Motif ID: NKX2-1,4.p2

Z-value: 0.847


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_36058648-0.175.3e-01Click!
NKX2-4chr20_-_21326046-0.087.7e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_-_37211467 1.336 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chrX_+_78087484 1.279 NM_014499
NM_198333
 P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr1_+_180836050 1.242


chr4_-_185963859 0.723 ACSL1
acyl-CoA synthetase long-chain family member 1
chrX_+_46967360 0.719 NM_001170460
 CDK16
cyclin-dependent kinase 16
chr11_+_66152309 0.635


chr14_-_94669547 0.622 NM_001195573
 DICER1
dicer 1, ribonuclease type III
chr22_-_27787793 0.562 NM_015370
 C22orf31
chromosome 22 open reading frame 31
chr9_+_102380156 0.562 NM_001018116
 MURC
muscle-related coiled-coil protein
chr11_+_118259684 0.551 NM_001716
 CXCR5
chemokine (C-X-C motif) receptor 5
chrX_-_33139349 0.535 NM_004006
 DMD
dystrophin
chr4_-_174774368 0.524 NM_006792
 MORF4
mortality factor 4
chrX_+_71280758 0.506 NM_207422
 FLJ44635
TPT1-like protein
chr9_-_33385265 0.495 AQP7
aquaporin 7
chrX_-_131989963 0.484 NM_031907
 USP26
ubiquitin specific peptidase 26
chr20_-_1298493 0.479 FKBP1A
FK506 binding protein 1A, 12kDa
chr2_-_37727472 0.446 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr2_-_100125402 0.444 NM_002285
 AFF3
AF4/FMR2 family, member 3
chr4_+_102954005 0.439 NM_001083907
 BANK1
B-cell scaffold protein with ankyrin repeats 1
chr11_+_57554977 0.439 NM_001005186
 OR6Q1
olfactory receptor, family 6, subfamily Q, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
3.41 1.79e-02 GO:0046649 lymphocyte activation
2.44 1.13e-02 GO:0001775 cell activation
2.05 4.13e-02 GO:0006955 immune response
1.50 1.73e-03 GO:0007275 multicellular organismal development
1.50 1.96e-02 GO:0048731 system development
1.48 1.33e-02 GO:0048856 anatomical structure development
1.42 1.81e-02 GO:0032502 developmental process
1.40 2.32e-04 GO:0032501 multicellular organismal process
1.31 5.47e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
4.29 1.12e-03 GO:0031968 organelle outer membrane
4.16 1.65e-03 GO:0019867 outer membrane
3.84 1.62e-02 GO:0030016 myofibril
3.62 2.85e-02 GO:0043292 contractile fiber
1.75 4.01e-02 GO:0044421 extracellular region part
1.35 1.29e-02 GO:0071944 cell periphery
1.35 1.48e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.98 7.20e-03 GO:0004930 G-protein coupled receptor activity
1.55 1.43e-02 GO:0004871 signal transducer activity
1.55 1.43e-02 GO:0060089 molecular transducer activity