• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: NHLH1,2.p2

Z-value: 1.933

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr7_+_17304707	5.010	NM_001621	AHR	aryl hydrocarbon receptor
chr2_+_109112428	2.893	NM_001099289	SH3RF3	SH3 domain containing ring finger 3
chr17_-_36533903	2.826	NM_031854	KRTAP4-12	keratin associated protein 4-12
chr3_-_62835601	2.701
chr2_+_202949289	2.695	NM_001204	BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr2_-_6923215	2.359	NM_207315	CMPK2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr2_+_46779827	2.252	NM_144949	SOCS5	suppressor of cytokine signaling 5
chr4_+_144325533	2.244		USP38	ubiquitin specific peptidase 38
chr2_+_208979800	2.137	NM_005048	PTH2R	parathyroid hormone 2 receptor
chr4_+_144325502	2.081	NM_032557	USP38	ubiquitin specific peptidase 38
chr17_+_36665161	2.010	NM_030975	KRTAP9-9	keratin associated protein 9-9
chr17_+_36636404	1.990	NM_031961	KRTAP9-2	keratin associated protein 9-2
chr6_+_124166767	1.970	NM_001040214 NM_153355	NKAIN2	Na+/K+ transporting ATPase interacting 2
chr4_+_95592067	1.967		PDLIM5	PDZ and LIM domain 5
chr4_+_95592030	1.933	NM_001011513 NM_001011515 NM_001011516 NM_006457	PDLIM5	PDZ and LIM domain 5
chr3_-_121550767	1.916	NM_001099678	LRRC58	leucine rich repeat containing 58
chr17_+_36659464	1.743	NM_033191	KRTAP9-4	keratin associated protein 9-4
chr13_+_77170470	1.718	NM_001040153	SLAIN1	SLAIN motif family, member 1
chr17_+_36642240	1.632	NM_031962	KRTAP9-9 KRTAP9-3	keratin associated protein 9-9 keratin associated protein 9-3
chr17_-_36570508	1.604	NM_032524	KRTAP4-4	keratin associated protein 4-4
chr17_-_36559579	1.576	NM_033188	KRTAP4-5	keratin associated protein 4-5
chr4_+_82171142	1.544	NM_001201	BMP3	bone morphogenetic protein 3
chr9_+_107046811	1.540		SLC44A1	solute carrier family 44, member 1
chr14_+_30413393	1.526	NM_001135058 NM_004086	COCH	coagulation factor C homolog, cochlin (Limulus polyphemus)
chr14_+_59785739	1.501		PPM1A	protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr4_-_40911212	1.491	NM_001166050 NM_004307 NM_173075	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2
chr20_+_20296744	1.422	NM_002196	INSM1	insulinoma-associated 1
chr12_+_19484044	1.394		AEBP2	AE binding protein 2
chr13_+_25726238	1.374		CDK8	cyclin-dependent kinase 8
chr9_+_113433364	1.364	NM_001015882 NM_004125	DNAJC25 DNAJC25-GNG10	DnaJ (Hsp40) homolog, subfamily C , member 25 DNAJC25-GNG10 readthrough
chr20_+_25176698	1.362	NM_002862	PYGB	phosphorylase, glycogen; brain
chr4_-_1097313	1.355	NM_001131034 NM_001193318 NM_194439	RNF212	ring finger protein 212
chr8_-_16903911	1.318	NM_019851	FGF20	fibroblast growth factor 20
chr14_+_64040979	1.315	NM_001123329 NM_014950	ZBTB1	zinc finger and BTB domain containing 1
chr8_+_56177567	1.288	NM_052898	XKR4	XK, Kell blood group complex subunit-related family, member 4
chr14_+_56927066	1.288		NAA30	N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr4_-_113656762	1.285	NM_024019	NEUROG2	neurogenin 2
chr20_-_44713466	1.279	NM_001193339 NM_001193342 NM_022829	SLC13A3	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
chrX_+_153767803	1.275	NM_001007523 NM_001007524 NM_012151	F8A2 F8A3 F8A1	coagulation factor VIII-associated (intronic transcript) 2 coagulation factor VIII-associated (intronic transcript) 3 coagulation factor VIII-associated (intronic transcript) 1
