Motif ID: NKX2-1,4.p2

Z-value: 0.847


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_36058648-0.175.3e-01Click!
NKX2-4chr20_-_21326046-0.087.7e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_-_37211467 1.336 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chrX_+_78087484 1.279 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr1_+_180836050 1.242


chr4_-_185963859 0.723 ACSL1
acyl-CoA synthetase long-chain family member 1
chrX_+_46967360 0.719 NM_001170460
CDK16
cyclin-dependent kinase 16
chr11_+_66152309 0.635


chr14_-_94669547 0.622 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr22_-_27787793 0.562 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr9_+_102380156 0.562 NM_001018116
MURC
muscle-related coiled-coil protein
chr11_+_118259684 0.551 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chrX_-_33139349 0.535 NM_004006
DMD
dystrophin
chr4_-_174774368 0.524 NM_006792
MORF4
mortality factor 4
chrX_+_71280758 0.506 NM_207422
FLJ44635
TPT1-like protein
chr9_-_33385265 0.495 AQP7
aquaporin 7
chrX_-_131989963 0.484 NM_031907
USP26
ubiquitin specific peptidase 26
chr20_-_1298493 0.479 FKBP1A
FK506 binding protein 1A, 12kDa
chr2_-_37727472 0.446 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr2_-_100125402 0.444 NM_002285
AFF3
AF4/FMR2 family, member 3
chr4_+_102954005 0.439 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr11_+_57554977 0.439 NM_001005186
OR6Q1
olfactory receptor, family 6, subfamily Q, member 1
chr7_+_129720209 0.426 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr10_-_104201234 0.423 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr5_-_88004891 0.417 LOC645323
hypothetical LOC645323
chr17_-_7434113 0.414 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chrX_-_110542040 0.412 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr6_+_101953389 0.411 GRIK2
glutamate receptor, ionotropic, kainate 2
chr10_+_123744131 0.407 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_-_151852128 0.402 NM_080388
S100A16
S100 calcium binding protein A16
chr12_-_110410730 0.392 ATXN2
ataxin 2
chr4_+_111053488 0.391 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr11_-_16380967 0.389 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chrX_+_54963953 0.386 NM_001039705
NM_016157
NM_177556
TRO


trophinin


chr11_+_59979857 0.374 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chrX_+_128966844 0.371 NM_021946
BCORL1
BCL6 corepressor-like 1
chr16_+_70646008 0.366 NM_001126102
NM_005143
HP

haptoglobin

chr2_-_104834344 0.364 LOC100506421
hypothetical LOC100506421
chrX_+_70682204 0.362 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chrX_+_144716619 0.356 NM_004709
CXorf1
chromosome X open reading frame 1
chrX_-_100920493 0.354 GK
glycerol kinase
chr19_-_10152056 0.349


chr10_-_32707549 0.330 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr8_-_30826074 0.329 NM_031271
TEX15
testis expressed 15
chr5_-_134810696 0.326 NM_130848
C5orf20
chromosome 5 open reading frame 20
chrX_+_48427103 0.324 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chrX_+_41468351 0.319 NM_080817
GPR82
G protein-coupled receptor 82
chr4_+_37638450 0.309 NM_006607
PTTG2
pituitary tumor-transforming 2
chr15_-_29734833 0.307 NM_130901
OTUD7A
OTU domain containing 7A
chr1_-_201465395 0.304 NM_003465
CHIT1
chitinase 1 (chitotriosidase)
chr11_+_34599163 0.301 NM_012153
EHF
ets homologous factor
chr8_-_82536312 0.300 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr18_-_44723116 0.298 NM_001190823
SMAD7
SMAD family member 7
chr1_+_226462363 0.297 NM_001098623
NM_052843
OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

