Motif ID: NHLH1,2.p2

Z-value: 1.933


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NHLH2chr1_-_1161852150.391.3e-01Click!
NHLH1chr1_+_158603480-0.126.5e-01Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_17304707 5.010 NM_001621
AHR
aryl hydrocarbon receptor
chr2_+_109112428 2.893 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr17_-_36533903 2.826 NM_031854
KRTAP4-12
keratin associated protein 4-12
chr3_-_62835601 2.701


chr2_+_202949289 2.695 NM_001204
BMPR2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr2_-_6923215 2.359 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr2_+_46779827 2.252 NM_144949
SOCS5
suppressor of cytokine signaling 5
chr4_+_144325533 2.244 USP38
ubiquitin specific peptidase 38
chr2_+_208979800 2.137 NM_005048
PTH2R
parathyroid hormone 2 receptor
chr4_+_144325502 2.081 NM_032557
USP38
ubiquitin specific peptidase 38
chr17_+_36665161 2.010 NM_030975
KRTAP9-9
keratin associated protein 9-9
chr17_+_36636404 1.990 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr6_+_124166767 1.970 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr4_+_95592067 1.967 PDLIM5
PDZ and LIM domain 5
chr4_+_95592030 1.933 NM_001011513
NM_001011515
NM_001011516
NM_006457
PDLIM5



PDZ and LIM domain 5



chr3_-_121550767 1.916 NM_001099678
LRRC58
leucine rich repeat containing 58
chr17_+_36659464 1.743 NM_033191
KRTAP9-4
keratin associated protein 9-4
chr13_+_77170470 1.718 NM_001040153
SLAIN1
SLAIN motif family, member 1
chr17_+_36642240 1.632 NM_031962
KRTAP9-9
KRTAP9-3
keratin associated protein 9-9
keratin associated protein 9-3
chr17_-_36570508 1.604 NM_032524
KRTAP4-4
keratin associated protein 4-4
chr17_-_36559579 1.576 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr4_+_82171142 1.544 NM_001201
BMP3
bone morphogenetic protein 3
chr9_+_107046811 1.540 SLC44A1
solute carrier family 44, member 1
chr14_+_30413393 1.526 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr14_+_59785739 1.501 PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr4_-_40911212 1.491 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr20_+_20296744 1.422 NM_002196
INSM1
insulinoma-associated 1
chr12_+_19484044 1.394 AEBP2
AE binding protein 2
chr13_+_25726238 1.374 CDK8
cyclin-dependent kinase 8
chr9_+_113433364 1.364 NM_001015882
NM_004125
DNAJC25
DNAJC25-GNG10
DnaJ (Hsp40) homolog, subfamily C , member 25
DNAJC25-GNG10 readthrough
chr20_+_25176698 1.362 NM_002862
PYGB
phosphorylase, glycogen; brain
chr4_-_1097313 1.355 NM_001131034
NM_001193318
NM_194439
RNF212


ring finger protein 212


chr8_-_16903911 1.318 NM_019851
FGF20
fibroblast growth factor 20
chr14_+_64040979 1.315 NM_001123329
NM_014950
ZBTB1

zinc finger and BTB domain containing 1

chr8_+_56177567 1.288 NM_052898
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr14_+_56927066 1.288 NAA30
N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr4_-_113656762 1.285 NM_024019
NEUROG2
neurogenin 2
chr20_-_44713466 1.279 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chrX_+_153767803 1.275 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr2_+_196230096 1.251 NM_020342
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr12_+_27824429 1.242 NM_020782
KLHDC5
kelch domain containing 5
chr7_-_84654106 1.241 SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr13_-_35603432 1.228 DCLK1
doublecortin-like kinase 1
chr10_+_17726129 1.225 NM_003473
STAM
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
chr1_+_84316217 1.218 NM_002731
NM_207578
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr3_+_35656012 1.215 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr14_+_89933118 1.211 CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr5_+_113725914 1.211 NM_021614
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr14_+_56927014 1.199 NM_001011713
NAA30
N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr20_+_13150417 1.174 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr7_+_93977267 1.169 CASD1
CAS1 domain containing 1
chr13_-_95503566 1.159 NM_020121
UGGT2
UDP-glucose glycoprotein glucosyltransferase 2
chrX_-_153767625 1.153 NM_019863
F8
coagulation factor VIII, procoagulant component
chr13_+_34414390 1.152 NM_015678
NBEA
neurobeachin
chr13_-_35603513 1.148 NM_004734
DCLK1
doublecortin-like kinase 1
chr5_-_70621688 1.145 SMA4
glucuronidase, beta pseudogene
chr2_+_233270286 1.136 GIGYF2
GRB10 interacting GYF protein 2
chr15_-_100082134 1.127 NM_152334
TARSL2
threonyl-tRNA synthetase-like 2
chr2_+_79593679 1.127 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr14_+_59786047 1.121 PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr4_-_13155135 1.118 NM_001189
NKX3-2
NK3 homeobox 2
chr5_-_94646033 1.113 NM_024717
MCTP1
multiple C2 domains, transmembrane 1
chr3_-_135096986 1.107 RAB6B
RAB6B, member RAS oncogene family
chr14_+_64041170 1.107 ZBTB1
zinc finger and BTB domain containing 1
chr11_+_33235743 1.106 NM_001048200
NM_005734
HIPK3

