Motif ID: NANOG.p2

Z-value: 1.351


Transcription factors associated with NANOG.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NANOGchr12_+_7833261-0.361.7e-01Click!


Activity profile for motif NANOG.p2.

activity profile for motif NANOG.p2


Sorted Z-values histogram for motif NANOG.p2

Sorted Z-values for motif NANOG.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_169713458 2.367 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr7_-_13992351 2.340 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr6_+_34314545 2.238 NM_145905
HMGA1
high mobility group AT-hook 1
chr1_+_154449389 2.068 NM_007221
PMF1-BGLAP
PMF1
PMF1-BGLAP read-through transcript
polyamine-modulated factor 1
chr3_-_12916547 1.989 IQSEC1
IQ motif and Sec7 domain 1
chr11_-_2149591 1.827 NM_000360
NM_199292
NM_199293
TH


tyrosine hydroxylase


chr1_+_180836050 1.612


chr12_-_51114372 1.612 NM_004693
KRT75
keratin 75
chr19_-_46504831 1.511


chr3_+_130730171 1.480 NM_000539
RHO
rhodopsin
chr7_-_25234582 1.470 NM_022150
NPVF
neuropeptide VF precursor
chr6_+_44076281 1.464 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr1_+_100776280 1.441 NM_022049
GPR88
G protein-coupled receptor 88
chr12_-_55614311 1.384 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr7_-_96471544 1.343 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr9_+_117955890 1.337 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr7_+_116238309 1.321 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr9_-_132759045 1.306 NM_198180
QRFP
pyroglutamylated RFamide peptide
chr12_-_120725210 1.293 LOC338799
hypothetical LOC338799
chr18_+_18989786 1.264 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr21_+_43024936 1.255 PDE9A
phosphodiesterase 9A
chr2_+_128119908 1.231 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr7_+_2524022 1.217 NM_002304
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr1_-_30977931 1.139 LAPTM5
lysosomal protein transmembrane 5
chr17_-_9635325 1.136 NM_001105571
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr13_+_97856148 1.126


chr13_+_108079570 1.103 NM_001198950
MYO16
myosin XVI
chr3_-_11598829 1.100 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr3_+_16191159 1.043 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr11_+_7574992 1.034 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr6_+_167624792 1.028 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr5_-_148738980 1.027 NM_014443
IL17B
interleukin 17B
chr7_+_150376537 1.004 NM_004769
NM_020321
NM_020322
ACCN3


amiloride-sensitive cation channel 3


chr7_+_129771865 0.998 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr14_-_80934523 0.994 NM_033104
STON2
stonin 2
chr1_+_20489998 0.984 NM_001039500
VWA5B1
von Willebrand factor A domain containing 5B1
chr1_+_207944807 0.968 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr22_+_38652555 0.933 GRAP2
GRB2-related adaptor protein 2
chr4_-_26100986 0.903 NM_000730
CCKAR
cholecystokinin A receptor
chr5_+_176744037 0.886 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr10_-_32707549 0.867 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr19_-_38052481 0.859 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chrX_-_19727828 0.858 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr1_-_20682541 0.857


chr19_+_53016910 0.853 NM_000554
CRX
cone-rod homeobox
chr17_-_40401138 0.836 NM_006688
C1QL1
complement component 1, q subcomponent-like 1
chr2_+_161980865 0.835 NM_006593
TBR1
T-box, brain, 1
chr4_+_3341521 0.833 NM_198227
RGS12
regulator of G-protein signaling 12
chr14_-_94306104 0.826 NM_173849
GSC
goosecoid homeobox
chr12_-_14024187 0.825 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr17_-_19290745 0.823