chr3_-_69120188 0.294 C3orf64
chromosome 3 open reading frame 64
chr4_-_100359353 0.291 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr15_+_78520634 0.290 ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr19_-_15906669 0.289 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr9_+_114671635 0.286 SNX30
sorting nexin family member 30
chr5_+_131424245 0.285 NM_000588
IL3
interleukin 3 (colony-stimulating factor, multiple)
chr13_+_110637173 0.283 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr1_-_43168247 0.282 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr11_-_57643491 0.281 NM_001005211
OR9I1
olfactory receptor, family 9, subfamily I, member 1
chr11_+_34599227 0.277 EHF
ets homologous factor
chr12_+_1608672 0.275 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chr9_+_135994734 0.274 NM_052821
WDR5
WD repeat domain 5
chrX_-_154216929 0.274 NM_001289
CLIC2
chloride intracellular channel 2
chr12_+_108310906 0.269 NM_001101421
MYO1H
myosin IH
chr3_-_127810087 0.267 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr17_+_71235324 0.266 ITGB4
integrin, beta 4
chr17_-_10393664 0.263 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr4_+_114433551 0.261 ANK2
ankyrin 2, neuronal
chrX_+_111005934 0.259 NM_001195576
NM_001195578
LOC100329135

hypothetical LOC100329135

chrX_-_137649180 0.257 NM_033642
FGF13
fibroblast growth factor 13
chr1_-_21478571 0.249 NM_001113347
ECE1
endothelin converting enzyme 1
chr16_+_510732 0.248 RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr2_+_161701711 0.243 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr19_-_50688310 0.243 NM_206901
RTN2
reticulon 2
chr17_+_7846636 0.238 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr13_-_35842289 0.238 NM_001142294
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr9_+_126158935 0.232


chr14_+_63752424 0.229 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr2_+_161980865 0.225 NM_006593
TBR1
T-box, brain, 1
chr2_-_217433018 0.224 NM_003284
TNP1
transition protein 1 (during histone to protamine replacement)
chr9_+_130485754 0.223 NM_001122821
SET
SET nuclear oncogene
chr8_+_62363078 0.223 NM_173519
CLVS1
clavesin 1
chr9_-_124329392 0.219 NM_012363
OR1N1
olfactory receptor, family 1, subfamily N, member 1
chr7_+_38984133 0.218 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr1_-_13325242 0.215 NM_001099854
PRAMEF14
PRAME family member 14
chr3_-_197103848 0.213 TNK2
tyrosine kinase, non-receptor, 2
chr16_+_3002457 0.210 NM_020982
CLDN9
claudin 9
chr1_+_144124547 0.206 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr19_+_50196526 0.205 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr17_+_7563763 0.205 NM_020877
DNAH2
dynein, axonemal, heavy chain 2
chr3_+_191588354 0.205 NM_006580
CLDN16
claudin 16
chr5_-_131907071 0.200 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr11_+_63775567 0.198 NM_000932
NM_001184883
PLCB3

phospholipase C, beta 3 (phosphatidylinositol-specific)

chr17_+_69875140 0.198 NM_181790
GPR142
G protein-coupled receptor 142
chr9_+_130485926 0.197 SET
SET nuclear oncogene
chr16_+_11966464 0.196 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr10_-_127454379 0.196 NM_147191
MMP21
matrix metallopeptidase 21
chr6_-_155818728 0.195 NM_015718
NOX3
NADPH oxidase 3
chr15_-_53350383 0.194 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr15_+_38430517 0.194 NM_001145643
PHGR1
proline/histidine/glycine-rich 1
chr1_-_12880674 0.192 NM_001039361
PRAMEF10
PRAME family member 10
chrX_-_138617994 0.190 NM_001099855
NM_001171876
MCF2

MCF.2 cell line derived transforming sequence

chr6_-_88917600 0.189 NM_001160260
CNR1
cannabinoid receptor 1 (brain)
chr1_+_156590109 0.188 NM_001042583
NM_001042584
NM_001042585
NM_001042586
NM_001042587
NM_001185107
NM_001185108
NM_001185110
NM_001185112
NM_001185113
NM_001185114
NM_001185115
NM_030893
CD1E