homeodomain interacting protein kinase 3

chr3_+_30623376 1.096 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr10_+_17311347 1.096 VIM
vimentin
chr13_-_35603466 1.093 DCLK1
doublecortin-like kinase 1
chr5_+_67547357 1.083 PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_+_85819004 1.072 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr2_+_54536780 1.063 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr10_+_17311283 1.061 VIM
vimentin
chr10_+_17311307 1.059 VIM
vimentin
chr3_-_62836052 1.058 NM_003716
NM_183393
NM_183394
CADPS


Ca++-dependent secretion activator


chr10_-_15801661 1.055 NM_003638
ITGA8
integrin, alpha 8
chr20_-_21326046 1.053 NM_033176
NKX2-4
NK2 homeobox 4
chr17_-_36594652 1.052 NM_033060
KRTAP4-1
keratin associated protein 4-1
chr14_-_70345485 1.049 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr3_+_123996655 1.041 DIRC2
disrupted in renal carcinoma 2
chr4_+_184602784 1.040 CDKN2AIP
CDKN2A interacting protein
chr14_+_61231795 1.039 NM_001530
NM_181054
HIF1A

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

chr3_+_57236818 1.032 APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr5_+_113726203 1.028 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr20_+_13924263 1.027 MACROD2
MACRO domain containing 2
chr10_+_17311242 1.018 VIM
vimentin
chr2_+_191453792 1.015 GLS
glutaminase
chr10_+_17311282 1.014 VIM
vimentin
chr4_+_48038259 1.012 NM_020846
SLAIN2
SLAIN motif family, member 2
chr8_+_17058377 1.007 ZDHHC2
zinc finger, DHHC-type containing 2
chr11_+_32870935 1.003 NM_001076786
QSER1
glutamine and serine rich 1
chr6_+_133604203 1.000 EYA4
eyes absent homolog 4 (Drosophila)
chr2_+_79593567 0.989 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr10_+_27833167 0.980 NM_021252
RAB18
RAB18, member RAS oncogene family
chr2_+_191454036 0.980 GLS
glutaminase
chr5_+_139473873 0.973 NM_005859
PURA
purine-rich element binding protein A
chr7_-_11838260 0.963 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr20_-_48980858 0.959 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr11_-_65841077 0.948 NM_020404
CD248
CD248 molecule, endosialin
chr18_+_65219114 0.936 NM_152721
DOK6
docking protein 6
chr14_-_47213906 0.925 NM_001113498
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr9_+_17124974 0.909 NM_001114395
NM_017738
CNTLN

centlein, centrosomal protein

chr14_+_64041257 0.909 ZBTB1
zinc finger and BTB domain containing 1
chr2_+_191453813 0.909 GLS
glutaminase
chr6_+_129245978 0.908 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr10_+_89613347 0.908 PTEN
phosphatase and tensin homolog
chrX_-_154341451 0.902 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr9_+_32773496 0.894 NM_212558
TMEM215
transmembrane protein 215
chr20_+_48781457 0.891 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr12_+_100615530 0.887 NM_020244
CHPT1
choline phosphotransferase 1
chr6_+_126153750 0.879 NCOA7
nuclear receptor coactivator 7
chr15_+_72620570 0.867 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr1_-_92724181 0.866 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr5_+_72148173 0.863 NM_002270
TNPO1
transportin 1
chr2_+_191453791 0.863 NM_014905
GLS
glutaminase
chr4_+_39376058 0.862 NM_001111112
NM_001111113
NM_005339
UBE2K


ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)


chr9_+_109085386 0.862 RAD23B
RAD23 homolog B (S. cerevisiae)
chr5_-_58370693 0.861 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr20_+_17498507 0.860 NM_001011546
NM_006870
DSTN

destrin (actin depolymerizing factor)

chr14_-_64040072 0.855 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr2_+_191818124 0.854 NM_001130158
NM_012223
NM_001161819
MYO1B


myosin IB


chr21_-_44803049 0.852 NM_198696
KRTAP10-3
keratin associated protein 10-3
chr7_+_39956633 0.850 CDK13
cyclin-dependent kinase 13
chr10_+_89613399 0.850 PTEN
phosphatase and tensin homolog
chr2_+_231285780 0.843 NM_016289
CAB39
calcium binding protein 39
chr3_+_114192489 0.842 NM_014170
NM_138485
GTPBP8

GTP-binding protein 8 (putative)

chr14_-_44673408 0.839 FKBP3
FK506 binding protein 3, 25kDa
chr17_+_57909979 0.835 NM_001112707
NM_006852
TLK2

tousled-like kinase 2

chr21_-_30666417 0.833 NM_181621
KRTAP13-2
keratin associated protein 13-2
chr1_+_246167115 0.832 NM_175911
OR2L13
olfactory receptor, family 2, subfamily L, member 13
chr21_-_44784499 0.824 NM_198691
KRTAP10-1
keratin associated protein 10-1
chr13_-_71338144 0.820 DACH1
dachshund homolog 1 (Drosophila)
chr17_-_36528113 0.819 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr6_+_147567200 0.818 NM_001127715
NM_139244
STXBP5

syntaxin binding protein 5 (tomosyn)

chr4_-_123073642 0.817 NM_003305
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr15_-_58671929 0.815 NM_134262
RORA
RAR-related orphan receptor A
chr13_-_71338558 0.812 DACH1
dachshund homolog 1 (Drosophila)
chr1_+_67168470 0.810 NM_001077701
NM_001077704
MIER1

mesoderm induction early response 1 homolog (Xenopus laevis)

chr18_+_9324820 0.808 TWSG1
twisted gastrulation homolog 1 (Drosophila)
chr2_+_137239583 0.808 THSD7B
thrombospondin, type I, domain containing 7B
chr19_+_12166829 0.807 LOC100289333
hypothetical LOC100289333
chr17_-_36451189 0.801 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr10_+_112247614 0.801 NM_004419
DUSP5
dual specificity phosphatase 5
chr17_+_59053518 0.798 NM_002401
NM_203351
MAP3K3

mitogen-activated protein kinase kinase kinase 3

chr3_+_43303005 0.797 NM_001100594
NM_017719
SNRK

SNF related kinase

chr3_+_114192467 0.796 GTPBP8
GTP-binding protein 8 (putative)
chr2_+_191454157 0.794 GLS
glutaminase
chr1_+_35507145 0.793 NM_005095
ZMYM4
zinc finger, MYM-type 4
chr10_+_93160066 0.791 NM_173497
NM_182765
HECTD2

HECT domain containing 2

chr10_+_89613071 0.789 NM_000314
PTEN
phosphatase and tensin homolog
chr2_-_230287442 0.788 NM_139072
DNER
delta/notch-like EGF repeat containing
chr15_+_83724743 0.786 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr4_-_168392307 0.781 NM_001040159
NM_016950
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr19_+_12166869 0.779


chr2_+_231285868 0.772 CAB39
calcium binding protein 39
chr15_-_60139857 0.768 NM_001018088
NM_017684
NM_018080
NM_020821
VPS13C



vacuolar protein sorting 13 homolog C (S. cerevisiae)



chr14_-_44673418 0.768 NM_002013
FKBP3
FK506 binding protein 3, 25kDa
chr15_-_29950070 0.763 OTUD7A
OTU domain containing 7A
chr9_-_21999270 0.759 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr5_+_49998528 0.758 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr9_+_109085372 0.757 RAD23B
RAD23 homolog B (S. cerevisiae)
chr14_+_75688042 0.749 C14orf118
chromosome 14 open reading frame 118
chr6_+_127629677 0.749 NM_030963
RNF146
ring finger protein 146
chr9_+_109085337 0.745 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr2_+_190981257 0.743 NM_017694
MFSD6
major facilitator superfamily domain containing 6
chr18_+_9324762 0.742 NM_020648
TWSG1
twisted gastrulation homolog 1 (Drosophila)
chr7_-_22363036 0.739 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr4_+_184257337 0.733 NM_024949
WWC2
WW and C2 domain containing 2
chr16_+_9093035 0.729 NM_014117
C16orf72
chromosome 16 open reading frame 72
chr3_+_57236816 0.727 APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr15_-_29950188 0.727 OTUD7A
OTU domain containing 7A
chr20_+_1154763 0.725 NM_001136566
RAD21L1
RAD21-like 1 (S. pombe)
chr3_-_135097111 0.721 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr3_+_57236769 0.721 NM_012096
APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr4_+_86968069 0.721 ARHGAP24
Rho GTPase activating protein 24
chr13_+_48692472 0.720 NM_001507
MLNR
motilin receptor
chr2_+_115635982 0.720 NM_001178034
NM_001004360
DPP10