chr2_+_196230096	1.251	NM_020342	SLC39A10	solute carrier family 39 (zinc transporter), member 10
chr12_+_27824429	1.242	NM_020782	KLHDC5	kelch domain containing 5
chr7_-_84654106	1.241		SEMA3D	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr13_-_35603432	1.228		DCLK1	doublecortin-like kinase 1
chr10_+_17726129	1.225	NM_003473	STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
chr1_+_84316217	1.218	NM_002731 NM_207578	PRKACB	protein kinase, cAMP-dependent, catalytic, beta
chr3_+_35656012	1.215		ARPP21	cAMP-regulated phosphoprotein, 21kDa
chr14_+_89933118	1.211		CALM1	calmodulin 1 (phosphorylase kinase, delta)
chr5_+_113725914	1.211	NM_021614	KCNN2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr14_+_56927014	1.199	NM_001011713	NAA30	N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr20_+_13150417	1.174	NM_080826	ISM1	isthmin 1 homolog (zebrafish)
chr7_+_93977267	1.169		CASD1	CAS1 domain containing 1
chr13_-_95503566	1.159	NM_020121	UGGT2	UDP-glucose glycoprotein glucosyltransferase 2
chrX_-_153767625	1.153	NM_019863	F8	coagulation factor VIII, procoagulant component
chr13_+_34414390	1.152	NM_015678	NBEA	neurobeachin
chr13_-_35603513	1.148	NM_004734	DCLK1	doublecortin-like kinase 1
chr5_-_70621688	1.145		SMA4	glucuronidase, beta pseudogene
chr2_+_233270286	1.136		GIGYF2	GRB10 interacting GYF protein 2
chr15_-_100082134	1.127	NM_152334	TARSL2	threonyl-tRNA synthetase-like 2
chr2_+_79593679	1.127		CTNNA2	catenin (cadherin-associated protein), alpha 2
chr14_+_59786047	1.121		PPM1A	protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr4_-_13155135	1.118	NM_001189	NKX3-2	NK3 homeobox 2
chr5_-_94646033	1.113	NM_024717	MCTP1	multiple C2 domains, transmembrane 1
chr3_-_135096986	1.107		RAB6B	RAB6B, member RAS oncogene family
chr14_+_64041170	1.107		ZBTB1	zinc finger and BTB domain containing 1
chr11_+_33235743	1.106	NM_001048200 NM_005734	HIPK3	homeodomain interacting protein kinase 3
chr3_+_30623376	1.096		TGFBR2	transforming growth factor, beta receptor II (70/80kDa)
chr10_+_17311347	1.096		VIM	vimentin
chr13_-_35603466	1.093		DCLK1	doublecortin-like kinase 1
chr5_+_67547357	1.083		PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_+_85819004	1.072	NM_001554	CYR61	cysteine-rich, angiogenic inducer, 61
chr2_+_54536780	1.063	NM_003128	SPTBN1	spectrin, beta, non-erythrocytic 1
chr10_+_17311283	1.061		VIM	vimentin
chr10_+_17311307	1.059		VIM	vimentin
chr3_-_62836052	1.058	NM_003716 NM_183393 NM_183394	CADPS	Ca++-dependent secretion activator
chr10_-_15801661	1.055	NM_003638	ITGA8	integrin, alpha 8
chr20_-_21326046	1.053	NM_033176	NKX2-4	NK2 homeobox 4
chr17_-_36594652	1.052	NM_033060	KRTAP4-1	keratin associated protein 4-1
chr14_-_70345485	1.049	NM_033141	MAP3K9	mitogen-activated protein kinase kinase kinase 9
chr3_+_123996655	1.041		DIRC2	disrupted in renal carcinoma 2
chr4_+_184602784	1.040		CDKN2AIP	CDKN2A interacting protein
chr14_+_61231795	1.039	NM_001530 NM_181054	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr3_+_57236818	1.032		APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr5_+_113726203	1.028		KCNN2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr20_+_13924263	1.027		MACROD2	MACRO domain containing 2
chr10_+_17311242	1.018		VIM	vimentin
chr2_+_191453792	1.015		GLS	glutaminase
chr10_+_17311282	1.014		VIM	vimentin
