NM_005632
SOLH
small optic lobes homolog (Drosophila)
chr1_-_32002222 1.055 NM_001703
BAI2
brain-specific angiogenesis inhibitor 2
chr9_+_90339835 1.050 NM_001161625
NM_145283
NXNL2

nucleoredoxin-like 2

chr22_+_48740143 1.043 NM_001001852
PIM3
pim-3 oncogene
chr20_+_60918836 1.041 NM_001853
COL9A3
collagen, type IX, alpha 3
chr9_-_138560058 1.035 NM_017617
NOTCH1
notch 1
chr11_+_76455574 1.035 NM_004055
CAPN5
calpain 5
chrX_-_152389796 1.033 NM_017518
HAUS7
HAUS augmin-like complex, subunit 7
chr11_-_67028415 1.032 PITPNM1
phosphatidylinositol transfer protein, membrane-associated 1
chr17_+_77780177 1.032 NM_004207
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr22_+_20101661 1.030 NM_015094
HIC2
hypermethylated in cancer 2
chr19_+_40900965 1.028 MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr1_+_1940605 1.028 NM_000815
GABRD
gamma-aminobutyric acid (GABA) A receptor, delta
chr6_-_170442090 1.026


chr3_-_52065130 1.024 NM_001947
DUSP7
dual specificity phosphatase 7
chr3_-_50515857 1.023 NM_001005505
NM_001174051
NM_006030
CACNA2D2


calcium channel, voltage-dependent, alpha 2/delta subunit 2


chr16_+_1143241 1.019 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr10_-_131652364 1.015 EBF3
early B-cell factor 3
chr9_-_139042526 1.011 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr2_+_100087812 1.009


chr17_+_72880831 1.008 NM_001113493
SEPT9
septin 9
chr15_+_65904994 1.004 NM_001031807
SKOR1
SKI family transcriptional corepressor 1
chr7_+_45580606 1.002 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr6_+_37245860 0.999 NM_002648
PIM1
pim-1 oncogene
chr20_-_61639104 0.997 NM_005975
PTK6
PTK6 protein tyrosine kinase 6
chr11_+_64878857 0.997 NM_145719
TIGD3
tigger transposable element derived 3
chr22_+_18081968 0.989 NM_002688
SEPT5
septin 5
chr1_-_1525309 0.982 LOC643988
hypothetical LOC643988
chr22_-_18635614 0.975 NM_023004
RTN4R
reticulon 4 receptor
chr7_-_150283794 0.966 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr2_+_56264627 0.960 NM_001080433
CCDC85A
coiled-coil domain containing 85A
chr20_+_34206070 0.959 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr17_+_45993338 0.958 NM_018896
NM_198376
NM_198377
NM_198378
NM_198379
NM_198380
NM_198382
NM_198383
NM_198384
NM_198385
NM_198386
NM_198387
NM_198388
NM_198396
NM_198397
CACNA1G














calcium channel, voltage-dependent, T type, alpha 1G subunit














chr9_+_125813672 0.953 NM_004789
LHX2
LIM homeobox 2
chr19_+_2427122 0.943 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr11_-_2863536 0.942 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr14_+_104338423 0.941 ZBTB42
zinc finger and BTB domain containing 42
chr8_+_146248593 0.938 NM_023080
C8orf33
chromosome 8 open reading frame 33
chr11_+_69726916 0.936 NM_003824
FADD
Fas (TNFRSF6)-associated via death domain
chr2_-_278181 0.932 NM_001002919
FAM150B
family with sequence similarity 150, member B
chr16_+_84202515 0.932 NM_001134473
KIAA0182
KIAA0182
chr20_+_61963009 0.929 NM_080622
ABHD16B
abhydrolase domain containing 16B
chr19_+_50963484 0.926


chr1_-_226467929 0.924 C1orf145
chromosome 1 open reading frame 145
chr6_+_170441715 0.919 FAM120B
family with sequence similarity 120B
chrX_-_152389209 0.915 TREX2
HAUS7
three prime repair exonuclease 2
HAUS augmin-like complex, subunit 7
chr20_-_62181231 0.915 NM_005873
RGS19
regulator of G-protein signaling 19
chr12_+_48737753 0.906 NM_001095
NM_020039
ACCN2

amiloride-sensitive cation channel 2, neuronal

chr22_-_45311730 0.905 NM_014246
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr19_+_540849 0.903 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr11_+_6368213 0.898 NM_000543
NM_001007593
SMPD1

