Motif ID: NFE2.p2

Z-value: 1.033


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2chr12_-_529758230.514.3e-02Click!


Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_21495273 4.794


chr22_+_21370394 4.550 IGL@
immunoglobulin lambda locus
chr22_+_21053972 2.889


chr22_+_21079355 2.067


chr17_-_37022465 1.835 NM_005557
KRT16
keratin 16
chr7_+_72883128 1.834 NM_001305
CLDN4
claudin 4
chr22_+_20715340 1.773


chr22_+_21340757 1.736


chr22_+_19699441 1.716 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr22_+_21042091 1.678 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr7_+_1543644 1.670 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr22_+_21464980 1.598


chr22_+_20899155 1.570


chr22_+_21393107 1.544 IGLJ3
immunoglobulin lambda joining 3
chr22_+_21359175 1.530 IGLV3-25
immunoglobulin lambda variable 3-25
chr22_+_18388656 1.526 C22orf25
chromosome 22 open reading frame 25
chr22_+_21552897 1.406 LOC100290481
immunoglobulin lambda light chain-like
chr11_+_118463906 1.362 NM_001024382
HMBS
hydroxymethylbilane synthase
chr7_-_5533621 1.310 ACTB
actin, beta
chr11_+_1812115 1.279 NM_138567
SYT8
synaptotagmin VIII
chr7_-_150561233 1.270


chr1_+_226399026 1.238 NM_001159391
GUK1
guanylate kinase 1
chr22_+_21006814 1.238


chr22_+_21011653 1.221


chr1_-_6474346 1.175 NM_020631
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr5_+_176807931 1.173 NM_001174102
PRR7
proline rich 7 (synaptic)
chr22_+_21116283 1.165


chr10_+_134751398 1.133 NM_001083909
GPR123
G protein-coupled receptor 123
chr3_-_195571748 1.070 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chr15_+_38849450 0.998 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr16_+_2023279 0.987 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr10_+_70745615 0.973 NM_033496
HK1
hexokinase 1
chr7_-_33047042 0.972 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr19_-_40673185 0.970 NM_207392
KRTDAP
keratinocyte differentiation-associated protein
chr8_+_22266256 0.941 PIWIL2
piwi-like 2 (Drosophila)
chr22_+_20929199 0.935 NM_007128
VPREB1
pre-B lymphocyte 1
chr1_+_27591738 0.924 NM_005281
GPR3
G protein-coupled receptor 3
chr22_+_21065134 0.908 LOC100290481
immunoglobulin lambda light chain-like
chr7_+_1536847 0.892 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr19_+_40895669 0.892 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr22_+_21065202 0.864


chr9_+_139255559 0.855 TUBB2C
tubulin, beta 2C
chr8_+_22900863 0.852 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr1_+_109827975 0.848 NM_153340
ATXN7L2
ataxin 7-like 2
chr6_-_41781655 0.824 TFEB
transcription factor EB
chr8_-_145088679 0.823 NM_201383
PLEC
plectin
chr15_+_78520634 0.818 ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr6_+_31190505 0.806 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr9_+_139255519 0.805 NM_006088
TUBB2C
tubulin, beta 2C
chr1_-_115682374 0.794 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr9_+_139255563 0.787 TUBB2C
tubulin, beta 2C
chr5_+_150000394 0.780 NM_001109974
NM_007286
SYNPO

synaptopodin

chr6_-_31853027 0.777 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr17_+_25292748 0.772 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr7_+_99865189 0.764 NM_019606
MEPCE
methylphosphate capping enzyme
chr8_-_143848225 0.746 NM_177458
LYNX1
Ly6/neurotoxin 1
chr1_-_43168247 0.746 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr17_-_975809 0.744 ABR
active BCR-related gene
chr17_+_45965076 0.732 EPN3
epsin 3
chr11_+_67107641 0.725 NM_000852
GSTP1
glutathione S-transferase pi 1
chr22_+_21065207 0.724 IGLJ3
immunoglobulin lambda joining 3
chr16_+_87765661 0.721 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr1_-_153209625 0.721 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr11_-_117305277 0.719 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr22_+_20880159 0.714 IGLV6-57
immunoglobulin lambda variable 6-57
chr1_-_109651140 0.700 NM_001010985
MYBPHL
myosin binding protein H-like
chr11_+_67107852 0.691 GSTP1
glutathione S-transferase pi 1
chr17_+_71109734 0.691 MYO15B
myosin XVB pseudogene
chr7_+_101978777 0.687 NM_001166339
NM_001031618
SPDYE2L
SPDYE2
WBSCR19-like protein 3
speedy homolog E2 (Xenopus laevis)
chr3_+_154035425 0.684 NM_002563
P2RY1
purinergic receptor P2Y, G-protein coupled, 1
chr22_-_17846711 0.673 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr21_+_45699830 0.672 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chr6_+_34314545 0.671 NM_145905
HMGA1
high mobility group AT-hook 1
chr19_+_3317589 0.669 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr6_+_41712907 0.663 MDFI
MyoD family inhibitor
chr17_-_36928604 0.661 NM_002275
KRT15
keratin 15
chr9_-_101621964 0.660