chr4_+_48038259	1.012	NM_020846	SLAIN2	SLAIN motif family, member 2
chr8_+_17058377	1.007		ZDHHC2	zinc finger, DHHC-type containing 2
chr11_+_32870935	1.003	NM_001076786	QSER1	glutamine and serine rich 1
chr6_+_133604203	1.000		EYA4	eyes absent homolog 4 (Drosophila)
chr2_+_79593567	0.989	NM_001164883 NM_004389	CTNNA2	catenin (cadherin-associated protein), alpha 2
chr10_+_27833167	0.980	NM_021252	RAB18	RAB18, member RAS oncogene family
chr2_+_191454036	0.980		GLS	glutaminase
chr5_+_139473873	0.973	NM_005859	PURA	purine-rich element binding protein A
chr7_-_11838260	0.963	NM_015204	THSD7A	thrombospondin, type I, domain containing 7A
chr20_-_48980858	0.959	NM_015339 NM_181442	ADNP	activity-dependent neuroprotector homeobox
chr11_-_65841077	0.948	NM_020404	CD248	CD248 molecule, endosialin
chr18_+_65219114	0.936	NM_152721	DOK6	docking protein 6
chr14_-_47213906	0.925	NM_001113498	MDGA2	MAM domain containing glycosylphosphatidylinositol anchor 2
chr9_+_17124974	0.909	NM_001114395 NM_017738	CNTLN	centlein, centrosomal protein
chr14_+_64041257	0.909		ZBTB1	zinc finger and BTB domain containing 1
chr2_+_191453813	0.909		GLS	glutaminase
chr6_+_129245978	0.908	NM_000426 NM_001079823	LAMA2	laminin, alpha 2
chr10_+_89613347	0.908		PTEN	phosphatase and tensin homolog
chrX_-_154341451	0.902	NM_001007523 NM_001007524 NM_012151	F8A2 F8A3 F8A1	coagulation factor VIII-associated (intronic transcript) 2 coagulation factor VIII-associated (intronic transcript) 3 coagulation factor VIII-associated (intronic transcript) 1
chr9_+_32773496	0.894	NM_212558	TMEM215	transmembrane protein 215
chr20_+_48781457	0.891	NM_032521	PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)
chr12_+_100615530	0.887	NM_020244	CHPT1	choline phosphotransferase 1
chr6_+_126153750	0.879		NCOA7	nuclear receptor coactivator 7
chr15_+_72620570	0.867	NM_006465	ARID3B	AT rich interactive domain 3B (BRIGHT-like)
chr1_-_92724181	0.866	NM_001127216	GFI1	growth factor independent 1 transcription repressor
chr5_+_72148173	0.863	NM_002270	TNPO1	transportin 1
chr2_+_191453791	0.863	NM_014905	GLS	glutaminase
chr4_+_39376058	0.862	NM_001111112 NM_001111113 NM_005339	UBE2K	ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
chr9_+_109085386	0.862		RAD23B	RAD23 homolog B (S. cerevisiae)
chr5_-_58370693	0.861	NM_001197221 NM_001197222	PDE4D	phosphodiesterase 4D, cAMP-specific
chr20_+_17498507	0.860	NM_001011546 NM_006870	DSTN	destrin (actin depolymerizing factor)
chr14_-_64040072	0.855	NM_006977	ZBTB25	zinc finger and BTB domain containing 25
chr2_+_191818124	0.854	NM_001130158 NM_012223 NM_001161819	MYO1B	myosin IB
chr21_-_44803049	0.852	NM_198696	KRTAP10-3	keratin associated protein 10-3
chr7_+_39956633	0.850		CDK13	cyclin-dependent kinase 13
chr10_+_89613399	0.850		PTEN	phosphatase and tensin homolog
chr2_+_231285780	0.843	NM_016289	CAB39	calcium binding protein 39
chr3_+_114192489	0.842	NM_014170 NM_138485	GTPBP8	GTP-binding protein 8 (putative)
chr14_-_44673408	0.839		FKBP3	FK506 binding protein 3, 25kDa
chr17_+_57909979	0.835	NM_001112707 NM_006852	TLK2	tousled-like kinase 2
chr21_-_30666417	0.833	NM_181621	KRTAP13-2	keratin associated protein 13-2
chr1_+_246167115	0.832	NM_175911	OR2L13	olfactory receptor, family 2, subfamily L, member 13
chr21_-_44784499	0.824	NM_198691	KRTAP10-1	keratin associated protein 10-1
chr13_-_71338144	0.820		DACH1	dachshund homolog 1 (Drosophila)
