Motif ID: NFKB1_REL_RELA.p2

Z-value: 1.808


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RELAchr11_-_651824110.543.2e-02Click!
RELchr2_+_609622060.351.9e-01Click!
NFKB1chr4_+_103641762-0.185.1e-01Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_45993338 2.487 NM_018896
NM_198376
NM_198377
NM_198378
NM_198379
NM_198380
NM_198382
NM_198383
NM_198384
NM_198385
NM_198386
NM_198387
NM_198388
NM_198396
NM_198397
 CACNA1G














calcium channel, voltage-dependent, T type, alpha 1G subunit














chr15_+_65217412 2.125 NM_001145103
 SMAD3
SMAD family member 3
chr9_+_126094388 1.702 NM_001166169
 NEK6
NIMA (never in mitosis gene a)-related kinase 6
chr15_+_80434362 1.662 UBE2Q2P2
ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 2
chr6_+_41622267 1.454 FOXP4
forkhead box P4
chr1_+_6767968 1.439 NM_001195563
NM_015215
 CAMTA1

calmodulin binding transcription activator 1

chr3_+_38470782 1.399 NM_001106
 ACVR2B
activin A receptor, type IIB
chr9_+_126094067 1.361 NM_001166170
NM_001166171
 NEK6

NIMA (never in mitosis gene a)-related kinase 6

chr6_+_41622111 1.322 NM_001012426
NM_001012427
NM_138457
 FOXP4


forkhead box P4


chr2_+_170363573 1.307 NM_003142
 SSB
Sjogren syndrome antigen B (autoantigen La)
chr7_+_142723340 1.253 NM_000083
 CLCN1
chloride channel 1, skeletal muscle
chr5_+_56505412 1.173 NM_022913
 GPBP1
GC-rich promoter binding protein 1
chr5_+_10617431 1.166 NM_001164440
 ANKRD33B
ankyrin repeat domain 33B
chr16_-_65516919 1.166 NM_001128850
NM_004165
 RRAD

Ras-related associated with diabetes

chr6_+_87921980 1.147 NM_015021
 ZNF292
zinc finger protein 292
chr3_-_50311666 1.140 NM_012191
NM_003549
 NAT6
HYAL3
N-acetyltransferase 6 (GCN5-related)
hyaluronoglucosaminidase 3
chr3_-_50311262 1.116 NAT6
HYAL3
N-acetyltransferase 6 (GCN5-related)
hyaluronoglucosaminidase 3
chr5_+_56505608 1.090 GPBP1
GC-rich promoter binding protein 1
chr10_+_30763056 1.073 MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr11_+_101693403 1.015 NM_001165
NM_182962
 BIRC3

baculoviral IAP repeat containing 3


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 41 entries
enrichment   p-value GO term description
1.95 5.86e-05 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.88 1.53e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.87 6.02e-06 GO:0045892 negative regulation of transcription, DNA-dependent
1.83 1.76e-05 GO:0051253 negative regulation of RNA metabolic process
1.77 9.96e-06 GO:0010558 negative regulation of macromolecule biosynthetic process
1.77 2.70e-05 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.76 3.69e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.75 7.57e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.73 2.65e-05 GO:0031327 negative regulation of cellular biosynthetic process
1.73 1.54e-04 GO:0010629 negative regulation of gene expression
1.71 4.39e-05 GO:0009890 negative regulation of biosynthetic process
1.71 1.99e-02 GO:0032583 regulation of gene-specific transcription
1.55 3.33e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.51 3.11e-02 GO:0006955 immune response
1.50 7.73e-03 GO:0031324 negative regulation of cellular metabolic process
1.48 1.84e-02 GO:0009611 response to wounding
1.47 2.34e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.44 6.65e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.42 7.91e-03 GO:0002376 immune system process
1.42 1.48e-02 GO:0031325 positive regulation of cellular metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
4.61 2.18e-02 GO:0031519 PcG protein complex
2.65 8.07e-04 GO:0005925 focal adhesion
2.62 6.92e-04 GO:0005924 cell-substrate adherens junction
2.52 1.56e-03 GO:0030055 cell-substrate junction
2.22 3.25e-03 GO:0005912 adherens junction
2.00 3.08e-02 GO:0070161 anchoring junction
1.83 3.70e-02 GO:0016323 basolateral plasma membrane
1.29 5.15e-03 GO:0005829 cytosol
1.14 4.62e-02 GO:0005634 nucleus
1.10 1.33e-02 GO:0005737 cytoplasm
1.09 4.58e-02 GO:0043227 membrane-bounded organelle
1.09 4.64e-02 GO:0043231 intracellular membrane-bounded organelle
1.07 1.67e-02 GO:0044424 intracellular part
1.07 2.11e-02 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.85 4.29e-03 GO:0008134 transcription factor binding
1.56 2.39e-03 GO:0043565 sequence-specific DNA binding
1.46 2.57e-03 GO:0001071 nucleic acid binding transcription factor activity
1.46 2.57e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.45 4.30e-02 GO:0019899 enzyme binding
1.23 2.64e-13 GO:0005515 protein binding
1.09 5.49e-05 GO:0005488 binding