chr2_+_87536106 0.659 NCRNA00152
non-protein coding RNA 152
chr19_+_3317536 0.649 NM_005597
NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr19_-_1989937 0.648 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr19_+_56337368 0.643 NM_014385
NM_016543
SIGLEC7

sialic acid binding Ig-like lectin 7

chr8_-_145097031 0.641 NM_201380
PLEC
plectin
chr1_+_31855873 0.639 NM_001525
HCRTR1
hypocretin (orexin) receptor 1
chr1_+_201363458 0.637 NM_000674
NM_001048230
ADORA1

adenosine A1 receptor

chr8_-_143820825 0.631 NM_020427
SLURP1
secreted LY6/PLAUR domain containing 1
chr22_+_21484240 0.628


chr1_+_148747110 0.624 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chr22_-_17846621 0.620 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr6_-_149847718 0.617 ZC3H12D
zinc finger CCCH-type containing 12D
chr4_-_38710376 0.612 NM_024943
TMEM156
transmembrane protein 156
chr7_-_5534252 0.609 ACTB
actin, beta
chr2_+_87536174 0.609 NCRNA00152
non-protein coding RNA 152
chr16_-_2848106 0.608 NM_022119
PRSS22
protease, serine, 22
chr2_+_119905812 0.602 NM_183240
TMEM37
transmembrane protein 37
chr11_+_56984702 0.597 NM_178570
RTN4RL2
reticulon 4 receptor-like 2
chr7_+_99864349 0.594 MEPCE
methylphosphate capping enzyme
chr7_+_99864348 0.587 NM_001194990
NM_001194991
NM_001194992
MEPCE


methylphosphate capping enzyme


chr19_+_45564549 0.585 PLD3
phospholipase D family, member 3
chr22_+_20316968 0.581 NM_152612
CCDC116
coiled-coil domain containing 116
chr1_+_12046020 0.580 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr1_+_158426908 0.579 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr9_-_130006309 0.578 NM_001131015
NM_012127
CIZ1

CDKN1A interacting zinc finger protein 1

chr7_+_150065594 0.570 GIMAP5
GTPase, IMAP family member 5
chr7_+_111850367 0.563 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr1_-_45045543 0.563 NM_001013632
TCTEX1D4
Tctex1 domain containing 4
chr19_+_3317575 0.563 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr7_+_139175420 0.560 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr1_-_232810443 0.558


chrX_-_19598912 0.557 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr1_-_24311212 0.556 NM_152372
MYOM3
myomesin family, member 3
chr3_-_48607596 0.555 NM_000094
COL7A1
collagen, type VII, alpha 1
chr19_+_56319948 0.551 NM_001198558
NM_014441
SIGLEC9

sialic acid binding Ig-like lectin 9

chr10_-_30064600 0.541 NM_003174
SVIL
supervillin
chr8_-_145085616 0.540 NM_201384
PLEC
plectin
chr21_+_39951123 0.536 NM_006057
NM_033170
NM_033171
NM_033172
NM_033173
B3GALT5




UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5




chr1_+_17404206 0.534 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr10_-_46601687 0.531 NM_001137556
NM_001137549
NM_001137548
FAM25B
FAM25G
FAM25C
family with sequence similarity 25, member B
family with sequence similarity 25, member G
family with sequence similarity 25, member C
chr22_-_17846725 0.530 NM_001035247
NM_005659
UFD1L

ubiquitin fusion degradation 1 like (yeast)

chr7_+_142205266 0.529


chr3_-_152403636 0.527 NM_013308
GPR171
G protein-coupled receptor 171
chr6_-_149847809 0.525 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chrX_-_19727828 0.521 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr21_+_42364494 0.519 NM_001004416
NM_173568
UMODL1

uromodulin-like 1

chr1_-_232810478 0.517


chr11_-_71458739 0.512 NUMA1
nuclear mitotic apparatus protein 1
chr19_+_12810258 0.510 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr11_+_10433241 0.509 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr10_-_48877824 0.505 NM_001137556
NM_001137549
NM_001137548
FAM25B
FAM25G
FAM25C
family with sequence similarity 25, member B
family with sequence similarity 25, member G
family with sequence similarity 25, member C
chr1_-_45760115 0.503 NM_002574
NM_181696
NM_181697
PRDX1


peroxiredoxin 1


chr4_-_26100986 0.500 NM_000730
CCKAR
cholecystokinin A receptor
chr9_+_131291224 0.494 LOC100506190
hypothetical LOC100506190
chr9_+_131291144 0.492


chr6_-_30793436 0.491 NM_014641
MDC1
mediator of DNA-damage checkpoint 1
chr4_-_159312973 0.488 FAM198B
family with sequence similarity 198, member B
chr12_+_54808220 0.488 NM_001184796
NM_015292
ESYT1

