Motif ID: NFE2L2.p2

Z-value: 1.378


Transcription factors associated with NFE2L2.p2:

Gene SymbolEntrez IDGene Name
NFE2L2 4780 nuclear factor (erythroid-derived 2)-like 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2L2chr2_-_1778367730.581.9e-02Click!


Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_21484240 8.890


chr22_+_21340757 7.620


chr22_+_21359175 4.638 IGLV3-25
immunoglobulin lambda variable 3-25
chr22_+_21370394 4.509 IGL@
immunoglobulin lambda locus
chr22_+_21495273 3.803


chr22_+_21079355 3.350


chr22_+_21053972 3.345


chr22_+_21407066 3.246


chr22_+_21393107 3.134 IGLJ3
immunoglobulin lambda joining 3
chr22_+_20899155 3.037


chr1_-_24307514 2.755 MYOM3
myomesin family, member 3
chr9_+_129962292 2.568 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr22_+_21094094 2.392


chr22_+_21116283 2.260


chr22_+_18388656 2.253 C22orf25
chromosome 22 open reading frame 25
chr22_+_21042091 2.252 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr22_+_21559959 2.047 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr22_+_20316968 2.042 NM_152612
CCDC116
coiled-coil domain containing 116
chr1_+_24522116 1.880 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr22_+_21065134 1.823 LOC100290481
immunoglobulin lambda light chain-like
chr22_+_21006814 1.774


chr1_-_6474346 1.743 NM_020631
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr22_+_21552897 1.707 LOC100290481
immunoglobulin lambda light chain-like
chr22_+_21065207 1.703 IGLJ3
immunoglobulin lambda joining 3
chr22_-_17846711 1.659 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr22_-_17846621 1.654 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr22_+_21065202 1.651


chr22_+_19699441 1.589 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr6_+_34314545 1.582 NM_145905
HMGA1
high mobility group AT-hook 1
chr1_+_17571277 1.541 NM_207421
PADI6
peptidyl arginine deiminase, type VI
chr1_+_3378030 1.533 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr22_+_21011653 1.499


chr22_-_17846725 1.478 NM_001035247
NM_005659
UFD1L

ubiquitin fusion degradation 1 like (yeast)

chr11_+_118463906 1.462 NM_001024382
HMBS
hydroxymethylbilane synthase
chr22_+_20880159 1.454 IGLV6-57
immunoglobulin lambda variable 6-57
chr7_-_150561233 1.390


chr1_-_45760115 1.384 NM_002574
NM_181696
NM_181697
PRDX1


peroxiredoxin 1


chr21_+_45699830 1.374 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chr7_+_1536847 1.369 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr16_+_2023279 1.363 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr17_-_37022465 1.236 NM_005557
KRT16
keratin 16
chr2_+_87536174 1.235 NCRNA00152
non-protein coding RNA 152
chr6_-_31853027 1.224 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr2_+_87536106 1.208 NCRNA00152
non-protein coding RNA 152
chr11_+_1812115 1.207 NM_138567
SYT8
synaptotagmin VIII
chr1_+_17404206 1.201 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr7_+_150065594 1.184 GIMAP5
GTPase, IMAP family member 5
chr7_+_1543644 1.172 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr10_+_85889164 1.091 NM_014394
GHITM
growth hormone inducible transmembrane protein
chr3_-_195571748 1.075 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chr7_-_100667750 1.066 NM_014343
CLDN15
claudin 15
chr15_-_81037554 1.039 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr7_+_72883128 1.020 NM_001305
CLDN4
claudin 4
chr5_+_150000394 1.004 NM_001109974
NM_007286
SYNPO