chr17_-_36528113	0.819	NM_033059	KRTAP4-11	keratin associated protein 4-11
chr6_+_147567200	0.818	NM_001127715 NM_139244	STXBP5	syntaxin binding protein 5 (tomosyn)
chr4_-_123073642	0.817	NM_003305	TRPC3	transient receptor potential cation channel, subfamily C, member 3
chr15_-_58671929	0.815	NM_134262	RORA	RAR-related orphan receptor A
chr13_-_71338558	0.812		DACH1	dachshund homolog 1 (Drosophila)
chr1_+_67168470	0.810	NM_001077701 NM_001077704	MIER1	mesoderm induction early response 1 homolog (Xenopus laevis)
chr18_+_9324820	0.808		TWSG1	twisted gastrulation homolog 1 (Drosophila)
chr2_+_137239583	0.808		THSD7B	thrombospondin, type I, domain containing 7B
chr19_+_12166829	0.807		LOC100289333	hypothetical LOC100289333
chr17_-_36451189	0.801	NM_030967	KRTAP1-3 KRTAP1-1	keratin associated protein 1-3 keratin associated protein 1-1
chr10_+_112247614	0.801	NM_004419	DUSP5	dual specificity phosphatase 5
chr17_+_59053518	0.798	NM_002401 NM_203351	MAP3K3	mitogen-activated protein kinase kinase kinase 3
chr3_+_43303005	0.797	NM_001100594 NM_017719	SNRK	SNF related kinase
chr3_+_114192467	0.796		GTPBP8	GTP-binding protein 8 (putative)
chr2_+_191454157	0.794		GLS	glutaminase
chr1_+_35507145	0.793	NM_005095	ZMYM4	zinc finger, MYM-type 4
chr10_+_93160066	0.791	NM_173497 NM_182765	HECTD2	HECT domain containing 2
chr10_+_89613071	0.789	NM_000314	PTEN	phosphatase and tensin homolog
chr2_-_230287442	0.788	NM_139072	DNER	delta/notch-like EGF repeat containing
chr15_+_83724743	0.786	NM_006738 NM_007200	AKAP13	A kinase (PRKA) anchor protein 13
chr4_-_168392307	0.781	NM_001040159 NM_016950	SPOCK3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr19_+_12166869	0.779
chr2_+_231285868	0.772		CAB39	calcium binding protein 39
chr15_-_60139857	0.768	NM_001018088 NM_017684 NM_018080 NM_020821	VPS13C	vacuolar protein sorting 13 homolog C (S. cerevisiae)
chr14_-_44673418	0.768	NM_002013	FKBP3	FK506 binding protein 3, 25kDa
chr15_-_29950070	0.763		OTUD7A	OTU domain containing 7A
chr9_-_21999270	0.759	NM_004936 NM_078487	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr5_+_49998528	0.758	NM_001178056 NM_024615	PARP8	poly (ADP-ribose) polymerase family, member 8
chr9_+_109085372	0.757		RAD23B	RAD23 homolog B (S. cerevisiae)
chr14_+_75688042	0.749		C14orf118	chromosome 14 open reading frame 118
chr6_+_127629677	0.749	NM_030963	RNF146	ring finger protein 146
chr9_+_109085337	0.745	NM_002874	RAD23B	RAD23 homolog B (S. cerevisiae)
chr2_+_190981257	0.743	NM_017694	MFSD6	major facilitator superfamily domain containing 6
chr18_+_9324762	0.742	NM_020648	TWSG1	twisted gastrulation homolog 1 (Drosophila)
chr7_-_22363036	0.739	NM_012294	RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5
chr4_+_184257337	0.733	NM_024949	WWC2	WW and C2 domain containing 2
chr16_+_9093035	0.729	NM_014117	C16orf72	chromosome 16 open reading frame 72
chr3_+_57236816	0.727		APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr15_-_29950188	0.727		OTUD7A	OTU domain containing 7A
chr20_+_1154763	0.725	NM_001136566	RAD21L1	RAD21-like 1 (S. pombe)
chr3_-_135097111	0.721	NM_016577	RAB6B	RAB6B, member RAS oncogene family
chr3_+_57236769	0.721	NM_012096	APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr4_+_86968069	0.721		ARHGAP24	Rho GTPase activating protein 24
chr13_+_48692472	0.720	NM_001507	MLNR	motilin receptor