dipeptidyl-peptidase 10 (non-functional)

chr9_-_83493415 0.720 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr7_+_29200850 0.711 CHN2
chimerin (chimaerin) 2
chr9_-_21549696 0.709 LOC554202
hypothetical LOC554202
chr13_+_98951772 0.709 TM9SF2
transmembrane 9 superfamily member 2
chrX_-_1532648 0.709 NM_001173473
ASMTL
acetylserotonin O-methyltransferase-like
chr8_+_42129620 0.709 NM_001134296
NM_006803
AP3M2

adaptor-related protein complex 3, mu 2 subunit

chr16_+_9093072 0.702 C16orf72
chromosome 16 open reading frame 72
chr7_-_139408808 0.699 PARP12
poly (ADP-ribose) polymerase family, member 12
chr4_+_99401543 0.697 NM_001100426
NM_001100427
NM_001100428
NM_001100429
NM_001100430
NM_021159
RAP1GDS1





RAP1, GTP-GDP dissociation stimulator 1





chr4_-_168392266 0.694 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr2_+_47021816 0.693 NM_020458
TTC7A
tetratricopeptide repeat domain 7A
chr14_-_37795290 0.690 NM_175060
CLEC14A
C-type lectin domain family 14, member A
chr2_+_196229715 0.689 NM_001127257
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr4_-_120769275 0.687 NM_001083
PDE5A
phosphodiesterase 5A, cGMP-specific
chr20_+_34523555 0.687 NM_183006
DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr11_-_617172 0.686 NM_021920
SCT
secretin
chr9_+_109085643 0.686 RAD23B
RAD23 homolog B (S. cerevisiae)
chr6_+_89848229 0.686 PNRC1
proline-rich nuclear receptor coactivator 1
chr6_-_151754337 0.683 NM_020861
ZBTB2
zinc finger and BTB domain containing 2
chr13_-_35686665 0.680 NM_017826
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr4_+_55956877 0.673 TMEM165
transmembrane protein 165
chr13_+_23051426 0.670 NM_018647
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr10_+_93160033 0.669


chr21_+_18539016 0.668 NM_024944
CHODL
chondrolectin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.06 2.24e-04 GO:0009987 cellular process
1.24 3.85e-03 GO:0007399 nervous system development
1.23 4.94e-03 GO:0023051 regulation of signaling
1.10 6.29e-03 GO:0044237 cellular metabolic process
1.21 7.69e-03 GO:0006464 protein modification process
1.08 2.21e-02 GO:0050794 regulation of cellular process
1.30 2.30e-02 GO:0051128 regulation of cellular component organization
1.48 3.21e-02 GO:0032535 regulation of cellular component size
2.43 3.50e-02 GO:0043242 negative regulation of protein complex disassembly
2.06 4.07e-02 GO:0030832 regulation of actin filament length

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 3.86e-15 GO:0044424 intracellular part
1.09 6.21e-15 GO:0005622 intracellular
1.13 1.17e-14 GO:0005737 cytoplasm
1.08 2.15e-06 GO:0043226 organelle
1.08 2.86e-06 GO:0043229 intracellular organelle
1.11 5.26e-05 GO:0044444 cytoplasmic part
1.74 1.58e-03 GO:0005912 adherens junction
1.03 2.82e-03 GO:0044464 cell part
1.03 2.98e-03 GO:0005623 cell
1.60 2.97e-02 GO:0070161 anchoring junction
1.74 4.41e-02 GO:0005924 cell-substrate adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.09 1.17e-04 GO:0005515 protein binding
1.05 1.72e-03 GO:0005488 binding
3.18 5.32e-03 GO:0004675 transmembrane receptor protein serine/threonine kinase activity
1.63 3.19e-02 GO:0004721 phosphoprotein phosphatase activity
1.09 3.58e-02 GO:0003824 catalytic activity
1.28 4.57e-02 GO:0019899 enzyme binding