extended synaptotagmin-like protein 1

chr22_+_21094094 0.486


chr19_+_59107802 0.483 NM_031896
CACNG7
calcium channel, voltage-dependent, gamma subunit 7
chr12_+_54808310 0.482 ESYT1
extended synaptotagmin-like protein 1
chr16_-_3025542 0.480 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr1_+_32485404 0.478 NM_032648
FAM167B
family with sequence similarity 167, member B
chr1_-_7923464 0.475 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr16_+_30293598 0.475 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chrX_+_109548940 0.473 NM_020769
RGAG1
retrotransposon gag domain containing 1
chr6_+_44302973 0.473 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr16_+_30903963 0.469 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chrX_-_19727775 0.467 SH3KBP1
SH3-domain kinase binding protein 1
chr1_-_232810111 0.467 IRF2BP2
interferon regulatory factor 2 binding protein 2
chr6_+_44322831 0.465 HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr12_+_54808469 0.462 ESYT1
extended synaptotagmin-like protein 1
chr8_+_144428083 0.462 GLI4
GLI family zinc finger 4
chr22_-_17892859 0.462 NM_001130861
NM_003277
CLDN5

claudin 5

chr3_+_130730171 0.461 NM_000539
RHO
rhodopsin
chr14_-_104507862 0.460 AHNAK2
AHNAK nucleoprotein 2
chr1_-_169888373 0.459 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr1_+_148747208 0.459 ECM1
extracellular matrix protein 1
chr12_+_54808344 0.458 ESYT1
extended synaptotagmin-like protein 1
chr8_-_30704984 0.458 NM_000637
NM_001195102
NM_001195103
NM_001195104
GSR



glutathione reductase



chr19_-_55914837 0.458


chr22_+_20880112 0.458


chr1_+_89763030 0.453 LRRC8B
leucine rich repeat containing 8 family, member B
chr12_+_54808316 0.453 ESYT1
extended synaptotagmin-like protein 1
chr1_+_24522116 0.451 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr22_+_21027538 0.450


chr7_+_150319076 0.449 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr12_-_54646061 0.448 NM_006928
PMEL
premelanosome protein
chr4_+_170817787 0.447 CLCN3
chloride channel 3
chr16_+_56219802 0.443 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr16_+_29984647 0.441 ALDOA
aldolase A, fructose-bisphosphate
chr2_-_113752957 0.436 NM_003466
NM_013952
NM_013953
NM_013992
PAX8



paired box 8



chr22_-_43040063 0.436 NM_001099294
KIAA1644
KIAA1644
chrX_+_9391314 0.434 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr19_-_53935648 0.432 NM_017805
RASIP1
Ras interacting protein 1
chrX_-_48654178 0.432 NM_001042498
SLC35A2
solute carrier family 35 (UDP-galactose transporter), member A2
chr4_-_8180278 0.431 ABLIM2
actin binding LIM protein family, member 2
chr16_+_88515917 0.429 NM_001197181
TUBB3
tubulin, beta 3
chr6_+_1556543 0.427 FOXC1
forkhead box C1
chr1_-_20014180 0.426 NM_019062
RNF186
ring finger protein 186
chr6_+_44322764 0.425 NM_007355
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr11_+_62405801 0.424 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr22_-_28972683 0.421 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr16_-_27806978 0.417 NM_144675
GSG1L
GSG1-like
chr20_+_44070946 0.415 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr1_-_117554999 0.412 NM_024626
VTCN1
V-set domain containing T cell activation inhibitor 1
chr16_+_1246273 0.411 NM_012217
TPSD1
tryptase delta 1
chr7_+_150065376 0.410 NM_018384
GIMAP5
GTPase, IMAP family member 5
chr16_+_57091546 0.410 NDRG4
NDRG family member 4
chr9_-_139042526 0.405 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr7_-_36396220 0.401 NM_001100425
KIAA0895
KIAA0895
chr1_-_240228987 0.401 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr1_+_110683586 0.400 RBM15
RNA binding motif protein 15
chr21_-_36774257 0.399 NM_001146079
NM_144492
CLDN14

claudin 14

chr1_-_150092702 0.399 NM_182578
THEM5
thioesterase superfamily member 5
chr7_+_157339985 0.399 LOC100506585
hypothetical LOC100506585
chr9_+_139292094 0.398 NM_017723
C9orf167
chromosome 9 open reading frame 167
chrX_-_100527799 0.396 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr3_-_152517204 0.394 NM_023915
GPR87
G protein-coupled receptor 87
chr8_-_103735194 0.389 NM_001032282
KLF10
Kruppel-like factor 10
chr11_+_62136788 0.382 NM_000327
ROM1
retinal outer segment membrane protein 1
chr9_-_116920232 0.380 NM_002160
TNC
tenascin C
chr13_+_51334117 0.379 NM_031290
CCDC70
coiled-coil domain containing 70

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.61 8.77e-03 GO:0002376 immune system process
1.28 2.34e-02 GO:0051716 cellular response to stimulus
1.21 3.00e-02 GO:0050896 response to stimulus
1.31 4.02e-02 GO:0007165 signal transduction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.44 3.75e-04 GO:0044420 extracellular matrix part
1.42 1.83e-03 GO:0044459 plasma membrane part
2.17 6.31e-03 GO:0005578 proteinaceous extracellular matrix
1.59 7.77e-03 GO:0044421 extracellular region part
1.94 3.81e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.03 4.99e-02 GO:0003779 actin binding