synaptopodin

chr7_+_139175420 0.974 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr1_-_153209625 0.945 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr7_+_150065376 0.929 NM_018384
GIMAP5
GTPase, IMAP family member 5
chr16_+_56219802 0.914 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr16_-_68843295 0.913 NM_058219
EXOSC6
exosome component 6
chr19_-_56279278 0.910 NM_022046
KLK14
kallikrein-related peptidase 14
chr6_-_29563657 0.909 NM_052967
MAS1L
MAS1 oncogene-like
chr1_-_45045543 0.902 NM_001013632
TCTEX1D4
Tctex1 domain containing 4
chr22_+_21027538 0.886


chr22_+_17273735 0.885 NM_005675
DGCR6
DiGeorge syndrome critical region gene 6
chr6_+_160462852 0.874 NM_003057
NM_153187
SLC22A1

solute carrier family 22 (organic cation transporter), member 1

chr15_+_38520594 0.853 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr1_-_115039614 0.852 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr7_-_150352484 0.848 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr7_+_111850367 0.847 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr1_+_17507276 0.846 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chrX_+_100361588 0.842 NM_001171184
NM_001939
DRP2

dystrophin related protein 2

chr6_-_35804337 0.830 NM_001145775
FKBP5
FK506 binding protein 5
chr22_+_20880112 0.828


chr6_+_41712907 0.819 MDFI
MyoD family inhibitor
chr17_+_45965076 0.781 EPN3
epsin 3
chr11_+_72660894 0.778 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr7_+_133862883 0.774 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr17_-_74433048 0.771 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr13_+_112746908 0.769 MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_-_7923464 0.768 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr19_+_45564549 0.765 PLD3
phospholipase D family, member 3
chr8_-_38505331 0.756 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr17_-_74432800 0.755 TIMP2
TIMP metallopeptidase inhibitor 2
chr19_-_59438411 0.750 NM_024318
LILRB3
LILRA6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr19_+_55398680 0.741 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chrX_-_19598912 0.740 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr20_+_61337679 0.738 NM_022161
NM_139317
BIRC7

baculoviral IAP repeat containing 7

chr11_+_10433241 0.726 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr7_-_102772304 0.718 NM_001129887
NM_014377
DNAJC2

DnaJ (Hsp40) homolog, subfamily C, member 2

chr11_+_67107852 0.707 GSTP1
glutathione S-transferase pi 1
chr1_-_43168247 0.707 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr2_-_112907577 0.706 NM_001164463
RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5
chr6_-_24827265 0.700 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr19_-_54212158 0.694 NM_000894
LHB
luteinizing hormone beta polypeptide
chr7_+_130445394 0.683 NM_001145354
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr16_-_66075216 0.681 NM_001138
AGRP
agouti related protein homolog (mouse)
chr16_+_1230678 0.678 NM_003294
TPSB2
TPSAB1
tryptase beta 2 (gene/pseudogene)
tryptase alpha/beta 1
chr21_+_38566298 0.668 NM_170737
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr6_-_28429950 0.663 NM_145909
ZNF323
zinc finger protein 323
chr17_+_71109734 0.663 MYO15B
myosin XVB pseudogene
chr1_+_27591738 0.661 NM_005281
GPR3
G protein-coupled receptor 3
chr3_+_46894239 0.649 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr19_+_3317589 0.646 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr7_+_150319076 0.643 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr12_-_46405477 0.635 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr12_-_49897743 0.623 POU6F1
POU class 6 homeobox 1
chr11_+_67107641 0.620 NM_000852
GSTP1
glutathione S-transferase pi 1
chr6_+_43373986 0.618 SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chrX_+_12903145 0.613 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr1_+_158426908 0.611 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chrX_-_109570113 0.609 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr10_-_76538859 0.598 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr7_+_129720209 0.597 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr1_-_115682374 0.595 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr11_+_62136788 0.592 NM_000327
ROM1
retinal outer segment membrane protein 1
chrX_-_48713194 0.583 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr19_+_3317575 0.577 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr8_-_143820825 0.571 NM_020427
SLURP1
secreted LY6/PLAUR domain containing 1
chr16_-_27806978 0.570 NM_144675
GSG1L
GSG1-like
chr11_-_62136778 0.568 NM_153265
EML3
echinoderm microtubule associated protein like 3
chr6_+_31190505 0.558 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr19_+_56319948 0.556 NM_001198558
NM_014441
SIGLEC9