sphingomyelin phosphodiesterase 1, acid lysosomal

chr7_+_989321 0.896 NM_017781
CYP2W1
cytochrome P450, family 2, subfamily W, polypeptide 1
chr14_-_104718565 0.891 NM_177533
NUDT14
nudix (nucleoside diphosphate linked moiety X)-type motif 14
chr6_+_336738 0.890 NM_001195286
NM_002460
IRF4

interferon regulatory factor 4

chr6_-_99904251 0.888 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr7_+_150442652 0.872 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr6_-_170441493 0.872 NM_005618
DLL1
delta-like 1 (Drosophila)
chr1_+_29011240 0.870 NM_000911
OPRD1
opioid receptor, delta 1
chr2_-_40532651 0.869 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr7_+_5289079 0.866 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr16_-_79395379 0.863 NM_152342
CDYL2
chromodomain protein, Y-like 2
chr19_-_36531958 0.859 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr10_-_88116181 0.859 NM_017551
GRID1
glutamate receptor, ionotropic, delta 1
chr1_+_2975590 0.859 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr22_+_17337970 0.849 DGCR5
DiGeorge syndrome critical region gene 5 (non-protein coding)
chr16_+_25610847 0.846 NM_006040
HS3ST4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr12_+_6513865 0.843 NM_002046
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr17_-_40401138 0.839 NM_006688
C1QL1
complement component 1, q subcomponent-like 1
chr21_+_44566063 0.838 PFKL
phosphofructokinase, liver
chr22_+_24895623 0.837 SEZ6L
seizure related 6 homolog (mouse)-like
chr7_+_45580704 0.835 ADCY1
adenylate cyclase 1 (brain)
chr16_+_11669736 0.832 NM_003498
SNN
stannin
chr14_-_36052727 0.832 NM_001101341
SFTA3
surfactant associated 3
chr19_+_12966970 0.830 NM_002501
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_+_242146791 0.822 NM_032515
BOK
BCL2-related ovarian killer
chr12_-_41269679 0.819 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr14_+_20608179 0.813 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr16_+_1299637 0.812 NM_003345
NM_194259
UBE2I

ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)

chr16_+_2510323 0.811 NM_001145815
NM_015944
AMDHD2

amidohydrolase domain containing 2

chr21_+_44544349 0.810 NM_002626
PFKL
phosphofructokinase, liver
chr12_+_111980044 0.806 NM_004416
DTX1
deltex homolog 1 (Drosophila)
chr11_-_788196 0.805 NM_001191061
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr19_+_52469939 0.804 NM_178511
PRR24
proline rich 24
chr16_+_55180767 0.804 NM_005954
MT3
metallothionein 3
chr22_-_49310827 0.804 NM_001169111
NM_005138
SCO2

SCO cytochrome oxidase deficient homolog 2 (yeast)

chr2_-_100087560 0.802 AFF3
AF4/FMR2 family, member 3
chrX_-_39841599 0.802 NM_001123385
NM_017745
BCOR

BCL6 corepressor

chr16_+_54782802 0.801 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr19_+_482688 0.800 NM_004359
CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr22_-_49050847 0.798 NM_002751
MAPK11
mitogen-activated protein kinase 11
chr14_+_72773957 0.797 NM_173462
NDRG2
PAPLN
NDRG family member 2
papilin, proteoglycan-like sulfated glycoprotein
chr12_+_6846844 0.795 NM_001159287
NM_000365
TPI1