chr12_-_89922888 0.815 NM_004950
EPYC
epiphycan
chr1_+_559618 0.808


chr1_+_196874839 0.792 PTPRC
protein tyrosine phosphatase, receptor type, C
chrX_+_28515479 0.791 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr7_-_36992221 0.785 NM_130442
ELMO1
engulfment and cell motility 1
chr7_-_5429702 0.772 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr19_+_59333287 0.769 CNOT3
CCR4-NOT transcription complex, subunit 3
chr15_-_91078307 0.768 FAM174B
family with sequence similarity 174, member B
chr1_+_158426908 0.761 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr17_-_37590910 0.759 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr17_-_78391178 0.746 NM_024702
ZNF750
zinc finger protein 750
chr12_-_52016270 0.730 NM_001173467
SP7
Sp7 transcription factor
chr8_+_55691179 0.729 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chrX_-_137649180 0.724 NM_033642
FGF13
fibroblast growth factor 13
chr1_-_158098962 0.722 NM_001013661
VSIG8
V-set and immunoglobulin domain containing 8
chr11_-_69343128 0.714 NM_005247
FGF3
fibroblast growth factor 3
chrX_-_19727775 0.702 SH3KBP1
SH3-domain kinase binding protein 1
chr7_+_120752656 0.698 NM_016087
WNT16
wingless-type MMTV integration site family, member 16
chr14_-_104330982 0.685 NM_005163
AKT1
v-akt murine thymoma viral oncogene homolog 1
chr10_-_48036698 0.683 NM_016204
GDF2
growth differentiation factor 2
chr7_+_141054621 0.682 NM_001105558
WEE2
WEE1 homolog 2 (S. pombe)
chr19_+_40632456 0.678 NM_005306
FFAR2
free fatty acid receptor 2
chr1_-_109957195 0.675 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr10_+_11246934 0.673 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr1_+_109884016 0.670 NM_031936
GPR61
G protein-coupled receptor 61
chr12_-_6103945 0.667 NM_000552
VWF
von Willebrand factor
chr5_+_137701122 0.665 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr2_+_95326753 0.652 NM_013434
KCNIP3
Kv channel interacting protein 3, calsenilin
chr2_-_144994038 0.647 ZEB2
zinc finger E-box binding homeobox 2
chr17_-_39094787 0.645 NM_001040002
MEOX1
mesenchyme homeobox 1
chr8_-_10550026 0.644 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr12_+_50981915 0.641 NM_002284
KRT86
keratin 86
chr7_-_41709191 0.639 NM_002192
INHBA
inhibin, beta A
chr10_-_101680645 0.634 DNMBP
dynamin binding protein
chr16_-_29817841 0.622 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr13_+_100902942 0.619 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr14_+_104117100 0.616 NM_001008404
C14orf180
chromosome 14 open reading frame 180
chr1_+_168898898 0.614 PRRX1
paired related homeobox 1
chr2_+_121271336 0.612 NM_005270
GLI2
GLI family zinc finger 2
chr20_+_43691797 0.610 NM_080753
WFDC10A
WAP four-disulfide core domain 10A
chr12_-_51065629 0.603 NM_033045
KRT84
keratin 84
chr8_-_134156353 0.601 SLA
Src-like-adaptor
chr12_+_25096755 0.600 LRMP
lymphoid-restricted membrane protein
chr1_+_50342168 0.599 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_-_108736983 0.599 NM_001177431
NM_001177428
NM_001177433
NM_147204
TRPV4



transient receptor potential cation channel, subfamily V, member 4



chr3_+_150675117 0.599 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr17_+_56843893 0.598 NM_203425
C17orf82
chromosome 17 open reading frame 82
chr1_+_196874759 0.596 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr4_-_186815116 0.593 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr22_+_38903825 0.592 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr8_-_142333339 0.590 SLC45A4
solute carrier family 45, member 4
chr19_-_43926953 0.581 NM_144691
CAPN12
calpain 12
chr9_+_674193 0.579


chr12_-_51233001 0.569 NM_033448
KRT71
keratin 71
chr2_-_40510923 0.566 NM_001112800
NM_001112801
NM_021097
SLC8A1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr4_+_71418886 0.564 NM_212557
AMTN
amelotin
chr6_+_32713160 0.558 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr12_+_48443232 0.556 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr12_-_89922875 0.555 EPYC
epiphycan
chr7_+_129693938 0.555 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr6_+_34312979 0.555 HMGA1
high mobility group AT-hook 1
chr19_+_7874701 0.553 MAP2K7
mitogen-activated protein kinase kinase 7
chr6_+_34312906 0.547 HMGA1
high mobility group AT-hook 1
chr2_+_157822355 0.546 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr6_-_154719560 0.546 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr10_+_44726635 0.541 NM_001123376
TMEM72
transmembrane protein 72
chr2_+_161981138 0.541 TBR1
T-box, brain, 1
chr10_-_21475493 0.539 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr15_+_56511466 0.537 NM_000236
LIPC
lipase, hepatic
chr5_+_176786279 0.533 NM_001004105
NM_001004106
NM_002082
GRK6