CD1e molecule












chrX_-_108611940 0.188 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chrX_-_84250629 0.188 NM_001012980
SATL1
spermidine/spermine N1-acetyl transferase-like 1
chr4_+_70896236 0.186 NM_001009181
NM_003154
STATH

statherin

chr9_-_72926333 0.186 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr1_+_159817752 0.186 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chrX_+_105823723 0.184 NM_024539
RNF128
ring finger protein 128
chr15_-_81271859 0.184 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr5_+_140166842 0.184 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr11_+_65740789 0.183 PACS1
phosphofurin acidic cluster sorting protein 1
chr1_-_89364273 0.183 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr4_-_24590867 0.182 NM_173463
CCDC149
coiled-coil domain containing 149
chr2_-_242205556 0.182 NM_001164356
THAP4
THAP domain containing 4
chr3_-_121445831 0.182 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr5_-_22248630 0.182 CDH12
cadherin 12, type 2 (N-cadherin 2)
chrX_-_72351381 0.180 NAP1L2
nucleosome assembly protein 1-like 2
chr9_-_21472311 0.179 NM_176891
IFNE
interferon, epsilon
chr17_+_20048890 0.178 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr4_-_21155376 0.177 NM_001035004
KCNIP4
Kv channel interacting protein 4
chrX_+_77889861 0.176 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr8_-_7207899 0.176 NM_001164457
ZNF705G
zinc finger protein 705G
chr4_-_100492854 0.176 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr2_-_74235860 0.175


chr3_-_48646282 0.173 NM_001040454
SLC26A6
solute carrier family 26, member 6
chr5_-_111119846 0.172 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chrX_+_69371229 0.172 NM_001013579
AWAT1
acyl-CoA wax alcohol acyltransferase 1
chr17_-_31353196 0.170 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr9_-_3213007 0.168


chr10_+_118295417 0.168 NM_000936
PNLIP
pancreatic lipase
chrX_-_72351392 0.167 NM_021963
NAP1L2
nucleosome assembly protein 1-like 2
chrX_-_109570113 0.165 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr17_+_63346625 0.161 BPTF
bromodomain PHD finger transcription factor
chr9_-_111230926 0.161 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr5_-_88155360 0.159 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr2_+_28892366 0.158 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr3_-_127719283 0.158 NM_001165974
NM_144639
UROC1

urocanase domain containing 1

chr7_-_107230867 0.157 NM_000111
SLC26A3
solute carrier family 26, member 3
chr5_-_147996769 0.156 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr5_-_137882303 0.155 ETF1
eukaryotic translation termination factor 1
chr12_+_130004404 0.153 NM_198827
GPR133
G protein-coupled receptor 133
chr11_+_56705796 0.153 NM_001005210
LRRC55
leucine rich repeat containing 55
chr5_-_101862447 0.153 NM_173488
SLCO6A1
solute carrier organic anion transporter family, member 6A1
chr11_-_119499188 0.149 TRIM29
tripartite motif containing 29
chr22_-_40856821 0.148 NM_000106
NM_001025161
CYP2D6

cytochrome P450, family 2, subfamily D, polypeptide 6

chrX_-_100999204 0.147 NM_032946
NXF5
nuclear RNA export factor 5
chr3_+_190831909 0.147 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chrX_+_106048245 0.146 NM_001171095
CLDN2
claudin 2
chr16_+_70654625 0.146 NM_020995
HPR
haptoglobin-related protein
chr3_+_46894239 0.144 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr14_+_51025604 0.143 NM_001042481
FRMD6
FERM domain containing 6
chr8_-_134156437 0.142 SLA
Src-like-adaptor
chr3_-_188492163 0.141 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chrX_-_83644054 0.141 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr1_-_156937065 0.140 NM_001005279
OR6K2
olfactory receptor, family 6, subfamily K, member 2
chr11_+_63775572 0.139 PLCB3
phospholipase C, beta 3 (phosphatidylinositol-specific)
chr5_+_147423727 0.139 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr4_-_77547481 0.139 NM_001042784
CCDC158
coiled-coil domain containing 158
chrX_-_85189194 0.139 NM_000390
NM_001145414
CHM