triosephosphate isomerase 1

chr10_+_134751398 0.795 NM_001083909
GPR123
G protein-coupled receptor 123
chr22_-_30356783 0.794 NM_014338
PISD
phosphatidylserine decarboxylase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.57 5.46e-23 GO:0007399 nervous system development
1.68 4.70e-19 GO:0022008 neurogenesis
1.31 5.09e-19 GO:0007275 multicellular organismal development
1.69 8.42e-19 GO:0048699 generation of neurons
1.35 3.61e-18 GO:0048731 system development
1.27 1.86e-15 GO:0032502 developmental process
1.30 6.73e-15 GO:0048856 anatomical structure development
1.69 1.63e-14 GO:0030182 neuron differentiation
1.10 3.15e-14 GO:0009987 cellular process
1.37 8.48e-14 GO:0030154 cell differentiation
1.35 1.37e-12 GO:0048869 cellular developmental process
1.39 6.54e-12 GO:0023051 regulation of signaling
1.14 3.76e-11 GO:0065007 biological regulation
1.15 1.11e-10 GO:0050794 regulation of cellular process
1.60 2.26e-10 GO:0045595 regulation of cell differentiation
1.59 3.32e-10 GO:0009790 embryo development
1.50 4.78e-10 GO:0048468 cell development
1.22 6.60e-10 GO:0023052 signaling
1.14 8.96e-10 GO:0050789 regulation of biological process
1.48 4.61e-09 GO:0050793 regulation of developmental process
1.30 5.32e-09 GO:0048523 negative regulation of cellular process
1.67 7.15e-09 GO:0031175 neuron projection development
1.44 8.78e-09 GO:0010646 regulation of cell communication
1.66 9.65e-09 GO:0000904 cell morphogenesis involved in differentiation
1.36 1.11e-08 GO:0009653 anatomical structure morphogenesis
1.61 1.25e-08 GO:0048666 neuron development
1.39 1.55e-08 GO:0051239 regulation of multicellular organismal process
1.28 2.00e-08 GO:0048519 negative regulation of biological process
1.36 3.88e-08 GO:0009966 regulation of signal transduction
1.80 6.15e-08 GO:0060284 regulation of cell development
1.69 7.82e-08 GO:0007409 axonogenesis
1.66 1.56e-07 GO:0048812 neuron projection morphogenesis
1.66 1.60e-07 GO:0048667 cell morphogenesis involved in neuron differentiation
1.49 2.65e-07 GO:2000026 regulation of multicellular organismal development
1.29 3.49e-07 GO:0048513 organ development
1.24 3.52e-07 GO:0048518 positive regulation of biological process
1.60 4.64e-07 GO:0007417 central nervous system development
1.25 5.01e-07 GO:0048522 positive regulation of cellular process
1.74 6.29e-07 GO:0007411 axon guidance
1.83 2.05e-06 GO:0050767 regulation of neurogenesis
1.19 2.78e-06 GO:0080090 regulation of primary metabolic process
1.77 3.36e-06 GO:0051960 regulation of nervous system development
1.20 3.67e-06 GO:0007165 signal transduction
1.39 4.92e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.66 4.96e-06 GO:0043009 chordate embryonic development
1.65 5.43e-06 GO:0009792 embryo development ending in birth or egg hatching
1.53 8.01e-06 GO:0051253 negative regulation of RNA metabolic process
1.48 8.10e-06 GO:0007167 enzyme linked receptor protein signaling pathway
1.50 1.12e-05 GO:0000902 cell morphogenesis
1.48 1.16e-05 GO:0030030 cell projection organization
1.54 1.49e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.76 1.64e-05 GO:0045596 negative regulation of cell differentiation
1.53 1.79e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.54 1.80e-05 GO:0048858 cell projection morphogenesis
1.49 1.90e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.18 2.08e-05 GO:0031323 regulation of cellular metabolic process
1.27 2.59e-05 GO:0007166 cell surface receptor linked signaling pathway
1.49 2.71e-05 GO:0009887 organ morphogenesis
1.19 3.10e-05 GO:0060255 regulation of macromolecule metabolic process
1.53 3.49e-05 GO:0032990 cell part morphogenesis
1.26 4.15e-05 GO:0048583 regulation of response to stimulus
1.64 4.32e-05 GO:0007389 pattern specification process
1.41 4.46e-05 GO:0051128 regulation of cellular component organization
1.45 4.84e-05 GO:0009719 response to endogenous stimulus
1.47 5.35e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.47 6.40e-05 GO:0010629 negative regulation of gene expression
1.64 7.45e-05 GO:0045597 positive regulation of cell differentiation
1.90 9.60e-05 GO:0030155 regulation of cell adhesion
1.58 1.04e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.20 1.21e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.45 1.32e-04 GO:0001932 regulation of protein phosphorylation