G protein-coupled receptor kinase 6


chr11_+_63775567 0.533 NM_000932
NM_001184883
PLCB3

phospholipase C, beta 3 (phosphatidylinositol-specific)

chr1_-_50661716 0.530 NM_032110
DMRTA2
DMRT-like family A2
chr7_+_18501876 0.529 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr4_+_71806538 0.524 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr12_-_51200347 0.522 NM_000424
KRT5
keratin 5
chr3_+_63859114 0.520 NM_001177387
ATXN7
ataxin 7
chr5_+_155686333 0.520 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr19_+_50663089 0.518 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr6_-_136888771 0.512 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr6_+_155579788 0.505 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr5_+_170668892 0.499 NM_021025
TLX3
T-cell leukemia homeobox 3
chr9_+_135491305 0.493 NM_000787
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr12_+_111714096 0.492 RPH3A
rabphilin 3A homolog (mouse)
chrX_-_48713194 0.492 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr5_+_140703784 0.488 NM_018916
NM_032011
PCDHGA3

protocadherin gamma subfamily A, 3

chr5_+_140509803 0.484 NM_018939
PCDHB6
protocadherin beta 6
chr2_+_161981046 0.481 TBR1
T-box, brain, 1
chr5_+_128468785 0.479 ISOC1
isochorismatase domain containing 1
chr3_-_57209319 0.479 NM_003865
HESX1
HESX homeobox 1
chr17_-_10393664 0.476 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr13_-_93929719 0.475 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr7_+_116447527 0.472 ST7
suppression of tumorigenicity 7
chrX_+_21960841 0.471 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr11_+_123986661 0.471 NM_052959
PANX3
pannexin 3
chr11_-_85107569 0.463 NM_206929
SYTL2
synaptotagmin-like 2
chr3_-_55489973 0.463 WNT5A
wingless-type MMTV integration site family, member 5A
chr8_-_134156437 0.458 SLA
Src-like-adaptor
chr2_+_169465995 0.454 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr14_-_56342097 0.453 NM_172337
OTX2
orthodenticle homeobox 2
chr11_-_16380967 0.445 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr3_+_69895310 0.442 NM_001184967
MITF
microphthalmia-associated transcription factor
chrX_-_131089552 0.440 NM_194277
FRMD7
FERM domain containing 7
chr7_-_99555399 0.439 NM_001190415
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr2_-_158439868 0.439 NM_001105
ACVR1
activin A receptor, type I
chr3_+_69895651 0.436 NM_006722
MITF
microphthalmia-associated transcription factor
chr8_+_26569709 0.434 DPYSL2
dihydropyrimidinase-like 2
chr19_+_59333232 0.428 NM_014516
CNOT3
CCR4-NOT transcription complex, subunit 3
chrX_+_70682204 0.427 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr9_+_137553104 0.427 NM_002297
LCN1
lipocalin 1 (tear prealbumin)
chrX_+_71280758 0.426 NM_207422
FLJ44635
TPT1-like protein
chr21_+_42583259 0.425 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr3_-_139315011 0.423 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr3_-_113842553 0.423 CCDC80
coiled-coil domain containing 80
chrX_+_102918409 0.422 NM_000533
NM_199478
PLP1

proteolipid protein 1

chr15_-_53349775 0.422 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr6_+_50894397 0.421 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr20_+_36365965 0.421 NM_001725
BPI
bactericidal/permeability-increasing protein
chr15_-_70838703 0.416