sialic acid binding Ig-like lectin 9

chr11_-_6298284 0.554 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr1_+_36327039 0.550 NM_017825
ADPRHL2
ADP-ribosylhydrolase like 2
chr3_-_152403636 0.548 NM_013308
GPR171
G protein-coupled receptor 171
chr8_-_42742729 0.547 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr7_+_1050704 0.540


chr16_+_82544327 0.540 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr1_+_19511326 0.534 NM_001040125
NM_001040126
NM_017765
PQLC2


PQ loop repeat containing 2


chr22_-_18687511 0.529 NM_033257
DGCR6L
DiGeorge syndrome critical region gene 6-like
chr7_+_106991638 0.526 NM_181581
DUS4L
dihydrouridine synthase 4-like (S. cerevisiae)
chr19_-_43955984 0.522 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr7_-_75280962 0.522 NM_002991
CCL24
chemokine (C-C motif) ligand 24
chr6_-_154719560 0.510 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr11_-_116605761 0.507 PCSK7
proprotein convertase subtilisin/kexin type 7
chr19_+_56337368 0.505 NM_014385
NM_016543
SIGLEC7

sialic acid binding Ig-like lectin 7

chrX_+_153423652 0.505 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr11_+_64079665 0.501 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr19_-_8118367 0.493 NM_032447
FBN3
fibrillin 3
chr3_+_130730171 0.491 NM_000539
RHO
rhodopsin
chr22_+_17498320 0.485 NM_053006
TSSK2
testis-specific serine kinase 2
chr4_-_38710376 0.484 NM_024943
TMEM156
transmembrane protein 156
chr6_-_170704251 0.482 PSMB1
proteasome (prosome, macropain) subunit, beta type, 1
chr7_+_157339985 0.482 LOC100506585
hypothetical LOC100506585
chr11_+_74548472 0.481 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr7_+_142768916 0.478 ZYX
zyxin
chr15_+_32304477 0.469 NM_016454
TMEM85
transmembrane protein 85
chr21_+_31953803 0.468 NM_000454
SOD1
superoxide dismutase 1, soluble
chr22_+_18090118 0.463 SEPT5-GP1BB
SEPT5-GP1BB read-through transcript
chr1_+_153232685 0.461 NM_018655
LENEP
lens epithelial protein
chr5_-_75954807 0.460 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr9_-_139042526 0.456 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr1_-_45249603 0.456 NM_024602
HECTD3
HECT domain containing 3
chr10_-_73167586 0.452 NM_001168390
C10orf105
chromosome 10 open reading frame 105
chr12_+_63084317 0.448 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr15_-_71830868 0.448 NM_001039614
C15orf59
chromosome 15 open reading frame 59
chr19_-_40711034 0.448 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr15_+_39638445 0.445 NM_006293
TYRO3
TYRO3 protein tyrosine kinase
chrX_+_133198742 0.435 NM_001101357
CCDC160
coiled-coil domain containing 160
chr1_-_33139425 0.433 NM_033504
TMEM54
transmembrane protein 54
chr19_+_3317536 0.432 NM_005597
NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr9_-_139042416 0.432 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr21_+_46367216 0.422 COL6A2
collagen, type VI, alpha 2
chr8_+_22266256 0.421 PIWIL2
piwi-like 2 (Drosophila)
chr9_+_139255559 0.420 TUBB2C
tubulin, beta 2C
chrX_-_100527799 0.417 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr2_+_173794692 0.417 ZAK
sterile alpha motif and leucine zipper containing kinase AZK
chr11_-_62539857 0.415 NM_001184732
NM_001184733
NM_001184736
NM_004254
SLC22A8