1.13 1.40e-04 GO:0032501 multicellular organismal process
1.18 1.53e-04 GO:0016043 cellular component organization
1.16 1.53e-04 GO:0019222 regulation of metabolic process
1.36 1.54e-04 GO:0042127 regulation of cell proliferation
1.45 1.70e-04 GO:0032989 cellular component morphogenesis
1.22 2.59e-04 GO:0042221 response to chemical stimulus
1.53 2.68e-04 GO:0032583 regulation of gene-specific transcription
1.42 2.86e-04 GO:0019220 regulation of phosphate metabolic process
1.42 2.86e-04 GO:0051174 regulation of phosphorus metabolic process
2.11 3.14e-04 GO:0010720 positive regulation of cell development
1.53 3.31e-04 GO:0023057 negative regulation of signaling
1.17 3.33e-04 GO:0071840 cellular component organization or biogenesis
1.41 3.64e-04 GO:0009890 negative regulation of biosynthetic process
1.52 3.89e-04 GO:0010648 negative regulation of cell communication
1.82 4.22e-04 GO:0014070 response to organic cyclic compound
1.16 4.41e-04 GO:0051179 localization
1.15 5.08e-04 GO:0051716 cellular response to stimulus
1.36 5.53e-04 GO:0040011 locomotion
1.41 5.66e-04 GO:0042325 regulation of phosphorylation
1.57 5.75e-04 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.39 5.87e-04 GO:0006468 protein phosphorylation
1.53 6.91e-04 GO:0009968 negative regulation of signal transduction
1.43 7.79e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.21 7.90e-04 GO:0051252 regulation of RNA metabolic process
1.41 8.27e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.59 1.02e-03 GO:0051093 negative regulation of developmental process
2.28 1.05e-03 GO:0010721 negative regulation of cell development
1.35 1.20e-03 GO:0006351 transcription, DNA-dependent
1.33 1.28e-03 GO:0009892 negative regulation of metabolic process
1.50 1.32e-03 GO:0051094 positive regulation of developmental process
1.18 1.46e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.40 1.50e-03 GO:0010628 positive regulation of gene expression
1.40 1.80e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.34 1.83e-03 GO:0031324 negative regulation of cellular metabolic process
2.40 2.01e-03 GO:0050768 negative regulation of neurogenesis
1.75 2.19e-03 GO:0032582 negative regulation of gene-specific transcription
1.73 2.23e-03 GO:0045664 regulation of neuron differentiation
1.33 2.24e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.69 2.27e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.18 2.48e-03 GO:0071842 cellular component organization at cellular level
1.31 2.52e-03 GO:0007154 cell communication
1.34 2.52e-03 GO:0009888 tissue development
1.55 3.15e-03 GO:0044057 regulation of system process
1.17 3.22e-03 GO:0006810 transport
1.45 3.25e-03 GO:0048585 negative regulation of response to stimulus
1.58 3.56e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.52 3.94e-03 GO:0048598 embryonic morphogenesis
1.77 4.08e-03 GO:0030900 forebrain development
1.53 4.24e-03 GO:0007420 brain development
1.18 4.35e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.90 4.76e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.83 4.89e-03 GO:0045165 cell fate commitment
1.18 4.91e-03 GO:0010468 regulation of gene expression
1.65 5.20e-03 GO:0003002 regionalization
2.14 5.46e-03 GO:0050769 positive regulation of neurogenesis
1.30 5.51e-03 GO:0006793 phosphorus metabolic process
1.30 5.51e-03 GO:0006796 phosphate metabolic process
1.20 6.03e-03 GO:0006355 regulation of transcription, DNA-dependent
1.88 6.35e-03 GO:0022604 regulation of cell morphogenesis
1.69 6.84e-03 GO:0001701 in utero embryonic development
1.33 7.22e-03 GO:0016310 phosphorylation
1.16 7.47e-03 GO:0051234 establishment of localization
1.63 7.77e-03 GO:0001558 regulation of cell growth
1.39 7.79e-03 GO:0009725 response to hormone stimulus
1.26 7.95e-03 GO:0010033 response to organic substance
1.30 8.45e-03 GO:0032879 regulation of localization
1.65 8.97e-03 GO:0002009 morphogenesis of an epithelium
1.57 1.03e-02 GO:0051270 regulation of cellular component movement
1.43 1.14e-02 GO:0019226 transmission of nerve impulse
1.43 1.14e-02 GO:0035637 multicellular organismal signaling
2.09 1.15e-02 GO:0008016 regulation of heart contraction