chrX_+_102918453 0.414 PLP1
proteolipid protein 1
chr11_-_83071084 0.414 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr10_+_94584449 0.413 NM_001013848
EXOC6
exocyst complex component 6
chr9_+_115303527 0.410 NM_130795
RGS3
regulator of G-protein signaling 3
chr1_+_242283129 0.409 NM_006352
ZNF238
zinc finger protein 238
chr11_-_30558495 0.409 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chr19_+_3713650 0.406 NM_172251
MRPL54
mitochondrial ribosomal protein L54
chr11_+_4427100 0.397 NM_001005172
OR52K2
olfactory receptor, family 52, subfamily K, member 2
chr13_+_26896614 0.397 NM_002097
GTF3A
general transcription factor IIIA
chr1_+_559129 0.395


chr12_-_14740694 0.393 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr17_-_76720342 0.393 AATK
apoptosis-associated tyrosine kinase
chr1_-_203579932 0.390 KLHDC8A
kelch domain containing 8A
chr12_+_103677388 0.389 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr22_-_16127520 0.387 CECR3
cat eye syndrome chromosome region, candidate 3
chr2_-_180135559 0.385 NM_001113398
ZNF385B
zinc finger protein 385B
chr7_+_150321771 0.385 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr8_+_67201684 0.385 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chrX_+_135397790 0.383 NM_001727
BRS3
bombesin-like receptor 3
chr3_-_11585264 0.382 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr11_+_130745580 0.382 NM_001048209
NTM
neurotrimin
chr12_-_51457371 0.381 NM_015848
KRT76
keratin 76
chr6_-_116973465 0.381 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr7_+_113842284 0.377 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr5_+_60969392 0.377 NM_173667
FLJ37543
hypothetical protein FLJ37543
chr8_-_42353719 0.376 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr22_-_37211467 0.376 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr19_+_59973074 0.375 NM_014218
KIR2DS2
KIR2DL1
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
chr14_+_77939845 0.374 NM_004796
NRXN3
neurexin 3
chr3_+_157877146 0.374 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr1_+_151456683 0.374 NM_001195571
PRR9
proline rich 9

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.48 8.09e-11 GO:0032501 multicellular organismal process
1.56 3.83e-09 GO:0032502 developmental process
1.58 1.01e-08 GO:0007275 multicellular organismal development
1.61 1.50e-08 GO:0048856 anatomical structure development
1.63 9.54e-08 GO:0048731 system development
1.80 2.07e-07 GO:0048513 organ development
2.37 2.31e-05 GO:0009887 organ morphogenesis
2.17 2.09e-04 GO:0045595 regulation of cell differentiation
1.67 2.29e-03 GO:0009653 anatomical structure morphogenesis
1.91 3.02e-03 GO:0009888 tissue development
1.87 4.22e-03 GO:0050793 regulation of developmental process
1.22 6.72e-03 GO:0050789 regulation of biological process
2.52 7.48e-03 GO:0051093 negative regulation of developmental process
3.21 1.53e-02 GO:0048562 embryonic organ morphogenesis
1.22 1.59e-02 GO:0050794 regulation of cellular process
1.46 1.78e-02 GO:0048519 negative regulation of biological process
1.49 1.91e-02 GO:0048523 negative regulation of cellular process
2.28 2.04e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.59 2.83e-02 GO:0007399 nervous system development
2.87 2.96e-02 GO:0007517 muscle organ development
2.40 3.90e-02 GO:0060284 regulation of cell development
1.19 4.72e-02 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.62 1.19e-05 GO:0005576 extracellular region
1.39 1.45e-05 GO:0071944 cell periphery
1.39 1.85e-05 GO:0005886 plasma membrane
2.44 3.73e-04 GO:0031012 extracellular matrix
2.48 1.61e-03 GO:0005578 proteinaceous extracellular matrix
1.48 2.07e-03 GO:0044459 plasma membrane part
1.73 2.86e-03 GO:0044421 extracellular region part
2.11 1.49e-02 GO:0044463 cell projection part
3.77 2.30e-02 GO:0045095 keratin filament
12.58 4.82e-02 GO:0005614 interstitial matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.72 7.11e-03 GO:0001071 nucleic acid binding transcription factor activity
1.72 7.11e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.86 1.23e-02 GO:0043565 sequence-specific DNA binding