choroideremia (Rab escort protein 1)

chr21_-_31049566 0.138 NM_181619
KRTAP21-1
keratin associated protein 21-1
chr7_-_108311872 0.137 NM_001024607
C7orf66
chromosome 7 open reading frame 66
chr12_-_94914133 0.136 NM_002108
HAL
histidine ammonia-lyase
chrX_+_48427137 0.135 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr11_-_66431910 0.135 NM_022172
PC
pyruvate carboxylase
chr11_+_6823458 0.134 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr14_+_75058518 0.134 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr11_-_113971681 0.129 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr17_+_39990124 0.128 NM_001466
FZD2
frizzled homolog 2 (Drosophila)
chr1_+_169747788 0.128 PRRC2C
proline-rich coiled-coil 2C
chrX_+_135558001 0.128 NM_000074
CD40LG
CD40 ligand
chr12_+_48737753 0.126 NM_001095
NM_020039
ACCN2

amiloride-sensitive cation channel 2, neuronal

chr2_+_178893216 0.125 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr1_-_195302973 0.125 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr1_-_238842071 0.125 NM_022469
GREM2
gremlin 2
chr12_+_21481804 0.124 NM_024854
PYROXD1
pyridine nucleotide-disulphide oxidoreductase domain 1
chr8_-_72431274 0.123 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr9_+_108726257 0.123 ZNF462
zinc finger protein 462
chr12_+_102859354 0.122 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr4_+_54790020 0.121 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr5_-_93102952 0.119 NM_153216
POU5F2
POU domain class 5, transcription factor 2
chr19_+_46640902 0.118 NM_001130514
C19orf69
chromosome 19 open reading frame 69
chr14_+_55148488 0.118 KTN1
kinectin 1 (kinesin receptor)
chrX_+_41433169 0.116 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr6_-_76838944 0.116 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr4_-_123761615 0.114 NM_021803
IL21
interleukin 21
chr21_-_31123797 0.114 NM_181606
KRTAP7-1
keratin associated protein 7-1 (gene/pseudogene)
chr8_+_124264054 0.113 FAM83A
family with sequence similarity 83, member A
chr6_+_83129641 0.112 NM_006670
TPBG
trophoblast glycoprotein
chr14_-_56342097 0.112 NM_172337
OTX2
orthodenticle homeobox 2
chr17_-_1211263 0.110 YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr7_+_29840865 0.109 NM_001080529
WIPF3
WAS/WASL interacting protein family, member 3
chr4_-_68678181 0.109 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chrX_+_119622570 0.109 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chrX_-_72351348 0.108 NAP1L2
nucleosome assembly protein 1-like 2
chr3_-_51971915 0.108 NM_033010
PCBP4
poly(rC) binding protein 4
chr1_+_159899528 0.106 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.40 2.32e-04 GO:0032501 multicellular organismal process
1.50 1.73e-03 GO:0007275 multicellular organismal development
1.31 5.47e-03 GO:0050896 response to stimulus
2.44 1.13e-02 GO:0001775 cell activation
1.48 1.33e-02 GO:0048856 anatomical structure development
3.41 1.79e-02 GO:0046649 lymphocyte activation
1.42 1.81e-02 GO:0032502 developmental process
1.50 1.96e-02 GO:0048731 system development
2.05 4.13e-02 GO:0006955 immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.29 1.12e-03 GO:0031968 organelle outer membrane
4.16 1.65e-03 GO:0019867 outer membrane
1.35 1.29e-02 GO:0071944 cell periphery
1.35 1.48e-02 GO:0005886 plasma membrane
3.84 1.62e-02 GO:0030016 myofibril
3.62 2.85e-02 GO:0043292 contractile fiber
1.75 4.01e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.98 7.20e-03 GO:0004930 G-protein coupled receptor activity
1.55 1.43e-02 GO:0004871 signal transducer activity
1.55 1.43e-02 GO:0060089 molecular transducer activity