1.83 1.21e-02 GO:0016055 Wnt receptor signaling pathway
1.29 1.60e-02 GO:0009605 response to external stimulus
1.33 1.67e-02 GO:0031399 regulation of protein modification process
1.25 1.81e-02 GO:0035556 intracellular signal transduction
1.19 1.82e-02 GO:0065008 regulation of biological quality
1.36 1.86e-02 GO:0051254 positive regulation of RNA metabolic process
1.21 2.11e-02 GO:0006464 protein modification process
1.26 2.28e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.57 2.97e-02 GO:0030334 regulation of cell migration
1.09 3.24e-02 GO:0044237 cellular metabolic process
1.80 3.53e-02 GO:0030111 regulation of Wnt receptor signaling pathway
1.73 3.55e-02 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.51 3.57e-02 GO:0001501 skeletal system development
1.36 3.89e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.49 4.00e-02 GO:0071495 cellular response to endogenous stimulus
1.39 4.26e-02 GO:0008284 positive regulation of cell proliferation
1.44 4.48e-02 GO:0040008 regulation of growth
1.17 4.49e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.43 4.57e-02 GO:0008285 negative regulation of cell proliferation
1.53 4.60e-02 GO:0007423 sensory organ development
1.52 4.68e-02 GO:0048729 tissue morphogenesis
1.32 4.71e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.07 5.43e-09 GO:0005622 intracellular
1.07 2.36e-08 GO:0044424 intracellular part
1.09 8.33e-06 GO:0005737 cytoplasm
1.08 1.36e-05 GO:0043226 organelle
1.08 1.90e-05 GO:0043229 intracellular organelle
1.03 5.66e-05 GO:0044464 cell part
1.03 6.01e-05 GO:0005623 cell
1.53 6.05e-05 GO:0045202 synapse
1.08 8.73e-05 GO:0043227 membrane-bounded organelle
1.08 1.08e-04 GO:0043231 intracellular membrane-bounded organelle
1.11 9.17e-04 GO:0044422 organelle part
1.10 1.74e-03 GO:0044446 intracellular organelle part
1.20 3.41e-03 GO:0031981 nuclear lumen
1.66 6.83e-03 GO:0044297 cell body
1.50 8.35e-03 GO:0044456 synapse part
1.17 8.47e-03 GO:0044459 plasma membrane part
1.65 1.06e-02 GO:0043025 neuronal cell body
1.44 1.07e-02 GO:0031012 extracellular matrix
1.17 1.59e-02 GO:0044428 nuclear part
1.09 1.87e-02 GO:0005634 nucleus
1.68 1.90e-02 GO:0005912 adherens junction
2.32 1.91e-02 GO:0017053 transcriptional repressor complex
1.09 1.97e-02 GO:0044444 cytoplasmic part
1.46 2.24e-02 GO:0005578 proteinaceous extracellular matrix
1.63 2.73e-02 GO:0070161 anchoring junction
1.21 2.77e-02 GO:0005654 nucleoplasm
1.40 2.82e-02 GO:0043005 neuron projection
1.83 2.87e-02 GO:0005925 focal adhesion
1.32 3.60e-02 GO:0030054 cell junction
1.15 4.52e-02 GO:0070013 intracellular organelle lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 2.20e-12 GO:0005515 protein binding
1.45 1.60e-09 GO:0001071 nucleic acid binding transcription factor activity
1.45 1.60e-09 GO:0003700 sequence-specific DNA binding transcription factor activity
1.52 2.20e-08 GO:0043565 sequence-specific DNA binding
1.07 3.55e-07 GO:0005488 binding
1.37 2.31e-06 GO:0030528 transcription regulator activity
1.39 2.74e-05 GO:0016301 kinase activity
1.41 3.88e-05 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.43 1.16e-04 GO:0004672 protein kinase activity
1.59 2.69e-04 GO:0016564 transcription repressor activity
1.33 3.45e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.71 1.45e-03 GO:0005244 voltage-gated ion channel activity
1.71 1.45e-03 GO:0022832 voltage-gated channel activity
1.67 1.79e-03 GO:0000975 regulatory region DNA binding
1.67 1.79e-03 GO:0001067 regulatory region nucleic acid binding
1.67 1.79e-03 GO:0044212 transcription regulatory region DNA binding
1.67 3.10e-03 GO:0010843 promoter binding
1.52 4.09e-03 GO:0022836 gated channel activity
1.54 7.72e-03 GO:0005261 cation channel activity
1.73 1.63e-02 GO:0022843 voltage-gated cation channel activity
1.40 2.22e-02 GO:0004674 protein serine/threonine kinase activity
1.91 2.78e-02 GO:0003704 specific RNA polymerase II transcription factor activity
1.47 2.89e-02 GO:0016563 transcription activator activity
1.41 2.91e-02 GO:0022838 substrate-specific channel activity
1.41 3.03e-02 GO:0015267 channel activity
1.40 3.43e-02 GO:0022803 passive transmembrane transporter activity
1.19 4.04e-02 GO:0016740 transferase activity