solute carrier family 22 (organic anion transporter), member 8



chr22_-_43040063 0.413 NM_001099294
KIAA1644
KIAA1644
chr1_+_46578976 0.413 NM_199044
NSUN4
NOP2/Sun domain family, member 4
chr19_-_40696393 0.406 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr6_-_3102690 0.403 NM_001069
TUBB2A
tubulin, beta 2A
chr19_+_991079 0.403 NM_019112
ABCA7
ATP-binding cassette, sub-family A (ABC1), member 7
chr2_+_113591940 0.403 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr10_+_75202258 0.401 FUT11
fucosyltransferase 11 (alpha (1,3) fucosyltransferase)
chr1_-_84237316 0.398 NM_024686
TTLL7
tubulin tyrosine ligase-like family, member 7
chr6_-_30793436 0.397 NM_014641
MDC1
mediator of DNA-damage checkpoint 1
chr9_+_139255519 0.395 NM_006088
TUBB2C
tubulin, beta 2C
chr11_-_64906683 0.393 NM_001077241
NM_182556
SLC25A45

solute carrier family 25, member 45

chr1_-_153195219 0.388 PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr10_+_75202071 0.388 FUT11
fucosyltransferase 11 (alpha (1,3) fucosyltransferase)
chr7_-_115458047 0.387 TFEC
transcription factor EC
chr7_-_33047042 0.386 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr6_-_2580296 0.383 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr1_-_45249554 0.382 HECTD3
HECT domain containing 3
chr1_-_111908085 0.380 NM_001081976
ADORA3
adenosine A3 receptor
chr6_+_31782618 0.380 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr9_+_94776538 0.377 NM_033086
FGD3
FYVE, RhoGEF and PH domain containing 3
chr9_+_131291224 0.377 LOC100506190
hypothetical LOC100506190
chr6_-_32929721 0.377 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr16_+_28413421 0.377 NM_018690
APOBR
apolipoprotein B receptor
chr9_+_131291144 0.374


chr1_-_43523825 0.373 NM_182517
NM_001164829
C1orf210

chromosome 1 open reading frame 210

chr9_-_99974994 0.373 NM_003389
CORO2A
coronin, actin binding protein, 2A
chr16_+_87765661 0.372 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr6_-_33655995 0.362 NM_001188
BAK1
BCL2-antagonist/killer 1
chr3_+_5204430 0.361 EDEM1
ER degradation enhancer, mannosidase alpha-like 1
chr7_-_76667045 0.361 NM_006682
FGL2
fibrinogen-like 2
chr2_+_74635019 0.358 NM_001381
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr1_-_240228987 0.358 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.13 5.77e-03 GO:0009987 cellular process
5.20 1.17e-02 GO:0006521 regulation of cellular amino acid metabolic process
1.67 2.49e-02 GO:0050790 regulation of catalytic activity
3.54 3.70e-02 GO:0000077 DNA damage checkpoint
3.97 3.84e-02 GO:0051351 positive regulation of ligase activity
4.23 4.10e-02 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
5.01 4.36e-02 GO:0032313 regulation of Rab GTPase activity
5.01 4.36e-02 GO:0032483 regulation of Rab protein signal transduction
4.52 4.80e-02 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
4.52 4.80e-02 GO:0072395 signal transduction involved in cell cycle checkpoint
4.52 4.80e-02 GO:0072401 signal transduction involved in DNA integrity checkpoint
4.52 4.80e-02 GO:0072404 signal transduction involved in G1/S transition checkpoint
4.52 4.80e-02 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
4.52 4.80e-02 GO:0072422 signal transduction involved in DNA damage checkpoint
4.52 4.80e-02 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
4.52 4.80e-02 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.37 1.01e-02 GO:0000502 proteasome complex
7.51 2.76e-02 GO:0005839 proteasome core complex
2.41 3.78e-02 GO:0016323 basolateral plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.91 1.22e-02 GO:0005097 Rab GTPase activator activity