chr2_+_115635982	0.720	NM_001178034 NM_001004360	DPP10	dipeptidyl-peptidase 10 (non-functional)
chr9_-_83493415	0.720	NM_005077	TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr7_+_29200850	0.711		CHN2	chimerin (chimaerin) 2
chr9_-_21549696	0.709		LOC554202	hypothetical LOC554202
chr13_+_98951772	0.709		TM9SF2	transmembrane 9 superfamily member 2
chrX_-_1532648	0.709	NM_001173473	ASMTL	acetylserotonin O-methyltransferase-like
chr8_+_42129620	0.709	NM_001134296 NM_006803	AP3M2	adaptor-related protein complex 3, mu 2 subunit
chr16_+_9093072	0.702		C16orf72	chromosome 16 open reading frame 72
chr7_-_139408808	0.699		PARP12	poly (ADP-ribose) polymerase family, member 12
chr4_+_99401543	0.697	NM_001100426 NM_001100427 NM_001100428 NM_001100429 NM_001100430 NM_021159	RAP1GDS1	RAP1, GTP-GDP dissociation stimulator 1
chr4_-_168392266	0.694		SPOCK3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr2_+_47021816	0.693	NM_020458	TTC7A	tetratricopeptide repeat domain 7A
chr14_-_37795290	0.690	NM_175060	CLEC14A	C-type lectin domain family 14, member A
chr2_+_196229715	0.689	NM_001127257	SLC39A10	solute carrier family 39 (zinc transporter), member 10
chr4_-_120769275	0.687	NM_001083	PDE5A	phosphodiesterase 5A, cGMP-specific
chr20_+_34523555	0.687	NM_183006	DLGAP4	discs, large (Drosophila) homolog-associated protein 4
chr11_-_617172	0.686	NM_021920	SCT	secretin
chr9_+_109085643	0.686		RAD23B	RAD23 homolog B (S. cerevisiae)
chr6_+_89848229	0.686		PNRC1	proline-rich nuclear receptor coactivator 1
chr6_-_151754337	0.683	NM_020861	ZBTB2	zinc finger and BTB domain containing 2
chr13_-_35686665	0.680	NM_017826	SOHLH2	spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr4_+_55956877	0.673		TMEM165	transmembrane protein 165
chr13_+_23051426	0.670	NM_018647	TNFRSF19	tumor necrosis factor receptor superfamily, member 19
chr10_+_93160033	0.669
chr21_+_18539016	0.668	NM_024944	CHODL	chondrolectin

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.06	2.24e-04	GO:0009987	cellular process
1.24	3.85e-03	GO:0007399	nervous system development
1.23	4.94e-03	GO:0023051	regulation of signaling
1.10	6.29e-03	GO:0044237	cellular metabolic process
1.21	7.69e-03	GO:0006464	protein modification process
1.08	2.21e-02	GO:0050794	regulation of cellular process
1.30	2.30e-02	GO:0051128	regulation of cellular component organization
1.48	3.21e-02	GO:0032535	regulation of cellular component size
2.43	3.50e-02	GO:0043242	negative regulation of protein complex disassembly
2.06	4.07e-02	GO:0030832	regulation of actin filament length

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.09	3.86e-15	GO:0044424	intracellular part
1.09	6.21e-15	GO:0005622	intracellular
1.13	1.17e-14	GO:0005737	cytoplasm
1.08	2.15e-06	GO:0043226	organelle
1.08	2.86e-06	GO:0043229	intracellular organelle
1.11	5.26e-05	GO:0044444	cytoplasmic part
1.74	1.58e-03	GO:0005912	adherens junction
1.03	2.82e-03	GO:0044464	cell part
1.03	2.98e-03	GO:0005623	cell
1.60	2.97e-02	GO:0070161	anchoring junction
1.74	4.41e-02	GO:0005924	cell-substrate adherens junction

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.09	1.17e-04	GO:0005515	protein binding
1.05	1.72e-03	GO:0005488	binding
3.18	5.32e-03	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
1.63	3.19e-02	GO:0004721	phosphoprotein phosphatase activity
1.09	3.58e-02	GO:0003824	catalytic activity
1.28	4.57e-02	GO:0019899	enzyme binding